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Gene: Crnkl1 (crooked neck pre-mRNA splicing factor 1) Rattus norvegicus

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Symbol:

Crnkl1 (Ensembl: LOC102548514)

Name:

crooked neck pre-mRNA splicing factor 1 (Ensembl:crooked neck-like protein 1-like)

RGD ID:

620507

Description:

Predicted to enable RNA binding activity. Involved in cellular response to brain-derived neurotrophic factor stimulus; cellular response to leukemia inhibitory factor; and cerebral cortex development. Predicted to be located in nucleus. Predicted to be part of Prp19 complex; U2-type catalytic step 2 spliceosome; and post-mRNA release spliceosomal complex. Human ortholog(s) of this gene implicated in basal cell carcinoma. Orthologous to human CRNKL1 (crooked neck pre-mRNA splicing factor 1); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Crn; Crn, crooked neck-like 1; Crn, crooked neck-like 1 (Drosophila); crooked neck homolog; crooked neck pre-mRNA splicing factor-like 1; crooked neck pre-mRNA splicing factor-like 1 (Drosophila); crooked neck protein; crooked neck-like 1 protein-like; crooked neck-like protein 1; crooked neck-like protein 1-like; LOC100360434; LOC100910202; MGC93283

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CRNKL1 (crooked neck pre-mRNA splicing factor 1)	RGD	RGD
Mus musculus (house mouse):	Crnkl1 (crooked neck pre-mRNA splicing factor 1)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Crnkl1 (crooked neck pre-mRNA splicing factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CRNKL1 (crooked neck pre-mRNA splicing factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CRNKL1 (crooked neck pre-mRNA splicing factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Crnkl1 (crooked neck pre-mRNA splicing factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CRNKL1 (crooked neck pre-mRNA splicing factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CRNKL1 (crooked neck pre-mRNA splicing factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Crnkl1 (crooked neck pre-mRNA splicing factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Crnkl1 (crooked neck pre-mRNA splicing factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CRNKL1 (crooked neck pre-mRNA splicing factor 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Crnkl1 (crooked neck pre-mRNA splicing factor 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	crnkl1 (crooked neck pre-mRNA splicing factor 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	CLF1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	M03F8.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	crn	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	crnkl1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	crnkl1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Related Pseudogenes:

Crnkl1-ps1

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	153,764,718 - 153,807,973 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	6,894,292 - 6,896,635 (+)	Ensembl				GRCr8
GRCr8 Ensembl	3	153,791,879 - 153,807,614 (-)	Ensembl				GRCr8
mRatBN7.2	3	133,338,593 - 133,354,329 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	133,337,039 - 133,354,302 (-)	Ensembl				mRatBN7.2
mRatBN7.2 Ensembl	6	1,140,615 - 1,142,918 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	1,362,744 - 1,365,058 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	1,672,026 - 1,674,340 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	1,196,426 - 1,198,740 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	3	151,867,451 - 151,883,071 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	3	158,812,806 - 158,828,426 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	3	150,672,822 - 150,688,442 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	3	131,989,691 - 132,005,311 (-)	NCBI		F344_StmMcwi
Rnor_6.0	6	18,349,226 - 18,351,540 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	18,349,167 - 18,351,536 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	28,249,112 - 28,251,426 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	134,538,940 - 134,554,660 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	957,687 - 960,001 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

basal cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP,ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

benzene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bisphenol F (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carnosic acid (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

flavonoids (EXP)

gentamycin (EXP)

lead diacetate (ISO)

methylmercury chloride (ISO)

nickel sulfate (ISO)

ozone (ISO)

perfluorooctane-1-sulfonic acid (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tetrachloromethane (EXP)

thapsigargin (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to brain-derived neurotrophic factor stimulus (IEP)

cellular response to leukemia inhibitory factor (IEP)

cerebral cortex development (IEP)

mRNA processing (IEA)

mRNA splicing, via spliceosome (IBA,IEA,ISO,ISS)

RNA processing (IEA)

RNA splicing (IEA)

spliceosomal complex assembly (IBA,ISO,ISS)

