Herpud1 (homocysteine inducible ER protein with ubiquitin like domain 1) - Rat Genome Database

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Gene: Herpud1 (homocysteine inducible ER protein with ubiquitin like domain 1) Rattus norvegicus
Analyze
Symbol: Herpud1
Name: homocysteine inducible ER protein with ubiquitin like domain 1
RGD ID: 620818
Description: Predicted to enable transmembrane transporter binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in endoplasmic reticulum unfolded protein response; intracellular calcium ion homeostasis; and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in Lewy body core; endoplasmic reticulum quality control compartment; and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; Sup
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,604,360 - 10,624,168 (-)NCBIGRCr8
mRatBN7.21910,598,411 - 10,609,002 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,598,417 - 10,618,424 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,561,735 - 10,572,117 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,328,571 - 11,338,953 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,615,556 - 10,625,938 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,046,905 - 11,057,440 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,046,909 - 11,057,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,027,622 - 11,038,305 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,036,567 - 11,046,914 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11911,041,392 - 11,051,740 (-)NCBI
Celera1910,486,005 - 10,496,352 (-)NCBICelera
Cytogenetic Map19p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutylamine  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bexarotene  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
boric acid  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
D-glucose  (ISO)
DDE  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elesclomol  (ISO)
endosulfan  (EXP)
epoxiconazole  (EXP,ISO)
Erionite  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
fluoranthene  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
inulin  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
L-serine  (ISO)
lead diacetate  (ISO)
levofloxacin  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP,ISO)
nimesulide  (EXP)
nitrofen  (EXP)
Nivalenol  (ISO)
organoselenium compound  (ISO)
oxidopamine  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
phorone  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (EXP)
progesterone  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
sertraline  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant alpha-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins. Belal C, etal., Hum Mol Genet. 2012 Mar 1;21(5):963-77. doi: 10.1093/hmg/ddr502. Epub 2011 Nov 1.
2. Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress. Chan SL, etal., J Biol Chem 2004 Jul 2;279(27):28733-43. Epub 2004 Apr 21.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Role of Herp in the endoplasmic reticulum stress response. Hori O, etal., Genes Cells 2004 May;9(5):457-69.
6. Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress. Kokame K, etal., J Biol Chem 2000 Oct 20;275(42):32846-53.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic beta-cells. Tiwari A, etal., J Cell Sci. 2013 May 1;126(Pt 9):1962-8. doi: 10.1242/jcs.117374. Epub 2013 Feb 26.
Additional References at PubMed
PMID:10708769   PMID:18307982   PMID:19788048   PMID:19946888   PMID:21600962   PMID:25637874   PMID:25660456   PMID:25792451   PMID:27871950   PMID:36812708  


Genomics

Comparative Map Data
Herpud1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,604,360 - 10,624,168 (-)NCBIGRCr8
mRatBN7.21910,598,411 - 10,609,002 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,598,417 - 10,618,424 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,561,735 - 10,572,117 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,328,571 - 11,338,953 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,615,556 - 10,625,938 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,046,905 - 11,057,440 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,046,909 - 11,057,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,027,622 - 11,038,305 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,036,567 - 11,046,914 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11911,041,392 - 11,051,740 (-)NCBI
Celera1910,486,005 - 10,496,352 (-)NCBICelera
Cytogenetic Map19p13NCBI
HERPUD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,932,142 - 56,944,864 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,932,142 - 56,944,864 (+)EnsemblGRCh38hg38GRCh38
GRCh371656,966,054 - 56,978,776 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,523,249 - 55,535,294 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,523,248 - 55,535,294NCBI
Celera1641,466,026 - 41,478,076 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,835,319 - 42,847,282 (+)NCBIHuRef
CHM1_11658,373,967 - 58,385,760 (+)NCBICHM1_1
T2T-CHM13v2.01662,728,473 - 62,741,195 (+)NCBIT2T-CHM13v2.0
Herpud1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,113,057 - 95,121,999 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,113,066 - 95,122,005 (+)EnsemblGRCm39 Ensembl
GRCm38894,386,429 - 94,395,371 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,386,438 - 94,395,377 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,910,400 - 96,919,258 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,275,629 - 97,284,487 (+)NCBIMGSCv36mm8
Celera898,718,356 - 98,727,224 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.46NCBI
Herpud1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543314,608,375 - 14,621,839 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543314,609,275 - 14,621,774 (+)NCBIChiLan1.0ChiLan1.0
HERPUD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,403,188 - 66,416,171 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,323,881 - 72,336,865 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,210,170 - 37,221,961 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,343,025 - 56,355,164 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,343,025 - 56,355,164 (+)Ensemblpanpan1.1panPan2
HERPUD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,388,492 - 59,400,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,388,494 - 59,400,003 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,017,333 - 56,028,868 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,927,541 - 59,939,082 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,927,546 - 59,939,082 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,758,736 - 56,770,263 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,766,037 - 57,777,356 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,660,262 - 58,671,800 (-)NCBIUU_Cfam_GSD_1.0
Herpud1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,486,978 - 50,497,944 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,091,176 - 9,102,109 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,091,115 - 9,102,101 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HERPUD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,901,297 - 18,913,424 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1618,901,171 - 18,913,427 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HERPUD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1542,877,812 - 42,889,576 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl542,877,781 - 42,890,298 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604733,458,778 - 33,470,865 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Herpud1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474629,068,350 - 29,081,085 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474629,069,995 - 29,081,085 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Herpud1
62 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:56
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000025559
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat

Markers in Region
Herpud1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,598,550 - 10,598,772 (+)MAPPERmRatBN7.2
Rnor_6.01911,047,043 - 11,047,264NCBIRnor6.0
Rnor_5.01911,027,765 - 11,027,986UniSTSRnor5.0
Celera1910,486,141 - 10,486,362UniSTS
Cytogenetic Map19p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000025559   ⟹   ENSRNOP00000025559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1910,598,417 - 10,618,424 (-)Ensembl
Rnor_6.0 Ensembl1911,046,909 - 11,057,254 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110882   ⟹   ENSRNOP00000095807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1910,598,417 - 10,618,418 (-)Ensembl
RefSeq Acc Id: NM_053523   ⟹   NP_445975
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,604,360 - 10,614,707 (-)NCBI
mRatBN7.21910,598,415 - 10,608,762 (-)NCBI
Rnor_6.01911,046,907 - 11,057,254 (-)NCBI
Rnor_5.01911,027,622 - 11,038,305 (-)NCBI
RGSC_v3.41911,036,567 - 11,046,914 (-)RGD
Celera1910,486,005 - 10,496,352 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255133   ⟹   XP_006255195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,604,360 - 10,624,168 (-)NCBI
mRatBN7.21910,598,411 - 10,609,002 (-)NCBI
Rnor_6.01911,046,905 - 11,057,440 (-)NCBI
Rnor_5.01911,027,622 - 11,038,305 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_445975 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255195 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61849 (Get FASTA)   NCBI Sequence Viewer  
  BAB16047 (Get FASTA)   NCBI Sequence Viewer  
  EDL87344 (Get FASTA)   NCBI Sequence Viewer  
  EDL87345 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025559.4
  ENSRNOP00000095807.1
RefSeq Acc Id: NP_445975   ⟸   NM_053523
- UniProtKB: Q9ESS9 (UniProtKB/TrEMBL),   A6JY67 (UniProtKB/TrEMBL),   F7F5G8 (UniProtKB/TrEMBL),   Q6P739 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255195   ⟸   XM_006255133
- Peptide Label: isoform X1
- UniProtKB: A0A8I6B3C5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025559   ⟸   ENSRNOT00000025559
Ensembl Acc Id: ENSRNOP00000095807   ⟸   ENSRNOT00000110882
Protein Domains
Ubiquitin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ESS9-F1-model_v2 AlphaFold Q9ESS9 1-391 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700946
Promoter ID:EPDNEW_R11470
Type:multiple initiation site
Name:Herpud1_1
Description:homocysteine inducible ER protein with ubiquitin like domain1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01911,057,260 - 11,057,320EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620818 AgrOrtholog
BioCyc Gene G2FUF-6493 BioCyc
Ensembl Genes ENSRNOG00000018796 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025559.6 UniProtKB/TrEMBL
  ENSRNOT00000110882.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621877 IMAGE-MGC_LOAD
InterPro HERPUD1/2 UniProtKB/TrEMBL
  Ubiquitin UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:85430 UniProtKB/TrEMBL
MGC_CLONE MGC:72340 IMAGE-MGC_LOAD
NCBI Gene 85430 ENTREZGENE
PANTHER HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UBIQUITIN-LIKE DOMAIN MEMBER 1 PROTEIN UniProtKB/TrEMBL
  PTHR12943 UniProtKB/TrEMBL
Pfam ubiquitin UniProtKB/TrEMBL
PhenoGen Herpud1 PhenoGen
PROSITE UBIQUITIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018796 RatGTEx
SMART UBQ UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
UniProt A0A8I6B3C5 ENTREZGENE, UniProtKB/TrEMBL
  A6JY66_RAT UniProtKB/TrEMBL
  A6JY67 ENTREZGENE, UniProtKB/TrEMBL
  F7F5G8 ENTREZGENE, UniProtKB/TrEMBL
  Q6P739 ENTREZGENE, UniProtKB/TrEMBL
  Q9ESS9 ENTREZGENE
UniProt Secondary Q9ESS9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Herpud1  homocysteine inducible ER protein with ubiquitin like domain 1  Herpud1  homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Herpud1  homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Herpud1  homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1      Symbol and Name status set to provisional 70820 PROVISIONAL