Pnliprp2 (pancreatic lipase related protein 2) - Rat Genome Database

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Gene: Pnliprp2 (pancreatic lipase related protein 2) Rattus norvegicus
Analyze
Symbol: Pnliprp2
Name: pancreatic lipase related protein 2
RGD ID: 620793
Description: Enables galactolipase activity; phospholipase activity; and triacylglycerol lipase activity. Involved in several processes, including galactolipid catabolic process; response to food; and response to glucocorticoid. Located in extracellular space; neuron projection; and zymogen granule membrane. Orthologous to human PNLIPRP2 (pancreatic lipase related protein 2 (gene/pseudogene)); PARTICIPATES IN retinol metabolic pathway; glycerolipid metabolic pathway; INTERACTS WITH 1,2-didecanoylglycerol; atrazine; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytotoxic T lymphocyte lipase; galactolipase; pancreatic lipase-related protein 2; PL-RP2; secretory glycoprotein GP-3; triacylglycerol lipase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81267,883,906 - 267,902,572 (+)NCBIGRCr8
mRatBN7.21257,897,766 - 257,916,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1257,897,766 - 257,916,434 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1266,101,911 - 266,120,618 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01272,807,924 - 272,826,613 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01265,450,439 - 265,469,037 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01279,896,973 - 279,927,600 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1279,896,973 - 279,927,600 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01287,257,993 - 287,290,491 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41265,267,609 - 265,285,920 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11265,478,653 - 265,496,965 (+)NCBI
Celera1253,553,443 - 253,571,751 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
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Original Reference(s)
Pnliprp2Ratsyndromic microphthalmia 11  ISORGD:7336008554872ClinVar Annotator: match by term: Microphthalmia, syndromic 11ClinVarPMID:28492532

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Original Reference(s)
Pnliprp2Rat1,2-didecanoylglycerol increases metabolic processingEXP 6480464PNLIPRP2 protein results in increased metabolism of 1,2-didecanoylglycerolCTDPMID:9822688
Pnliprp2Rat1,2-dimethylhydrazine increases expressionISORGD:73360164804641,2-Dimethylhydrazine results in increased expression of PNLIPRP2 mRNACTDPMID:22206623
Pnliprp2Rat17alpha-ethynylestradiol multiple interactionsISORGD:7336016480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PNLIPRP2 mRNACTDPMID:17942748
Pnliprp2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:7336016480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PNLIPRP2 mRNACTDPMID:17942748
Pnliprp2Rat4,4'-sulfonyldiphenol decreases methylationISORGD:7336016480464bisphenol S results in decreased methylation of PNLIPRP2 promoterCTDPMID:33297965
Pnliprp2Rataflatoxin B1 increases methylationISORGD:7336006480464Aflatoxin B1 results in increased methylation of PNLIPRP2 intronCTDPMID:30157460
Pnliprp2Rataldrin increases expressionISORGD:7336016480464Aldrin results in increased expression of PNLIPRP2 mRNACTDPMID:18579281
Pnliprp2Ratatrazine affects methylationEXP 6480464Atrazine affects the methylation of PNLIPRP2 geneCTDPMID:28931070
Pnliprp2Ratbelinostat decreases expressionISORGD:7336006480464belinostat results in decreased expression of PNLIPRP2 mRNACTDPMID:27188386
Pnliprp2Ratbenzo[a]pyrene multiple interactionsISORGD:7336016480464Benzo(a)pyrene promotes the reaction [AHR protein binds to PNLIPRP2 promoter]CTDPMID:19654925
Pnliprp2Ratbenzo[a]pyrene decreases methylationISORGD:7336006480464Benzo(a)pyrene results in decreased methylation of PNLIPRP2 promoterCTDPMID:27901495
Pnliprp2RatBenzo[ghi]perylene increases expressionISORGD:73360164804641,12-benzoperylene results in increased expression of PNLIPRP2 mRNACTDPMID:26377693
Pnliprp2Ratbezafibrate increases expressionISORGD:7336016480464Bezafibrate results in increased expression of PNLIPRP2 mRNACTDPMID:18787029
Pnliprp2Ratbis(2-ethylhexyl) phthalate multiple interactionsISORGD:7336016480464[Streptozocin co-treated with Diethylhexyl Phthalate] results in decreased expression of PNLIPRP2 mRNACTDPMID:31606821
Pnliprp2Ratbutanal increases expressionISORGD:7336006480464butyraldehyde results in increased expression of PNLIPRP2 mRNACTDPMID:26079696
Pnliprp2Ratcarbon nanotube decreases expressionISORGD:7336016480464Nanotubes, Carbon analog results in decreased expression of PNLIPRP2 mRNA; Nanotubes, Carbon results in decreased more ...CTDPMID:25620056
Pnliprp2Ratchloroethene increases expressionISORGD:7336016480464Vinyl Chloride results in increased expression of PNLIPRP2 mRNACTDPMID:18579281
Pnliprp2Ratciguatoxin CTX1B affects expressionISORGD:7336016480464Ciguatoxins affects the expression of PNLIPRP2 mRNACTDPMID:18353800
Pnliprp2Ratcopper atom increases expressionEXP 6480464Copper deficiency results in increased expression of PNLIPRP2 mRNACTDPMID:19821111
Pnliprp2Ratcopper(0) increases expressionEXP 6480464Copper deficiency results in increased expression of PNLIPRP2 mRNACTDPMID:19821111

