Ltc4s (leukotriene C4 synthase) - Rat Genome Database

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Gene: Ltc4s (leukotriene C4 synthase) Rattus norvegicus
Analyze
Symbol: Ltc4s
Name: leukotriene C4 synthase
RGD ID: 620677
Description: Enables glutathione binding activity and leukotriene-C4 synthase activity. Involved in several processes, including cellular response to lipopolysaccharide; cellular response to vitamin A; and leukotriene biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and nuclear outer membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Biomarker of glomerulonephritis and peripheral nervous system disease. Orthologous to human LTC4S (leukotriene C4 synthase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 7,12-dimethyltetraphene; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione S-transferase LTC4; leukotriene-C(4) synthase; LTC4 synthase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bmd4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,060,002 - 35,066,466 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1035,061,437 - 35,063,768 (-)EnsemblGRCr8
mRatBN7.21034,560,476 - 34,562,790 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,560,360 - 34,562,651 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1039,235,902 - 39,237,857 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,775,154 - 7,777,109 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,229,574 - 34,231,529 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,736,486 - 35,743,088 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,737,664 - 35,739,625 (-)Ensemblrn6Rnor6.0
Rnor_5.01035,498,195 - 35,506,088 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41035,786,877 - 35,788,838 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1033,909,805 - 33,911,766 (-)NCBICelera
RGSC_v3.11035,787,925 - 35,789,881 (-)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acetohydrazide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP)
bisphenol F  (ISO)
bucladesine  (ISO)
carbon nanotube  (ISO)
chlorohydrocarbon  (EXP)
chromium(6+)  (ISO)
chrysene  (ISO)
clofibric acid  (EXP)
colforsin daropate hydrochloride  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (EXP)
diethyl maleate  (EXP)
etazolate  (ISO)
flavonoids  (EXP)
fucoxanthin  (ISO)
furan  (EXP)
glucose  (ISO)
histamine  (ISO)
leukotriene C4  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (EXP)
montelukast  (ISO)
N-nitrosodiethylamine  (EXP)
nitroprusside  (EXP)
orphenadrine  (EXP)
parthenolide  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
resveratrol  (ISO)
rolipram  (ISO)
SB 203580  (ISO)
SCH 23390  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Induction of leukotriene C4 synthase after the differentiation of rat basophilic leukemia cells with retinoic acid and a low dose of actinomycin D and its suppression with methylprednisolone. Abe M, etal., J Cell Physiol 2003 Jul;196(1):154-64.
2. Possible involvement of the lipoxygenase and leukotriene signaling pathways in cisplatin-mediated renal toxicity. Alkhamees OA, etal., Cancer Chemother Pharmacol. 2017 Jul;80(1):55-64. doi: 10.1007/s00280-017-3331-8. Epub 2017 May 13.
3. Analysis of 927T > C CYSLTR1 and -444A > C LTC4S polymorphisms in children with asthma. Arriba-Méndez S, etal., Allergol Immunopathol (Madr). 2008 Sep-Oct;36(5):259-63. doi: 10.1016/s0301-0546(08)75220-0.
4. Leukotriene C4 synthase gene A(-444)C polymorphism and clinical response to a CYS-LT(1) antagonist, pranlukast, in Japanese patients with moderate asthma. Asano K, etal., Pharmacogenetics. 2002 Oct;12(7):565-70. doi: 10.1097/00008571-200210000-00009.
5. Impact of pharmacokinetics and pharmacogenetics on the efficacy of pranlukast in Japanese asthmatics. Asano K, etal., Respirology. 2009 Aug;14(6):822-7. doi: 10.1111/j.1440-1843.2009.01552.x.
6. Association of Leukotriene C4 Synthase A-444C Polymorphism with Asthma and Asthma Phenotypes in Romanian Population. Berghea EC, etal., Maedica (Bucur). 2015 Jun;10(2):91-96.
