Ptpro (protein tyrosine phosphatase, receptor type, O) - Rat Genome Database

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Pathways
Gene: Ptpro (protein tyrosine phosphatase, receptor type, O) Rattus norvegicus
Analyze
Symbol: Ptpro
Name: protein tyrosine phosphatase, receptor type, O
RGD ID: 62068
Description: Enables protein tyrosine phosphatase activity. Involved in negative regulation of glomerular filtration. Predicted to be located in apical plasma membrane; dendritic spine; and lateral plasma membrane. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GLEPP1; Glomerular epithelial protein 1; receptor-type protein tyrosine phosphatase D30; receptor-type tyrosine-protein phosphatase O; RPTP-BK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Kidm48
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84171,895,104 - 172,105,911 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4171,895,232 - 172,105,903 (+)EnsemblGRCr8
mRatBN7.24170,164,071 - 170,374,790 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4170,164,431 - 170,374,771 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4176,455,604 - 176,666,205 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04172,240,800 - 172,451,487 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04170,861,264 - 171,071,868 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04171,250,766 - 171,461,571 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4171,250,818 - 171,461,677 (+)Ensemblrn6Rnor6.0
Rnor_5.04235,507,823 - 235,718,691 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44174,376,396 - 174,586,694 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4158,744,680 - 158,954,298 (+)NCBICelera
RGSC_v3.14174,621,519 - 174,831,818 (+)NCBI
Cytogenetic Map4q43-q44NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-bromohexadecanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
clothianidin  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dimethylarsinic acid  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-tocopherol  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
progesterone  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Antibodies to protein tyrosine phosphatase receptor type O (PTPro) increase glomerular albumin permeability (P(alb)). Charba DS, etal., Am J Physiol Renal Physiol. 2009 Jul;297(1):F138-44. doi: 10.1152/ajprenal.00122.2008. Epub 2009 Apr 29.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. GLEPP1 receptor tyrosine phosphatase (Ptpro) in rat PAN nephrosis. A marker of acute podocyte injury. Kim YH, etal., Nephron 2002 Apr;90(4):471-6.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Identification of a receptor-type protein tyrosine phosphatase expressed in postmitotic maturing neurons: its structure and expression in the central nervous system. Tagawa M, etal., Biochem J 1997 Feb 1;321 ( Pt 3)(30):865-71.
12. Identification of a rat protein tyrosine phosphatase gene preferentially expressed in the embryonal brain. Tagawa M, etal., Cell Mol Biol Res 1994;40(7-8):627-31.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:11086029   PMID:15673668   PMID:15978577   PMID:17457373   PMID:19056867   PMID:19167335   PMID:19233845   PMID:19573017   PMID:19800005   PMID:19924828   PMID:20398064   PMID:20633639  
PMID:20804755   PMID:21722858   PMID:23376485   PMID:26063811   PMID:28871037   PMID:28926625   PMID:35906634   PMID:38565385  


Genomics

Comparative Map Data
Ptpro
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84171,895,104 - 172,105,911 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4171,895,232 - 172,105,903 (+)EnsemblGRCr8
mRatBN7.24170,164,071 - 170,374,790 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4170,164,431 - 170,374,771 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4176,455,604 - 176,666,205 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04172,240,800 - 172,451,487 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04170,861,264 - 171,071,868 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04171,250,766 - 171,461,571 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4171,250,818 - 171,461,677 (+)Ensemblrn6Rnor6.0
Rnor_5.04235,507,823 - 235,718,691 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44174,376,396 - 174,586,694 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4158,744,680 - 158,954,298 (+)NCBICelera
RGSC_v3.14174,621,519 - 174,831,818 (+)NCBI
Cytogenetic Map4q43-q44NCBI
PTPRO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381215,322,508 - 15,598,331 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1215,322,257 - 15,602,175 (+)Ensemblhg38GRCh38
GRCh371215,475,442 - 15,751,265 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361215,366,754 - 15,641,602 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341215,590,552 - 15,641,602NCBI
Celera1220,620,432 - 20,895,225 (+)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1215,244,485 - 15,520,600 (+)NCBIHuRef
CHM1_11215,441,256 - 15,717,221 (+)NCBICHM1_1
T2T-CHM13v2.01215,199,775 - 15,475,561 (+)NCBIT2T-CHM13v2.0
Ptpro
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396137,229,189 - 137,440,251 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6137,229,317 - 137,440,231 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm386137,252,299 - 137,464,634 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6137,252,319 - 137,463,233 (+)Ensemblmm10GRCm38
MGSCv376137,200,820 - 137,413,155 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366137,216,661 - 137,427,429 (+)NCBIMGSCv36mm8
Celera6140,313,708 - 140,529,181 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.75NCBI
Ptpro
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541312,018,888 - 12,248,807 (+)Ensembl
ChiLan1.0NW_00495541312,019,026 - 12,248,026 (+)NCBIChiLan1.0ChiLan1.0
PTPRO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21020,775,178 - 21,040,639 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,771,989 - 21,037,405 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01215,329,314 - 15,594,787 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11215,725,447 - 15,990,532 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1215,725,917 - 15,990,532 (+)EnsemblpanPan2panpan1.1
PTPRO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12731,082,334 - 31,322,024 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2731,084,544 - 31,322,022 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2715,127,226 - 15,366,211 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02731,403,012 - 31,640,473 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2731,403,562 - 31,640,210 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12731,291,842 - 31,530,890 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02731,247,444 - 31,488,513 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02714,846,836 - 15,088,282 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptpro
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494592,239,451 - 92,460,970 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365871,964,665 - 2,188,672 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365871,967,079 - 2,188,651 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl557,019,745 - 57,263,346 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1557,021,819 - 57,263,395 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2560,237,424 - 60,286,938 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11115,225,375 - 15,494,559 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1115,392,926 - 15,495,807 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606919,805,301 - 20,076,839 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpro
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475222,445,311 - 22,700,904 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475222,446,203 - 22,700,925 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ptpro
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1611,973,388 - 12,179,315 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ptpro
1231 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:714
Count of miRNA genes:301
Interacting mature miRNAs:389
Transcripts:ENSRNOT00000040576
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat

Markers in Region
RH127867  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24170,283,489 - 170,283,689 (+)MAPPERmRatBN7.2
Rnor_6.04171,370,284 - 171,370,483NCBIRnor6.0
Rnor_5.04235,627,170 - 235,627,369UniSTSRnor5.0
RGSC_v3.44174,495,293 - 174,495,492UniSTSRGSC3.4
Celera4158,863,125 - 158,863,324UniSTS
RH 3.4 Map41024.4UniSTS
Cytogenetic Map4q44UniSTS
RH141958  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24170,374,393 - 170,374,612 (+)MAPPERmRatBN7.2
Rnor_6.04171,461,173 - 171,461,391NCBIRnor6.0
Rnor_5.04235,718,295 - 235,718,513UniSTSRnor5.0
Celera4158,953,921 - 158,954,139UniSTS
RH 3.4 Map41024.8UniSTS
Cytogenetic Map4q44UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
18 12 67 176 91 90 59 92 59 6 367 192 11 155 90 93 31 24 24

Sequence


Ensembl Acc Id: ENSRNOT00000040576   ⟹   ENSRNOP00000044055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4171,895,232 - 172,105,903 (+)Ensembl
mRatBN7.2 Ensembl4170,276,715 - 170,374,771 (+)Ensembl
Rnor_6.0 Ensembl4171,250,818 - 171,461,677 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095117   ⟹   ENSRNOP00000095771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4170,164,431 - 170,374,771 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097203   ⟹   ENSRNOP00000077071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4171,895,444 - 172,105,903 (+)Ensembl
mRatBN7.2 Ensembl4170,164,431 - 170,374,771 (+)Ensembl
RefSeq Acc Id: NM_017336   ⟹   NP_059032
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,895,511 - 172,105,911 (+)NCBI
mRatBN7.24170,164,373 - 170,374,790 (+)NCBI
Rnor_6.04171,251,243 - 171,461,550 (+)NCBI
Rnor_5.04235,507,823 - 235,718,691 (+)NCBI
RGSC_v3.44174,376,396 - 174,586,694 (+)RGD
Celera4158,744,680 - 158,954,298 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237571   ⟹   XP_006237633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84172,053,885 - 172,105,910 (+)NCBI
mRatBN7.24170,322,746 - 170,374,790 (+)NCBI
Rnor_6.04171,409,565 - 171,461,571 (+)NCBI
Rnor_5.04235,507,823 - 235,718,691 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592851   ⟹   XP_017448340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,895,104 - 172,105,910 (+)NCBI
mRatBN7.24170,164,098 - 170,374,790 (+)NCBI
Rnor_6.04171,250,766 - 171,461,571 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039108278   ⟹   XP_038964206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,895,207 - 172,078,060 (+)NCBI
mRatBN7.24170,164,071 - 170,346,047 (+)NCBI
RefSeq Acc Id: XM_039108279   ⟹   XP_038964207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,895,210 - 172,078,060 (+)NCBI
mRatBN7.24170,164,074 - 170,346,047 (+)NCBI
RefSeq Acc Id: NP_059032   ⟸   NM_017336
- Peptide Label: precursor
- UniProtKB: Q62797 (UniProtKB/TrEMBL),   A0A8I6AS38 (UniProtKB/TrEMBL),   F7F9Z5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237633   ⟸   XM_006237571
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017448340   ⟸   XM_017592851
- Peptide Label: isoform X1
- UniProtKB: A0A8I5YC57 (UniProtKB/TrEMBL),   F7F9Z5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044055   ⟸   ENSRNOT00000040576
RefSeq Acc Id: XP_038964206   ⟸   XM_039108278
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038964207   ⟸   XM_039108279
- Peptide Label: isoform X3
- UniProtKB: A6IMK3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095771   ⟸   ENSRNOT00000095117
Ensembl Acc Id: ENSRNOP00000077071   ⟸   ENSRNOT00000097203
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62797-F1-model_v2 AlphaFold Q62797 1-1216 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62068 AgrOrtholog
BioCyc Gene G2FUF-42576 BioCyc
Ensembl Genes ENSRNOG00000006231 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040576 ENTREZGENE
  ENSRNOT00000040576.5 UniProtKB/TrEMBL
  ENSRNOT00000097203 ENTREZGENE
  ENSRNOT00000097203.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Fibronectin_type3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPRO UniProtKB/TrEMBL
  Tyr/Dual-specificity_Pase UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_rcpt/non-rcpt UniProtKB/TrEMBL
KEGG Report rno:50677 UniProtKB/TrEMBL
NCBI Gene 50677 ENTREZGENE
PANTHER PTHR47028 UniProtKB/TrEMBL
  RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE O UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PhenoGen Ptpro PhenoGen
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006231 RatGTEx
SMART FN3 UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
TIGR TC218827
UniProt A0A8I5YC57 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AS38 ENTREZGENE, UniProtKB/TrEMBL
  A6IMK3 ENTREZGENE, UniProtKB/TrEMBL
  F7F9Z5 ENTREZGENE, UniProtKB/TrEMBL
  Q62797 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ptpro  protein tyrosine phosphatase, receptor type, O       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology has similarity to Drosophila DPTP10D, also an embryonic central nervous system-specific tyrosine phosphatase 633820