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Gene: Mmp16 (matrix metallopeptidase 16) Rattus norvegicus

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Symbol:

Mmp16

Name:

matrix metallopeptidase 16

RGD ID:

620199

Description:

Predicted to enable metalloaminopeptidase activity; metalloendopeptidase activity; and zinc ion binding activity. Involved in response to odorant. Predicted to be located in extracellular matrix; extracellular region; and membrane. Predicted to be active in extracellular space and plasma membrane. Orthologous to human MMP16 (matrix metallopeptidase 16); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

matrix metalloproteinase 16; matrix metalloproteinase-16; membrane-type matrix metalloproteinase 3; membrane-type-3 matrix metalloproteinase; MMP-16; MT-MMP 3; Mt3-mmp; MT3MMP; MTMMP3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MMP16 (matrix metallopeptidase 16)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Mmp16 (matrix metallopeptidase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mmp16 (matrix metallopeptidase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MMP16 (matrix metallopeptidase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MMP16 (matrix metallopeptidase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mmp16 (matrix metallopeptidase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MMP16 (matrix metallopeptidase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MMP16 (matrix metallopeptidase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mmp16 (matrix metallopeptidase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mmp16 (matrix metallopeptidase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MMP16 (matrix metallopeptidase 16)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mmp16 (matrix metallopeptidase 16)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mmp16a (matrix metallopeptidase 16a (membrane-inserted))	Alliance	DIOPT (OrthoFinder\|PhylomeDB)
Danio rerio (zebrafish):	mmp16b (matrix metallopeptidase 16b (membrane-inserted))	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Mmp1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Mmp1	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	zmp-5	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	zmp-5	Alliance	DIOPT (InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Mmp2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Mmp2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mmp16	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Candidate Gene For:

Vetf3

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	36,109,265 - 36,353,252 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	36,109,265 - 36,353,252 (+)	Ensembl				GRCr8
mRatBN7.2	5	31,312,280 - 31,556,276 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	31,312,280 - 31,548,388 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	33,458,804 - 33,703,762 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	35,051,511 - 35,296,458 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	34,991,048 - 35,235,995 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	31,568,344 - 31,818,368 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	31,568,419 - 31,810,484 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	36,239,463 - 36,484,341 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	32,352,311 - 32,586,469 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	30,477,009 - 30,710,815 (+)	NCBI		Celera
RGSC_v3.1	5	32,352,489 - 32,586,648 (+)	NCBI
Cytogenetic Map	5	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (EXP)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-palmitoylglycerol (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (EXP)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

acetamide (EXP)

acrylamide (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

alpha-Zearalanol (EXP)

amitriptyline (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

Butylbenzyl phthalate (ISO)

calcitriol (ISO)

cefaloridine (EXP)

chromium(6+) (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

colforsin daropate hydrochloride (ISO)

coumestrol (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

diclofenac (ISO)

diethyl phthalate (ISO)

diisobutyl phthalate (ISO)

diisononyl phthalate (ISO)

diuron (EXP)

dorsomorphin (ISO)

elemental selenium (ISO)

entinostat (ISO)

ethanol (ISO)

geldanamycin (ISO)

genistein (ISO)

gentamycin (EXP)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

mercury dibromide (ISO)

methotrexate (ISO)

methylmercury chloride (ISO)

microcystin-LR (ISO)

mifepristone (ISO)

N-methyl-4-phenylpyridinium (ISO)

nickel sulfate (ISO)

okadaic acid (ISO)

ozone (ISO)

paclitaxel (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (EXP)

phenylmercury acetate (ISO)

pirinixic acid (EXP)

potassium chromate (ISO)

progesterone (ISO)

resveratrol (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

thimerosal (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bone development (ISO)

chondrocyte proliferation (ISO)

collagen catabolic process (IBA,IEA,ISO)

craniofacial suture morphogenesis (ISO)

embryonic cranial skeleton morphogenesis (ISO)

endochondral ossification (ISO)

extracellular matrix organization (IBA)

ossification (ISO)

protein processing (IEA,ISO)

proteolysis (IEA,ISO)

response to odorant (IEP)

skeletal system development (IBA)

Cellular Component

extracellular matrix (IEA)

extracellular space (IBA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

hydrolase activity (IEA)

metal ion binding (IEA)

metalloaminopeptidase activity (IEA,ISO)

metalloendopeptidase activity (IBA,IEA,ISO)

metallopeptidase activity (IEA)

peptidase activity (IEA)

zinc ion binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus.	Irwin LN and Byers DM, Brain Res. 2012 Dec 13;1489:1-7. doi: 10.1016/j.brainres.2012.10.034. Epub 2012 Oct 26.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Expression of three membrane-type matrix metalloproteinases (MT-MMPs) in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domain.	Shofuda K, etal., J Biol Chem 1997 Apr 11;272(15):9749-54.