7. Bronchial mast cells are the dominating LTC4S-expressing cells in aspirin-tolerant asthma. Cai Y, etal., Am J Respir Cell Mol Biol. 2003 Dec;29(6):683-93. doi: 10.1165/rcmb.2002-0174OC. Epub 2003 Jun 19.
8. Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. Cowburn AS, etal., J Clin Invest. 1998 Feb 15;101(4):834-46. doi: 10.1172/JCI620.
9. Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitis. de Alarcón A, etal., Am J Rhinol. 2006 Sep-Oct;20(5):545-9. doi: 10.2500/ajr.2006.20.2934.
10. Leukotriene C4 synthase A-444C gene polymorphism in patients with allergic rhinitis. Eskandari HG, etal., Otolaryngol Head Neck Surg. 2006 Jun;134(6):997-1000. doi: 10.1016/j.otohns.2006.02.007.
11. Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals. Freiberg JJ, etal., J Mol Cell Cardiol. 2009 Apr;46(4):579-86. doi: 10.1016/j.yjmcc.2009.01.002.
12. Novel mutations in leukotriene C4 synthase and risk of cardiovascular disease based on genotypes from 50,000 individuals. Freiberg JJ, etal., J Thromb Haemost. 2010 Aug;8(8):1694-701. doi: 10.1111/j.1538-7836.2010.03903.x. Epub 2010 May 4.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4. Jame AJ, etal., Clin Exp Allergy. 2007 Jun;37(6):880-92.
15. Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma. Kawagishi Y, etal., J Allergy Clin Immunol. 2002 Jun;109(6):936-42. doi: 10.1067/mai.2002.124466.
16. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
17. The leukotriene C4 synthase (A-444C) promoter polymorphism is associated with the severity of exercise-induced asthma in Korean children. Kim HB, etal., J Allergy Clin Immunol. 2006 May;117(5):1191-2. doi: 10.1016/j.jaci.2005.12.1361.
18. Resveratrol prevents development of eosinophilic rhinosinusitis with nasal polyps in a mouse model. Kim SW, etal., Allergy. 2013 Jul;68(7):862-9. doi: 10.1111/all.12132. Epub 2013 Jun 10.
19. Association of the -1072G/A polymorphism in the LTC4S gene with asthma in an Indian population. Kumar A, etal., Int Arch Allergy Immunol. 2012;159(3):271-7. doi: 10.1159/000336675. Epub 2012 Jun 21.
20. Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model. Ma KF, etal., World J Gastroenterol. 2008 May 7;14(17):2748-56.
21. The membrane organization of leukotriene synthesis. Mandal AK, etal., Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6587-92. Epub 2004 Apr 14.
22. Hypersensitivity to aspirin: common eicosanoid alterations in urticaria and asthma. Mastalerz L, etal., J Allergy Clin Immunol. 2004 Apr;113(4):771-5.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Leukotriene receptor antagonist reduces inflammation and alveolar bone loss in a rat model of experimental periodontitis. Moro MG, etal., J Periodontol. 2021 Aug;92(8):e84-e93. doi: 10.1002/JPER.20-0718. Epub 2021 Feb 19.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain. Okubo M, etal., Glia. 2010 Apr;58(5):599-610.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Association between leukotriene C4 synthase A-444C polymorphism and asthma in Chinese Han population in Beijing. Pan MM, etal., Chin Med J (Engl). 2006 Nov 5;119(21):1834-8.
29. Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis. Petric R, etal., Biochim Biophys Acta. 1995 Jan 20;1254(2):207-15.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
32. Prostaglandin, leukotriene, and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis. Pérez-Novo CA, etal., J Allergy Clin Immunol. 2005 Jun;115(6):1189-96. doi: 10.1016/j.jaci.2005.02.029.
