Dctn1 (dynactin subunit 1) - Rat Genome Database

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Gene: Dctn1 (dynactin subunit 1) Rattus norvegicus
Analyze
Symbol: Dctn1 (Ensembl: C4h2orf81)
Name: dynactin subunit 1 (Ensembl:similar to human chromosome 2 open reading frame 81)
RGD ID: 62038
Description: Enables identical protein binding activity; microtubule binding activity; and molecular adaptor activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; plasma membrane bounded cell projection organization; and regulation of microtubule cytoskeleton organization. Predicted to act upstream of or within melanosome transport. Part of cytoplasmic dynein complex. Biomarker of synucleinopathy. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and autosomal dominant distal hereditary motor neuronopathy 14. Orthologous to human DCTN1 (dynactin subunit 1); PARTICIPATES IN mitochondria transport pathway; N-cadherin signaling pathway; Huntington's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 150 kDa dynein-associated polypeptide; DAP-150; DP-150; dynactin 1; p150-glued
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,228,722 - 117,261,528 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4117,219,349 - 117,261,528 (+)EnsemblGRCr8
mRatBN7.24115,671,024 - 115,703,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,661,638 - 115,703,815 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4121,160,751 - 121,180,548 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,935,930 - 116,955,727 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,550,197 - 115,569,992 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04114,876,770 - 114,896,567 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4114,876,770 - 114,896,573 (+)Ensemblrn6Rnor6.0
Rnor_5.04179,465,836 - 179,485,633 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44117,390,323 - 117,410,119 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4104,678,158 - 104,697,955 (+)NCBICelera
RGSC_v3.14117,634,803 - 117,654,601 (+)NCBI
Cytogenetic Map4q34NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IBA)
cell cortex  (IEA,ISO,ISS)
cell leading edge  (IEA,ISO)
centriolar subdistal appendage  (IEA,ISO)
centriole  (IEA,ISO,ISS)
centrosome  (IEA,ISO,ISS)
ciliary basal body  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytoplasmic dynein complex  (IDA)
cytoskeleton  (IEA)
cytosol  (IEA)
dynein complex  (IEA)
endosome membrane  (IEA,ISO)
intercellular bridge  (IEA,ISO)
kinetochore  (IBA,IEA,ISO,ISS)
microtubule  (IEA,ISO,ISS)
microtubule associated complex  (IBA,IEA,ISO)
microtubule cytoskeleton  (IEA,ISO)
microtubule plus-end  (IEA,ISO,ISS)
neuron projection  (IEA,ISO)
neuronal cell body  (IEA,ISO)
nuclear envelope  (IEA,ISO,ISS)
protein-containing complex  (IEA,ISO)
retromer complex  (IEA,ISO)
spindle  (IEA,ISO,ISS)
spindle pole  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin. Chevalier-Larsen ES, etal., Hum Mol Genet. 2008 Jul 1;17(13):1946-55. Epub 2008 Mar 25.
2. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. Chung CY, etal., J Neurosci. 2009 Mar 18;29(11):3365-73. doi: 10.1523/JNEUROSCI.5427-08.2009.
3. Human DCTN1: genomic structure and evaluation as a candidate for Alstrom syndrome. Collin GB, etal., Genomics 1998 Nov 1;53(3):359-64.
4. DCTN1 mutations in Perry syndrome. Farrer MJ, etal., Nat Genet. 2009 Feb;41(2):163-5. Epub 2009 Jan 11.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Conformational Flexibility of p150Glued(1-191) Subunit of Dynactin Assembled with Microtubules. Guo C, etal., Biophys J. 2019 Sep 3;117(5):938-949. doi: 10.1016/j.bpj.2019.07.036. Epub 2019 Jul 30.
7. Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued. Holzbaur EL, etal., Nature 1991 Jun 13;351(6327):579-83.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Regulation of mitochondrial transport in neurons. Lin MY and Sheng ZH, Exp Cell Res. 2015 May 15;334(1):35-44. doi: 10.1016/j.yexcr.2015.01.004. Epub 2015 Jan 19.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Autonomic failures in Perry syndrome with DCTN1 mutation. Ohshima S, etal., Parkinsonism Relat Disord. 2010 Nov;16(9):612-4. Epub 2010 Aug 11.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Dynactin. Schroer TA, Annu Rev Cell Dev Biol. 2004;20:759-79.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Autoregulatory mechanism for dynactin control of processive and diffusive dynein transport. Tripathy SK, etal., Nat Cell Biol. 2014 Dec;16(12):1192-201. doi: 10.1038/ncb3063. Epub 2014 Nov 24.
