Fdx1 (ferredoxin 1) - Rat Genome Database

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Gene: Fdx1 (ferredoxin 1) Rattus norvegicus
Analyze
Symbol: Fdx1
Name: ferredoxin 1
RGD ID: 62036
Description: Enables electron transfer activity; enzyme binding activity; and iron ion binding activity. Contributes to NADPH-adrenodoxin reductase activity and cholesterol monooxygenase (side-chain-cleaving) activity. Involved in several processes, including NADPH oxidation; cellular response to epinephrine stimulus; and cellular response to leptin stimulus. Located in mitochondrial crista and mitochondrial matrix. Biomarker of pancreatitis. Orthologous to human FDX1 (ferredoxin 1); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; estradiol biosynthetic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adrenal ferredoxin; adrenodoxin, mitochondrial; ferredoxin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8861,164,839 - 61,183,645 (-)NCBIGRCr8
mRatBN7.2852,268,536 - 52,287,344 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl852,268,536 - 52,287,414 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx857,817,827 - 57,836,608 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0856,096,794 - 56,115,575 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0853,961,051 - 53,979,836 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0856,373,729 - 56,393,199 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl856,373,723 - 56,393,233 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0854,958,315 - 54,977,222 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4855,291,396 - 55,310,507 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1855,323,249 - 55,329,561 (-)NCBI
Celera851,793,129 - 51,811,786 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aconitine  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
caffeine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
diuron  (ISO)
endosulfan  (EXP)
ethanol  (EXP)
ferulic acid  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
glafenine  (EXP)
hydrogen peroxide  (ISO)
inulin  (ISO)
ketoconazole  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methoxyacetic acid  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (EXP)
myricetin  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phosgene  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
tert-butyl ethyl ether  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Leptin attenuates follicular apoptosis and accelerates the onset of puberty in immature rats. Almog B, etal., Mol Cell Endocrinol. 2001 Oct 25;183(1-2):179-91.
2. Localization of multiple forms of inducible cytochromes P450 in rat liver mitochondria: immunological characteristics and patterns of xenobiotic substrate metabolism. Anandatheerthavarada HK, etal., Arch Biochem Biophys. 1997 Mar 1;339(1):136-50.
3. Leptin modulates the glucocorticoid-induced ovarian steroidogenesis. Barkan D, etal., Endocrinology. 1999 Apr;140(4):1731-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells. Hanukoglu I, etal., J Cell Biol. 1990 Oct;111(4):1373-81.
6. Gonadotropin stimuli increase adrenodoxin immunoreactivity in the mitochondria of rat ovarian cells. Izumi S and Mitani F, Acta Histochem. 2005;107(4):269-77. Epub 2005 Sep 1.
7. Pancreatic gene expression during the initiation of acute pancreatitis: identification of EGR-1 as a key regulator. Ji B, etal., Physiol Genomics. 2003 Jun 24;14(1):59-72.
8. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Mitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activity. Robin MA, etal., J Biol Chem. 2001 Jul 6;276(27):24680-9. Epub 2001 Apr 26.
15. Expression of the P450 side-chain cleavage and adrenodoxin genes begins during early stages of adrenal cortex development. Rogler LE and Pintar JE, Mol Endocrinol. 1993 Mar;7(3):453-61.
16. cDNA cloning, overproduction and characterization of rat adrenodoxin reductase. Sagara Y, etal., Biochim Biophys Acta 1999 Oct 12;1434(2):284-95.
17. Purification and characterization of rat adrenodoxin. Sagara Y, etal., Biochimie. 1995;77(9):719-23.
18. Cloning and sequence analysis of a full-length cDNA of rat adrenodoxin. Sagara Y, etal., Biol Pharm Bull 1996 Jan;19(1):39-41.