Additional References at PubMed

PMID:7559440	PMID:18022611	PMID:18784838	PMID:24970228	PMID:27229514

Genomics

Comparative Map Data

Mmp16
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	36,109,265 - 36,353,252 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	36,109,265 - 36,353,252 (+)	Ensembl				GRCr8
mRatBN7.2	5	31,312,280 - 31,556,276 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	31,312,280 - 31,548,388 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	33,458,804 - 33,703,762 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	35,051,511 - 35,296,458 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	34,991,048 - 35,235,995 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	31,568,344 - 31,818,368 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	31,568,419 - 31,810,484 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	36,239,463 - 36,484,341 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	32,352,311 - 32,586,469 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	30,477,009 - 30,710,815 (+)	NCBI		Celera
RGSC_v3.1	5	32,352,489 - 32,586,648 (+)	NCBI
Cytogenetic Map	5	q13	NCBI

MMP16
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	88,032,011 - 88,327,483 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	88,032,011 - 88,328,025 (-)	Ensembl			hg38	GRCh38
GRCh37	8	89,044,239 - 89,339,712 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	89,118,576 - 89,408,833 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	8	89,150,576 - 89,408,664	NCBI
Celera	8	85,244,102 - 85,534,339 (-)	NCBI		Celera
Cytogenetic Map	8	q21.3	NCBI
HuRef	8	84,259,378 - 84,549,728 (-)	NCBI		HuRef
CHM1_1	8	89,091,126 - 89,381,311 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	89,155,362 - 89,450,838 (-)	NCBI		T2T-CHM13v2.0

Mmp16
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	17,853,072 - 18,117,479 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	17,852,893 - 18,119,145 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	17,853,072 - 18,117,479 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	17,852,893 - 18,119,145 (+)	Ensembl			mm10	GRCm38
MGSCv37	4	17,780,629 - 18,045,881 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	17,780,629 - 18,043,779 (+)	NCBI		MGSCv36	mm8
Celera	4	17,643,862 - 17,905,148 (+)	NCBI		Celera
Cytogenetic Map	4	A3	NCBI
cM Map	4	7.08	NCBI

Mmp16
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955417	5,303,290 - 5,545,589 (-)	Ensembl
ChiLan1.0	NW_004955417	5,298,334 - 5,545,121 (-)	NCBI	ChiLan1.0	ChiLan1.0

MMP16
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	105,448,631 - 105,738,792 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	80,982,570 - 81,272,589 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	84,736,752 - 85,026,711 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	86,693,022 - 86,983,028 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	86,701,882 - 86,982,518 (-)	Ensembl			panPan2	panpan1.1

MMP16
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	33,896,133 - 34,207,560 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	33,917,907 - 34,207,466 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	34,056,176 - 34,360,687 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	34,093,268 - 34,403,773 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	34,120,818 - 34,403,822 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	34,106,198 - 34,398,221 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	34,114,566 - 34,418,869 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	34,536,488 - 34,840,936 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mmp16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	45,246,022 - 45,504,496 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936544	2,298,028 - 2,546,689 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936544	2,297,698 - 2,546,683 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MMP16
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	48,556,967 - 48,862,985 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	48,556,826 - 48,867,959 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	53,295,213 - 53,606,489 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MMP16
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	83,122,904 - 83,407,910 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	83,132,315 - 83,407,933 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666039	57,498,698 - 57,789,347 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mmp16
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624744	3,544,552 - 3,796,821 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624744	3,544,258 - 3,806,097 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mmp16
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	125,385,082 - 125,626,902 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mmp16
1040 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	583
Count of miRNA genes:	265
Interacting mature miRNAs:	342
Transcripts:	ENSRNOT00000050137
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293666	Bmd38	Bone mineral density QTL 38	4.4		femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	5	13731153	43590997	Rat
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	32751649	77751649	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	6922282	81330203	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33311673	78311673	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	23671493	79046465	Rat
1300117	Hrtrt8	Heart rate QTL 8	3.49		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	8627230	52665523	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	14606078	59606078	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	17576633	62576633	Rat
1578774	Tcas8	Tongue tumor susceptibility QTL 8	3.47		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	15707451	60707451	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	91770353	Rat
2312562	Pur18	Proteinuria QTL 18	2.6	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	5	6922282	37468560	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	7065535	74335773	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	33311673	78311673	Rat
1641903	Alcrsp3	Alcohol response QTL 3			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	17486080	62486080	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	32751649	77751649	Rat
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	87027358	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	26023211	71023211	Rat
2303577	Gluco47	Glucose level QTL 47	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	16520019	61520019	Rat
1549901	Neudeg2	Neurodegradation QTL 2	4	0	nervous system integrity trait (VT:0010566)	mononuclear cell count (CMO:0002119)	5	31130421	48841739	Rat
1641922	Alcrsp8	Alcohol response QTL 8			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	5	17486080	62486080	Rat
2313085	Bss59	Bone structure and strength QTL 59	2.9	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	5	8627230	53627230	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	23671493	68671493	Rat