Cellular Component

catalytic step 2 spliceosome (ISO)

nuclear speck (IEA)

nucleus (IEA,ISO,ISS)

post-mRNA release spliceosomal complex (IBA)

Prp19 complex (IBA)

spliceosomal complex (IEA,ISO,ISS)

U2-type catalytic step 2 spliceosome (IBA,ISO,ISS)

Molecular Function

protein binding (ISO)

RNA binding (ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

spliceosome pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	A novel rat orthologue and homologue for the Drosophila crooked neck gene in neural stem cells and their immediate descendants.	Amada N, etal., J Biochem (Tokyo) 2003 May;133(5):615-23.
2.	Splicing and beyond: the many faces of the Prp19 complex.	Chanarat S and Strasser K, Biochim Biophys Acta. 2013 Oct;1833(10):2126-34. doi: 10.1016/j.bbamcr.2013.05.023. Epub 2013 Jun 3.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Mutational landscape of basal cell carcinomas by whole-exome sequencing.	Jayaraman SS, etal., J Invest Dermatol. 2014 Jan;134(1):213-20. doi: 10.1038/jid.2013.276. Epub 2013 Jun 17.
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	Drosophila crooked-neck protein co-fractionates in a multiprotein complex with splicing factors.	Raisin-Tani S and Leopold P, Biochem Biophys Res Commun 2002 Aug 16;296(2):288-92.
9.	GOA pipeline	RGD automated data pipeline
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:11991638	PMID:12084575	PMID:12477932	PMID:15489334	PMID:22681889	PMID:28076346

Genomics

Comparative Map Data

Crnkl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	153,764,718 - 153,807,973 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	6,894,292 - 6,896,635 (+)	Ensembl				GRCr8
GRCr8 Ensembl	3	153,791,879 - 153,807,614 (-)	Ensembl				GRCr8
mRatBN7.2	3	133,338,593 - 133,354,329 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	133,337,039 - 133,354,302 (-)	Ensembl				mRatBN7.2
mRatBN7.2 Ensembl	6	1,140,615 - 1,142,918 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	1,362,744 - 1,365,058 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	1,672,026 - 1,674,340 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	1,196,426 - 1,198,740 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	3	151,867,451 - 151,883,071 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	3	158,812,806 - 158,828,426 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	3	150,672,822 - 150,688,442 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	3	131,989,691 - 132,005,311 (-)	NCBI		F344_StmMcwi
Rnor_6.0	6	18,349,226 - 18,351,540 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	18,349,167 - 18,351,536 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	28,249,112 - 28,251,426 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	134,538,940 - 134,554,660 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	957,687 - 960,001 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

CRNKL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	20,034,368 - 20,056,046 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	20,034,368 - 20,056,046 (-)	Ensembl			hg38	GRCh38
GRCh37	20	20,015,012 - 20,036,690 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	19,963,012 - 19,984,690 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	20	19,963,011 - 19,984,690	NCBI
Celera	20	20,089,029 - 20,110,711 (-)	NCBI		Celera
Cytogenetic Map	20	p11.23	NCBI
HuRef	20	19,976,670 - 19,998,362 (-)	NCBI		HuRef
CHM1_1	20	20,015,382 - 20,037,072 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	20,088,648 - 20,110,326 (-)	NCBI		T2T-CHM13v2.0

Crnkl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	145,759,402 - 145,776,620 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	145,759,399 - 145,776,934 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	145,917,482 - 145,934,700 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	145,917,479 - 145,935,014 (-)	Ensembl			mm10	GRCm38
MGSCv37	2	145,743,218 - 145,760,436 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	145,608,923 - 145,626,141 (-)	NCBI		MGSCv36	mm8
Celera	2	147,153,324 - 147,170,535 (-)	NCBI		Celera
Cytogenetic Map	2	G1	NCBI
cM Map	2	71.28	NCBI

Crnkl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	28,158,351 - 28,172,055 (-)	Ensembl
ChiLan1.0	NW_004955415	28,158,351 - 28,171,335 (-)	NCBI	ChiLan1.0	ChiLan1.0

CRNKL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	20,924,252 - 20,940,546 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	20,919,773 - 20,937,382 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	19,992,092 - 20,010,809 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	19,957,545 - 19,975,809 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	19,959,356 - 19,979,094 (-)	Ensembl			panPan2	panpan1.1