19. Establishment and characterization of steroidogenic granulosa cells expressing beta(2)-adrenergic receptor: regulation of adrenodoxin and steroidogenic acute regulatory protein by adrenergic agents. Selvaraj N, etal., Mol Cell Endocrinol. 2000 Oct 25;168(1-2):53-63.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1863358   PMID:7495857   PMID:14651853   PMID:18614015   PMID:21636783   PMID:37858707  


Genomics

Comparative Map Data
Fdx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8861,164,839 - 61,183,645 (-)NCBIGRCr8
mRatBN7.2852,268,536 - 52,287,344 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl852,268,536 - 52,287,414 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx857,817,827 - 57,836,608 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0856,096,794 - 56,115,575 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0853,961,051 - 53,979,836 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0856,373,729 - 56,393,199 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl856,373,723 - 56,393,233 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0854,958,315 - 54,977,222 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4855,291,396 - 55,310,507 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1855,323,249 - 55,329,561 (-)NCBI
Celera851,793,129 - 51,811,786 (-)NCBICelera
Cytogenetic Map8q24NCBI
FDX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811110,429,331 - 110,464,884 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11110,429,948 - 110,464,884 (+)EnsemblGRCh38hg38GRCh38
GRCh3711110,300,672 - 110,335,608 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611109,805,804 - 109,840,815 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411109,805,803 - 109,840,814NCBI
Celera11107,454,082 - 107,489,091 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11106,225,358 - 106,260,247 (+)NCBIHuRef
CHM1_111110,183,752 - 110,218,730 (+)NCBICHM1_1
T2T-CHM13v2.011110,439,522 - 110,475,104 (+)NCBIT2T-CHM13v2.0
Fdx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39951,854,323 - 51,874,902 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl951,854,606 - 51,874,856 (-)EnsemblGRCm39 Ensembl
GRCm38951,943,023 - 51,963,602 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl951,943,306 - 51,963,556 (-)EnsemblGRCm38mm10GRCm38
MGSCv37951,751,412 - 51,771,638 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36951,695,672 - 51,715,898 (-)NCBIMGSCv36mm8
Celera949,216,519 - 49,236,839 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map928.62NCBI
Fdx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541212,286,408 - 12,316,707 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541212,280,900 - 12,312,930 (+)NCBIChiLan1.0ChiLan1.0
FDX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29111,170,868 - 111,207,767 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111112,262,007 - 112,298,701 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011105,311,613 - 105,345,414 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111109,158,419 - 109,190,869 (+)NCBIpanpan1.1PanPan1.1panPan2
FDX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1522,452,011 - 22,485,581 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl522,451,209 - 22,485,395 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha522,371,400 - 22,404,749 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0522,477,844 - 22,511,361 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl522,479,333 - 22,511,216 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1522,536,376 - 22,569,968 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0522,436,016 - 22,540,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0522,485,417 - 22,518,946 (-)NCBIUU_Cfam_GSD_1.0
Fdx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494792,799,925 - 92,827,430 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366123,874,748 - 3,905,825 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366123,878,179 - 3,905,678 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FDX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl938,375,984 - 38,404,832 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1938,376,147 - 38,399,026 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FDX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11101,777,499 - 101,813,753 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1101,777,678 - 101,816,379 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604324,135,097 - 24,172,218 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fdx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247845,406,459 - 5,460,581 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fdx1
