Rasgrf1 (RAS protein-specific guanine nucleotide-releasing factor 1) - Rat Genome Database

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Gene: Rasgrf1 (RAS protein-specific guanine nucleotide-releasing factor 1) Rattus norvegicus
Analyze
Symbol: Rasgrf1
Name: RAS protein-specific guanine nucleotide-releasing factor 1
RGD ID: 620395
Description: Enables receptor tyrosine kinase binding activity and small GTPase binding activity. Involved in several processes, including cellular response to insulin stimulus; modulation of chemical synaptic transmission; and positive regulation of Ras protein signal transduction. Located in several cellular components, including apical dendrite; apicolateral plasma membrane; and basolateral plasma membrane. Is active in glutamatergic synapse and postsynapse. Biomarker of fetal alcohol spectrum disorder. Orthologous to human RASGRF1 (Ras protein specific guanine nucleotide releasing factor 1); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GNRP; guanine nucleotide-releasing protein; P140 RAS-GRF; ras-GRF1; ras-specific guanine nucleotide-releasing factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8899,324,986 - 99,454,099 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl899,324,749 - 99,454,089 (+)EnsemblGRCr8
mRatBN7.2890,445,154 - 90,574,274 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl890,445,154 - 90,574,269 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx896,124,511 - 96,254,135 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0894,323,932 - 94,453,555 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0892,167,140 - 92,296,111 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0897,277,250 - 97,405,095 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl897,277,456 - 97,405,102 (+)Ensemblrn6Rnor6.0
Rnor_5.0896,778,440 - 96,905,934 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4894,802,467 - 94,811,501 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera889,989,217 - 90,117,860 (+)NCBICelera
RGSC_v3.1894,955,729 - 94,955,978 (+)NCBI
Cytogenetic Map8q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. Anborgh PH, etal., Mol Cell Biol. 1999 Jul;19(7):4611-22.
2. SCLIP, a microtubule-destabilizing factor, interacts with RasGRF1 and inhibits its ability to promote Rac activation and neurite outgrowth. Baldassa S, etal., J Biol Chem. 2007 Jan 26;282(4):2333-45. Epub 2006 Nov 29.
3. Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia. Fasano S, etal., Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21824-9. doi: 10.1073/pnas.1012071107. Epub 2010 Nov 29.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Krapivinsky G, etal., Neuron. 2003 Nov 13;40(4):775-84.
7. p75-Ras-GRF1 is a c-Jun/AP-1 target protein: its up regulation results in increased Ras activity and is necessary for c-Jun-induced nonadherent growth of Rat1a cells. Leaner VD, etal., Mol Cell Biol. 2005 Apr;25(8):3324-37.
8. Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory. Lee KJ, etal., Neuron. 2011 Mar 10;69(5):957-73. doi: 10.1016/j.neuron.2011.02.004.
9. Activity-dependent interaction of the intracellular domain of rat trkA with intermediate filament proteins, the beta-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3. MacDonald JI, etal., J Mol Neurosci. 1999 Aug-Oct;13(1-2):141-58.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Association between ZIC2, RASGRF1, and SHISA6 genes and high myopia in Japanese subjects. Oishi M, etal., Invest Ophthalmol Vis Sci. 2013 Nov 13;54(12):7492-7. doi: 10.1167/iovs.13-12825.
13. Amphetamine alters Ras-guanine nucleotide-releasing factor expression in the rat striatum in vivo. Parelkar NK, etal., Eur J Pharmacol. 2009 Oct 1;619(1-3):50-6. doi: 10.1016/j.ejphar.2009.08.006. Epub 2009 Aug 14.
14. A direct repeat sequence at the Rasgrf1 locus and imprinted expression. Pearsall RS, etal., Genomics 1999 Jan 15;55(2):194-201.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21. Shou C, etal., Nature. 1992 Jul 23;358(6384):351-4.
20. Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression. Tunc-Ozcan E, etal., Alcohol Clin Exp Res. 2013 Nov;37(11):1986-95. doi: 10.1111/acer.12183. Epub 2013 Jun 13.
21. A 54-kDa protein related to ras-guanine nucleotide release factor expressed in the rat exocrine pancreas. Tung PS, etal., Cell Tissue Res. 1997 Sep;289(3):505-15.
22. Phosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortex. Yang H, etal., J Biol Chem. 2003 Apr 11;278(15):13278-85. Epub 2003 Jan 21.
23. Decreased expression of Ras-GRF1 in the brain tissue of the intractable epilepsy patients and experimental rats. Zhu Q, etal., Brain Res. 2013 Feb 1;1493:99-109. doi: 10.1016/j.brainres.2012.11.033. Epub 2012 Nov 27.