23. The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). Waterman-Storer CM, etal., Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1634-8.
Additional References at PubMed
PMID:14718566   PMID:16505168   PMID:16954346   PMID:17139249   PMID:17600711   PMID:18305234   PMID:18331715   PMID:19468067   PMID:19619496   PMID:19946888   PMID:20679239   PMID:20719959  
PMID:21399614   PMID:21525035   PMID:21911489   PMID:22275436   PMID:22327364   PMID:22728878   PMID:22777741   PMID:22871113   PMID:23027904   PMID:23213374   PMID:23386061   PMID:23509069  
PMID:23523350   PMID:23874158   PMID:23985322   PMID:24625528   PMID:25774020   PMID:26296893   PMID:26765568   PMID:26972003   PMID:28000671   PMID:30053369   PMID:32357304  


Genomics

Comparative Map Data
Dctn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,228,722 - 117,261,528 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4117,219,349 - 117,261,528 (+)EnsemblGRCr8
mRatBN7.24115,671,024 - 115,703,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,661,638 - 115,703,815 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4121,160,751 - 121,180,548 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,935,930 - 116,955,727 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,550,197 - 115,569,992 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04114,876,770 - 114,896,567 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4114,876,770 - 114,896,573 (+)Ensemblrn6Rnor6.0
Rnor_5.04179,465,836 - 179,485,633 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44117,390,323 - 117,410,119 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4104,678,158 - 104,697,955 (+)NCBICelera
RGSC_v3.14117,634,803 - 117,654,601 (+)NCBI
Cytogenetic Map4q34NCBI
DCTN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,361,155 - 74,391,866 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,361,154 - 74,392,087 (-)Ensemblhg38GRCh38
GRCh37274,588,282 - 74,618,993 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,441,790 - 74,461,472 (-)NCBIBuild 36Build 36hg18NCBI36
Celera274,419,471 - 74,450,404 (-)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,324,594 - 74,355,527 (-)NCBIHuRef
CHM1_1274,517,708 - 74,548,641 (-)NCBICHM1_1
T2T-CHM13v2.0274,369,715 - 74,400,439 (-)NCBIT2T-CHM13v2.0
Dctn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,142,702 - 83,177,103 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,142,902 - 83,177,099 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38683,165,909 - 83,200,118 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,165,920 - 83,200,117 (+)Ensemblmm10GRCm38
MGSCv37683,129,583 - 83,150,112 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36683,145,512 - 83,165,628 (+)NCBIMGSCv36mm8
Celera685,162,534 - 85,183,062 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Dctn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,392,812 - 11,413,140 (+)Ensembl
ChiLan1.0NW_00495542411,362,240 - 11,413,140 (+)NCBIChiLan1.0ChiLan1.0
DCTN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,997,142 - 52,029,528 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,999,894 - 52,032,281 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,428,060 - 74,458,574 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A75,934,408 - 75,965,012 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A75,934,752 - 75,953,296 (-)EnsemblpanPan2panpan1.1
DCTN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,728,096 - 48,759,187 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,728,270 - 48,759,147 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1748,369,513 - 48,400,598 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01749,587,461 - 49,618,608 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,599,639 - 49,618,608 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,604,305 - 48,635,379 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,670,770 - 48,701,845 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,229,002 - 49,260,088 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dctn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629210,105,790 - 10,136,346 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556601,548 - 621,609 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936556601,550 - 632,321 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCTN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,643,247 - 68,673,604 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1368,642,562 - 68,673,605 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,751,232 - 71,779,855 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCTN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,885,483 - 32,916,491 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,885,623 - 32,916,145 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604579,251,156 - 79,282,059 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dctn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474929,115,561 - 29,137,276 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474929,105,310 - 29,135,124 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dctn1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1663,028,636 - 63,061,274 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dctn1