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Biological Process
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Original Reference(s)
Pnliprp2Ratcellular defense response acts_upstream_of_or_withinISORGD:7336011624291MGI:1934269 PMID:9813028RGDPMID:9813028
Pnliprp2Ratcholesterol homeostasis involved_inIBAMGI:96216|PANTHER:PTN000906454|UniProtKB:P06858|UniProtKB:P11150|UniProtKB:Q9Y5X91600115GO_REF:0000033GO_CentralGO_REF:0000033
Pnliprp2Ratfatty acid biosynthetic process involved_inIBAPANTHER:PTN000906454|UniProtKB:P06858|UniProtKB:P11150|UniProtKB:P111511600115GO_REF:0000033GO_CentralGO_REF:0000033
Pnliprp2Ratgalactolipid catabolic process  IDA 2303162 RGD 
Pnliprp2Ratgalactolipid catabolic process involved_inISORGD:7336001624291 PMID:15287741, PMID:17401110, PMID:18702514, PMID:20083229RGDPMID:15287741|PMID:17401110|PMID:18702514|PMID:20083229
Pnliprp2Rathigh-density lipoprotein particle remodeling involved_inIBAPANTHER:PTN000906454|RGD:3009|UniProtKB:P11150|UniProtKB:Q9Y5X91600115GO_REF:0000033GO_CentralGO_REF:0000033
Pnliprp2Ratintestinal lipid catabolic process acts_upstream_of_or_withinISORGD:7336011624291MGI:1934269 PMID:9813028RGDPMID:9813028
Pnliprp2Ratlipid catabolic process involved_inIEAARBA:ARBA000289091600115GO_REF:0000117UniProtGO_REF:0000117
Pnliprp2Ratlipid catabolic process involved_inIEAUniProtKB-KW:KW-04421600115GO_REF:0000043UniProtGO_REF:0000043
Pnliprp2Ratlipid metabolic process involved_inIEAInterPro:IPR002331|InterPro:IPR016272|InterPro:IPR0339061600115GO_REF:0000002InterProGO_REF:0000002
Pnliprp2Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Pnliprp2Ratphosphatidylcholine catabolic process involved_inISSUniProtKB:P543171600115GO_REF:0000024UniProtGO_REF:0000024
Pnliprp2Ratphosphatidylcholine catabolic process involved_inISORGD:7336001624291 PMID:17401110RGDPMID:17401110
Pnliprp2Ratphospholipid catabolic process involved_inISSUniProtKB:P543171600115GO_REF:0000024UniProtGO_REF:0000024
Pnliprp2Ratphospholipid catabolic process involved_inIBAPANTHER:PTN000176925|UniProtKB:P543171600115GO_REF:0000033GO_CentralGO_REF:0000033
Pnliprp2Ratphospholipid catabolic process involved_inISORGD:7336001624291 PMID:18702514RGDPMID:18702514
Pnliprp2Ratphospholipid metabolic process involved_inIMP 127285397PMID:32963038UniProt 
Pnliprp2Ratpost-embryonic development  IEP 728275 RGD 
Pnliprp2Ratresponse to bacterium acts_upstream_of_or_withinISORGD:7336011624291 PMID:23012479RGDPMID:23012479
Pnliprp2Ratresponse to food  IEP 2303156 RGD 
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Cellular Component
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Original Reference(s)
Pnliprp2Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Pnliprp2Ratcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
Pnliprp2Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Pnliprp2Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Pnliprp2Ratextracellular space located_inISORGD:7336001624291 PMID:18702514RGDPMID:18702514
Pnliprp2Ratextracellular space  IDA 2303160 RGD 