24. Hypoinsulinemia alleviates the GRF1/Ras/Akt anti-apoptotic pathway and induces alterations of mitochondrial ras trafficking in neuronal cells. Zhuravliova E, etal., Neurochem Res. 2009 Jun;34(6):1076-82. doi: 10.1007/s11064-008-9877-4. Epub 2008 Nov 11.
Additional References at PubMed
PMID:8889548   PMID:11749043   PMID:12024021   PMID:12477932   PMID:12805218   PMID:14749369   PMID:15029245   PMID:16710293   PMID:17931779   PMID:19446794   PMID:20107120   PMID:22871113  
PMID:25644714   PMID:26890742   PMID:27856453   PMID:30053369   PMID:31245854  


Genomics

Comparative Map Data
Rasgrf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8899,324,986 - 99,454,099 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl899,324,749 - 99,454,089 (+)EnsemblGRCr8
mRatBN7.2890,445,154 - 90,574,274 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl890,445,154 - 90,574,269 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx896,124,511 - 96,254,135 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0894,323,932 - 94,453,555 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0892,167,140 - 92,296,111 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0897,277,250 - 97,405,095 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl897,277,456 - 97,405,102 (+)Ensemblrn6Rnor6.0
Rnor_5.0896,778,440 - 96,905,934 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4894,802,467 - 94,811,501 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera889,989,217 - 90,117,860 (+)NCBICelera
RGSC_v3.1894,955,729 - 94,955,978 (+)NCBI
Cytogenetic Map8q31NCBI
RASGRF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,959,906 - 79,090,780 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,959,906 - 79,090,780 (-)Ensemblhg38GRCh38
GRCh371579,252,248 - 79,383,122 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361577,041,341 - 77,169,895 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341577,041,340 - 77,085,057NCBI
Celera1556,188,621 - 56,319,894 (-)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1556,012,219 - 56,142,688 (-)NCBIHuRef
CHM1_11579,370,538 - 79,501,430 (-)NCBICHM1_1
T2T-CHM13v2.01576,823,565 - 76,954,487 (-)NCBIT2T-CHM13v2.0
Rasgrf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39989,791,565 - 89,909,032 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl989,791,961 - 89,909,030 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38989,909,508 - 90,026,979 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl989,909,908 - 90,026,977 (+)Ensemblmm10GRCm38
MGSCv37989,804,613 - 89,921,817 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36989,707,668 - 89,827,694 (+)NCBIMGSCv36mm8
Celera989,525,851 - 89,642,271 (+)NCBICelera
Cytogenetic Map9E3.1NCBI
cM Map947.31NCBI
Rasgrf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495553370,897 - 167,460 (-)Ensembl
ChiLan1.0NW_00495553369,736 - 167,626 (-)NCBIChiLan1.0ChiLan1.0
RASGRF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21668,218,024 - 68,348,582 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11572,383,681 - 72,514,345 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,933,152 - 58,063,824 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11576,891,556 - 77,022,437 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,891,556 - 77,022,534 (-)EnsemblpanPan2panpan1.1
RASGRF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,995,092 - 58,085,395 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,995,786 - 58,085,380 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha360,655,204 - 60,748,389 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0358,431,317 - 58,524,707 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl358,431,335 - 58,524,707 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1357,928,254 - 58,021,585 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0358,136,616 - 58,229,853 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0358,484,151 - 58,578,346 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rasgrf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640119,325,532 - 119,429,648 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647137,171,297 - 37,278,529 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647137,173,595 - 37,278,356 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RASGRF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl748,121,419 - 48,246,749 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1748,121,415 - 48,246,749 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2753,659,631 - 53,785,342 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RASGRF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,298,091 - 4,431,606 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,299,116 - 4,432,420 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048137,418,910 - 137,548,979 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rasgrf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624941110,676 - 222,092 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624941110,752 - 222,143 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Rasgrf1
