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Gene: Ppat (phosphoribosyl pyrophosphate amidotransferase) Rattus norvegicus

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Symbol:

Ppat

Name:

phosphoribosyl pyrophosphate amidotransferase

RGD ID:

620237

Description:

Enables amidophosphoribosyltransferase activity and identical protein binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; L-glutamine catabolic process; and lactation. Biomarker of hepatocellular carcinoma and renal cell carcinoma. Orthologous to human PPAT (phosphoribosyl pyrophosphate amidotransferase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

amidophosphoribosyltransferase; Atase; glutamine phosphoribosylpyrophosphate amidotransferase; GPAT; MGC93251

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PPAT (phosphoribosyl pyrophosphate amidotransferase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ppat (phosphoribosyl pyrophosphate amidotransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ppat (phosphoribosyl pyrophosphate amidotransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PPAT (phosphoribosyl pyrophosphate amidotransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PPAT (phosphoribosyl pyrophosphate amidotransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ppat (phosphoribosyl pyrophosphate amidotransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PPAT (phosphoribosyl pyrophosphate amidotransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PPAT (phosphoribosyl pyrophosphate amidotransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ppat (phosphoribosyl pyrophosphate amidotransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ppat (phosphoribosyl pyrophosphate amidotransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PPAT (phosphoribosyl pyrophosphate amidotransferase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ppat (phosphoribosyl pyrophosphate amidotransferase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ppat (phosphoribosyl pyrophosphate amidotransferase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ADE4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Prat	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Prat2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ppat-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ppat	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ppat	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	31,570,010 - 31,604,410 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	31,551,388 - 31,604,405 (+)	Ensembl				GRCr8
mRatBN7.2	14	31,215,741 - 31,250,144 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	31,216,165 - 31,250,144 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	31,593,072 - 31,627,368 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	32,901,403 - 32,935,708 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	31,386,077 - 31,420,375 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	33,580,541 - 33,614,919 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	33,580,541 - 33,614,919 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	33,371,454 - 33,405,854 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	33,509,364 - 33,543,743 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	30,529,492 - 30,563,868 (+)	NCBI		Celera
RGSC_v3.1	14	33,509,363 - 33,543,743 (+)	NCBI
Cytogenetic Map	14	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Diabetes Mellitus (IEP)

Experimental Liver Neoplasms (ISO)

hepatocellular carcinoma (IEP)

Myocardial Ischemia (ISO)

renal cell carcinoma (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-alpha-phellandrene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dinitrotoluene (EXP)

2-bromohexadecanoic acid (ISO)

2-butoxyethanol (ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

coumestrol (ISO)

DDE (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

Dibutyl phosphate (ISO)

dioxygen (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

Enterolactone (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

flavonoids (EXP)

flutamide (EXP)

folic acid (ISO)

glutathione (EXP)

ivermectin (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

nefazodone (EXP)

okadaic acid (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

parathion (ISO)

pentachlorophenol (ISO)

phenobarbital (ISO)

phorone (EXP)

pinosylvin (ISO)

pirinixic acid (EXP,ISO)

rotenone (EXP)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

tamibarotene (ISO)

tamoxifen (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trans-pinosylvin (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

'de novo' AMP biosynthetic process (IEA,ISO)

'de novo' IMP biosynthetic process (IEA,ISO)

'de novo' XMP biosynthetic process (IEA,ISO)

animal organ regeneration (IEP)

cellular response to insulin stimulus (IEP)

cellular response to xenobiotic stimulus (IEP)

G1/S transition of mitotic cell cycle (IEP)

GMP biosynthetic process (IEA,ISO)

kidney development (IEP)

L-glutamine catabolic process (IDA)

lactation (IEP)

maternal process involved in female pregnancy (IEP)

purine nucleobase biosynthetic process (IEA)

purine nucleotide biosynthetic process (IBA,IEA)

response to xenobiotic stimulus (IEP)

Molecular Function

4 iron, 4 sulfur cluster binding (IEA)

amidophosphoribosyltransferase activity (IBA,IDA,IEA,ISO)

catalytic activity (IEA)

glycosyltransferase activity (IEA)

identical protein binding (IPI)

iron-sulfur cluster binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

2-hydroxyglutaric aciduria pathway (ISO)

adenine phoshoribosyltransferase deficiency pathway (ISO)

adenosine monophosphate deaminase deficiency pathway (ISO)

adenylosuccinate lyase deficiency pathway (ISO)