Pnliprp2Ratextracellular space is_active_inIBAMGI:96216|MGI:96820|PANTHER:PTN008325466|RGD:1310740|RGD:3009|RGD:3017|RGD:3360|RGD:620792|RGD:620793|UniProtKB:P06858|UniProtKB:P11150|UniProtKB:P11151|UniProtKB:P16233|UniProtKB:P54317|UniProtKB:Q6XZB0|UniProtKB:Q8WWY8|UniProtKB:Q9Y5X91600115GO_REF:0000033GO_CentralGO_REF:0000033
Pnliprp2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Pnliprp2Ratneuron projection located_inIEAUniProtKB-SubCell:SL-05181600115GO_REF:0000044UniProtGO_REF:0000044
Pnliprp2Ratneuron projection located_inIDA 127285397PMID:32963038UniProt 
Pnliprp2Ratzymogen granule membrane located_inIEAUniProtKB-SubCell:SL-05491600115GO_REF:0000044UniProtGO_REF:0000044
Pnliprp2Ratzymogen granule membrane  IDA 633718 RGD 
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Molecular Function
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Original Reference(s)
Pnliprp2Ratcalcium ion binding enablesISSUniProtKB:P543171600115GO_REF:0000024UniProtGO_REF:0000024
Pnliprp2Ratcalcium ion binding enablesISORGD:7336001624291 PMID:18702514RGDPMID:18702514
Pnliprp2Ratcarboxylic ester hydrolase activity enablesIEAInterPro:IPR0162721600115GO_REF:0000002InterProGO_REF:0000002
Pnliprp2Ratgalactolipase activity  IDA 2303162 RGD 
Pnliprp2Ratgalactolipase activity enablesIBAPANTHER:PTN000176925|RGD:620793|UniProtKB:P543171600115GO_REF:0000033GO_CentralGO_REF:0000033
Pnliprp2Ratgalactolipase activity enablesIEAEC:3.1.1.261600115GO_REF:0000003UniProtGO_REF:0000003
Pnliprp2Ratgalactolipase activity enablesIEARHEA:131891600115GO_REF:0000116RHEAGO_REF:0000116
Pnliprp2Ratgalactolipase activity enablesISORGD:7336001624291 PMID:15287741, PMID:17401110, PMID:18702514, PMID:20083229RGDPMID:15287741|PMID:17401110|PMID:18702514|PMID:20083229
Pnliprp2Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Pnliprp2Ratlipase activity enablesIEAInterPro:IPR000734|InterPro:IPR0138181600115GO_REF:0000002InterProGO_REF:0000002
Pnliprp2Ratlipase activity  IDA 2303159 RGD 
Pnliprp2Ratlipoprotein lipase activity enablesIBAMGI:96820|PANTHER:PTN000906454|RGD:3017|UniProtKB:P06858|UniProtKB:P111511600115GO_REF:0000033GO_CentralGO_REF:0000033
Pnliprp2Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Pnliprp2Ratmonoacylglycerol lipase activity enablesISSUniProtKB:P543171600115GO_REF:0000024UniProtGO_REF:0000024
Pnliprp2Ratmonoacylglycerol lipase activity enablesISORGD:7336001624291 PMID:17401110, PMID:18702514RGDPMID:17401110|PMID:18702514
Pnliprp2Ratphospholipase A1 activity enablesIBAPANTHER:PTN000906454|RGD:3009|UniProtKB:P06858|UniProtKB:P11150|UniProtKB:Q9Y5X91600115GO_REF:0000033GO_CentralGO_REF:0000033
Pnliprp2Ratphospholipase activity enablesISORGD:7336001624291 PMID:17401110, PMID:18702514RGDPMID:17401110|PMID:18702514
Pnliprp2Ratphospholipase activity  IDA 2303166 RGD 
Pnliprp2Ratprotein binding enablesISORGD:7336001624291UniProtKB:Q96F86 PMID:33961781RGDPMID:33961781
Pnliprp2Rattriacylglycerol lipase activity  IDA 2303166 RGD 
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RGD Manual Annotations