CRNKL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	3,294,607 - 3,310,846 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	3,294,616 - 3,310,702 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	3,322,820 - 3,338,912 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	3,703,030 - 3,719,137 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	3,702,577 - 3,720,541 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	3,298,774 - 3,314,853 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	3,401,816 - 3,417,906 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	3,679,794 - 3,695,883 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Crnkl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	151,896,734 - 151,919,612 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	327,835 - 350,132 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	328,077 - 351,323 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CRNKL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	28,077,707 - 28,111,558 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	17	28,079,541 - 28,111,871 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	31,810,243 - 31,816,810 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CRNKL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	49,052,304 - 49,070,600 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	49,054,125 - 49,070,576 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666078	3,838,825 - 3,857,376 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Crnkl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	20,564,474 - 20,581,716 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624741	20,565,686 - 20,581,708 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Crnkl1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	125,555,750 - 125,573,485 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Crnkl1
139 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	154
Count of miRNA genes:	112
Interacting mature miRNAs:	123
Transcripts:	ENSRNOT00000014632, ENSRNOT00000061588
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	141555229	186555229	Rat
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141555229	186555229	Rat
1582233	Insul10	Insulin level QTL 10	5.4	0.0015	blood insulin amount (VT:0001560)	serum insulin level times blood glucose level (CMO:0002040)	3	133259579	178259579	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	141555229	186555229	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	141555229	186555229	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	151075912	189428310	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	129154923	182114333	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	141555229	186555229	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	141555229	186555229	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	133134628	178134628	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	141508991	166376254	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	152055202	189428310	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	112250810	157250810	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	142898802	187898802	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	145335553	189428310	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	117537367	162537367	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	125116475	170116475	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	110225882	155225882	Rat
1358204	Insglur1	Insulin/glucose ratio QTL 1	3.8		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	3	136091420	155634702	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	139299381	184299381	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	122395989	167395989	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	141508991	177728348	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	131036586	176036586	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	137114333	182114333	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	131036586	176036586	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	98651826	167012663	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	151075912	189428310	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	151075912	189428310	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	110634702	155634702	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	141555229	186555229	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	144575244	189428310	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	116188400	161188400	Rat

Markers in Region

AU022874

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	133,340,200 - 133,341,018 (+)	MAPPER	mRatBN7.2
mRatBN7.2	6	1,142,239 - 1,142,445 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	18,349,710 - 18,349,915	NCBI	Rnor6.0
Rnor_6.0	3	140,127,552 - 140,128,369	NCBI	Rnor6.0
Rnor_5.0	6	28,249,596 - 28,249,801	UniSTS	Rnor5.0
Rnor_5.0	3	146,547,713 - 146,548,530	UniSTS	Rnor5.0
RGSC_v3.4	3	134,540,543 - 134,541,360	UniSTS	RGSC3.4
RGSC_v3.4	6	17,490,336 - 17,490,541	UniSTS	RGSC3.4
Celera	6	959,312 - 959,517	UniSTS
Celera	3	132,205,323 - 132,206,140	UniSTS
Cytogenetic Map	3	q41	UniSTS

RH143622

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	1,142,376 - 1,142,663 (-)	MAPPER	mRatBN7.2
Rnor_6.0	3	140,127,068 - 140,127,620	NCBI	Rnor6.0
Rnor_6.0	6	18,349,492 - 18,349,778	NCBI	Rnor6.0
Rnor_5.0	6	28,249,378 - 28,249,664	UniSTS	Rnor5.0
Rnor_5.0	3	146,547,229 - 146,547,781	UniSTS	Rnor5.0
RGSC_v3.4	3	134,539,206 - 134,540,611	UniSTS	RGSC3.4
RGSC_v3.4	6	17,490,118 - 17,490,404	UniSTS	RGSC3.4
Celera	6	959,449 - 959,735	UniSTS
Celera	3	132,204,005 - 132,205,391	UniSTS
Cytogenetic Map	3	q41	UniSTS

