Txnip (thioredoxin interacting protein) - Rat Genome Database

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Gene: Txnip (thioredoxin interacting protein) Rattus norvegicus
Analyze
Symbol: Txnip
Name: thioredoxin interacting protein
RGD ID: 620886
Description: Predicted to enable enzyme inhibitor activity and ubiquitin protein ligase binding activity. Involved in several processes, including response to estradiol; response to hydrogen peroxide; and response to progesterone. Predicted to be active in cytoplasm. Used to study renal cell carcinoma. Biomarker of colorectal cancer; glaucoma; and stomach cancer. Orthologous to human TXNIP (thioredoxin interacting protein); INTERACTS WITH (S)-colchicine; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC94673; thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; Vdup1; vitamin D3 up-regulated protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,781,933 - 186,785,736 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2186,781,163 - 186,785,731 (+)EnsemblGRCr8
mRatBN7.22184,093,079 - 184,096,882 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,092,991 - 184,096,886 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2191,764,537 - 191,768,337 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,557,131 - 189,560,931 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,397,095 - 184,400,895 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,683,168 - 198,686,971 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,683,159 - 198,686,974 (+)Ensemblrn6Rnor6.0
Rnor_5.02218,170,102 - 218,173,905 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42191,356,954 - 191,360,757 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2176,618,301 - 176,622,104 (+)NCBICelera
RGSC_v3.12191,319,631 - 191,323,506 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(-)-demecolcine  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (ISO)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
aconitine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
Aflatoxin G1  (ISO)
Aflatoxin G2  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP,ISO)
allose  (ISO)
alpha-D-galactose  (ISO)
AM-251  (ISO)
amphotericin B  (ISO)
andrographolide  (ISO)
anthocyanin  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (EXP)
atrazine  (ISO)
aucubin  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
baicalin  (ISO)
barium sulfate  (EXP)
beauvericin  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
ceric oxide  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
Cinobufagin  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
Clofop  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethyl maleate  (EXP)
diethyl phthalate  (ISO)
difenoconazole  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
enniatin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
estriol  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
Evodiamine  (EXP)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
fentin chloride  (EXP)
fipronil  (EXP)
fluoranthene  (ISO)
flusilazole  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
formononetin  (ISO)
fructose  (EXP)
furan  (EXP)
galactose  (ISO)
Ganoderic acid A  (ISO)
gedunin  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroxychloroquine  (ISO)
indometacin  (ISO)
inulin  (ISO)
ionomycin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron dextran  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isobutanol  (ISO)
isoprenaline  (EXP)
ketamine  (EXP)
L-ascorbic acid  (EXP)
lead diacetate  (EXP,ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lutein  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
menadione  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
Muraglitazar  (EXP)
N(4)-hydroxycytidine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-ethyl-5'-carboxamidoadenosine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
NMN zwitterion  (EXP,ISO)
nobiletin  (EXP,ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
progesterone  (EXP,ISO)
propiconazole  (EXP,ISO)
propylparaben  (ISO)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
Ruscogenin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (EXP,ISO)
SB 431542  (ISO)
Securinine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
tributylstannane  (EXP)
tricalcium bis(phosphate)  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
verapamil  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein. Chen J, etal., Biochem Biophys Res Commun. 2006 Aug 4;346(3):1067-74. Epub 2006 Jun 13.
2. Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis. Dutta KK, etal., Lab Invest. 2005 Jun;85(6):798-807.
3. Identification of novel differentially expressed genes by the effect of a high-fat n-6 diet in experimental breast cancer. Escrich E, etal., Mol Carcinog. 2004 Jun;40(2):73-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured Rat-1 fibroblasts. Hirota T, etal., J Biol Chem 2002 Nov 15;277(46):44244-51.
6. Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals. Hui TY, etal., J Biol Chem. 2004 Jun 4;279(23):24387-93. Epub 2004 Mar 26.
7. Vitamin D3 up-regulated protein 1 (VDUP1) expression in gastrointestinal cancer and its relation to stage of disease. Ikarashi M, etal., Anticancer Res. 2002 Nov-Dec;22(6C):4045-8.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Deletion of Thioredoxin-interacting protein ameliorates high fat diet-induced non-alcoholic steatohepatitis through modulation of Toll-like receptor 2-NLRP3-inflammasome axis: Histological and immunohistochemical study. Mohamed IN, etal., Acta Histochem. 2018 Apr;120(3):242-254. doi: 10.1016/j.acthis.2018.02.006. Epub 2018 Feb 23.
10. Redox proteins thioredoxin 1 and thioredoxin 2 support retinal ganglion cell survival in experimental glaucoma. Munemasa Y, etal., Gene Ther. 2009 Jan;16(1):17-25. Epub 2008 Aug 14.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. High glucose-induced thioredoxin-interacting protein in renal proximal tubule cells is independent of transforming growth factor-beta1. Qi W, etal., Am J Pathol. 2007 Sep;171(3):744-54. Epub 2007 Aug 3.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Rapid induction and Ca(2+) influx-mediated suppression of vitamin D3 up-regulated protein 1 (VDUP1) mRNA in cerebellar granule neurons undergoing apoptosis. Saitoh T, etal., J Neurochem. 2001 Sep;78(6):1267-76.
