Zfp36 (zinc finger protein 36) - Rat Genome Database

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Gene: Zfp36 (zinc finger protein 36) Rattus norvegicus
Analyze
Symbol: Zfp36
Name: zinc finger protein 36
RGD ID: 620722
Description: Enables mRNA 3'-UTR binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; cellular response to epidermal growth factor stimulus; and regulation of gene expression. Predicted to act upstream of or within several processes, including negative regulation of cell differentiation; negative regulation of inflammatory response; and regulation of RNA metabolic process. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleus. Predicted to be part of CCR4-NOT complex and ribonucleoprotein complex. Orthologous to human ZFP36 (ZFP36 ring finger protein); INTERACTS WITH 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: mRNA decay activator protein ZFP36; Tis11; TPA-induced sequence 11; tristetraprolin; tristetraproline; TTP; zfp-36
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,796,628 - 92,799,108 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl192,796,628 - 92,799,108 (-)EnsemblGRCr8
mRatBN7.2183,669,084 - 83,671,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,669,084 - 83,671,564 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx189,079,138 - 89,081,618 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,537,626 - 97,540,106 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,835,008 - 90,837,488 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,380,088 - 85,382,565 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,380,088 - 85,382,569 (+)Ensemblrn6Rnor6.0
Rnor_5.0186,595,418 - 86,597,898 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,486,643 - 83,489,123 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,065,353 - 78,067,833 (-)NCBICelera
RGSC_v3.1183,564,759 - 83,567,219 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chlorohydrocarbon  (EXP)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
dimethyl sulfoxide  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ferric oxide  (ISO)
ferrostatin-1  (ISO)
fluoranthene  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP,ISO)
glucose  (ISO)
GSK-J4  (ISO)
hemin  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
isoeugenol  (ISO)
ketamine  (EXP)
KT 5720  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
succimer  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tobramycin  (ISO)
topotecan  (EXP)
toxaphene  (EXP)
trans-isoeugenol  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA destabilization  (IEA,ISO,ISS)
3'-UTR-mediated mRNA stabilization  (IEA,ISO,ISS)
cellular response to epidermal growth factor stimulus  (IEA,ISO,ISS)
cellular response to fibroblast growth factor stimulus  (IEA,ISO,ISS)
cellular response to glucocorticoid stimulus  (IEA,ISO,ISS)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (IEA,ISO,ISS)
cellular response to lipopolysaccharide  (IEA,ISO,ISS)
cellular response to tumor necrosis factor  (IEA,ISO,ISS)
intracellular signal transduction  (ISO)
MAPK cascade  (IEA,ISO,ISS)
miRNA-mediated gene silencing by inhibition of translation  (ISO,ISS)
mRNA catabolic process  (ISO,ISS)
mRNA transport  (IEA,ISO,ISS)
negative regulation of 3'-UTR-mediated mRNA stabilization  (IEA,ISO)
negative regulation of cytokine production involved in inflammatory response  (IEA,ISO)
negative regulation of erythrocyte differentiation  (IEA,ISO,ISS)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-2 production  (ISO,ISS)
negative regulation of myeloid cell differentiation  (ISO)
negative regulation of polynucleotide adenylyltransferase activity  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of viral transcription  (IEA,ISO,ISS)
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IEA,ISO)
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay  (IEA,ISO,ISS)
nuclear-transcribed mRNA poly(A) tail shortening  (IBA,IEA,ISO)
p38MAPK cascade  (ISO,ISS)
positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA  (IEA,ISO,ISS)
positive regulation of fat cell differentiation  (ISO,ISS)
positive regulation of intracellular mRNA localization  (IEA,ISO,ISS)
positive regulation of miRNA-mediated gene silencing  (IEA,ISO,ISS)
positive regulation of mRNA catabolic process  (ISO,ISS)
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IEA,ISO,ISS)
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  (IEA,ISO,ISS)
regulation of keratinocyte apoptotic process  (IEA,ISO,ISS)
regulation of keratinocyte differentiation  (IEA,ISO,ISS)
regulation of keratinocyte proliferation  (IEA,ISO,ISS)
regulation of mRNA stability  (IEA,ISO,ISS)
regulation of transcription by RNA polymerase II  (ISO)
regulation of tumor necrosis factor production  (IEA,ISO,ISS)
response to starvation  (IEA,ISO,ISS)
response to wounding  (IEA,ISO,ISS)
RNA destabilization  (ISO)