1000 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:480
Count of miRNA genes:218
Interacting mature miRNAs:253
Transcripts:ENSRNOT00000018702, ENSRNOT00000018794
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
D8Rat20  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8899,388,267 - 99,388,414 (+)Marker Load Pipeline
mRatBN7.2890,508,442 - 90,508,589 (+)MAPPERmRatBN7.2
Rnor_6.0897,339,298 - 97,339,444NCBIRnor6.0
Rnor_5.0896,840,137 - 96,840,283UniSTSRnor5.0
RGSC_v3.4894,870,173 - 94,870,319UniSTSRGSC3.4
RGSC_v3.4894,870,172 - 94,870,319RGDRGSC3.4
Celera890,052,436 - 90,052,582UniSTS
RGSC_v3.1894,889,628 - 94,889,774RGD
RH 3.4 Map81013.3RGD
RH 3.4 Map81013.3UniSTS
RH 2.0 Map8792.0RGD
SHRSP x BN Map852.75RGD
Cytogenetic Map8q31UniSTS
D8Got142  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2890,568,562 - 90,568,797 (+)MAPPERmRatBN7.2
Rnor_6.0897,399,384 - 97,399,618NCBIRnor6.0
Rnor_5.0896,900,223 - 96,900,457UniSTSRnor5.0
RGSC_v3.4894,930,961 - 94,931,195UniSTSRGSC3.4
RGSC_v3.4894,930,960 - 94,931,195RGDRGSC3.4
Celera890,112,168 - 90,112,396UniSTS
RGSC_v3.1894,950,416 - 94,950,650RGD
RH 3.4 Map81013.6UniSTS
RH 3.4 Map81013.6RGD
RH 2.0 Map8788.4RGD
Cytogenetic Map8q31UniSTS
D8Got309  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8899,409,435 - 99,409,533 (+)Marker Load Pipeline
mRatBN7.2890,529,607 - 90,529,705 (+)MAPPERmRatBN7.2
Rnor_6.0897,360,499 - 97,360,596NCBIRnor6.0
Rnor_5.0896,861,338 - 96,861,435UniSTSRnor5.0
RGSC_v3.4894,891,335 - 94,891,432UniSTSRGSC3.4
Celera890,073,494 - 90,073,585UniSTS
Cytogenetic Map8q31UniSTS
RH132198  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2890,451,928 - 90,452,125 (+)MAPPERmRatBN7.2
Rnor_6.0897,284,181 - 97,284,377NCBIRnor6.0
Rnor_5.0896,785,020 - 96,785,216UniSTSRnor5.0
RGSC_v3.4894,810,623 - 94,810,819UniSTSRGSC3.4
Celera889,995,984 - 89,996,180UniSTS
RH 3.4 Map81013.6UniSTS
Cytogenetic Map8q31UniSTS
RH133787  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8899,453,741 - 99,453,952 (+)Marker Load Pipeline
mRatBN7.2890,573,916 - 90,574,127 (+)MAPPERmRatBN7.2
Rnor_6.0897,404,738 - 97,404,948NCBIRnor6.0
Rnor_5.0896,905,577 - 96,905,787UniSTSRnor5.0
RGSC_v3.4894,936,315 - 94,936,525UniSTSRGSC3.4
Celera890,117,503 - 90,117,713UniSTS
RH 3.4 Map81013.3UniSTS
Cytogenetic Map8q31UniSTS
AU046538  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2890,444,761 - 90,444,897 (+)MAPPERmRatBN7.2
Rnor_6.0897,276,860 - 97,276,993NCBIRnor6.0
Rnor_5.0896,778,050 - 96,778,183UniSTSRnor5.0
RGSC_v3.4894,802,077 - 94,802,210UniSTSRGSC3.4
Celera889,988,827 - 89,988,960UniSTS
Cytogenetic Map8q31UniSTS
AU049054  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8899,336,052 - 99,336,254 (+)Marker Load Pipeline
mRatBN7.2890,456,224 - 90,456,426 (+)MAPPERmRatBN7.2
Rnor_6.0897,288,476 - 97,288,677NCBIRnor6.0
Rnor_5.0896,789,315 - 96,789,516UniSTSRnor5.0
RGSC_v3.4894,814,918 - 94,815,119UniSTSRGSC3.4
Celera890,000,279 - 90,000,480UniSTS
Cytogenetic Map8q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 9 30 158 51 50 19 29 19 6 143 88 11 137 13 85 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018794   ⟹   ENSRNOP00000018794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl899,324,749 - 99,454,089 (+)Ensembl
mRatBN7.2 Ensembl890,445,230 - 90,574,269 (+)Ensembl
Rnor_6.0 Ensembl897,291,580 - 97,405,102 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082757   ⟹   ENSRNOP00000070883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl899,324,749 - 99,444,726 (+)Ensembl
mRatBN7.2 Ensembl890,445,230 - 90,564,900 (+)Ensembl
Rnor_6.0 Ensembl897,277,456 - 97,404,768 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094519   ⟹   ENSRNOP00000090813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl899,324,986 - 99,326,791 (+)Ensembl