Markers in Region

D5Wox36

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	31,547,367 - 31,547,578 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	31,809,466 - 31,809,674	NCBI	Rnor6.0
Rnor_5.0	5	36,478,685 - 36,478,893	UniSTS	Rnor5.0
RGSC_v3.4	5	32,585,451 - 32,585,659	UniSTS	RGSC3.4
Celera	5	30,709,797 - 30,710,005	UniSTS
Cytogenetic Map	5	q13	UniSTS

AW532313

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	31,360,600 - 31,360,759 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	31,616,409 - 31,616,567	NCBI	Rnor6.0
Rnor_5.0	5	36,287,477 - 36,287,635	UniSTS	Rnor5.0
RGSC_v3.4	5	32,400,967 - 32,401,125	UniSTS	RGSC3.4
Celera	5	30,525,242 - 30,525,400	UniSTS
RH 3.4 Map	5	162.72	UniSTS
Cytogenetic Map	5	q13	UniSTS

AB021228

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	31,547,101 - 31,547,244 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	31,809,200 - 31,809,342	NCBI	Rnor6.0
Rnor_5.0	5	36,478,419 - 36,478,561	UniSTS	Rnor5.0
RGSC_v3.4	5	32,585,185 - 32,585,327	UniSTS	RGSC3.4
Celera	5	30,709,531 - 30,709,673	UniSTS
Cytogenetic Map	5	q13	UniSTS

BE115606

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	31,548,182 - 31,548,350 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	31,810,279 - 31,810,446	NCBI	Rnor6.0
Rnor_5.0	5	36,479,498 - 36,479,665	UniSTS	Rnor5.0
RGSC_v3.4	5	32,586,264 - 32,586,431	UniSTS	RGSC3.4
Celera	5	30,710,610 - 30,710,777	UniSTS
RH 3.4 Map	5	162.82	UniSTS
Cytogenetic Map	5	q13	UniSTS

MMP16_920

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	31,546,930 - 31,547,841 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	31,809,029 - 31,809,937	NCBI	Rnor6.0
Rnor_5.0	5	36,478,248 - 36,479,156	UniSTS	Rnor5.0
RGSC_v3.4	5	32,585,014 - 32,585,922	UniSTS	RGSC3.4
Celera	5	30,709,360 - 30,710,268	UniSTS
Cytogenetic Map	5	q13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	152	91	90	59	25	59	6	279	125	11	131	71	92	31	14	14

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_080776	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237921	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110732	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D63886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000050137 ⟹ ENSRNOP00000040229

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	36,109,265 - 36,353,252 (+)	Ensembl
mRatBN7.2 Ensembl	5	31,312,280 - 31,548,388 (+)	Ensembl
Rnor_6.0 Ensembl	5	31,568,419 - 31,810,484 (+)	Ensembl

RefSeq Acc Id:

NM_080776 ⟹ NP_542954

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	36,109,265 - 36,353,252 (+)	NCBI
mRatBN7.2	5	31,312,280 - 31,556,276 (+)	NCBI
Rnor_6.0	5	31,568,419 - 31,810,484 (+)	NCBI
Rnor_5.0	5	36,239,463 - 36,484,341 (+)	NCBI
RGSC_v3.4	5	32,352,311 - 32,586,469 (+)	RGD
Celera	5	30,477,009 - 30,710,815 (+)	RGD