61 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:46
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000068102
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat

Markers in Region
MARC_6321-6322:992007238:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84117,260,714 - 117,261,126 (+)Marker Load Pipeline
mRatBN7.24115,703,010 - 115,703,422 (+)MAPPERmRatBN7.2
Rnor_6.04114,895,762 - 114,896,173NCBIRnor6.0
Rnor_5.04179,484,828 - 179,485,239UniSTSRnor5.0
RGSC_v3.44117,409,315 - 117,409,726UniSTSRGSC3.4
Celera4104,697,150 - 104,697,561UniSTS
Cytogenetic Map4q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 94 59 6 365 194 11 143 88 95 31 18 18

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000013312   ⟹   ENSRNOP00000013311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,661,705 - 115,667,928 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000068102   ⟹   ENSRNOP00000059076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,241,732 - 117,261,524 (+)Ensembl
mRatBN7.2 Ensembl4115,684,021 - 115,703,815 (+)Ensembl
Rnor_6.0 Ensembl4114,876,770 - 114,896,566 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078175   ⟹   ENSRNOP00000072880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,241,707 - 117,261,519 (+)Ensembl
mRatBN7.2 Ensembl4115,684,021 - 115,703,815 (+)Ensembl
Rnor_6.0 Ensembl4114,876,833 - 114,896,573 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099116   ⟹   ENSRNOP00000080290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,228,738 - 117,261,523 (+)Ensembl
mRatBN7.2 Ensembl4115,671,043 - 115,703,813 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099394   ⟹   ENSRNOP00000085656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,228,385 - 117,261,525 (+)Ensembl
mRatBN7.2 Ensembl4115,672,998 - 115,703,813 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100284   ⟹   ENSRNOP00000095934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,228,776 - 117,261,521 (+)Ensembl
mRatBN7.2 Ensembl4115,686,230 - 115,703,815 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107740   ⟹   ENSRNOP00000082429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,219,349 - 117,261,519 (+)Ensembl
mRatBN7.2 Ensembl4115,661,638 - 115,703,813 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110975   ⟹   ENSRNOP00000080377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,241,723 - 117,261,528 (+)Ensembl
mRatBN7.2 Ensembl4115,689,749 - 115,703,815 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119334   ⟹   ENSRNOP00000094269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,665,569 - 115,667,928 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122195   ⟹   ENSRNOP00000106385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,228,731 - 117,261,525 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000167790   ⟹   ENSRNOP00000101755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,228,879 - 117,261,524 (+)Ensembl
RefSeq Acc Id: NM_024130   ⟹   NP_077044
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,241,723 - 117,261,528 (+)NCBI
mRatBN7.24115,684,021 - 115,703,824 (+)NCBI
Rnor_6.04114,876,770 - 114,896,567 (+)NCBI
Rnor_5.04179,465,836 - 179,485,633 (+)NCBI
RGSC_v3.44117,390,323 - 117,410,119 (+)RGD
Celera4104,678,158 - 104,697,955 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107182   ⟹   XP_038963110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,241,710 - 117,261,520 (+)NCBI
mRatBN7.24115,684,032 - 115,703,819 (+)NCBI
RefSeq Acc Id: XM_039107183   ⟹   XP_038963111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,228,722 - 117,261,520 (+)NCBI
mRatBN7.24115,671,024 - 115,703,819 (+)NCBI
RefSeq Acc Id: XM_039107184   ⟹   XP_038963112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,229,323 - 117,261,520 (+)NCBI
mRatBN7.24115,671,617 - 115,703,819 (+)NCBI
RefSeq Acc Id: XM_039107185   ⟹   XP_038963113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,241,707 - 117,261,520 (+)NCBI
mRatBN7.24115,684,033 - 115,703,819 (+)NCBI
RefSeq Acc Id: XM_063285663   ⟹   XP_063141733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,241,710 - 117,261,520 (+)NCBI
RefSeq Acc Id: XM_063285664   ⟹   XP_063141734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,241,710 - 117,261,520 (+)NCBI
RefSeq Acc Id: XM_063285665   ⟹   XP_063141735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,241,710 - 117,261,520 (+)NCBI
RefSeq Acc Id: XM_063285666   ⟹   XP_063141736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,241,710 - 117,261,520 (+)NCBI
RefSeq Acc Id: XM_063285667   ⟹   XP_063141737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,241,710 - 117,261,520 (+)NCBI
