Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Epha5 | Rat | (+)-catechin | multiple interactions | ISO | EPHA5 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of EPHA5 mRNA | CTD | PMID:24763279 | Epha5 | Rat | (+)-pilocarpine | decreases expression | EXP | | 6480464 | Pilocarpine results in decreased expression of EPHA5 mRNA and Pilocarpine results in decreased expression of EPHA5 protein | CTD | PMID:18772502 | Epha5 | Rat | 1,2-dichloroethane | increases expression | ISO | Epha5 (Mus musculus) | 6480464 | ethylene dichloride results in increased expression of EPHA5 mRNA | CTD | PMID:28960355 | Epha5 | Rat | 17beta-estradiol | increases expression | ISO | EPHA5 (Homo sapiens) | 6480464 | Estradiol results in increased expression of EPHA5 mRNA | CTD | PMID:25878060 | Epha5 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of EPHA5 mRNA | CTD | PMID:32741896 | Epha5 | Rat | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of EPHA5 mRNA | CTD | PMID:32741896 | Epha5 | Rat | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Epha5 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Epha5 | Rat | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Epha5 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Epha5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Epha5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of EPHA5 mRNA | CTD | PMID:21570461 | Epha5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EPHA5 mRNA | CTD | PMID:32109520 | Epha5 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | Epha5 | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Epha5 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of EPHA5 mRNA | CTD | PMID:20188158 | Epha5 | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of EPHA5 mRNA | CTD | PMID:30071829 | Epha5 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of EPHA5 mRNA | CTD | PMID:33150595 | Epha5 | Rat | 6-propyl-2-thiouracil | increases methylation | EXP | | 6480464 | Propylthiouracil results in increased methylation of EPHA5 promoter | CTD | PMID:33150595 | Epha5 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of EPHA5 mRNA | CTD | PMID:28959563 | Epha5 | Rat | acrylamide | decreases expression | ISO | EPHA5 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of EPHA5 mRNA | CTD | PMID:32763439 | Epha5 | Rat | aflatoxin B1 | decreases methylation | ISO | EPHA5 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of EPHA5 gene | CTD | PMID:27153756 | Epha5 | Rat | all-trans-retinoic acid | multiple interactions | ISO | Epha5 (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of EPHA5 mRNA | CTD | PMID:36189433 | Epha5 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of EPHA5 mRNA | CTD | PMID:16483693 | Epha5 | Rat | antirheumatic drug | increases expression | ISO | EPHA5 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of EPHA5 mRNA | CTD | PMID:24449571 | Epha5 | Rat | arsenite(3-) | increases expression | ISO | Epha5 (Mus musculus) | 6480464 | arsenite results in increased expression of EPHA5 mRNA | CTD | PMID:33053406 | Epha5 | Rat | arsenite(3-) | increases methylation | ISO | EPHA5 (Homo sapiens) | 6480464 | arsenite results in increased methylation of EPHA5 promoter | CTD | PMID:23974009 | Epha5 | Rat | benzo[a]pyrene | increases methylation | ISO | EPHA5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of EPHA5 exon | CTD | PMID:27901495 | Epha5 | Rat | benzo[a]pyrene | affects methylation | ISO | EPHA5 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of EPHA5 promoter | CTD | PMID:27901495 | Epha5 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of EPHA5 mRNA | CTD | PMID:25181051 | Epha5 | Rat | bisphenol A | decreases expression | ISO | Epha5 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of EPHA5 mRNA | CTD | PMID:32156529 | Epha5 | Rat | bisphenol A | increases methylation | ISO | EPHA5 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of EPHA5 gene | CTD | PMID:31601247 | Epha5 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of EPHA5 mRNA | CTD | PMID:30816183 and PMID:34947998 | Epha5 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of EPHA5 gene | CTD | PMID:28505145 | Epha5 | Rat | butanal | decreases expression | ISO | EPHA5 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of EPHA5 mRNA | CTD | PMID:26079696 | Epha5 | Rat | cadmium dichloride | multiple interactions | ISO | EPHA5 (Homo sapiens) | 6480464 | [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPHA5 mRNA | CTD | PMID:12634122 | Epha5 | Rat | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of EPHA5 mRNA | CTD | PMID:18668222 | Epha5 | Rat | cisplatin | decreases expression | ISO | EPHA5 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of EPHA5 mRNA | CTD | PMID:27392435 | Epha5 | Rat | cisplatin | multiple interactions | ISO | EPHA5 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of EPHA5 mRNA | CTD | PMID:27392435 | Epha5 | Rat | clofibrate | increases expression | ISO | Epha5 (Mus musculus) | 6480464 | Clofibrate results in increased expression of EPHA5 mRNA | CTD | PMID:17585979 | Epha5 | Rat | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of EPHA5 mRNA | CTD | PMID:15691709 | Epha5 | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of EPHA5 mRNA | CTD | PMID:26577399 | Epha5 | Rat | cyclosporin A | decreases expression | ISO | EPHA5 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of EPHA5 mRNA | CTD | PMID:20106945 | Epha5 | Rat | dichromium trioxide | multiple