AICA-ribosuria pathway (ISO)

alanine, aspartate and glutamate metabolic pathway (IEA)

azathioprine pharmacodynamics pathway (ISO)

de novo purine biosynthetic pathway (ISO)

glutamic acid/glutamate metabolic pathway (ISO)

homocarnosinosis pathway (ISO)

Kelley-Seegmiller syndrome pathway (ISO)

Lesch-Nyhan syndrome pathway (ISO)

mercaptopurine pharmacodynamics pathway (ISO)

mercaptopurine pharmacokinetics pathway (ISO)

molybdenum cofactor deficiency pathway (ISO)

purine metabolic pathway (IEA,ISO)

purine nucleoside phosphorylase deficiency pathway (ISO)

succinic semialdehyde dehydrogenase deficiency pathway (ISO)

tioguanine pharmacodynamics pathway (ISO)

xanthinuria type I pathway (ISO)

xanthinuria pathway (ISO)

xanthinuria type II pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Enzymes of the pathway of purine synthesis in the rat mammary gland. Changes in the lactation cycle and the effects of diabetes.	Beardsley S, etal., Biochem J. 1988 Mar 1;250(2):395-9.
2.	Pediatric neurological syndromes and inborn errors of purine metabolism.	Camici M, etal., Neurochem Int. 2010 Feb;56(3):367-78. Epub 2009 Dec 11.
3.	Rapid in vivo inactivation by acivicin of CTP synthetase, carbamoyl-phosphate synthetase II, and amidophosphoribosyltransferase in hepatoma.	Denton JE, etal., Life Sci. 1982 Mar 29;30(13):1073-80.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Increased rate of de novo purine synthesis and its mechanism in regenerating rat liver.	Itakura M, etal., Am J Physiol. 1986 Nov;251(5 Pt 1):G585-90.
7.	Malotilate (diisopropyl 1,3-dithiol-2-ylidenemalonate) increases liver de novo purine synthesis and amidophosphoribosyltransferase activity.	Itakura M, etal., J Pharmacol Exp Ther. 1986 Jun;237(3):794-8.
8.	Rat genomic structure of amidophosphoribosyltransferase, cDNA sequence of aminoimidazole ribonucleotide carboxylase, and cell cycle-dependent expression of these two physically linked genes.	Iwahana H, etal., Biochim Biophys Acta 1995 Apr 26;1261(3):369-80.
9.	An end-trimming method to amplify adjacent cDNA fragments by PCR.	Iwahana H, etal., Biotechniques 1994 Jan;16(1):94-8.
10.	Molecular cloning of rat amidophosphoribosyltransferase.	Iwahana H, etal., J Biol Chem 1993 Apr 5;268(10):7225-37.
11.	Renal hypertrophy in experimental diabetes. The activity of the 'de novo' and salvage pathways of purine synthesis.	Kunjara S, etal., Biochem J. 1988 Feb 1;249(3):911-4.
12.	Enzymic capacities of purine de Novo and salvage pathways for nucleotide synthesis in normal and neoplastic tissues.	Natsumeda Y, etal., Cancer Res. 1984 Jun;44(6):2475-9.
13.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
14.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
15.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
16.	Glutamine-phosphoribosylpyrophosphate amidotransferase (amidophosphoribosyltransferase, EC 2.4.2.14) activity in normal, differentiating, and neoplastic kidney.	Prajda N, etal., Cancer Res. 1979 Oct;39(10):3909-14.
17.	GOA pipeline	RGD automated data pipeline
18.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
19.	Increased de novo purine synthesis by insulin through selective enzyme induction in primary cultured rat hepatocytes.	Tsuchiya M, etal., Am J Physiol. 1990 May;258(5 Pt 1):C841-8.
20.	Rat liver glutamine 5-phosphoribosyl-1-pyrophosphate amidotransferase [EC 2.4.2.14]. Purification and properties.	Tsuda M, etal., J Biochem. 1979 May;85(5):1347-54.