18. Rat endometrial Vdup1 expression: changes related to sensitization for the decidual cell reaction and hormonal control. Simmons DG and Kennedy TG, Reproduction. 2004 Apr;127(4):475-82.
19. Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus. van Greevenbroek MM, etal., Diabet Med. 2007 May;24(5):498-504. Epub 2007 Mar 22.
20. Vitamin D(3)-up-regulated protein-1 is a stress-responsive gene that regulates cardiomyocyte viability through interaction with thioredoxin. Wang Y, etal., J Biol Chem 2002 Jul 19;277(29):26496-500.
21. Catalytic degradation of vitamin D up-regulated protein 1 mRNA enhances cardiomyocyte survival and prevents left ventricular remodeling after myocardial ischemia. Xiang G, etal., J Biol Chem. 2005 Nov 25;280(47):39394-402. Epub 2005 Sep 19.
22. Alteration of gene expression in rat mammary tumors induced by N-methyl-N-nitrosourea. Young LH, etal., Mol Carcinog 1996 Apr;15(4):251-60.
Additional References at PubMed
PMID:10843682   PMID:12477932   PMID:14632196   PMID:15123525   PMID:15128745   PMID:15489334   PMID:15520447   PMID:16938273   PMID:16983998   PMID:17023680   PMID:17143286   PMID:18541147  
PMID:18555775   PMID:19337063   PMID:19562690   PMID:19808645   PMID:19824090   PMID:19875615   PMID:19959470   PMID:20068034   PMID:20709139   PMID:20953987   PMID:21098642   PMID:21364670  
PMID:21434880   PMID:22194917   PMID:22474421   PMID:22871113   PMID:23305039   PMID:23353834   PMID:23647015   PMID:23803610   PMID:24201577   PMID:24925443   PMID:25054130   PMID:25391656  
PMID:25602171   PMID:25639671   PMID:25996168   PMID:26133299   PMID:26154105   PMID:26196303   PMID:26796253   PMID:26858253   PMID:26881256   PMID:27345365   PMID:27381856   PMID:27989964  
PMID:28420192   PMID:28490373   PMID:28492550   PMID:29110407   PMID:29792552   PMID:29905889   PMID:31017263   PMID:31173172   PMID:31344482   PMID:31505737   PMID:31652453   PMID:31763668  
PMID:31982825   PMID:31998437   PMID:32476292   PMID:32950473   PMID:32980492   PMID:33412212   PMID:33638792   PMID:34162834   PMID:34517790   PMID:35562171   PMID:36642539   PMID:37749991  
PMID:37814350   PMID:38614227  


Genomics

Comparative Map Data
Txnip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,781,933 - 186,785,736 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2186,781,163 - 186,785,731 (+)EnsemblGRCr8
mRatBN7.22184,093,079 - 184,096,882 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,092,991 - 184,096,886 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2191,764,537 - 191,768,337 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,557,131 - 189,560,931 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,397,095 - 184,400,895 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,683,168 - 198,686,971 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,683,159 - 198,686,974 (+)Ensemblrn6Rnor6.0
Rnor_5.02218,170,102 - 218,173,905 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42191,356,954 - 191,360,757 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2176,618,301 - 176,622,104 (+)NCBICelera
RGSC_v3.12191,319,631 - 191,323,506 (+)NCBI
Cytogenetic Map2q34NCBI
TXNIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381145,992,435 - 145,996,579 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1145,992,435 - 145,996,580 (-)Ensemblhg38GRCh38
GRCh371145,438,490 - 145,442,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361144,149,939 - 144,153,882 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341142,927,625 - 142,931,567NCBI
Celera1119,641,815 - 119,645,987 (+)NCBICelera
Cytogenetic Map1q21.1NCBI
HuRef1119,402,325 - 119,406,521 (+)NCBIHuRef
CHM1_11147,360,561 - 147,364,757 (-)NCBICHM1_1
T2T-CHM13v2.01145,109,270 - 145,113,414 (-)NCBIT2T-CHM13v2.0
Txnip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,465,273 - 96,469,173 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,465,273 - 96,469,199 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38396,557,957 - 96,561,857 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,557,957 - 96,561,883 (+)Ensemblmm10GRCm38
MGSCv37396,361,880 - 96,365,780 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36396,643,362 - 96,647,271 (+)NCBIMGSCv36mm8
Celera397,964,967 - 97,968,875 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.93NCBI
Txnip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955568103,762 - 107,785 (+)Ensembl
ChiLan1.0NW_004955568103,801 - 107,791 (+)NCBIChiLan1.0ChiLan1.0
LOC100971374
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21105,244,606 - 105,248,842 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11104,844,009 - 104,850,270 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0190,007,878 - 90,012,055 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11113,902,839 - 113,906,239 (-)NCBIPanPan1.1PanPan1.1panPan2
TXNIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,775,588 - 58,779,730 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,776,871 - 58,779,531 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1758,243,550 - 58,247,684 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01759,772,252 - 59,776,384 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1759,772,252 - 59,776,378 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11758,645,076 - 58,649,209 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01758,706,219 - 58,710,353 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01759,432,672 - 59,436,806 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Txnip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,846,422 - 20,850,485 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936867722,514 - 726,617 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936867722,544 - 726,595 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,348,490 - 99,352,755 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1499,348,589 - 99,351,760 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24108,991,390 - 108,994,561 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TXNIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12012,756,145 - 12,759,853 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2012,756,053 - 12,761,177 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603815,433,418 - 15,437,640 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txnip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477217,341,630 - 17,345,960 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477217,341,918 - 17,345,964 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Txnip
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1360,743,208 - 60,747,117 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Txnip
30 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:135
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000028793
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
RH128016  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22184,096,506 - 184,096,702 (+)MAPPERmRatBN7.2
Rnor_6.02198,686,596 - 198,686,791NCBIRnor6.0
Rnor_5.02218,173,530 - 218,173,725UniSTSRnor5.0
RGSC_v3.42191,360,382 - 191,360,577UniSTSRGSC3.4
Celera2176,621,729 - 176,621,924UniSTS
RH 3.4 Map21231.3UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028793   ⟹   ENSRNOP00000028793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2186,781,163 - 186,785,731 (+)Ensembl
mRatBN7.2 Ensembl2184,092,998 - 184,096,886 (+)Ensembl
Rnor_6.0 Ensembl2198,683,159 - 198,686,974 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115326   ⟹   ENSRNOP00000086202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2186,781,924 - 186,785,731 (+)Ensembl
mRatBN7.2 Ensembl2184,092,991 - 184,096,886 (+)Ensembl
RefSeq Acc Id: NM_001008767   ⟹   NP_001008767
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,781,933 - 186,785,736 (+)NCBI
mRatBN7.22184,093,079 - 184,096,882 (+)NCBI
Rnor_6.02198,683,168 - 198,686,971 (+)NCBI
Rnor_5.02218,170,102 - 218,173,905 (+)NCBI
RGSC_v3.42191,356,954 - 191,360,757 (+)RGD
Celera2176,618,301 - 176,622,104 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008767 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88411 (Get FASTA)   NCBI Sequence Viewer  
  EDL85625 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028793
  ENSRNOP00000028793.5
GenBank Protein Q5M7W1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008767   ⟸   NM_001008767
- UniProtKB: Q5M7W1 (UniProtKB/Swiss-Prot),   A6K374 (UniProtKB/TrEMBL),   A0A8I6A352 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028793   ⟸   ENSRNOT00000028793
Ensembl Acc Id: ENSRNOP00000086202   ⟸   ENSRNOT00000115326
Protein Domains
Arrestin C-terminal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M7W1-F1-model_v2 AlphaFold Q5M7W1 1-394 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691582
Promoter ID:EPDNEW_R2107
Type:single initiation site
Name:Txnip_1
Description:thioredoxin interacting protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02198,683,087 - 198,683,147EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620886 AgrOrtholog
BioCyc Gene G2FUF-51980 BioCyc
Ensembl Genes ENSRNOG00000021201 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028793 ENTREZGENE
  ENSRNOT00000028793.7 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.640 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7192327 IMAGE-MGC_LOAD
InterPro Arrestin-like_N UniProtKB/Swiss-Prot
  Arrestin_C UniProtKB/Swiss-Prot
  Arrestin_C-like UniProtKB/Swiss-Prot
  Arrestin_domain-protein UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
KEGG Report rno:117514 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94673 IMAGE-MGC_LOAD
NCBI Gene 117514 ENTREZGENE
PANTHER ARRESTIN DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot
  THIOREDOXIN-INTERACTING PROTEIN UniProtKB/Swiss-Prot
Pfam Arrestin_C UniProtKB/Swiss-Prot
  Arrestin_N UniProtKB/Swiss-Prot
PhenoGen Txnip PhenoGen
RatGTEx ENSRNOG00000021201 RatGTEx
SMART Arrestin_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot
UniProt A0A8I6A352 ENTREZGENE, UniProtKB/TrEMBL
  A6K374 ENTREZGENE, UniProtKB/TrEMBL
  Q5M7W1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-08-25   thioredoxin interacting protein  Txnip  upregulated by 1,25-dihydroxyvitamin D-3  Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Txnip  upregulated by 1,25-dihydroxyvitamin D-3  Vdup1    Symbol and Name updated 1299863 APPROVED
2002-08-07 Vdup1  upregulated by 1,25-dihydroxyvitamin D-3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is suppressed by biomechanical strain or hydrogen peroxide 727213