  
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Original Reference(s)
Pnliprp2Ratretinol metabolic pathway   ISORGD:7336006484679 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Pnliprp2Ratglycerolipid metabolic pathway  IEA 6907045 KEGGrno:00561

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#
Reference Title
Reference Citation
1. Pancreatic lipase-related protein 2 but not classical pancreatic lipase hydrolyzes galactolipids. Andersson L, etal., Biochim Biophys Acta. 1996 Aug 16;1302(3):236-40.
2. Pancreatic lipase and its related protein 2 are regulated by dietary polyunsaturated fat during the postnatal development of rats. Birk RZ, etal., Pediatr Res. 2004 Aug;56(2):256-62. Epub 2004 Jun 4.
3. Pancreatic lipase-related protein 1 (PLRP1) is present in the pancreatic juice of several species. De Caro J, etal., Biochim Biophys Acta. 1998 Sep 8;1387(1-2):331-41.
4. Leptin directly regulates exocrine pancreas lipase and two related proteins in the rat. Elinson N, etal., Br J Nutr. 2006 Oct;96(4):691-6.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Harrison EH Biochim Biophys Acta. 2012 Jan;1821(1):70-7. Epub 2011 Jun 12.
8. Rat GP-3 is a pancreatic lipase with kinetic properties that differ from colipase-dependent pancreatic lipase. Jennens ML and Lowe ME, J Lipid Res. 1995 Nov;36(11):2374-82.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids. Kuge H, etal., J Lipid Res. 2020 Dec;61(12):1747-1763. doi: 10.1194/jlr.RA120001087. Epub 2020 Sep 22.
11. Dexamethasone-regulated expression of pancreatic lipase and two related proteins in AR42J cells. Kullman J, etal., Am J Physiol. 1996 May;270(5 Pt 1):G746-51.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Rat pancreatic lipase and two related proteins: enzymatic properties and mRNA expression during development. Payne RM, etal., Am J Physiol 1994 May;266(5 Pt 1):G914-21.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Consequences of metabolic challenges on hypothalamic colipase and PLRP2 mRNA in rats. Rippe C, etal., Brain Res. 2007 Dec 14;1185:152-7. Epub 2007 Sep 20.
20. Structure and activity of rat pancreatic lipase-related protein 2. Roussel A, etal., J Biol Chem. 1998 Nov 27;273(48):32121-8.
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PMID:9813028   PMID:17805199   PMID:18702514   PMID:21382969   PMID:23012479  



Pnliprp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81267,883,906 - 267,902,572 (+)NCBIGRCr8
mRatBN7.21257,897,766 - 257,916,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1257,897,766 - 257,916,434 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1266,101,911 - 266,120,618 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01272,807,924 - 272,826,613 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01265,450,439 - 265,469,037 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01279,896,973 - 279,927,600 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1279,896,973 - 279,927,600 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01287,257,993 - 287,290,491 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41265,267,609 - 265,285,920 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11265,478,653 - 265,496,965 (+)NCBI
Celera1253,553,443 - 253,571,751 (+)NCBICelera
Cytogenetic Map1q55NCBI
PNLIPRP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810116,620,953 - 116,645,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10116,620,953 - 116,645,143 (+)EnsemblGRCh38hg38GRCh38
GRCh3710118,380,465 - 118,404,654 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610118,370,455 - 118,394,644 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410118,370,807 - 118,394,642NCBI
Celera10112,109,764 - 112,134,082 (+)NCBICelera
Cytogenetic Map10q25.3NCBI
HuRef10112,007,738 - 112,032,839 (+)NCBIHuRef
CHM1_110118,663,594 - 118,687,784 (+)NCBICHM1_1
T2T-CHM13v2.010117,515,050 - 117,539,456 (+)NCBIT2T-CHM13v2.0
Pnliprp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391958,748,155 - 58,765,966 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1958,748,151 - 58,765,966 (+)EnsemblGRCm39 Ensembl
GRCm381958,759,723 - 58,777,534 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1958,759,719 - 58,777,534 (+)EnsemblGRCm38mm10GRCm38
MGSCv371958,834,213 - 58,852,024 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361958,812,979 - 58,830,778 (+)NCBIMGSCv36mm8
Celera1960,956,809 - 60,974,415 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1954.5NCBI
Pnliprp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543121,425,330 - 21,442,979 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543121,425,345 - 21,442,979 (+)NCBIChiLan1.0ChiLan1.0
LOC100993654
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28128,480,002 - 128,514,403 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110128,485,341 - 128,519,742 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010113,203,170 - 113,216,890 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110116,634,191 - 116,658,075 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10116,634,538 - 116,658,075 (+)Ensemblpanpan1.1panPan2
PNLIPRP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12827,190,641 - 27,212,185 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2827,139,230 - 27,212,178 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2827,341,283 - 27,362,831 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02827,727,419 - 27,749,010 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2827,675,917 - 27,749,003 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12827,281,905 - 27,303,486 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02827,301,344 - 27,322,904 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02827,490,302 - 27,511,858 (+)NCBIUU_Cfam_GSD_1.0
PNLIPRP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14126,817,642 - 126,839,259 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114126,817,647 - 126,839,273 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214138,114,396 - 138,135,435 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103216568
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19109,428,235 - 109,453,687 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604870,683,089 - 70,708,007 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnliprp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473729,936,277 - 29,952,794 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473729,936,223 - 29,955,265 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Pnliprp2
133 total Variants