33. GOA pipeline RGD automated data pipeline
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Enhanced expression of the leukotriene C(4) synthase due to overactive transcription of an allelic variant associated with aspirin-intolerant asthma. Sanak M, etal., Am J Respir Cell Mol Biol. 2000 Sep;23(3):290-6. doi: 10.1165/ajrcmb.23.3.4051.
36. Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma. Sanak M, etal., Lancet. 1997 Nov 29;350(9091):1599-600. doi: 10.1016/s0140-6736(05)64015-9.
37. The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria. Sanchez-Borges M, etal., J Investig Allergol Clin Immunol. 2009;19(5):375-82.
38. Molecular and catalytic properties of three rat leukotriene C(4) synthase homologs. Schroder O, etal., Biochem Biophys Res Commun. 2003 Dec 12;312(2):271-6.
39. Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis. Schroder O, etal., Cell Mol Life Sci. 2005 Jan;62(1):87-94.
40. Expression and regulation of leukotriene-synthesis enzymes in rat liver cells. Shimada K, etal., Hepatology. 1998 Nov;28(5):1275-81.
41. 5-Lipoxygenase pathway gene polymorphisms: lack of association with asthma in a Spanish population. Torres-Galvan SM, etal., J Investig Allergol Clin Immunol. 2009;19(6):453-8.
42. Expression of leukotriene biosynthetic enzymes in tonsillar tissue of children with obstructive sleep apnea: a prospective nonrandomized study. Tsaoussoglou M, etal., JAMA Otolaryngol Head Neck Surg. 2014 Oct;140(10):944-50. doi: 10.1001/jamaoto.2014.1936.
43. [The mechanism of airway inflammation in eosinophilic bronchitis and cough variant asthma]. Wang JL, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2011 Jun;34(6):433-7.
44. High-level expression, purification, and crystallization of recombinant rat leukotriene C(4) synthase from the yeast Pichia pastoris. Wetterholm A, etal., Protein Expr Purif. 2008 Jul;60(1):1-6. Epub 2008 Mar 23.
45. [The relevance of leukotriene C(4) synthase gene A (-444) C polymorphism to clinical responsiveness to montelukast in patients with asthma]. Wu YH, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2008 Nov;31(11):806-10.
46. Bioinformatics‑based identification of key pathways and candidate genes for estrogen‑induced intrahepatic cholestasis using DNA microarray analysis. Xiang D, etal., Mol Med Rep. 2019 Jul;20(1):303-311. doi: 10.3892/mmr.2019.10256. Epub 2019 May 16.
47. Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats. Yang SL and Lou YJ, Biochem Pharmacol. 2007 Mar 1;73(5):724-35. Epub 2006 Nov 18.
48. Increased leukotriene c4 synthesis accompanied enhanced leukotriene c4 synthase expression and activities of ischemia-reperfusion-injured liver in rats. Yang SL, etal., J Surg Res. 2007 Jun 1;140(1):36-44. doi: 10.1016/j.jss.2006.11.009. Epub 2007 Mar 30.
49. Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. Yang SL, etal., Pharmacology. 2007;80(1):11-20. Epub 2007 May 10.
50. A novel single-nucleotide substitution, Glu 4 Lys, in the leukotriene C4 synthase gene associated with allergic diseases. Yoshikawa K, etal., Int J Mol Med. 2005 Nov;16(5):827-31.
51. Leukotriene synthesis is increased by transcriptional up-regulation of 5-lipoxygenase, leukotriene A4 hydrolase, and leukotriene C4 synthase in asthmatic children. Zaitsu M, etal., J Asthma. 2003 Apr;40(2):147-54. doi: 10.1081/jas-120017985.
