Lmnb1 (lamin B1) - Rat Genome Database

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Gene: Lmnb1 (lamin B1) Rattus norvegicus
Analyze
Symbol: Lmnb1
Name: lamin B1
RGD ID: 620522
Description: Predicted to enable phospholipase binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be a structural constituent of cytoskeleton and structural constituent of nuclear lamina. Involved in several processes, including cellular response to 2,3,7,8-tetrachlorodibenzodioxine; cellular response to L-glutamate; and cellular response to corticosterone stimulus. Located in nuclear lamina; nuclear matrix; and nuclear membrane. Human ortholog(s) of this gene implicated in atypical autosomal dominant adult-onset demyelinating leukodystrophy; autosomal dominant primary microcephaly 26; and typical adult-onset autosomal dominant demyelinating leukodystrophy. Orthologous to human LMNB1 (lamin B1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lamin-B1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81852,373,939 - 52,413,284 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1852,373,757 - 52,413,283 (+)EnsemblGRCr8
mRatBN7.21850,175,861 - 50,215,210 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1850,175,874 - 50,214,502 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1852,214,944 - 52,253,551 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01852,922,869 - 52,961,415 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01850,720,824 - 50,759,431 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01851,785,111 - 51,822,264 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1851,785,111 - 51,822,264 (+)Ensemblrn6Rnor6.0
Rnor_5.01850,979,862 - 51,018,232 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41852,470,605 - 52,508,022 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1848,320,757 - 48,358,598 (+)NCBICelera
RGSC_v3.11852,516,112 - 52,553,517 (+)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-ionone  (ISO)
betaxolol  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carteolol  (ISO)
cefaloridine  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cladribine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
diallyl trisulfide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP)
dimethylselenide  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lovastatin  (ISO)
menadione  (ISO)
mercury dichloride  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
mirex  (EXP)
mitoxantrone  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nobiletin  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
quinomethionate  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
intermediate filament  (IEA)
lamin filament  (IEA,ISO)
nuclear envelope  (IDA,IEA,ISO)
nuclear inner membrane  (IEA,ISO)
nuclear lamina  (IBA,IDA,IEA,ISO)
nuclear matrix  (IDA,IEA,ISO)
nuclear membrane  (IDA,IEA,ISO)
nuclear periphery  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Unraveling the organization of the internal nuclear matrix: RNA-dependent anchoring of NuMA to a lamin scaffold. Barboro P, etal., Exp Cell Res. 2002 Oct 1;279(2):202-18.
2. Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death. Chang KH, etal., Mol Biol Cell. 2011 May;22(9):1452-62. doi: 10.1091/mbc.E10-07-0654. Epub 2011 Mar 9.
3. Corticosteroids inhibit cell death induced by doxorubicin in cardiomyocytes: induction of antiapoptosis, antioxidant, and detoxification genes. Chen QM, etal., Mol Pharmacol. 2005 Jun;67(6):1861-73. Epub 2005 Mar 8.
4. Calphostin C, a remarkable multimodal photodynamic killer of neoplastic cells by selective nuclear lamin B1 destruction and apoptogenesis (Review). Chiarini A, etal., Oncol Rep. 2010 Apr;23(4):887-92.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Perineuronal germinal cells in the rat cerebral cortex. Kataoka Y, etal., Med Mol Morphol. 2006 Mar;39(1):28-32.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Lamin B1 duplications cause autosomal dominant leukodystrophy. Padiath QS, etal., Nat Genet. 2006 Oct;38(10):1114-23. Epub 2006 Sep 3.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Transcriptomic analysis of nephrotoxicity induced by cephaloridine, a representative cephalosporin antibiotic. Rokushima M, etal., Chem Res Toxicol. 2008 Jun;21(6):1186-96. doi: 10.1021/tx800008e. Epub 2008 May 23.
16. Quantitative analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced proteome alterations in 5L rat hepatoma cells using isotope-coded protein labels. Sarioglu H, etal., Proteomics. 2006 Apr;6(8):2407-21.