Sequence:

show sequence

CTGGAGGGGAGCAGAGAGGAGGGAAGGAGCAGCGGAGGCAGTGAGCTGGGAGCGGCTGAGGCCC
TTCCCGCAGAAACTGGGGGCACCGGCGGCGTAGGAGGTGGAGAAGGCGGAGGACGCACGGGCTG
GAGGCGGCGGCTGCGACTCGGCGGCGCTGGGAATCGGAACCGCGGGTGAACTTGGGCGCCACGT
TCCGGGCGACGGCCGGGTGAGGATGGTGAACACTTGCAGCCGCTGACCCTGCCTTTCCTCTGTT
TCCTCGCGGGTTGCCGAGCCTGGCGCCCATCCCCACCCCTGGACGGGTGGGTGAACCTGCAAGC
TTCTACCCACCCCAGGACTATTTTTTCTTTTAAAAGGAAACAGGGAGTGGGCATTCGGAAAGAG
GGAGAAAACGCAGGGGAGCTCGTCCATCCGTTGAGGCAGAGTTCACTATGATCTTACTCGCATT
CAGCTCTGGAAGAAGGTTGGATTTCGTGCATCGTTCGGGGGTGTTTTTCTTCCAAACCTTGCTT
TGGATTTTATGTGCTACAGTCTGCGGAACGGAGCAGTATTTCAATGTGGAGGTTTGGTTACAGA
AATACGGCTACCTTCCACCGACTGACCCCAGAATGTCTGTGCTGCGCTCTGCAGAGACCATGCA
GTCAGCCTTAGCTGCCATGCAGCAGTTCTATGGCATTAACATGACAGGAAAAGTGGACAGAAAC
ACAATTGACTGGATGAAGAAGCCTCGATGTGGTGTACCAGACCAAACAAGAGGCAGCTCTAAAT
TCAACATCCGACGAAAGCGCTATGCATTAACTGGGCAGAAGTGGCAACACAAGCATATCACTTA
CAGTATAAAGAACGTAACTCCCAAGGTTGGAGATCCTGAGACCCGGAGAGCAATTCGCCGTGCC
TTTGATGTGTGGCAGAATGTAACACCTCTAACGTTTGAAGAAGTTCCCTACAGTGAACTAGAAA
ATGGCAAACGTGATGTGGATATAACCATCATTTTTGCTTCTGGTTTCCATGGAGACAGATCCCC
CTTTGATGGGGAGGGAGGATTTTTGGCCCATGCTTATTTCCCTGGGCCAGGAATTGGAGGCGAT
ACTCATTTTGATTCTGATGAGCCATGGACACTGGGAAATCCCAATCATGATGGAAATGATTTAT
TTCTTGTAGCAGTCCATGAGCTGGGACATGCTCTAGGGCTGGAGCATTCCAACGACCCAACAGC
TATCATGGCACCATTTTACCAGTACATGGAAACAGACAACTTCAAGCTTCCTAATGATGATTTG
CAAGGCATCCAGAAGATATATGGTCCACCTGACAAGATCCCTCCACCTACAAGACCTCTACCGA
CAGTGCCCCCTCACCGATCTGTCCCTCCGGCCGACCCAAGGAAAAATGACAGGCCCAAACCTCC
TCGACCTCCCACTGGCAGACCTTCCTATCCAGGAGCCAAACCCAACATCTGTGATGGGAACTTC
AACACTCTAGCTATTCTTCGAAGGGAGATGTTTGTTTTCAAGGACCAGTGGTTTTGGCGAGTGA
GAAACAACAGGGTGATGGATGGATACCCCATGCAAATTACTTACTTCTGGCGGGGCCTTCCTCC
CAGTATTGATGCAGTTTATGAAAACAGTGATGGAAATTTTGTCTTCTTTAAAGGTAACAAATAC
TGGGTGTTCAAAGACACAACTCTTCAACCTGGATACCCTCATGACTTGATTACCCTTGGAAATG
GAATCCCCCCTCATGGTATTGATTCTGCCATATGGTGGGAAGATGTTGGCAAAACCTATTTCTT
CAAAGGCGACCGGTATTGGAGATATAGTGAAGAAATGAAAACCATGGACCCTGGCTATCCCAAG
CCCATCACCATCTGGAAAGGAATCCCTGAATCACCTCAGGGAGCTTTCGTCCACAAGGAAAATG
GCTTTACCTATTTCTACAAAGGAAAGGAGTATTGGAAATTCAACAACCAGATACTCAAAGTAGA
ACCTGGGTATCCAAGATCCATCCTCAAGGACTTTATGGGCTGTGATGGACCAACAGACCGAGAT
AAAGAAGGTCTCAGCCCACCACCATGATGTAGACATTGTCATCAAACTGGACAACACAGCCAGC
ACTGTGAAAGCCATAGCTATTGTCATTCCCTGCATCTTGGCCTTATGGCCTCCTTGTATTGGTT
TACACTGTGTTCCAGTTCAAGCGGAAAGGAACACCCCGCCACATACTGTACTGTAAACGCTCTA
TGCAAGAGTGGGTGTGATGTAGGGATTTCTTTTTTCTTTCTTTTCCGGAGTTTGTGGTAACTTG
AGATTCAAGACAAGAGCTGTTATGCTGTTTCCTAGCTAGGAGCAGGCTTGTGGCAGCTGATCGA
