Rsad2 (radical S-adenosyl methionine domain containing 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Rsad2 (radical S-adenosyl methionine domain containing 2) Rattus norvegicus
Analyze
Symbol: Rsad2
Name: radical S-adenosyl methionine domain containing 2
RGD ID: 620495
Description: Predicted to enable 4 iron, 4 sulfur cluster binding activity. Involved in ossification and regulation of ossification. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and mitochondrial membrane. Predicted to be active in endoplasmic reticulum and mitochondrion. Human ortholog(s) of this gene implicated in respiratory syncytial virus infectious disease. Orthologous to human RSAD2 (radical S-adenosyl methionine domain containing 2); PARTICIPATES IN influenza A pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Best5; bone-expressed sequence tag 5 protein; radical S-adenosyl methionine domain-containing protein 2; S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; SAND; Vig1; viperin; virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8648,774,985 - 48,788,245 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl648,774,985 - 48,788,320 (-)EnsemblGRCr8
mRatBN7.2643,046,514 - 43,059,737 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl643,047,658 - 43,059,699 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx643,359,103 - 43,372,219 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0643,673,963 - 43,687,086 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0643,107,103 - 43,120,223 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0645,655,947 - 45,669,083 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl645,655,954 - 45,669,148 (-)Ensemblrn6Rnor6.0
Rnor_5.0654,375,724 - 54,388,860 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4644,100,775 - 44,113,910 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera642,313,474 - 42,326,629 (-)NCBICelera
RGSC_v3.1644,103,900 - 44,117,036 (-)NCBI
Cytogenetic Map6q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroprene  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
DDT  (ISO)
deoxycholic acid  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
diquat  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gadodiamide hydrate  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Genipin  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 4064  (ISO)
hydroxychloroquine  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
malathion  (ISO)
manganese(II) chloride  (EXP)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methotrexate  (EXP,ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
prednisolone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (EXP)
succimer  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triclosan  (EXP,ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Best5: a novel interferon-inducible gene expressed during bone formation. Grewal TS, etal., FASEB J 2000 Mar;14(3):523-31.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9391139   PMID:11752458   PMID:16108059   PMID:16982913   PMID:17686841   PMID:19047684   PMID:19074433   PMID:19920176   PMID:20176015   PMID:21435586   PMID:21527675   PMID:21880757  
PMID:21957124   PMID:23160199  


Genomics

Comparative Map Data
Rsad2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8648,774,985 - 48,788,245 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl648,774,985 - 48,788,320 (-)EnsemblGRCr8
mRatBN7.2643,046,514 - 43,059,737 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl643,047,658 - 43,059,699 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx643,359,103 - 43,372,219 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0643,673,963 - 43,687,086 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0643,107,103 - 43,120,223 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0645,655,947 - 45,669,083 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl645,655,954 - 45,669,148 (-)Ensemblrn6Rnor6.0
Rnor_5.0654,375,724 - 54,388,860 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4644,100,775 - 44,113,910 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera642,313,474 - 42,326,629 (-)NCBICelera
RGSC_v3.1644,103,900 - 44,117,036 (-)NCBI
Cytogenetic Map6q16NCBI
RSAD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3826,865,885 - 6,898,239 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl26,865,557 - 6,898,239 (+)Ensemblhg38GRCh38
GRCh3727,006,016 - 7,038,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3626,935,247 - 6,955,814 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3426,968,505 - 6,988,515NCBI
Celera26,930,748 - 6,951,316 (+)NCBICelera
Cytogenetic Map2p25.2NCBI
HuRef26,865,409 - 6,885,974 (+)NCBIHuRef
CHM1_126,947,350 - 6,967,911 (+)NCBICHM1_1
T2T-CHM13v2.026,887,387 - 6,919,736 (+)NCBIT2T-CHM13v2.0
Rsad2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391226,492,742 - 26,506,451 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1226,492,745 - 26,506,451 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381226,442,743 - 26,456,452 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1226,442,746 - 26,456,452 (-)Ensemblmm10GRCm38
MGSCv371227,127,608 - 27,141,317 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361227,029,021 - 27,042,699 (-)NCBIMGSCv36mm8
Celera1227,901,184 - 27,914,822 (-)NCBICelera
Cytogenetic Map12A2NCBI
cM Map129.69NCBI
Rsad2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554871,987,405 - 2,001,731 (-)Ensembl
ChiLan1.0NW_0049554871,988,226 - 2,001,731 (-)NCBIChiLan1.0ChiLan1.0
RSAD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212119,613,920 - 119,646,167 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A119,617,895 - 119,650,127 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A6,873,821 - 6,906,087 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A7,010,762 - 7,042,500 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A7,021,937 - 7,042,961 (+)EnsemblpanPan2panpan1.1
RSAD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1174,488,202 - 4,508,705 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl174,487,957 - 4,507,181 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha174,413,914 - 4,434,446 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0174,590,443 - 4,611,109 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl174,590,447 - 4,611,103 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1174,478,041 - 4,498,585 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0174,486,485 - 4,506,800 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0174,500,286 - 4,520,826 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rsad2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629249,163,650 - 49,180,994 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365323,921,807 - 3,936,042 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365323,921,824 - 3,936,027 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RSAD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3128,877,186 - 128,897,815 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13128,880,853 - 128,897,809 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23137,666,404 - 137,683,529 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RSAD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114100,778,801 - 100,804,205 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14100,778,302 - 100,798,044 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604511,543,806 - 11,563,560 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rsad2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248463,395,406 - 3,408,626 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248463,395,536 - 3,408,616 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rsad2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1739,973,632 - 39,984,432 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rsad2
77 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:540
Count of miRNA genes:245
Interacting mature miRNAs:298
Transcripts:ENSRNOT00000010092
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)64005241156848866Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63902865963457441Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)63332884178328841Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)63332884178328841Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat

Markers in Region
RH130993  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2643,046,750 - 43,046,969 (+)MAPPERmRatBN7.2
Rnor_6.0645,656,184 - 45,656,402NCBIRnor6.0
Rnor_5.0654,375,961 - 54,376,179UniSTSRnor5.0
RGSC_v3.4644,101,012 - 44,101,230UniSTSRGSC3.4
Celera642,313,711 - 42,313,929UniSTS
RH 3.4 Map6257.8UniSTS
Cytogenetic Map6q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 165 91 90 59 92 59 6 354 190 11 144 81 91 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010092   ⟹   ENSRNOP00000010092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl648,774,985 - 48,788,320 (-)Ensembl
mRatBN7.2 Ensembl643,047,658 - 43,059,699 (-)Ensembl
Rnor_6.0 Ensembl645,655,954 - 45,669,148 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000157857   ⟹   ENSRNOP00000103974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl648,778,352 - 48,788,217 (-)Ensembl
RefSeq Acc Id: NM_138881   ⟹   NP_620236
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8648,774,985 - 48,788,120 (-)NCBI
mRatBN7.2643,046,514 - 43,059,651 (-)NCBI
Rnor_6.0645,655,947 - 45,669,083 (-)NCBI
Rnor_5.0654,375,724 - 54,388,860 (-)NCBI
RGSC_v3.4644,100,775 - 44,113,910 (-)RGD
Celera642,313,474 - 42,326,629 (-)RGD
Sequence:
RefSeq Acc Id: XM_039112917   ⟹   XP_038968845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8648,777,688 - 48,788,245 (-)NCBI
mRatBN7.2643,050,064 - 43,059,737 (-)NCBI
Protein Sequences
Protein RefSeqs NP_620236 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968845 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA68971 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010092
  ENSRNOP00000103974
GenBank Protein O70600 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620236   ⟸   NM_138881
- UniProtKB: O70600 (UniProtKB/Swiss-Prot),   A0A0H2UHF4 (UniProtKB/TrEMBL),   A6HAZ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010092   ⟸   ENSRNOT00000010092
RefSeq Acc Id: XP_038968845   ⟸   XM_039112917
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHF4 (UniProtKB/TrEMBL),   A6HAZ9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103974   ⟸   ENSRNOT00000157857
Protein Domains
Radical SAM core

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70600-F1-model_v2 AlphaFold O70600 1-360 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694528
Promoter ID:EPDNEW_R5051
Type:single initiation site
Name:Rsad2_1
Description:radical S-adenosyl methionine domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0645,669,096 - 45,669,156EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620495 AgrOrtholog
BioCyc Gene G2FUF-37995 BioCyc
Ensembl Genes ENSRNOG00000007539 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000010092 ENTREZGENE
  ENSRNOT00000157857 ENTREZGENE
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot
InterPro Aldolase_TIM UniProtKB/Swiss-Prot
  Elp3/MiaB/NifB UniProtKB/Swiss-Prot
  RSAD2 UniProtKB/Swiss-Prot
  RSAD2/Viperin_antiviral UniProtKB/Swiss-Prot
  rSAM UniProtKB/Swiss-Prot
KEGG Report rno:65190 UniProtKB/Swiss-Prot
NCBI Gene 65190 ENTREZGENE
PANTHER RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot
  RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot
Pfam Fer4_12 UniProtKB/Swiss-Prot
  Radical_SAM UniProtKB/Swiss-Prot
PhenoGen Rsad2 PhenoGen
PROSITE RADICAL_SAM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007539 RatGTEx
SMART Elp3 UniProtKB/Swiss-Prot
Superfamily-SCOP Radical SAM enzymes UniProtKB/Swiss-Prot
UniProt A0A0H2UHF4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LF61_RAT UniProtKB/TrEMBL
  A6HAZ9 ENTREZGENE, UniProtKB/TrEMBL
  O70600 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-22 Rsad2  radical S-adenosyl methionine domain containing 2  Best5  Best5 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-08-07 Best5  Best5 protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression is induced by interferon-alpha (IFN-alpha) or IFN-gamma in osteoblast cultures 631877