interactions | ISO | EPHA5 (Homo sapiens) | 6480464 | [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPHA5 mRNA | CTD | PMID:12634122 | Epha5 | Rat | ethanol | affects splicing | ISO | Epha5 (Mus musculus) | 6480464 | Ethanol affects the splicing of EPHA5 mRNA | CTD | PMID:30319688 | Epha5 | Rat | ethanol | increases expression | ISO | Epha5 (Mus musculus) | 6480464 | Ethanol results in increased expression of EPHA5 mRNA | CTD | PMID:30319688 | Epha5 | Rat | folic acid | decreases expression | ISO | Epha5 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of EPHA5 mRNA | CTD | PMID:25629700 | Epha5 | Rat | glycidol | decreases expression | EXP | | 6480464 | glycidol results in decreased expression of EPHA5 mRNA | CTD | PMID:33150645 | Epha5 | Rat | glycidol | increases methylation | EXP | | 6480464 | glycidol results in increased methylation of EPHA5 promoter | CTD | PMID:33150595 | Epha5 | Rat | indometacin | increases expression | EXP | | 6480464 | Indomethacin results in increased expression of EPHA5 protein | CTD | PMID:38701902 | Epha5 | Rat | lead diacetate | multiple interactions | ISO | EPHA5 (Homo sapiens) | 6480464 | [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPHA5 mRNA | CTD | PMID:12634122 | Epha5 | Rat | lithium chloride | decreases expression | EXP | | 6480464 | Lithium Chloride results in decreased expression of EPHA5 mRNA and Lithium Chloride results in decreased expression of EPHA5 protein | CTD | PMID:18772502 | Epha5 | Rat | melphalan | decreases expression | ISO | EPHA5 (Homo sapiens) | 6480464 | Melphalan results in decreased expression of EPHA5 mRNA | CTD | PMID:22363485 | Epha5 | Rat | miconazole | decreases expression | ISO | Epha5 (Mus musculus) | 6480464 | Miconazole results in decreased expression of EPHA5 mRNA | CTD | PMID:27462272 | Epha5 | Rat | mono(2-ethylhexyl) phthalate | multiple interactions | ISO | Epha5 (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of EPHA5 mRNA | CTD | PMID:36189433 | Epha5 | Rat | okadaic acid | increases expression | ISO | Epha5 (Mus musculus) | 6480464 | Okadaic Acid results in increased expression of EPHA5 mRNA | CTD | PMID:25270620 | Epha5 | Rat | paracetamol | increases expression | ISO | EPHA5 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of EPHA5 mRNA | CTD | PMID:29067470 | Epha5 | Rat | PCB138 | multiple interactions | ISO | Epha5 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Epha5 | Rat | perfluorononanoic acid | increases expression | ISO | EPHA5 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in increased expression of EPHA5 mRNA | CTD | PMID:25812627 | Epha5 | Rat | perfluorooctanoic acid | increases expression | ISO | EPHA5 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in increased expression of EPHA5 mRNA | CTD | PMID:25812627 | Epha5 | Rat | pioglitazone | multiple interactions | ISO | Epha5 (Mus musculus) | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of EPHA5 mRNA | CTD | PMID:27935865 | Epha5 | Rat | ponatinib | decreases activity | ISO | EPHA5 (Homo sapiens) | 6480464 | ponatinib results in decreased activity of EPHA5 protein | CTD | PMID:19878872 | Epha5 | Rat | sodium arsenite | multiple interactions | ISO | EPHA5 (Homo sapiens) | 6480464 | [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPHA5 mRNA | CTD | PMID:12634122 | Epha5 | Rat | sodium arsenite | affects methylation | ISO | EPHA5 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of EPHA5 gene | CTD | PMID:28589171 | Epha5 | Rat | sodium arsenite | increases expression | ISO | Epha5 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of EPHA5 mRNA | CTD | PMID:16014739 | Epha5 | Rat | sodium arsenite | increases expression | ISO | EPHA5 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of EPHA5 mRNA | CTD | PMID:12634122 | Epha5 | Rat | sunitinib | increases expression | ISO | EPHA5 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of EPHA5 mRNA | CTD | PMID:31533062 | Epha5 | Rat | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of EPHA5 mRNA | CTD | PMID:32741896 | Epha5 | Rat | tetrachloroethene | increases expression | ISO | EPHA5 (Homo sapiens) | 6480464 | Tetrachloroethylene results in increased expression of EPHA5 mRNA | CTD | PMID:16010555 | Epha5 | Rat | titanium dioxide | decreases methylation | ISO | Epha5 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of EPHA5 promoter | CTD | PMID:35295148 | Epha5 | Rat | valproic acid | decreases methylation | ISO | EPHA5 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of EPHA5 gene | CTD | PMID:29154799 | Epha5 | Rat | valproic acid | decreases expression | ISO | EPHA5 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of EPHA5 mRNA | CTD | PMID:27188386 | Epha5 | Rat | valproic acid | affects expression | ISO | EPHA5 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of EPHA5 mRNA | CTD | PMID:25979313 | Epha5 | Rat | venlafaxine hydrochloride | decreases expression | EXP | | 6480464 | Venlafaxine Hydrochloride results in decreased expression of EPHA5 mRNA | CTD | PMID:25423262 | Epha5 | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of EPHA5 mRNA | CTD | PMID:19015723 | Epha5 | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of EPHA5 mRNA | CTD | PMID:22615374 | Epha5 | Rat | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of EPHA5 gene | CTD | PMID:31079544 | Epha5 | Rat | XL147 | multiple interactions | ISO | Epha5 (Mus musculus) | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of EPHA5 mRNA | CTD | PMID:27935865 | |