Additional References at PubMed
PMID:7599836   PMID:8706658   PMID:9153254   PMID:11319240   PMID:12023288   PMID:12445492   PMID:15530365   PMID:16552728   PMID:17632546   PMID:17632548   PMID:18053799   PMID:19233132  
PMID:23505109   PMID:25540197   PMID:27791009  


Genomics

Comparative Map Data
Ltc4s
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,060,002 - 35,066,466 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1035,061,437 - 35,063,768 (-)EnsemblGRCr8
mRatBN7.21034,560,476 - 34,562,790 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,560,360 - 34,562,651 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1039,235,902 - 39,237,857 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,775,154 - 7,777,109 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,229,574 - 34,231,529 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,736,486 - 35,743,088 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,737,664 - 35,739,625 (-)Ensemblrn6Rnor6.0
Rnor_5.01035,498,195 - 35,506,088 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41035,786,877 - 35,788,838 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1033,909,805 - 33,911,766 (-)NCBICelera
RGSC_v3.11035,787,925 - 35,789,881 (-)NCBI
Cytogenetic Map10q22NCBI
LTC4S
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385179,793,986 - 179,796,647 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5179,793,980 - 179,796,647 (+)Ensemblhg38GRCh38
GRCh375179,220,987 - 179,223,648 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,153,592 - 179,156,119 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345179,153,591 - 179,156,119NCBI
Celera5174,846,142 - 174,848,669 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5173,947,161 - 173,949,688 (+)NCBIHuRef
CHM1_15178,653,394 - 178,655,921 (+)NCBICHM1_1
T2T-CHM13v2.05180,349,182 - 180,351,843 (+)NCBIT2T-CHM13v2.0
Ltc4s
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,127,288 - 50,129,378 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,127,288 - 50,129,443 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381150,236,461 - 50,238,532 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,236,461 - 50,238,616 (-)Ensemblmm10GRCm38
MGSCv371150,049,974 - 50,051,973 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361150,079,895 - 50,081,894 (-)NCBIMGSCv36mm8
Celera1154,797,050 - 54,799,049 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.4NCBI
Ltc4s
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955408788,856 - 791,505 (-)NCBIChiLan1.0ChiLan1.0
LTC4S
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24174,735,060 - 174,739,519 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15172,874,599 - 172,879,058 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05174,946,346 - 174,950,805 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15182,256,113 - 182,261,003 (+)NCBIPanPan1.1PanPan1.1panPan2
LTC4S
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,893,927 - 1,897,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,894,380 - 1,897,752 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha112,012,534 - 2,020,224 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0111,863,608 - 1,871,298 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl111,867,307 - 1,871,411 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1111,835,205 - 1,842,895 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0111,914,372 - 1,922,062 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0112,154,596 - 2,162,286 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ltc4s
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,765,712 - 119,768,688 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936739975,493 - 978,482 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936739975,494 - 978,426 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTC4S
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,799,449 - 78,802,285 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1278,799,446 - 78,802,281 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2280,365,497 - 80,368,339 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LTC4S
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12381,523,784 - 81,526,297 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2381,523,775 - 81,526,179 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607512,900,551 - 12,903,368 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ltc4s
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473342,670,632 - 42,672,846 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473342,668,963 - 42,673,385 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ltc4s