mRatBN7.2 Ensembl890,445,154 - 90,446,959 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106070   ⟹   ENSRNOP00000077058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl899,324,986 - 99,332,636 (+)Ensembl
mRatBN7.2 Ensembl890,445,154 - 90,452,807 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000160336   ⟹   ENSRNOP00000111797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl899,325,100 - 99,454,089 (+)Ensembl
RefSeq Acc Id: NM_001105753   ⟹   NP_001099223
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8899,324,986 - 99,332,636 (+)NCBI
mRatBN7.2890,445,154 - 90,452,807 (+)NCBI
Rnor_6.0897,277,250 - 97,285,059 (+)NCBI
Rnor_5.0896,778,440 - 96,905,934 (+)NCBI
RGSC_v3.4894,802,467 - 94,811,501 (+)RGD
Celera889,989,217 - 89,996,862 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001170531   ⟹   NP_001164002
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8899,325,062 - 99,454,099 (+)NCBI
mRatBN7.2890,445,230 - 90,574,274 (+)NCBI
Rnor_6.0897,277,326 - 97,405,095 (+)NCBI
Rnor_5.0896,778,440 - 96,905,934 (+)NCBI
Celera889,989,293 - 90,117,860 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001099223   ⟸   NM_001105753
- Peptide Label: isoform 2
- UniProtKB: A0A8I5Y148 (UniProtKB/TrEMBL),   A6I210 (UniProtKB/TrEMBL),   A0A8I6AEJ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001164002   ⟸   NM_001170531
- Peptide Label: isoform 1
- UniProtKB: P28818 (UniProtKB/Swiss-Prot),   A6I209 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070883   ⟸   ENSRNOT00000082757
Ensembl Acc Id: ENSRNOP00000018794   ⟸   ENSRNOT00000018794
Ensembl Acc Id: ENSRNOP00000077058   ⟸   ENSRNOT00000106070
Ensembl Acc Id: ENSRNOP00000090813   ⟸   ENSRNOT00000094519
Ensembl Acc Id: ENSRNOP00000111797   ⟸   ENSRNOT00000160336
Protein Domains
DH   IQ   N-terminal Ras-GEF   PH   Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28818-F1-model_v2 AlphaFold P28818 1-1244 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696178
Promoter ID:EPDNEW_R6700
Type:multiple initiation site
Name:Rasgrf1_1
Description:RAS protein-specific guanine nucleotide-releasing factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0897,291,549 - 97,291,609EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620395 AgrOrtholog
BioCyc Gene G2FUF-29576 BioCyc
Ensembl Genes ENSRNOG00000014025 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000106070 ENTREZGENE
  ENSRNOT00000160336 ENTREZGENE
Gene3D-CATH 1.10.840.10 UniProtKB/Swiss-Prot
  1.20.900.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7312874 IMAGE-MGC_LOAD
InterPro DBL_dom_sf UniProtKB/Swiss-Prot
  DH-domain UniProtKB/Swiss-Prot
  GDS_CDC24_CS UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  Ras-like_GEF UniProtKB/Swiss-Prot
  Ras-like_Gua-exchang_fac_N UniProtKB/Swiss-Prot
  Ras_G-nucl-exch_fac_CS UniProtKB/Swiss-Prot
  Ras_GEF_dom_sf UniProtKB/Swiss-Prot
  RASGEF_cat_dom UniProtKB/Swiss-Prot
  RASGEF_cat_dom_sf UniProtKB/Swiss-Prot
  SOS1_NGEF_PH UniProtKB/Swiss-Prot
KEGG Report rno:192213 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109293 IMAGE-MGC_LOAD
NCBI Gene 192213 ENTREZGENE
PANTHER PTHR23113 UniProtKB/Swiss-Prot
  PTHR23113:SF193 UniProtKB/Swiss-Prot
Pfam PF00169 UniProtKB/Swiss-Prot
  RasGEF UniProtKB/Swiss-Prot
  RasGEF_N UniProtKB/Swiss-Prot
  RhoGEF UniProtKB/Swiss-Prot
  SOS1_NGEF_PH UniProtKB/Swiss-Prot
PhenoGen Rasgrf1 PhenoGen
PROSITE DH_1 UniProtKB/Swiss-Prot
  DH_2 UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  PS50096 UniProtKB/Swiss-Prot
  RASGEF UniProtKB/Swiss-Prot
  RASGEF_CAT UniProtKB/Swiss-Prot
  RASGEF_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014025 RatGTEx
SMART RasGEF UniProtKB/Swiss-Prot
  RasGEFN UniProtKB/Swiss-Prot
  RhoGEF UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF48065 UniProtKB/Swiss-Prot
  SSF48366 UniProtKB/Swiss-Prot
UniProt A0A0G2JZ23_RAT UniProtKB/TrEMBL
  A0A8I5Y148 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEJ3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M145_RAT UniProtKB/TrEMBL
  A6I209 ENTREZGENE, UniProtKB/TrEMBL
  A6I210 ENTREZGENE, UniProtKB/TrEMBL
  F1LM43_RAT UniProtKB/TrEMBL
  P28818 ENTREZGENE
  Q5BJV1_RAT UniProtKB/TrEMBL
  Q71UW1_RAT UniProtKB/TrEMBL
  RGRF1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Rasgrf1  RAS protein-specific guanine nucleotide-releasing factor 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Rasgrf1  RAS protein-specific guanine nucleotide-releasing factor 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression paternal-specific monoallelic expression in neonatal brain 1299269