Ptpro (protein tyrosine phosphatase, receptor type, O) - Rat Genome Database

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Gene: Ptpro (protein tyrosine phosphatase, receptor type, O) Rattus norvegicus
Analyze
Symbol: Ptpro
Name: protein tyrosine phosphatase, receptor type, O
RGD ID: 62068
Description: Enables protein tyrosine phosphatase activity. Involved in negative regulation of glomerular filtration. Predicted to be located in apical plasma membrane; dendritic spine; and lateral plasma membrane. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GLEPP1; Glomerular epithelial protein 1; receptor-type protein tyrosine phosphatase D30; receptor-type tyrosine-protein phosphatase O; RPTP-BK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Kidm48
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84171,895,104 - 172,105,911 (+)NCBIGRCr8
mRatBN7.24170,164,071 - 170,374,790 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4170,164,431 - 170,374,771 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4176,455,604 - 176,666,205 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04172,240,800 - 172,451,487 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04170,861,264 - 171,071,868 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04171,250,766 - 171,461,571 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4171,250,818 - 171,461,677 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04235,507,823 - 235,718,691 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44174,376,396 - 174,586,694 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14174,621,519 - 174,831,818 (+)NCBI
Celera4158,744,680 - 158,954,298 (+)NCBICelera
Cytogenetic Map4q43-q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
clothianidin  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-tocopherol  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
progesterone  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Antibodies to protein tyrosine phosphatase receptor type O (PTPro) increase glomerular albumin permeability (P(alb)). Charba DS, etal., Am J Physiol Renal Physiol. 2009 Jul;297(1):F138-44. doi: 10.1152/ajprenal.00122.2008. Epub 2009 Apr 29.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. GLEPP1 receptor tyrosine phosphatase (Ptpro) in rat PAN nephrosis. A marker of acute podocyte injury. Kim YH, etal., Nephron 2002 Apr;90(4):471-6.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Identification of a receptor-type protein tyrosine phosphatase expressed in postmitotic maturing neurons: its structure and expression in the central nervous system. Tagawa M, etal., Biochem J 1997 Feb 1;321 ( Pt 3)(30):865-71.
12. Identification of a rat protein tyrosine phosphatase gene preferentially expressed in the embryonal brain. Tagawa M, etal., Cell Mol Biol Res 1994;40(7-8):627-31.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:11086029   PMID:15673668   PMID:15978577   PMID:17457373   PMID:19056867   PMID:19167335   PMID:19233845   PMID:19573017   PMID:19800005   PMID:19924828   PMID:20398064   PMID:20633639  
PMID:20804755   PMID:21722858   PMID:23376485   PMID:26063811   PMID:28871037   PMID:28926625   PMID:35906634  


Genomics

Comparative Map Data
Ptpro
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84171,895,104 - 172,105,911 (+)NCBIGRCr8
mRatBN7.24170,164,071 - 170,374,790 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4170,164,431 - 170,374,771 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4176,455,604 - 176,666,205 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04172,240,800 - 172,451,487 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04170,861,264 - 171,071,868 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04171,250,766 - 171,461,571 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4171,250,818 - 171,461,677 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04235,507,823 - 235,718,691 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44174,376,396 - 174,586,694 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14174,621,519 - 174,831,818 (+)NCBI
Celera4158,744,680 - 158,954,298 (+)NCBICelera
Cytogenetic Map4q43-q44NCBI
PTPRO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381215,322,508 - 15,598,331 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1215,322,257 - 15,602,175 (+)EnsemblGRCh38hg38GRCh38
GRCh371215,475,442 - 15,751,265 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361215,366,754 - 15,641,602 (+)NCBINCBI36Build 36hg18NCBI36
Build 341215,590,552 - 15,641,602NCBI
Celera1220,620,432 - 20,895,225 (+)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1215,244,485 - 15,520,600 (+)NCBIHuRef
CHM1_11215,441,256 - 15,717,221 (+)NCBICHM1_1
T2T-CHM13v2.01215,199,775 - 15,475,561 (+)NCBIT2T-CHM13v2.0
Ptpro
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396137,229,189 - 137,440,251 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6137,229,317 - 137,440,231 (+)EnsemblGRCm39 Ensembl
GRCm386137,252,299 - 137,464,634 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6137,252,319 - 137,463,233 (+)EnsemblGRCm38mm10GRCm38
MGSCv376137,200,820 - 137,413,155 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366137,216,661 - 137,427,429 (+)NCBIMGSCv36mm8
Celera6140,313,708 - 140,529,181 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.75NCBI
Ptpro
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541312,018,888 - 12,248,807 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541312,019,026 - 12,248,026 (+)NCBIChiLan1.0ChiLan1.0
PTPRO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21020,775,178 - 21,040,639 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,771,989 - 21,037,405 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01215,329,314 - 15,594,787 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11215,725,447 - 15,990,532 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1215,725,917 - 15,990,532 (+)Ensemblpanpan1.1panPan2
PTPRO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12731,082,334 - 31,322,024 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2731,084,544 - 31,322,022 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2715,127,226 - 15,366,211 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02731,403,012 - 31,640,473 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2731,403,562 - 31,640,210 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12731,291,842 - 31,530,890 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02731,247,444 - 31,488,513 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02714,846,836 - 15,088,282 (+)NCBIUU_Cfam_GSD_1.0
Ptpro
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494592,239,451 - 92,460,970 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365871,964,665 - 2,188,672 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365871,967,079 - 2,188,651 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl557,019,745 - 57,263,346 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1557,021,819 - 57,263,395 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2560,237,424 - 60,286,938 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11115,225,375 - 15,494,559 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1115,392,926 - 15,495,807 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606919,805,301 - 20,076,839 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpro
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475222,445,311 - 22,700,904 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475222,446,203 - 22,700,925 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptpro
877 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:714
Count of miRNA genes:301
Interacting mature miRNAs:389
Transcripts:ENSRNOT00000040576
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
RH127867  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24170,283,489 - 170,283,689 (+)MAPPERmRatBN7.2
Rnor_6.04171,370,284 - 171,370,483NCBIRnor6.0
Rnor_5.04235,627,170 - 235,627,369UniSTSRnor5.0
RGSC_v3.44174,495,293 - 174,495,492UniSTSRGSC3.4
Celera4158,863,125 - 158,863,324UniSTS
RH 3.4 Map41024.4UniSTS
Cytogenetic Map4q44UniSTS
RH141958  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24170,374,393 - 170,374,612 (+)MAPPERmRatBN7.2
Rnor_6.04171,461,173 - 171,461,391NCBIRnor6.0
Rnor_5.04235,718,295 - 235,718,513UniSTSRnor5.0
Celera4158,953,921 - 158,954,139UniSTS
RH 3.4 Map41024.8UniSTS
Cytogenetic Map4q44UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11 60 31 2 3
Low 3 33 57 41 8 41 8 11 14 4 37 8 8
Below cutoff 10 2