Cellular Component
CCR4-NOT complex  (ISO,ISS)
cytoplasm  (IEA,ISO,ISS)
cytoplasmic stress granule  (IEA,ISO,ISS)
cytosol  (IBA,IEA,ISO)
exosome (RNase complex)  (IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)
P-body  (IEA,ISO,ISS)
ribonucleoprotein complex  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Identification of an AP1-ZFP36 Regulatory Network Associated with Breast Cancer Prognosis. Canzoneri R, etal., J Mammary Gland Biol Neoplasia. 2020 Jun;25(2):163-172. doi: 10.1007/s10911-020-09448-1. Epub 2020 Apr 4.
2. ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway. Cao Y, etal., Cell Death Dis. 2021 Jul 8;12(7):685. doi: 10.1038/s41419-021-03950-y.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Sequence of a rat TIS11 cDNA, an immediate early gene induced by growth factors and phorbol esters. Kaneda N, etal., Gene 1992 Sep 10;118(2):289-91.
6. Cloning and characterization of the rat TIS11 gene. Kaneda N, etal., Mol Cell Biochem 2000 Oct;213(1-2):119-26.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Identification of nuclear import and export signals within the structure of the zinc finger protein TIS11. Murata T, etal., Biochem Biophys Res Commun 2002 May 17;293(4):1242-7.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin. Nowotarski SL, etal., Amino Acids. 2016 May 19.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:7768935   PMID:8630730   PMID:9703499   PMID:10330172   PMID:10751406   PMID:11279239   PMID:11533235   PMID:11588035   PMID:11719186   PMID:11782475   PMID:11796723   PMID:12198173  
PMID:12748283   PMID:14679154   PMID:14766228   PMID:15014438   PMID:15187101   PMID:15467755   PMID:15489334   PMID:15634918   PMID:15652343   PMID:15687258   PMID:15766526   PMID:15814898  
PMID:16364915   PMID:17288565   PMID:17369404   PMID:17971298   PMID:20166898   PMID:20221403   PMID:20410487   PMID:20595389   PMID:20702587   PMID:21278420   PMID:21784977   PMID:21964062  
PMID:22405826   PMID:22658674   PMID:22701344   PMID:22844456   PMID:23644599   PMID:24190969   PMID:24733888   PMID:25038453   PMID:27182009  


Genomics

Comparative Map Data
Zfp36
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,796,628 - 92,799,108 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl192,796,628 - 92,799,108 (-)EnsemblGRCr8
mRatBN7.2183,669,084 - 83,671,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,669,084 - 83,671,564 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx189,079,138 - 89,081,618 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,537,626 - 97,540,106 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,835,008 - 90,837,488 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,380,088 - 85,382,565 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,380,088 - 85,382,569 (+)Ensemblrn6Rnor6.0
Rnor_5.0186,595,418 - 86,597,898 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,486,643 - 83,489,123 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,065,353 - 78,067,833 (-)NCBICelera
RGSC_v3.1183,564,759 - 83,567,219 (-)NCBI
Cytogenetic Map1q21NCBI
ZFP36
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,406,847 - 39,409,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,406,847 - 39,409,407 (+)Ensemblhg38GRCh38
GRCh371939,897,487 - 39,900,047 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,589,327 - 44,591,885 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341944,589,326 - 44,591,885NCBI
Celera1936,699,177 - 36,701,735 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,344,174 - 36,346,739 (+)NCBIHuRef
CHM1_11939,898,190 - 39,900,755 (+)NCBICHM1_1
T2T-CHM13v2.01942,211,127 - 42,213,687 (+)NCBIT2T-CHM13v2.0
Zfp36
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,076,208 - 28,078,680 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,076,209 - 28,079,678 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38728,376,784 - 28,379,228 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,376,784 - 28,380,253 (-)Ensemblmm10GRCm38
MGSCv37729,161,803 - 29,164,247 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36728,085,544 - 28,087,988 (-)NCBIMGSCv36mm8
Celera722,938,422 - 22,940,866 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.72NCBI
Zfp36
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468152,744 - 155,140 (-)Ensembl
ChiLan1.0NW_004955468152,744 - 155,140 (-)NCBIChiLan1.0ChiLan1.0
ZFP36
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,702,255 - 45,704,872 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,572,812 - 47,575,456 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,505,056 - 36,507,693 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,052,797 - 45,055,390 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1945,052,801 - 45,055,390 (+)EnsemblpanPan2panpan1.1
ZFP36
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,815,972 - 113,818,093 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,816,273 - 113,818,065 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1113,219,568 - 113,221,705 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01114,416,855 - 114,418,992 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,417,021 - 114,418,955 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,975,583 - 113,977,718 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,608,361 - 113,610,498 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,603,453 - 114,605,590 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Zfp36
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,822,651 - 13,825,464 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,250,665 - 2,253,787 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,251,148 - 2,253,527 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFP36
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,063,677 - 48,066,250 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1648,063,732 - 48,066,235 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214143,677,781 - 143,680,284 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZFP36
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,011,073 - 34,013,665 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,011,031 - 34,013,870 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607312,032,267 - 12,034,907 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zfp36
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,734,191 - 12,737,971 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479412,732,222 - 12,738,006 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Zfp36
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12167,615,453 - 167,617,961 (+)NCBIRrattus_CSIRO_v1