Additional References at PubMed

PMID:12477932	PMID:15489334

Genomics

Comparative Map Data

Ppat
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	31,570,010 - 31,604,410 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	31,551,388 - 31,604,405 (+)	Ensembl				GRCr8
mRatBN7.2	14	31,215,741 - 31,250,144 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	31,216,165 - 31,250,144 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	31,593,072 - 31,627,368 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	32,901,403 - 32,935,708 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	31,386,077 - 31,420,375 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	33,580,541 - 33,614,919 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	33,580,541 - 33,614,919 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	33,371,454 - 33,405,854 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	33,509,364 - 33,543,743 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	30,529,492 - 30,563,868 (+)	NCBI		Celera
RGSC_v3.1	14	33,509,363 - 33,543,743 (+)	NCBI
Cytogenetic Map	14	p11	NCBI

PPAT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	56,393,362 - 56,435,615 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	56,393,362 - 56,435,616 (-)	Ensembl			hg38	GRCh38
GRCh37	4	57,259,528 - 57,301,781 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	56,954,285 - 56,996,602 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	4	57,100,458 - 57,142,773	NCBI
Celera	4	54,765,911 - 54,808,216 (-)	NCBI		Celera
Cytogenetic Map	4	q12	NCBI
HuRef	4	53,213,663 - 53,255,937 (-)	NCBI		HuRef
CHM1_1	4	57,294,641 - 57,336,915 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	59,881,364 - 59,923,605 (-)	NCBI		T2T-CHM13v2.0

Ppat
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	77,061,096 - 77,099,425 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	77,061,096 - 77,099,425 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	76,913,249 - 76,951,578 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	76,913,249 - 76,951,578 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	77,342,274 - 77,380,603 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	77,987,920 - 78,026,353 (-)	NCBI		MGSCv36	mm8
Celera	5	74,190,125 - 74,219,445 (-)	NCBI		Celera
Cytogenetic Map	5	C3.3	NCBI
cM Map	5	41.45	NCBI

Ppat
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955447	14,574,407 - 14,607,416 (+)	Ensembl
ChiLan1.0	NW_004955447	14,552,846 - 14,607,416 (+)	NCBI	ChiLan1.0	ChiLan1.0

PPAT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	73,347,602 - 73,390,036 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	73,553,280 - 73,595,555 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	67,491,407 - 67,533,822 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	74,059,967 - 74,102,002 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	74,059,966 - 74,102,002 (+)	Ensembl			panPan2	panpan1.1

PPAT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	48,618,460 - 48,656,164 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	48,620,714 - 48,655,780 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	48,509,175 - 48,546,691 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	49,233,071 - 49,270,374 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	49,207,789 - 49,270,306 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	48,904,984 - 48,942,482 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	48,433,951 - 48,471,441 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	49,380,077 - 49,417,387 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ppat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	27,649,519 - 27,693,748 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936482	18,606,124 - 18,648,681 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936482	18,606,124 - 18,648,989 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPAT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	55,654,377 - 55,701,077 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	55,652,194 - 55,701,077 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	57,820,418 - 57,896,880 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PPAT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	12,201,434 - 12,242,418 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	12,191,784 - 12,243,488 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666066	12,869,154 - 12,912,322 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ppat
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624761	12,980,513 - 13,019,011 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624761	12,980,508 - 13,017,818 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ppat
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	33,664,751 - 33,698,961 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ppat
129 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	1313
Count of miRNA genes:	350
Interacting mature miRNAs:	483
Transcripts:	ENSRNOT00000002905
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631528	Scl11	Serum cholesterol level QTL 11	4.9		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	14	17875645	36079022	Rat
7411573	Bw139	Body weight QTL 139	4.7	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	14	1	40068101	Rat
9589814	Gluco67	Glucose level QTL 67	4.54	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	40068101	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9393298	39411170	Rat
1300154	Bp189	Blood pressure QTL 189	3.04		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	14	31238080	72970315	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30674469	85041098	Rat
2324617	Coatc2	Coat color QTL 2		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	14	31121333	39507682	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8621398	53621398	Rat
61420	Pia6	Pristane induced arthritis QTL 6	4.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	14	18915454	42433608	Rat
7387267	Uae42	Urinary albumin excretion QTL 42		0.61	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	14	22521517	67521517	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11334716	100078267	Rat
2313397	Coatc1	Coat color QTL1			coat/hair pigmentation trait (VT:0010463)	coat/hair color measurement (CMO:0001808)	14	18895192	63895192	Rat
631262	Tcas4	Tongue tumor susceptibility QTL 4	7.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	14	17906726	54251504	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41415516	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1	31893212	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8621398	53621398	Rat

