Ugt1a7c (UDP glucuronosyltransferase 1 family, polypeptide A7C) - Rat Genome Database

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Gene: Ugt1a7c (UDP glucuronosyltransferase 1 family, polypeptide A7C) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ugt1a7c (Ensembl: Ugt1a5)
Name: UDP glucuronosyltransferase 1 family, polypeptide A7C (Ensembl:UDP glucuronosyltransferase family 1 member A5)
RGD ID: 620950
Description: Enables glucuronosyltransferase activity. Involved in several processes, including coumarin catabolic process; estrogen catabolic process; and response to 3-methylcholanthrene. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in alcoholic pancreatitis and pancreatic cancer. Orthologous to several human genes including UGT1A10 (UDP glucuronosyltransferase family 1 member A10); UGT1A7 (UDP glucuronosyltransferase family 1 member A7); and UGT1A8 (UDP glucuronosyltransferase family 1 member A8); PARTICIPATES IN ascorbate and aldarate metabolic pathway; O-linked glycan biosynthetic pathway; pentose and glucuronate interconversion pathway; INTERACTS WITH 1-naphthol; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A2; UDP glucuronosyltransferase 1A7; UDP glycosyltransferase 1 family, polypeptide A7; UDP-glucuronosyltransferase 1-7; UDP-glucuronosyltransferase 1A7; UDP-glucuronosyltransferase 1A7C; UDPGT; UDPGT 1-7; Ugt1; UGT1*7; UGT1-07; UGT1.7; Ugt1a7; Ugt1a8
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8996,187,382 - 96,256,264 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl996,144,786 - 96,256,264 (+)EnsemblGRCr8
mRatBN7.2988,739,577 - 88,808,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx997,163,558 - 97,232,360 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09102,299,750 - 102,368,552 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,667,775 - 100,736,659 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0995,233,957 - 95,302,822 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)Ensemblrn6Rnor6.0
Rnor_5.0994,921,740 - 94,990,037 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4987,029,500 - 87,098,362 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera986,300,921 - 86,369,556 (+)NCBICelera
RGSC_v3.1987,214,921 - 87,284,238 (+)NCBI
Cytogenetic Map9q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mono- and Diglucuronide formation from benzopyrene and chrysene diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase UGT1A7. Bock KW, etal., Biochem Pharmacol. 1999 Mar 15;57(6):653-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Distribution and inducibility by 3-methylcholanthrene of family 1 UDP-glucuronosyltransferases in the rat gastrointestinal tract. Grams B, etal., Arch Biochem Biophys. 2000 May 15;377(2):255-65.
4. Identification of a rat oltipraz-inducible UDP-glucuronosyltransferase (UGT1A7) with activity towards benzo(a)pyrene-7,8-dihydrodiol. Grove AD, etal., J Biol Chem 1997 Jan 17;272(3):1621-7.
5. Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases. Kessler FK, etal., Drug Metab Dispos 2002 Mar;30(3):324-30.
6. Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver. Kishi M, etal., Biochem Biophys Res Commun. 2008 Dec 19;377(3):815-9. Epub 2008 Oct 18.
7. Transcriptional activation of the UDP-glucuronosyltransferase 1A7 gene in rat liver by aryl hydrocarbon receptor ligands and oltipraz. Metz RP and Ritter JK, J Biol Chem 1998 Mar 6;273(10):5607-14.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. UDP glucuronosyltransferase (UGT1A7) gene polymorphisms increase the risk of chronic pancreatitis and pancreatic cancer. Ockenga J, etal., Gastroenterology. 2003 Jun;124(7):1802-8.
10. Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients. Piepoli A, etal., World J Gastroenterol. 2006 Oct 21;12(39):6343-8.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation. Vansell NR and Klaassen CD, Drug Metab Dispos. 2002 Mar;30(3):240-6.
16. Analysis of substrate specificities and tissue expression of rat UDP-glucuronosyltransferases UGT1A7 and UGT1A8. Webb LJ, etal., Drug Metab Dispos. 2005 Jan;33(1):77-82. Epub 2004 Oct 22.
17. Dysregulations of intestinal and colonic UDP-glucuronosyltransferases in rats with type 2 diabetes. Xie H, etal., Drug Metab Pharmacokinet. 2013;28(5):427-34. Epub 2013 Apr 2.
18. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, etal., Genome Res 2004 Jan;14(1):79-89. Epub 2003 Dec 12.
Additional References at PubMed
PMID:2112380   PMID:7608130   PMID:16141793   PMID:22846377   PMID:24694608  


Genomics

Variants

.
Variants in Ugt1a7c
696 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat

Markers in Region
D9Mco15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,786,718 - 88,787,007 (+)MAPPERmRatBN7.2
Rnor_6.0995,281,097 - 95,281,383NCBIRnor6.0
Rnor_5.0994,968,312 - 94,968,598UniSTSRnor5.0
RGSC_v3.4987,076,637 - 87,076,923UniSTSRGSC3.4
Celera986,348,016 - 86,348,299UniSTS
Cytogenetic Map9q35UniSTS
D9Wox40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,786,755 - 88,786,956 (+)MAPPERmRatBN7.2
Rnor_6.0995,281,134 - 95,281,332NCBIRnor6.0
Rnor_5.0994,968,349 - 94,968,547UniSTSRnor5.0
RGSC_v3.4987,076,674 - 87,076,872UniSTSRGSC3.4
Celera986,348,053 - 86,348,248UniSTS
Cytogenetic Map9q35UniSTS
RH130767  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,795,599 - 88,795,779 (+)MAPPERmRatBN7.2
Rnor_6.0995,289,976 - 95,290,155NCBIRnor6.0
Rnor_5.0994,977,191 - 94,977,370UniSTSRnor5.0
RGSC_v3.4987,085,516 - 87,085,695UniSTSRGSC3.4
Celera986,356,892 - 86,357,071UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map9q35-q36UniSTS
RH94830  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8996,255,939 - 96,256,140 (+)Marker Load Pipeline
mRatBN7.2988,808,140 - 88,808,341 (+)MAPPERmRatBN7.2
Rnor_6.0995,302,498 - 95,302,698NCBIRnor6.0
Rnor_5.0994,989,713 - 94,989,913UniSTSRnor5.0
RGSC_v3.4987,098,038 - 87,098,238UniSTSRGSC3.4
Celera986,369,232 - 86,369,432UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map9q35-q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 46 67 136 95 11 45 34 32 11 11

Sequence


RefSeq Acc Id: NM_130407   ⟹   NP_569091
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8996,187,382 - 96,256,264 (+)NCBI
mRatBN7.2988,739,577 - 88,808,465 (+)NCBI
Rnor_6.0995,233,957 - 95,302,822 (+)NCBI
Rnor_5.0994,921,740 - 94,990,037 (+)NCBI
RGSC_v3.4987,029,500 - 87,098,362 (+)RGD
Celera986,300,921 - 86,369,556 (+)RGD
Sequence:
RefSeq Acc Id: NP_569091   ⟸   NM_130407
- Peptide Label: precursor
- UniProtKB: Q6T5E8 (UniProtKB/TrEMBL),   A6JQH7 (UniProtKB/TrEMBL),   Q8VD43 (UniProtKB/TrEMBL),   F7F4L9 (UniProtKB/TrEMBL)
- Sequence:

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64633-F1-model_v2 AlphaFold Q64633 1-531 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696842
Promoter ID:EPDNEW_R7366
Type:initiation region
Name:Ugt1a7c_2
Description:UDP glucuronosyltransferase 1 family, polypeptide A7C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7367  EPDNEW_R7368  EPDNEW_R7370  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0995,233,922 - 95,233,982EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620950 AgrOrtholog
BioCyc Gene G2FUF-26826 BioCyc
Ensembl Genes ENSRNOG00000018740 Ensembl
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7127030 IMAGE-MGC_LOAD
InterPro UDP-glycosyltransferase UniProtKB/Swiss-Prot
  UDP_glucos_trans UniProtKB/Swiss-Prot
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot
MGC_CLONE MGC:93181 IMAGE-MGC_LOAD
NCBI Gene 154516 ENTREZGENE
PANTHER EG:EG0003.4 PROTEIN-RELATED UniProtKB/Swiss-Prot
  UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A1 UniProtKB/Swiss-Prot
Pfam UDPGT UniProtKB/Swiss-Prot
PhenoGen Ugt1a7c PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018740 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot
UniProt A6JQH7 ENTREZGENE, UniProtKB/TrEMBL
  F7EKA4_RAT UniProtKB/TrEMBL
  F7F4L9 ENTREZGENE, UniProtKB/TrEMBL
  Q64633 ENTREZGENE
  Q68G32_RAT UniProtKB/TrEMBL
  Q6T5E8 ENTREZGENE
  Q6T5E9_RAT UniProtKB/TrEMBL
  Q8VD43 ENTREZGENE, UniProtKB/TrEMBL
  UD17_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-31 Ugt1a7c  UDP glucuronosyltransferase 1 family, polypeptide A7C  Ugt1a7  UDP glycosyltransferase 1 family, polypeptide A7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Ugt1a7  UDP glycosyltransferase 1 family, polypeptide A7      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ugt1a7  UDP glycosyltransferase 1 family, polypeptide A7      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression and enzymatic activity are upregulated by xenobiotics beta-naphthoflavone or 4-methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione (oltipraz) 634474