RH141585

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	133,338,445 - 133,338,633 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	140,126,650 - 140,126,837	NCBI	Rnor6.0
Rnor_5.0	3	146,546,811 - 146,546,998	UniSTS	Rnor5.0
RGSC_v3.4	3	134,538,788 - 134,538,975	UniSTS	RGSC3.4
Celera	3	132,203,587 - 132,203,774	UniSTS
RH 3.4 Map	3	1168.59	UniSTS
Cytogenetic Map	3	q41	UniSTS

UniSTS:479086

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	1,142,217 - 1,142,756 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	18,349,399 - 18,349,937	NCBI	Rnor6.0
Rnor_5.0	6	28,249,285 - 28,249,823	UniSTS	Rnor5.0
RGSC_v3.4	6	17,490,025 - 17,490,563	UniSTS	RGSC3.4
Celera	6	959,290 - 959,828	UniSTS
Cytogenetic Map	3	q41	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
19	23	110	247	148	150	100	111	100	6	516	265	11	218	116	133	50	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC085718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000014632 ⟹ ENSRNOP00000014632

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	153,791,879 - 153,807,614 (-)	Ensembl
mRatBN7.2 Ensembl	3	133,337,039 - 133,354,302 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000061588 ⟹ ENSRNOP00000073513

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	1,140,615 - 1,142,918 (+)	Ensembl
Rnor_6.0 Ensembl	6	18,349,167 - 18,351,536 (-)	Ensembl

RefSeq Acc Id:

NM_053797 ⟹ NP_446249

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	153,791,879 - 153,807,614 (-)	NCBI
mRatBN7.2	3	133,338,593 - 133,354,329 (-)	NCBI
Dahl_SR_JrHsd	3	151,867,451 - 151,883,071 (-)	NCBI
Lyon_Normotensive	3	158,812,806 - 158,828,426 (-)	NCBI
Lyon_Hypertensive	3	150,672,822 - 150,688,442 (-)	NCBI
F344_StmMcwi	3	131,989,691 - 132,005,311 (-)	NCBI
Rnor_6.0	6	18,349,226 - 18,351,540 (-)	NCBI
Rnor_5.0	6	28,249,112 - 28,251,426 (-)	NCBI
RGSC_v3.4	3	134,538,940 - 134,554,660 (-)	RGD
Celera	6	957,687 - 960,001 (+)	NCBI

Sequence:

show sequence

CTCTGTGGTGCTGGCCGCGGGATTTTGAGGCGTGTATCTGAAGTCCGGGTGTGGGCCAGGGTCG
CTCGCGTTCCGCGGCTACAATCATGGCGGCTTCCACGGCAGCCGGGAAACAGCGGATTCCTAAA
GTGGCCAAGGTGAAGAACAAAGCGCCAGCAGAGGTGCAGATAACCGCAGAGCAGCTCTTAAGGG
AGGCTAAAGAAAGAGAGCTCGAGCTCCTCCCACCCCCACCTCAGCAGAAGATCACAGACGAGGA
AGAACTAAACGATTACAAACTACGGAAAAGGAAGACTTTCGAAGATAATATAAGAAAAAACAGA
ACTGTGATTAGCAACTGGATCAAATACGCACAATGGGAGGAAAGTCTGAAGGAAATTCAAAGGG
CCCGATCCATATACGAGCGTGCTTTAGATGTCGACTACCGAAATATCACACTCTGGCTGAAATA
TGCAGAAATGGAAATGAAGAACCGCCAGGTCAACCATGCCCGAAATATCTGGGACCGTGCCATA
ACAACCCTGCCGCGAGTCAACCAGTTCTGGTACAAATACACGTACATGGAGGAGATGCTGGGCA
ATGTTGCCGGTGCTCGTCAGGTGTTTGAGCGCTGGATGGAATGGCAGCCTGAGGAGCAGGCCTG
GCACTCCTACATCAACTTCGAGCTGAGATACAAAGAGGTGGAGCGGGCCCGCACCATTTATGAA
CGCTTTGTGCTCGTGCACCCTGCTGTGAAGAACTGGATCAAGTACGCTCGATTTGAAGAGAAGC
ATGCGTATTTTGCCCATGCGCGGAAAGTCTACGAGAGAGCAGTTGAGTTTTTTGGGGATGAGCA
TATGGACGAACACCTCTATGTGGCCTTTGCTAAATTTGAAGAAAATCAAAAAGAATTTGAAAGG
GTACGAGTTATCTACAAATATGCCCTGGATAGGATTTCCAAGCAAGAGGCCCAAGAGCTCTTTA
AAAACTATACCATCTTTGAGAAGAAGTTTGGTGACCGGAGGGGTATAGAAGACATCATCGTGAG
CAAACGGAGATTCCAGTATGAAGAAGAAGTGAAGGCTAATCCACACAATTATGATGCATGGTTT
GATTATTTACGCTTGGTGGAAAGTGATGCAGAAGCGGACACTGTGCGGGAAGTCTATGAGCGAG
CCATTGCCAATGTGCCACCCATCCAGGAGAAGAGGCACTGGAAACGCTACATCTACCTCTGGGT
TAACTACGCACTCTATGAAGAGCTGGAGGCCAAGGATCCTGAGAGGACAAGACAGGTGTATCAA
GCATCTTTGGAACTAATTCCTCACAAAAAGTTCACGTTTGCCAAAATGTGGTTATATTACGCAC
AGTTTGAAATAAGACAGAAAAATCTGCCATTTGCCAGAAGAGCTTTGGGAACTTCCATAGGCAA
ATGTCCCAAGAACAAGTTATTCAAAGGTTACATAGAACTGGAACTGCAGCTTCGAGAATTTGAC
AGATGCAGGAAGCTTTACGAAAAGTTTTTGGAATTTGGACCTGAAAATTGTACCTCGTGGATTA
AGTTTGCAGAATTAGAAACAATCCTTGGTGATATTGAGAGAGCTCGGGCAATCTATGAATTAGC
CATCAGCCAGCCACGCTTGGATATGCCAGAGGTACTTTGGAAATCATATATTGATTTTGAGATT
GAGCAGGAAGAAACTGAGAGAACACGAAATCTTTACCGACAGTTGCTTCAGCGAACACAGCACG
TCAAGGTATGGATCAGTTTTGCTCAGTTTGAATTATCTTCTGGGAAAGAAGGAAGTGTGGCTAA
ATGCAGACAGATTTATGAAGAAGCTAACAAAACCATGAGAAACTGTGAAGAAAAAGAAGAGAGG
CTTATGTTGCTGGAGTCCTGGCGAAGTTTCGAAGATGAATTTGGAACAGTATCAGACAAGGAGA
GAGTAGACAAACTCATGCCAGAAAAGGTCAAGAAGAGAAGAAAGGTCCAGGCTGACGATGGGTC
TGATGCCGGATGGGAAGAGTACTATGACTACATCTTTCCAGAGGATGCTGCCAACCAGCCTAAC
CTCAAGCTGCTGGCGATGGCCAAGCTTTGGAAGAAACAGCAACAAGAAAGAGAAGCTGCCGAAC
AGGATCCAGATAAGGACATTGATGAGAGTGAATCCTCATCTTTTTAAATGTTATTATTGCTTTG
TATAAATTAACAGTTTAGAACTTTGACTTCTGGATGTTTTTATATATTTACCCAGTAAGGAGTT
GTTTGACATCTTTGAATTATTTTTTAAAATCTCCTGGGTTAACTATGGATGAGAAACTGCAAGT
AAAGGAAATTTTTGTAACAGTTAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063282973 ⟹ XP_063139043

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	153,764,718 - 153,807,973 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_446249	(Get FASTA)	NCBI Sequence Viewer
	XP_063139043	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85718	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000014632
GenBank Protein	P63155	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446249 ⟸ NM_053797

- UniProtKB:

P63155 (UniProtKB/Swiss-Prot), A0A0G2K5Q2 (UniProtKB/TrEMBL), A6H999 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAASTAAGKQRIPKVAKVKNKAPAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKL
RKRKTFEDNIRKNRTVISNWIKYAQWEESLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKN
RQVNHARNIWDRAITTLPRVNQFWYKYTYMEEMLGNVAGARQVFERWMEWQPEEQAWHSYINFE
LRYKEVERARTIYERFVLVHPAVKNWIKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYV
AFAKFEENQKEFERVRVIYKYALDRISKQEAQELFKNYTIFEKKFGDRRGIEDIIVSKRRFQYE
EEVKANPHNYDAWFDYLRLVESDAEADTVREVYERAIANVPPIQEKRHWKRYIYLWVNYALYEE
LEAKDPERTRQVYQASLELIPHKKFTFAKMWLYYAQFEIRQKNLPFARRALGTSIGKCPKNKLF
KGYIELELQLREFDRCRKLYEKFLEFGPENCTSWIKFAELETILGDIERARAIYELAISQPRLD
MPEVLWKSYIDFEIEQEETERTRNLYRQLLQRTQHVKVWISFAQFELSSGKEGSVAKCRQIYEE
ANKTMRNCEEKEERLMLLESWRSFEDEFGTVSDKERVDKLMPEKVKKRRKVQADDGSDAGWEEY
YDYIFPEDAANQPNLKLLAMAKLWKKQQQEREAAEQDPDKDIDESESSSF

hide sequence

Ensembl Acc Id:

ENSRNOP00000073513 ⟸ ENSRNOT00000061588

Ensembl Acc Id:

ENSRNOP00000014632 ⟸ ENSRNOT00000014632

RefSeq Acc Id:	XP_063139043 ⟸ XM_063282973
- Peptide Label:	isoform X1

Protein Domains

Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P63155-F1-model_v2	AlphaFold	P63155	1-690	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620507	AgrOrtholog
BioCyc Gene	G2FUF-47575	BioCyc
Ensembl Genes	ENSRNOG00000010587	Ensembl, ENTREZGENE
	ENSRNOG00000040045	Ensembl
Ensembl Transcript	ENSRNOT00000014632	ENTREZGENE
Gene3D-CATH	1.25.40.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7190212	IMAGE-MGC_LOAD
InterPro	HAT	UniProtKB/Swiss-Prot
	HAT_Syf1_CNRKL1_C	UniProtKB/Swiss-Prot
	Syf1-like	UniProtKB/Swiss-Prot
	TPR-like_helical_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:100910202	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93283	IMAGE-MGC_LOAD
NCBI Gene	100910202	ENTREZGENE
PANTHER	CROOKED NECK-LIKE PROTEIN 1	UniProtKB/Swiss-Prot
	PTHR11246	UniProtKB/Swiss-Prot
Pfam	HAT_Syf1_CNRKL1_C	UniProtKB/Swiss-Prot
PhenoGen	Crnkl1	PhenoGen
RatGTEx	ENSRNOG00000010587	RatGTEx
	ENSRNOG00000040045	RatGTEx
SMART	HAT	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48452	UniProtKB/Swiss-Prot
UniProt	A0A0G2K5Q2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2Q6U6_RAT	UniProtKB/TrEMBL
	A6H999	ENTREZGENE, UniProtKB/TrEMBL
	CRNL1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	Q9CQC1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-29	Crnkl1	crooked neck pre-mRNA splicing factor 1	LOC100360434	crooked neck-like 1 protein-like	Data merged from RGD:2322122	737654	PROVISIONAL
2013-12-11	Crnkl1	crooked neck pre-mRNA splicing factor 1	Crnkl1	crooked neck pre-mRNA splicing factor-like 1 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-11-27	Crnkl1	crooked neck pre-mRNA splicing factor-like 1 (Drosophila)	LOC100910202	crooked neck-like protein 1-like	Data merged from RGD:6499894	737654	APPROVED
2012-07-05	LOC100910202	crooked neck-like protein 1-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2010-05-06	LOC100360434	crooked neck-like 1 protein-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-10-15	Crnkl1	crooked neck pre-mRNA splicing factor-like 1 (Drosophila)	Crnkl1	Crn, crooked neck-like 1 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Crnkl1	Crn, crooked neck-like 1 (Drosophila)		crooked neck protein	Name updated	1299863	APPROVED
2004-09-10	Crnkl1	crooked neck protein	Crn		Symbol and Name updated	1299863	APPROVED
2002-08-07	Crn	crooked neck protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)