RefSeq Acc Id: XM_063285668   ⟹   XP_063141738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,241,710 - 117,261,520 (+)NCBI
RefSeq Acc Id: XM_063285669   ⟹   XP_063141739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,241,707 - 117,261,520 (+)NCBI
RefSeq Acc Id: NP_077044   ⟸   NM_024130
- UniProtKB: P28023 (UniProtKB/Swiss-Prot),   A0A0G2K428 (UniProtKB/TrEMBL),   A6IAL4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072880   ⟸   ENSRNOT00000078175
Ensembl Acc Id: ENSRNOP00000059076   ⟸   ENSRNOT00000068102
RefSeq Acc Id: XP_038963111   ⟸   XM_039107183
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZPT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963112   ⟸   XM_039107184
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZPT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963110   ⟸   XM_039107182
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ASG8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963113   ⟸   XM_039107185
- Peptide Label: isoform X10
- UniProtKB: A0A8I6A3U0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000013311   ⟸   ENSRNOT00000013312
Ensembl Acc Id: ENSRNOP00000082429   ⟸   ENSRNOT00000107740
Ensembl Acc Id: ENSRNOP00000095934   ⟸   ENSRNOT00000100284
Ensembl Acc Id: ENSRNOP00000085656   ⟸   ENSRNOT00000099394
Ensembl Acc Id: ENSRNOP00000080377   ⟸   ENSRNOT00000110975
Ensembl Acc Id: ENSRNOP00000080290   ⟸   ENSRNOT00000099116
Ensembl Acc Id: ENSRNOP00000094269   ⟸   ENSRNOT00000119334
RefSeq Acc Id: XP_063141739   ⟸   XM_063285669
- Peptide Label: isoform X9
- UniProtKB: A0A8I6ASG8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141733   ⟸   XM_063285663
- Peptide Label: isoform X1
- UniProtKB: P28023 (UniProtKB/Swiss-Prot),   A0A8I6A3U0 (UniProtKB/TrEMBL),   A6IAL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141734   ⟸   XM_063285664
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ASG8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141736   ⟸   XM_063285666
- Peptide Label: isoform X5
- UniProtKB: A0A8I6ASG8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141738   ⟸   XM_063285668
- Peptide Label: isoform X8
- UniProtKB: A0A8I6A3U0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141735   ⟸   XM_063285665
- Peptide Label: isoform X4
- UniProtKB: A0A8I6ASG8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141737   ⟸   XM_063285667
- Peptide Label: isoform X7
- UniProtKB: A0A8I6A3U0 (UniProtKB/TrEMBL),   D4A8U7 (UniProtKB/TrEMBL),   G3V7A8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101755   ⟸   ENSRNOT00000167790
Ensembl Acc Id: ENSRNOP00000106385   ⟸   ENSRNOT00000122195
Protein Domains
CAP-Gly

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28023-F1-model_v2 AlphaFold P28023 1-1280 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693174
Promoter ID:EPDNEW_R3699
Type:multiple initiation site
Name:Dctn1_1
Description:dynactin subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04114,876,778 - 114,876,838EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62038 AgrOrtholog
BioCyc Gene G2FUF-44016 BioCyc
Ensembl Genes ENSRNOG00000010048 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000068102 ENTREZGENE
  ENSRNOT00000078175 ENTREZGENE
  ENSRNOT00000100284 ENTREZGENE
  ENSRNOT00000107740 ENTREZGENE
  ENSRNOT00000110975 ENTREZGENE
Gene3D-CATH 2.30.30.190 UniProtKB/Swiss-Prot
InterPro CAP-Gly_dom_sf UniProtKB/Swiss-Prot
  CAP-Gly_domain UniProtKB/Swiss-Prot
  Dynactin UniProtKB/Swiss-Prot
KEGG Report rno:29167 UniProtKB/Swiss-Prot
NCBI Gene 29167 ENTREZGENE
PANTHER DYNACTIN 1-RELATED MICROTUBULE-BINDING UniProtKB/Swiss-Prot
  DYNACTIN SUBUNIT 1 UniProtKB/Swiss-Prot
Pfam CAP_GLY UniProtKB/Swiss-Prot
  Dynactin UniProtKB/Swiss-Prot
PhenoGen Dctn1 PhenoGen
PROSITE CAP_GLY_1 UniProtKB/Swiss-Prot
  CAP_GLY_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010048 RatGTEx
SMART CAP_GLY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF74924 UniProtKB/Swiss-Prot
TIGR TC217509
UniProt A0A0G2K428 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPT7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZQJ2_RAT UniProtKB/TrEMBL
  A0A8I5ZUH0_RAT UniProtKB/TrEMBL
  A0A8I6A3U0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASG8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L9L7_RAT UniProtKB/TrEMBL
  A0ABK0LN67_RAT UniProtKB/TrEMBL
  A6IAL4 ENTREZGENE, UniProtKB/TrEMBL
  A6IAL5 ENTREZGENE, UniProtKB/TrEMBL
  D4A8U7 ENTREZGENE, UniProtKB/TrEMBL
  DCTN1_RAT UniProtKB/Swiss-Prot
  G3V7A8 ENTREZGENE
  P28023 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Dctn1  dynactin subunit 1  Dctn1  dynactin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Dctn1  dynactin 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease human homolog may be a candidate gene for neuromuscular diseases Alstrom syndrome, limb-girdle muscle dystrophpy, and Miyoshi myopathy 728226