Markers in Region

RH141568

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	31,249,660 - 31,249,860 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	33,614,458 - 33,614,657	NCBI	Rnor6.0
Rnor_5.0	14	33,405,371 - 33,405,570	UniSTS	Rnor5.0
RGSC_v3.4	14	33,543,282 - 33,543,481	UniSTS	RGSC3.4
Celera	14	30,563,407 - 30,563,606	UniSTS
RH 3.4 Map	14	382.98	UniSTS
Cytogenetic Map	14	p11	UniSTS

PMC312758P2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	31,216,183 - 31,216,360 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	33,580,984 - 33,581,160	NCBI	Rnor6.0
Rnor_5.0	14	33,371,897 - 33,372,073	UniSTS	Rnor5.0
RGSC_v3.4	14	33,509,807 - 33,509,983	UniSTS	RGSC3.4
Celera	14	30,529,935 - 30,530,111	UniSTS
Cytogenetic Map	14	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	91	59	6	355	191	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_057198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091566	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY724485	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC086999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D10853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D13373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D37978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000002905 ⟹ ENSRNOP00000002905

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	31,551,388 - 31,604,405 (+)	Ensembl
mRatBN7.2 Ensembl	14	31,216,165 - 31,250,144 (+)	Ensembl
Rnor_6.0 Ensembl	14	33,580,541 - 33,614,919 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100016 ⟹ ENSRNOP00000087004

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	31,570,426 - 31,604,387 (+)	Ensembl
mRatBN7.2 Ensembl	14	31,216,165 - 31,250,144 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000169394 ⟹ ENSRNOP00000106250

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	31,569,677 - 31,604,405 (+)	Ensembl

RefSeq Acc Id:

NM_057198 ⟹ NP_476546

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	31,570,010 - 31,604,388 (+)	NCBI
mRatBN7.2	14	31,215,741 - 31,250,122 (+)	NCBI
Rnor_6.0	14	33,580,541 - 33,614,919 (+)	NCBI
Rnor_5.0	14	33,371,454 - 33,405,854 (+)	NCBI
RGSC_v3.4	14	33,509,364 - 33,543,743 (+)	RGD
Celera	14	30,529,492 - 30,563,868 (+)	RGD

Sequence:

show sequence

CGGCTGGCTGCTCAGGGCAGGAACCGCGTCCCCAGGCTTCCCTCCACGCAGGCGTACTGACGCG
ACCCCGCTTCCGGCGGCCCCTCCCCCGCAGTCCGCGAAAAGTGGCGCGCAGGCTGCGGGCCCCC
GCCGGCCGGAGAGGTTTCTGGGTTGGATCGGACCAAGTCCTGATGGCCGGGGGACGGCGTGAGA
CCAGGGACACGCACGGCTCAGACTTTCTGAGGGACCAACGCGATTAACTACGCTACTCTCATCA
CCTACGCCTTGGGAGCGGGAAAATAACGGAGTCTCCCACGTGCAGGGAAAAGCAGCGATCCTGA
CCTCTGCCGCGGAGAATTAACCCCAGTCCCTTGACTCCATAGCTCCGCCCCCGTCCCGTGTCCT
AGCTGATTGGCCCGGAGCTGGAGGGCGCCGCCGCAGTAGCGAGATACTAGCCGGCGGGGAAGGA
GGAGGCAGTCTGTAGCTCGAGCCTGTGAGGCGCTCTATAGCGGAGCGGACAGCTGGTTGGCGCT
TGGACCACGCCGCAGCAGCAGGTCCCTCCACGTGCTTTCGGCGGCGCCATGGAACTGGAGGAGT
CGGGGATCCGTGAGGAATGTGGTGTGTTCGGGTGCATCGCTTCTGGAGACTGGCCCACGCAGCT
AGATGTGCCACATGTGATCACTCTGGGACTCGTGGGGCTTCAGCACCGAGGTCAGGAGAGCGCT
GGTATTGTGACCAGTGATGGGAGTTCAGTGCCTAAATTCAGGGTGCATAAGGGAATGGGCCTTG
TAAATCATGTTTTTACCGAAGACAATTTGAAGAAATTGTATGTCTCAAATCTTGGAATCGGACA
TACGCGGTACGCCACCACAGGGAAGTGTGAGCTGGAAAATTGCCAGCCGTTTGTTGTTGAGACT
CTGCATGGGAAAATAGCTGTGGCCCATAACGGAGAGCTGGTGAACGCAGCTCGGCTGAGGAAGA
AGCTTCTGCGGCATGGTATTGGGCTTTCCACATCCTCCGATAGTGAAATGATTACCCAGTTACT
CGCATATACCCCTCCTCAGGAACAAGATGATACTCCAGACTGGGTAGCAAGAATTAAGAACTTA
ATGAAGGAAGCGCCCGCAGCCTACTCCCTGGTCATAATGCACAGGGACGTCATTTACGCAGTGC
GAGATCCATACGGAAATCGTCCTCTATGCATCGGCCGTCTTATGCCAGTTTCTGACATAAATGA
CAAAGAGAAAAAGTCTTCAGAGACTGAAGGATGGGTGGTGTCCTCAGAGTCTTGCAGCTTTTTA
TCTATTGGTGCGAGATATTGCCATGAAGTGAAGCCTGGGGAAATTGTAGAAATATCCAGACATG
GTGTCAGAACTCTTGATATAATTCCAAGGTCTAATGGAGACCCAGTGGCTTTTTGTATCTTCGA
ATATGTTTATTTTGCAAGACCAGATAGTATGTTTGAAGACCAGATGGTTTATACGGTAAGGTAC
CGGTGTGGCCAGCAGCTGGCAGTTGAAGCACCAGTGGAGGCGGACCTGGTCAGCACAGTTCCAG
AATCTGCCACGCCTGCGGCCCTGGGGTATGCGACAAAGTGTGGGCTGCCATATGTGGAGGTGCT
GTGTAAGAACCGGTATGTAGGAAGAACCTTCATTCAGCCAAACATGAGGCTAAGACAACTTGGG
GTTGCAAAGAAATTCGGCGTGTTGTCTGACAACTTTAAAGGCAAAAGAATTGTTCTCATAGATG
ATTCCATTGTGAGAGGCAATACTATCTCACCCATCATAAAACTCCTCAAAGAATCCGGTGCAAA
GGAGGTACACATTCGAGTCGCTTCGCCACCAATAAAACATCCGTGCTTCATGGGAATAAACATT
CCTACAAAAGAAGAGCTTATAGCCAATAAGCCCGAATTTGAGTATCTTGCAGAGTACCTTGGAG
CAAACAGCGTTGTGTATCTGTCAGTGGAAGGACTAGTTTCGTCTGTGCAACAAGAAATAAAGTT
CAAGAAGCAGAAAGTTAAAAAGCGTGATATCACAATTCAAGAAAATGGAAATGGTCTGGAGTAT