69 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000016263
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat

Markers in Region
RH139364  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2852,268,792 - 52,269,036 (+)MAPPERmRatBN7.2
Rnor_6.0856,373,986 - 56,374,229NCBIRnor6.0
Rnor_5.0854,958,572 - 54,958,815UniSTSRnor5.0
RGSC_v3.4855,291,653 - 55,291,896UniSTSRGSC3.4
Celera851,793,386 - 51,793,629UniSTS
RH 3.4 Map8564.29UniSTS
Cytogenetic Map8q24UniSTS
AI237068  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2852,286,253 - 52,286,430 (+)MAPPERmRatBN7.2
Rnor_6.0856,392,109 - 56,392,285NCBIRnor6.0
Rnor_5.0854,976,132 - 54,976,308UniSTSRnor5.0
RGSC_v3.4855,309,417 - 55,309,593UniSTSRGSC3.4
Celera851,810,696 - 51,810,872UniSTS
RH 3.4 Map8566.5UniSTS
Cytogenetic Map8q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 30 6
Medium 21 141 197 147 69 147 36 45 242 115 139 57 24
Low 8
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000016263   ⟹   ENSRNOP00000016263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl852,268,538 - 52,287,414 (-)Ensembl
Rnor_6.0 Ensembl856,373,723 - 56,393,233 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117198   ⟹   ENSRNOP00000078211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl852,268,536 - 52,287,083 (-)Ensembl
RefSeq Acc Id: NM_017126   ⟹   NP_058822
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,164,839 - 61,183,645 (-)NCBI
mRatBN7.2852,268,536 - 52,287,344 (-)NCBI
Rnor_6.0856,373,729 - 56,393,199 (-)NCBI
Rnor_5.0854,958,315 - 54,977,222 (-)NCBI
RGSC_v3.4855,291,396 - 55,310,507 (-)RGD
Celera851,793,129 - 51,811,786 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058822 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABB72481 (Get FASTA)   NCBI Sequence Viewer  
  BAA08927 (Get FASTA)   NCBI Sequence Viewer  
  EDL95505 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016263.1
  ENSRNOP00000078211.1
  ENSRNOP00055040808
  ENSRNOP00060020150
  ENSRNOP00065021090
GenBank Protein P24483 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058822   ⟸   NM_017126
- Peptide Label: precursor
- UniProtKB: P24483 (UniProtKB/Swiss-Prot),   G3V7L0 (UniProtKB/TrEMBL),   A6J4I2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016263   ⟸   ENSRNOT00000016263
Ensembl Acc Id: ENSRNOP00000078211   ⟸   ENSRNOT00000117198
Protein Domains
2Fe-2S ferredoxin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24483-F1-model_v2 AlphaFold P24483 1-188 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695964
Promoter ID:EPDNEW_R6488
Type:initiation region
Name:Fdx1_1
Description:ferredoxin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0856,393,224 - 56,393,284EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62036 AgrOrtholog
BioCyc Gene G2FUF-30489 BioCyc
Ensembl Genes ENSRNOG00000012123 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055028656 UniProtKB/Swiss-Prot
  ENSRNOG00060014799 UniProtKB/Swiss-Prot
  ENSRNOG00065016136 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016263.4 UniProtKB/TrEMBL
  ENSRNOT00000117198.1 UniProtKB/TrEMBL
  ENSRNOT00055049605 UniProtKB/Swiss-Prot
  ENSRNOT00060025290 UniProtKB/Swiss-Prot
  ENSRNOT00065026846 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.20.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 2Fe-2S_ferredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S_ferredoxin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adrenodoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adrenodoxin_Fe-S_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta-grasp_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29189 UniProtKB/Swiss-Prot
NCBI Gene 29189 ENTREZGENE
PANTHER ADRENODOXIN, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23426 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Fer2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fdx1 PhenoGen
PRINTS ADRENODOXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 2FE2S_FER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012123 RatGTEx
  ENSRNOG00055028656 RatGTEx
  ENSRNOG00060014799 RatGTEx
  ENSRNOG00065016136 RatGTEx
Superfamily-SCOP SSF54292 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217098
UniProt A0A8I5Y749_RAT UniProtKB/TrEMBL
  A6J4I2 ENTREZGENE, UniProtKB/TrEMBL
  ADX_RAT UniProtKB/Swiss-Prot
  G3V7L0 ENTREZGENE, UniProtKB/TrEMBL
  P24483 ENTREZGENE
  Q2XTA9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fdx1  ferredoxin 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in rat adrenal 61585
gene_protein 124 amino acid residues 61585