Sequence


RefSeq Acc Id: ENSRNOT00000040576   ⟹   ENSRNOP00000044055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4170,276,715 - 170,374,771 (+)Ensembl
Rnor_6.0 Ensembl4171,250,818 - 171,461,677 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095117   ⟹   ENSRNOP00000095771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4170,164,431 - 170,374,771 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097203   ⟹   ENSRNOP00000077071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4170,164,431 - 170,374,771 (+)Ensembl
RefSeq Acc Id: NM_017336   ⟹   NP_059032
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,895,511 - 172,105,911 (+)NCBI
mRatBN7.24170,164,373 - 170,374,790 (+)NCBI
Rnor_6.04171,251,243 - 171,461,550 (+)NCBI
Rnor_5.04235,507,823 - 235,718,691 (+)NCBI
RGSC_v3.44174,376,396 - 174,586,694 (+)RGD
Celera4158,744,680 - 158,954,298 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237571   ⟹   XP_006237633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84172,053,885 - 172,105,910 (+)NCBI
mRatBN7.24170,322,746 - 170,374,790 (+)NCBI
Rnor_6.04171,409,565 - 171,461,571 (+)NCBI
Rnor_5.04235,507,823 - 235,718,691 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592851   ⟹   XP_017448340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,895,104 - 172,105,910 (+)NCBI
mRatBN7.24170,164,098 - 170,374,790 (+)NCBI
Rnor_6.04171,250,766 - 171,461,571 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039108278   ⟹   XP_038964206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,895,207 - 172,078,060 (+)NCBI
mRatBN7.24170,164,071 - 170,346,047 (+)NCBI
RefSeq Acc Id: XM_039108279   ⟹   XP_038964207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,895,210 - 172,078,060 (+)NCBI
mRatBN7.24170,164,074 - 170,346,047 (+)NCBI
RefSeq Acc Id: NP_059032   ⟸   NM_017336
- Peptide Label: precursor
- UniProtKB: Q62797 (UniProtKB/TrEMBL),   A0A8I6AS38 (UniProtKB/TrEMBL),   F7F9Z5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237633   ⟸   XM_006237571
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017448340   ⟸   XM_017592851
- Peptide Label: isoform X1
- UniProtKB: A0A8I5YC57 (UniProtKB/TrEMBL),   F7F9Z5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044055   ⟸   ENSRNOT00000040576
RefSeq Acc Id: XP_038964206   ⟸   XM_039108278
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038964207   ⟸   XM_039108279
- Peptide Label: isoform X3
- UniProtKB: A6IMK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000095771   ⟸   ENSRNOT00000095117
RefSeq Acc Id: ENSRNOP00000077071   ⟸   ENSRNOT00000097203
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62797-F1-model_v2 AlphaFold Q62797 1-1216 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62068 AgrOrtholog
BioCyc Gene G2FUF-42576 BioCyc
Ensembl Genes ENSRNOG00000006231 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040576.4 UniProtKB/TrEMBL
  ENSRNOT00000095117 ENTREZGENE
  ENSRNOT00000095117.1 UniProtKB/TrEMBL
  ENSRNOT00000097203.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Fibronectin_type3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPRO UniProtKB/TrEMBL
  Tyr/Dual-specificity_Pase UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_rcpt/non-rcpt UniProtKB/TrEMBL
KEGG Report rno:50677 UniProtKB/TrEMBL
NCBI Gene 50677 ENTREZGENE
PANTHER PTHR47028 UniProtKB/TrEMBL
  RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE O UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PhenoGen Ptpro PhenoGen
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006231 RatGTEx
SMART FN3 UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
TIGR TC218827
UniProt A0A8I5YC57 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AS38 ENTREZGENE, UniProtKB/TrEMBL
  A6IMK3 ENTREZGENE, UniProtKB/TrEMBL
  F7F9Z5 ENTREZGENE, UniProtKB/TrEMBL
  Q62797 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ptpro  protein tyrosine phosphatase, receptor type, O       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology has similarity to Drosophila DPTP10D, also an embryonic central nervous system-specific tyrosine phosphatase 633820