17. Expression alterations of genes on both neuronal and glial development in rats after developmental exposure to 6-propyl-2-thiouracil. Shiraki A, etal., Toxicol Lett. 2014 Aug 4;228(3):225-34. doi: 10.1016/j.toxlet.2014.04.018. Epub 2014 Apr 26.
18. Characterization of inositol 1,4,5-trisphosphate (IP3) receptor subtypes at rat colonic epithelium. Siefjediers A, etal., Cell Calcium. 2007 Apr;41(4):303-15. Epub 2006 Sep 6.
19. Cellular prion protein localizes to the nucleus of endocrine and neuronal cells and interacts with structural chromatin components. Strom A, etal., Eur J Cell Biol. 2011 May;90(5):414-9. doi: 10.1016/j.ejcb.2010.11.015. Epub 2011 Jan 28.
20. Differential expression of nuclear lamin, the major component of nuclear lamina, during neurogenesis in two germinal regions of adult rat brain. Takamori Y, etal., Eur J Neurosci. 2007 Mar;25(6):1653-62.
21. Knockdown of dystrophin Dp71 impairs PC12 cells cycle: localization in the spindle and cytokinesis structures implies a role for Dp71 in cell division. Villarreal-Silva M, etal., PLoS One. 2011;6(8):e23504. doi: 10.1371/journal.pone.0023504. Epub 2011 Aug 19.
22. Nuclear lamins are differentially expressed in retinal neurons of the adult rat retina. Wakabayashi T, etal., Histochem Cell Biol. 2011 Oct;136(4):427-36. doi: 10.1007/s00418-011-0853-8. Epub 2011 Aug 14.
Additional References at PubMed
PMID:2023931   PMID:8032679   PMID:9053846   PMID:9305626   PMID:10791971   PMID:12714744   PMID:16128803   PMID:16283426   PMID:16364897   PMID:16641100   PMID:16791210   PMID:19028838  
PMID:19946888   PMID:20153721   PMID:20457914   PMID:21503901   PMID:21610090   PMID:21700703   PMID:21874024   PMID:22871113   PMID:23028340   PMID:23106098   PMID:23117660   PMID:23166514  
PMID:25123547   PMID:25931508   PMID:29476059   PMID:29484800   PMID:30924780   PMID:33300615   PMID:33450132  


Genomics

Comparative Map Data
Lmnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81852,373,939 - 52,413,284 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1852,373,757 - 52,413,283 (+)EnsemblGRCr8
mRatBN7.21850,175,861 - 50,215,210 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1850,175,874 - 50,214,502 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1852,214,944 - 52,253,551 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01852,922,869 - 52,961,415 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01850,720,824 - 50,759,431 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01851,785,111 - 51,822,264 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1851,785,111 - 51,822,264 (+)Ensemblrn6Rnor6.0
Rnor_5.01850,979,862 - 51,018,232 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41852,470,605 - 52,508,022 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1848,320,757 - 48,358,598 (+)NCBICelera
RGSC_v3.11852,516,112 - 52,553,517 (+)NCBI
Cytogenetic Map18q12.1NCBI
LMNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385126,776,623 - 126,837,020 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5126,776,623 - 126,837,232 (+)Ensemblhg38GRCh38
GRCh375126,112,315 - 126,172,712 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365126,140,732 - 126,200,608 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345126,140,731 - 126,200,608NCBI
Celera5122,068,688 - 122,128,577 (+)NCBICelera
Cytogenetic Map5q23.2NCBI
HuRef5121,304,338 - 121,364,498 (+)NCBIHuRef
CHM1_15125,544,889 - 125,605,473 (+)NCBICHM1_1
T2T-CHM13v2.05127,296,579 - 127,357,028 (+)NCBIT2T-CHM13v2.0
Lmnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391856,840,885 - 56,886,496 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1856,840,885 - 56,886,496 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381856,707,813 - 56,753,424 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1856,707,813 - 56,753,424 (+)Ensemblmm10GRCm38
MGSCv371856,867,467 - 56,913,078 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361856,833,242 - 56,878,791 (+)NCBIMGSCv36mm8
Celera1858,016,751 - 58,063,869 (+)NCBICelera
Cytogenetic Map18D3NCBI
cM Map1830.84NCBI
Lmnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555214,583,671 - 4,612,271 (+)Ensembl
ChiLan1.0NW_0049555214,583,691 - 4,612,271 (+)NCBIChiLan1.0ChiLan1.0
LMNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24122,088,569 - 122,150,100 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15120,228,131 - 120,289,089 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05122,179,513 - 122,240,848 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15127,949,457 - 128,010,721 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5127,949,457 - 128,010,721 (+)EnsemblpanPan2panpan1.1
LMNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11115,996,627 - 16,052,719 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1115,930,436 - 16,052,127 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1114,788,442 - 14,844,580 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01116,721,688 - 16,778,072 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1116,721,265 - 16,778,626 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11115,451,725 - 15,508,065 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01115,298,132 - 15,354,432 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,895,575 - 15,951,943 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lmnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213138,583,486 - 138,637,939 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936504157,453 - 211,967 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936504157,459 - 211,916 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LMNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2129,807,318 - 129,872,270 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12129,807,228 - 129,862,211 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22135,104,017 - 135,158,937 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LMNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12329,759,133 - 29,814,332 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2329,759,514 - 29,814,314 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603448,254,893 - 48,313,748 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lmnb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477414,805,465 - 14,863,241 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477414,806,585 - 14,863,543 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lmnb1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11575,083,432 - 75,125,925 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lmnb1
394 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:70
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000019351
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184891705460064728Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019351   ⟹   ENSRNOP00000019351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1852,373,757 - 52,413,283 (+)Ensembl
mRatBN7.2 Ensembl1850,175,874 - 50,214,502 (+)Ensembl
Rnor_6.0 Ensembl1851,785,111 - 51,822,264 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104660   ⟹   ENSRNOP00000089957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1850,175,874 - 50,206,806 (+)Ensembl
RefSeq Acc Id: NM_053905   ⟹   NP_446357
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81852,373,939 - 52,413,284 (+)NCBI
mRatBN7.21850,175,861 - 50,215,210 (+)NCBI
Rnor_6.01851,785,111 - 51,822,264 (+)NCBI
Rnor_5.01850,979,862 - 51,018,232 (+)NCBI
RGSC_v3.41852,470,605 - 52,508,022 (+)RGD
Celera1848,320,757 - 48,358,598 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446357 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB09600 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019351
GenBank Protein P70615 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446357   ⟸   NM_053905
- UniProtKB: P70615 (UniProtKB/Swiss-Prot),   G3V7U4 (UniProtKB/TrEMBL),   A6IX67 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019351   ⟸   ENSRNOT00000019351
Ensembl Acc Id: ENSRNOP00000089957   ⟸   ENSRNOT00000104660
Protein Domains
IF rod   LTD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70615-F1-model_v2 AlphaFold P70615 1-587 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700792
Promoter ID:EPDNEW_R11316
Type:initiation region
Name:Lmnb1_1
Description:lamin B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01851,785,163 - 51,785,223EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620522 AgrOrtholog
BioCyc Gene G2FUF-7440 BioCyc
Ensembl Genes ENSRNOG00000013774 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000019351 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  2.60.40.1260 UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Lamin_tail_dom UniProtKB/Swiss-Prot
  Lamin_tail_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:116685 UniProtKB/Swiss-Prot
NCBI Gene 116685 ENTREZGENE
PANTHER LAMIN DM0-RELATED UniProtKB/Swiss-Prot
  LAMIN-B1 UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
  LTD UniProtKB/Swiss-Prot
PhenoGen Lmnb1 PhenoGen
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
  LTD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013774 RatGTEx
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
  SSF74853 UniProtKB/Swiss-Prot
UniProt A6IX67 ENTREZGENE, UniProtKB/TrEMBL
  G3V7U4 ENTREZGENE, UniProtKB/TrEMBL
  LMNB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Lmnb1  lamin B1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Lmnb1  lamin B1      Symbol and Name status set to provisional 70820 PROVISIONAL