Variants

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Variants in Zfp36
24 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:95
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000026661
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat

Markers in Region
D1Bda11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,669,498 - 83,669,873 (-)MAPPERmRatBN7.2
Rnor_6.0185,381,779 - 85,382,153NCBIRnor6.0
Rnor_5.0186,597,109 - 86,597,483UniSTSRnor5.0
RGSC_v3.4183,487,058 - 83,487,432UniSTSRGSC3.4
Celera178,065,768 - 78,066,142UniSTS
Cytogenetic Map1q21UniSTS
Zfp36  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0186,597,131 - 86,597,295NCBIRnor5.0
RGSC_v3.4183,487,246 - 83,487,409UniSTSRGSC3.4
Celera178,065,956 - 78,066,119UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000090129   ⟹   ENSRNOP00000073413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,796,628 - 92,799,108 (-)Ensembl
mRatBN7.2 Ensembl183,669,084 - 83,671,564 (-)Ensembl
Rnor_6.0 Ensembl185,380,088 - 85,382,569 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000137406   ⟹   ENSRNOP00000112653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,796,637 - 92,799,069 (-)Ensembl
RefSeq Acc Id: NM_133290   ⟹   NP_579824
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,796,628 - 92,799,108 (-)NCBI
mRatBN7.2183,669,084 - 83,671,564 (-)NCBI
Rnor_6.0185,380,088 - 85,382,565 (+)NCBI
Rnor_5.0186,595,418 - 86,597,898 (+)NCBI
RGSC_v3.4183,486,643 - 83,489,123 (-)RGD
Celera178,065,353 - 78,067,833 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_579824 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH60308 (Get FASTA)   NCBI Sequence Viewer  
  BAB12432 (Get FASTA)   NCBI Sequence Viewer  
  EDM07897 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073413
GenBank Protein P47973 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_579824   ⟸   NM_133290
- UniProtKB: Q54AH1 (UniProtKB/Swiss-Prot),   P47973 (UniProtKB/Swiss-Prot),   G3V8K6 (UniProtKB/TrEMBL),   A6J9I7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073413   ⟸   ENSRNOT00000090129
Ensembl Acc Id: ENSRNOP00000112653   ⟸   ENSRNOT00000137406
Protein Domains
C3H1-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47973-F1-model_v2 AlphaFold P47973 1-320 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689871
Promoter ID:EPDNEW_R396
Type:single initiation site
Name:Zfp36_1
Description:zinc finger protein 36
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0185,380,088 - 85,380,148EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620722 AgrOrtholog
BioCyc Gene G2FUF-60245 BioCyc
Ensembl Genes ENSRNOG00000058388 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000090129 ENTREZGENE
Gene3D-CATH Zinc finger, CCCH-type UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6922188 IMAGE-MGC_LOAD
InterPro ZFP36-like UniProtKB/Swiss-Prot
  Znf_CCCH UniProtKB/Swiss-Prot
  Znf_CCCH_sf UniProtKB/Swiss-Prot
KEGG Report rno:79426 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72649 IMAGE-MGC_LOAD
NCBI Gene 79426 ENTREZGENE
PANTHER MRNA DECAY ACTIVATOR PROTEIN ZFP36 UniProtKB/Swiss-Prot
  PTHR12547 UniProtKB/Swiss-Prot
Pfam zf-CCCH UniProtKB/Swiss-Prot
PhenoGen Zfp36 PhenoGen
PROSITE ZF_C3H1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000058388 RatGTEx
SMART ZnF_C3H1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF90229 UniProtKB/Swiss-Prot
UniProt A0ABK0M3L4_RAT UniProtKB/TrEMBL
  A6J9I7 ENTREZGENE, UniProtKB/TrEMBL
  G3V8K6 ENTREZGENE, UniProtKB/TrEMBL
  P47973 ENTREZGENE
  Q54AH1 ENTREZGENE
  TTP_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q54AH1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Zfp36  zinc finger protein 36      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Zfp36        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization may shuttle between the nucleus and cytoplasm 727988
gene_product member of the CCCH zinc finger protein family 727988