TTTGAGAAGACGGGACACTGTACGGCTTGCCTCACTGGCCAGTACCCTGTGGATCTGGAATGGT
AGCTGCCTGGACCGATGTGCTGCTTCCAGACTGAAAGGTCATCAAGAAGTGGTTTACATGTGTT
CCTCAGTTGGTACAAAATGGACACCACTTGCTTATGTATTATACCTTAAGTTTTGAGATTTTCT
GAGGTCACTGAATTGCTATAATTGAATCATAAAGATTACATGTAATGCGACATGTGGGGATTCT
TTTTGTATAAGGACTGACTTTTCACCCAAGAGAAGGCAGGAAGTGGCATTTCCCAGACCCATGC
TTGAATGGTTCTAAAGAGGTGAGATAGGGAGGTTGTGTGCCCAGGACAGGAAGCTTTATAAAGT
TTCATGAAAAGCTTGAATTCATTGTGCCCCATATGTATCTAGTCTATGCAGTCAAGTCTGCAGT
TATGGCCTTGGTCTTTGATTCTTCCACCCCATACACACATGTATGGCTCTGGGGACCAGTGTAC
AACTCCTAAAAAATGAAAACCTATGTGGAAAGCTGAGGCAGGAGAGTCCTGAGTTCAAGGCCAA
CCTGGGTTTTCCTGTCTCAAGATAAAGAACCTCTTTCTGTGCCTCGGACTCCACATCTGTTTCC
TAAGTCATTCATAAACTTAATGCTTAGCGGGAACTTGTGTGTTTGTCTGGGAGGCTTAGAGCTG
CCGTTTTACCCCTGCTTCTTTACCATGCATGGTCAGTAGCTTCAGAAGCTAATGGTAATTAGCT
TTCACTAAATTAGTTTTCAGTTTCCTTGTGATGGAGGTTTGCAGACCTTTTCCATCTCTTTGGG
ATATACCAGAACGACTGAGAAATCTATCTGGAGCCCTGTTTTTCTACACTTGACAGAAAATATT
TAGCCTAGCAAATAACTTAGTAAGTACATTGGAAAGAGAAAATTTTAATTTCAAGTAAGCCTTT
ATCCTTGATTTGATTAAACTTGGCTGTTTGAATGAGTGCTTGATCATTTACAGAACTGTGTACT
TGTATACATGTATGCATTTGGTTTAAACAGAGGGAATAGAGACACAGTAGGGCCGATTTTGTTT
AAAGGCTGAGGGGACAGCCACTGTTTGGGGAATTAGATTGCCTGTACCCAAGCGTTAGCTCATG
ATCATGTTTTTTCTAATTTTTTTTGTTAGGTCTAGTGACATTTTTAATTTTTTTATGATGCAGA
TTTAGTGGATTGAGGTGATTTACTAACTCCTGTTTGTGTGGGATTTTTCACATGGAAAAATAAT
TGTCTCTATATTGCCAAAATTTGCTACTTTCCAAACCCACTTAGAAATATAATATTTATTAAAA
ACTGAAATCATTAGTCCACATTTGGTATATAGTGTGGTGTGTCACATATGGCAGGTCAAAATAA
ACTGTTAGGACTTCGAGGTCATGTGCTGCGTGCGGTGCCTGAGGTTGTCCTGTGGCATAGACAC
AGGCTGGCCTTTCACAGCCCTGGGGCCATTTTAGTGGGTGCAACCTCCTGTGTTACATGCATTG
TGTGTAATGGCGGCGTGGAGGGGTAAGGCCGTTAGGTCAGTTTTTAAATGGCCTTATTTAAATT
TGATGTTTTACAAAGAAACTCAGGGAAGGTACTACAACCAAAATCTCTAATTTGACTTTTGTGT
TCCACAGTTTTTATTTTGTTTTATTGGAATACTTTTATAAAGGGAAATAATAACCATGGTCGTT
TGTACAACTTTCTTAATTATTTCTTCATTGTTACCTTTTATTTTACAAGTTTCTGAATATGGAT
TAAATTAACATTTTACCAGTTTCAAGCCTTATTTTATCTGCTTTAAATGTATATAACTAGAGTA
CTATATGCTGAAAAGATGAAAAATGTGTTTGAAGACAGTTAACGTCCTAAACTAATGTAAGCCT
ACTTTTTGTTTTGTATGTGCCTGTGTGGTTTTTTGTTTTTTTGCAACAAATATATGTAATAAAC
GTGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039091566 ⟹ XP_038947494