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1932,900,641 - 32,902,690 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ltc4s
71 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:73
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000004359
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 163 91 90 59 79 59 6 331 178 11 136 70 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000004359   ⟹   ENSRNOP00000004359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1035,061,633 - 35,062,879 (-)Ensembl
mRatBN7.2 Ensembl1034,560,555 - 34,561,801 (-)Ensembl
Rnor_6.0 Ensembl1035,737,664 - 35,739,625 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110795   ⟹   ENSRNOP00000087343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1035,061,437 - 35,063,768 (-)Ensembl
mRatBN7.2 Ensembl1034,560,360 - 34,562,651 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000173148   ⟹   ENSRNOP00000107331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1035,061,633 - 35,063,511 (-)Ensembl
RefSeq Acc Id: NM_053639   ⟹   NP_446091
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,061,633 - 35,063,594 (-)NCBI
mRatBN7.21034,560,555 - 34,562,516 (-)NCBI
Rnor_6.01035,737,664 - 35,739,625 (-)NCBI
Rnor_5.01035,498,195 - 35,506,088 (-)NCBI
RGSC_v3.41035,786,877 - 35,788,838 (-)RGD
Celera1033,909,805 - 33,911,766 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246219   ⟹   XP_006246281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,061,562 - 35,063,505 (-)NCBI
mRatBN7.21034,560,484 - 34,562,427 (-)NCBI
Rnor_6.01035,736,486 - 35,739,535 (-)NCBI
Rnor_5.01035,498,195 - 35,506,088 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085020   ⟹   XP_038940948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,061,562 - 35,063,684 (-)NCBI
mRatBN7.21034,560,484 - 34,562,624 (-)NCBI
RefSeq Acc Id: XM_063268266   ⟹   XP_063124336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,060,002 - 35,066,466 (-)NCBI
RefSeq Acc Id: NP_446091   ⟸   NM_053639
- UniProtKB: Q925U2 (UniProtKB/Swiss-Prot),   G3V6E6 (UniProtKB/Swiss-Prot),   A0A8L2Q1E0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246281   ⟸   XM_006246219
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q1E0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004359   ⟸   ENSRNOT00000004359
RefSeq Acc Id: XP_038940948   ⟸   XM_039085020
- Peptide Label: isoform X3
- UniProtKB: A6HE07 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087343   ⟸   ENSRNOT00000110795
RefSeq Acc Id: XP_063124336   ⟸   XM_063268266
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000107331   ⟸   ENSRNOT00000173148

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q925U2-F1-model_v2 AlphaFold Q925U2 1-150 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697151
Promoter ID:EPDNEW_R7676
Type:single initiation site
Name:Ltc4s_1
Description:leukotriene C4 synthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01035,739,627 - 35,739,687EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620677 AgrOrtholog
BioCyc Gene G2FUF-25248 BioCyc
BioCyc Pathway PWY66-375 [leukotriene biosynthesis] BioCyc
BioCyc Pathway Image PWY66-375 BioCyc
Ensembl Genes ENSRNOG00000003244 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000004359 ENTREZGENE
  ENSRNOT00000110795 ENTREZGENE
  ENSRNOT00000173148 ENTREZGENE
Gene3D-CATH 1.20.120.550 UniProtKB/Swiss-Prot
InterPro 5_LipOase_AP UniProtKB/Swiss-Prot
  FLAP/GST2/LTC4S_CS UniProtKB/Swiss-Prot
  MAPEG UniProtKB/Swiss-Prot
  MAPEG-like_dom_sf UniProtKB/Swiss-Prot
  Membr-assoc_MAPEG UniProtKB/Swiss-Prot
KEGG Report rno:114097 UniProtKB/Swiss-Prot
NCBI Gene 114097 ENTREZGENE
PANTHER LEUKOTRIENE C4 SYNTHASE UniProtKB/Swiss-Prot
  MICROSOMAL GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot
Pfam MAPEG UniProtKB/Swiss-Prot
PharmGKB LTC4S RGD
PhenoGen Ltc4s PhenoGen
PRINTS 5LPOXGNASEAP UniProtKB/Swiss-Prot
PROSITE FLAP_GST2_LTC4S UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003244 RatGTEx
Superfamily-SCOP SSF161084 UniProtKB/Swiss-Prot
UniProt A0A8I6A7K1_RAT UniProtKB/TrEMBL
  A0A8L2Q1E0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LZ09_RAT UniProtKB/TrEMBL
  A6HE06_RAT UniProtKB/TrEMBL
  A6HE07 ENTREZGENE, UniProtKB/TrEMBL
  G3V6E6 ENTREZGENE
  LTC4S_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V6E6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Ltc4s  leukotriene C4 synthase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ltc4s  leukotriene C4 synthase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation inhibited by steroids at the transcriptional level 724432