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:96
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000068119
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 28 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat

1 to 10 of 28 rows
RH131336  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21257,916,217 - 257,916,431 (+)MAPPERmRatBN7.2
Rnor_6.01279,927,384 - 279,927,597NCBIRnor6.0
Rnor_5.01287,290,275 - 287,290,488UniSTSRnor5.0
RGSC_v3.41265,285,704 - 265,285,917UniSTSRGSC3.4
Celera1253,571,535 - 253,571,748UniSTS
RH 3.4 Map11690.1UniSTS
Cytogenetic Map1q55UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 8 43 52 34 33 18 17 18 127 68 44 31 47 15



Ensembl Acc Id: ENSRNOT00000068119   ⟹   ENSRNOP00000063609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1257,897,766 - 257,916,434 (+)Ensembl
Rnor_6.0 Ensembl1279,896,973 - 279,927,600 (+)Ensembl
RefSeq Acc Id: NM_057206   ⟹   NP_476554
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81267,883,906 - 267,902,572 (+)NCBI
mRatBN7.21257,897,766 - 257,916,434 (+)NCBI
Rnor_6.01279,896,973 - 279,927,600 (+)NCBI
Rnor_5.01287,257,993 - 287,290,491 (+)NCBI
RGSC_v3.41265,267,609 - 265,285,920 (+)RGD
Celera1253,553,443 - 253,571,751 (+)RGD
Sequence:
Protein RefSeqs NP_476554 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41250 (Get FASTA)   NCBI Sequence Viewer  
  EDL94542 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063609
GenBank Protein P54318 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476554   ⟸   NM_057206
- Peptide Label: precursor
- UniProtKB: P54318 (UniProtKB/Swiss-Prot),   D3ZX17 (UniProtKB/TrEMBL),   A6JI68 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063609   ⟸   ENSRNOT00000068119
PLAT

Name Modeler Protein Id AA Range Protein Structure
AF-P54318-F1-model_v2 AlphaFold P54318 1-468 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691010
Promoter ID:EPDNEW_R1535
Type:multiple initiation site
Name:Pnliprp2_1
Description:pancreatic lipase related protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01279,896,981 - 279,897,041EPDNEW


1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-55268 BioCyc
Ensembl Genes ENSRNOG00000017982 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000068119 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
  PLAT/LH2 domain UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  Lipase/vitellogenin UniProtKB/Swiss-Prot
  Lipase_LIPH UniProtKB/Swiss-Prot
  Lipase_N UniProtKB/Swiss-Prot
  Lipase_panc UniProtKB/Swiss-Prot
  PLAT/LH2_dom UniProtKB/Swiss-Prot
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot
  TAG_lipase UniProtKB/Swiss-Prot
KEGG Report rno:117554 UniProtKB/Swiss-Prot
NCBI Gene 117554 ENTREZGENE
PANTHER PANCREATIC LIPASE-RELATED PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR11610 UniProtKB/Swiss-Prot
Pfam Lipase UniProtKB/Swiss-Prot
  PLAT UniProtKB/Swiss-Prot
PhenoGen Pnliprp2 PhenoGen
PIRSF Lipoprotein_lipase_LIPH UniProtKB/Swiss-Prot
PRINTS PANCLIPASE UniProtKB/Swiss-Prot
  TAGLIPASE UniProtKB/Swiss-Prot
PROSITE LIPASE_SER UniProtKB/Swiss-Prot
  PLAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017982 RatGTEx
SMART LH2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49723 UniProtKB/Swiss-Prot
  SSF53474 UniProtKB/Swiss-Prot
UniProt A6JI68 ENTREZGENE, UniProtKB/TrEMBL
  D3ZX17 ENTREZGENE, UniProtKB/TrEMBL
  LIPR2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Pnliprp2  pancreatic lipase related protein 2  Pnliprp2  pancreatic lipase-related protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED

Note Type Note Reference
gene_expression expressed specifically in pancreas 633718
gene_protein 452 amino acids; 53 kDa glycoprotein 633718