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	31,570,565 - 31,604,410 (+)	NCBI
mRatBN7.2	14	31,216,234 - 31,250,144 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_476546	(Get FASTA)	NCBI Sequence Viewer
	XP_038947494	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH86999	(Get FASTA)	NCBI Sequence Viewer
	BAA01626	(Get FASTA)	NCBI Sequence Viewer
	BAA21036	(Get FASTA)	NCBI Sequence Viewer
	EDL89892	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002905.2
	ENSRNOP00000087004
	ENSRNOP00000106250
GenBank Protein	P35433	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_476546 ⟸ NM_057198

- UniProtKB:

P35433 (UniProtKB/Swiss-Prot), A6JCX0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MELEESGIREECGVFGCIASGDWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSVPKFRVH
KGMGLVNHVFTEDNLKKLYVSNLGIGHTRYATTGKCELENCQPFVVETLHGKIAVAHNGELVNA
ARLRKKLLRHGIGLSTSSDSEMITQLLAYTPPQEQDDTPDWVARIKNLMKEAPAAYSLVIMHRD
VIYAVRDPYGNRPLCIGRLMPVSDINDKEKKSSETEGWVVSSESCSFLSIGARYCHEVKPGEIV
EISRHGVRTLDIIPRSNGDPVAFCIFEYVYFARPDSMFEDQMVYTVRYRCGQQLAVEAPVEADL
VSTVPESATPAALGYATKCGLPYVEVLCKNRYVGRTFIQPNMRLRQLGVAKKFGVLSDNFKGKR
IVLIDDSIVRGNTISPIIKLLKESGAKEVHIRVASPPIKHPCFMGINIPTKEELIANKPEFEYL
AEYLGANSVVYLSVEGLVSSVQQEIKFKKQKVKKRDITIQENGNGLEYFEKTGHCTACLTGQYP
VDLEW

hide sequence

Ensembl Acc Id:

ENSRNOP00000002905 ⟸ ENSRNOT00000002905

RefSeq Acc Id:	XP_038947494 ⟸ XM_039091566
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A2E8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000087004 ⟸ ENSRNOT00000100016

Ensembl Acc Id:

ENSRNOP00000106250 ⟸ ENSRNOT00000169394

Protein Domains

Glutamine amidotransferase type-2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P35433-F1-model_v2	AlphaFold	P35433	1-517	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699271

Promoter ID:

EPDNEW_R9796

Type:

single initiation site

Name:

Ppat_1

Description:

phosphoribosyl pyrophosphate amidotransferase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R9798

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	33,580,527 - 33,580,587	EPDNEW

RGD ID:

13699273

Promoter ID:

EPDNEW_R9798

Type:

initiation region

Name:

Ppat_2

Description:

phosphoribosyl pyrophosphate amidotransferase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R9796

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	33,580,995 - 33,581,055	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620237	AgrOrtholog
BioCyc Gene	G2FUF-15963	BioCyc
Ensembl Genes	ENSRNOG00000002128	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000002905.4	UniProtKB/Swiss-Prot
	ENSRNOT00000100016	ENTREZGENE
	ENSRNOT00000169394	ENTREZGENE
Gene3D-CATH	3.40.50.2020	UniProtKB/Swiss-Prot
	3.60.20.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7189259	IMAGE-MGC_LOAD
InterPro	GATase_2_dom	UniProtKB/Swiss-Prot
	Ntn_hydrolases_N	UniProtKB/Swiss-Prot
	PRibTrfase_dom	UniProtKB/Swiss-Prot
	PRTase-like	UniProtKB/Swiss-Prot
	PurF	UniProtKB/Swiss-Prot
	PurF_N	UniProtKB/Swiss-Prot
KEGG Report	rno:117544	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93251	IMAGE-MGC_LOAD
NCBI Gene	117544	ENTREZGENE
PANTHER	AMIDOPHOSPHORIBOSYLTRANSFERASE	UniProtKB/Swiss-Prot
Pfam	GATase_6	UniProtKB/Swiss-Prot
PharmGKB	PPAT	RGD
PhenoGen	Ppat	PhenoGen
PIRSF	Amd_phspho_trans	UniProtKB/Swiss-Prot
PROSITE	GATASE_TYPE_2	UniProtKB/Swiss-Prot
	PUR_PYR_PR_TRANSFER	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000002128	RatGTEx
Superfamily-SCOP	SSF53271	UniProtKB/Swiss-Prot
	SSF56235	UniProtKB/Swiss-Prot
UniProt	A0A8I6A2E8	ENTREZGENE, UniProtKB/TrEMBL
	A6JCX0	ENTREZGENE, UniProtKB/TrEMBL
	P35433	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-26	Ppat	phosphoribosyl pyrophosphate amidotransferase			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Ppat	phosphoribosyl pyrophosphate amidotransferase			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	ubiquitously expressed; enriched in brain, heart, liver, and stomach	633710
gene_protein	517 amino acids; 57.4 kDa	633710

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)