GGCTGACCTTCCAAACCTAGATGGTTGCTGGTCCTGCACATGAGTGGAAATATATTCATGGAGA
AACTTCCATGATGCACAGTATCTGCCGTTCTTCAGTCCTCTGTCTTTCTTTGTCATTCAGTTCT
AGGCTTTCCTCTGCACGCTCAATGCCCAGTAAAATTTCAGGATTAACTGAAGAAGAGGAAATAT
AGAAGAAAAGTTTCTTCTTATTTTTTTTTAAAATACTTTTCCTTCTGAAATCTGAGCCCATTTC
TGGGAAAGAGAAAGAAAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAG
AGAAAGCAAATCAGAAAACCCATAGGTTTTTGCTTTAAAGCAAAAGAGAGTTTAAAAACAACAA
AATCCACAACTGAACTTTCAGAAAAGTGTGAAGATCCAAAACAGCTTTGTCTCCAAAGAAGATA
GCTCTGTGACCACTATGGATAGTTTCCTGCGCATTGTCTTGTCAGGTGGGAGATCTGGAACATA
CATGCAGGACGCTAGACTGTTGGGACAGACATTTTCCAACAAACAAGGGGCCAAAATATCTGCA
ATATAGTAACAGCCTTAATAATACATGCATTTTCATTTTCTACAGCTGTTCTCAACTATGTCCA
CAATGTATCATCACCTCCATACTCATAGCTGTATTCAAACAGGACCTTTTGGTTGTTTTGAAAT
GTTTCTGAACCCCCTCTTGCCTCCTGACACAGCATCATTGTGACATTCTTCCCAGTTGTGTTAG
GCCTTTGTCCCAGGCCGTCCATTGGTCTGTCAGCAATACTCAGCGCAAAGCAGAGCGAGAAGCA
TTGTGTCTCTGAAGTAAAGAAAGTGATGGTCATATTATAAAGATATGTTCCTCTTTAATACATC
GGTGTAACCCTTTGAGAACTATCAGACCAGCTTACAGAGTCAGGATGATCAGTCTTGCAATCTG
GTCATTTGTAGAAGTGGCCAAAAGGGAAAGCCATCACATGTTCGAGAAGTTCAGACTTGTAAAG
CATACCTTACAATCCCATGTAATTCTTTAATGACTGACAGTACTGCATAAATGCTTTTATAACA
AACAACAGTGGTGTGACTTGCCAAAACTTTTCTGGCAAATAAAAAAGATATTTTGTTAACAAT

hide sequence

RefSeq Acc Id:

XM_039110732 ⟹ XP_038966660

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	36,265,806 - 36,345,365 (+)	NCBI
mRatBN7.2	5	31,468,802 - 31,556,274 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_542954	(Get FASTA)	NCBI Sequence Viewer
	XP_038966660	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA22223	(Get FASTA)	NCBI Sequence Viewer
	EDL98489	(Get FASTA)	NCBI Sequence Viewer
	EDL98490	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000040229
GenBank Protein	O35548	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_542954 ⟸ NM_080776
- Peptide Label:	precursor
- UniProtKB:	O35548 (UniProtKB/Swiss-Prot), O35541 (UniProtKB/Swiss-Prot), F1M7F5 (UniProtKB/TrEMBL), A6IIB9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MILLAFSSGRRLDFVHRSGVFFFQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLR SAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFNIRRKRYALTGQKWQ HKHITYSIKNVTPKVGDPETRRAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGF HGDRSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEH SNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSVPPADPRKN DRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYF WRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGNGIPPHGIDSAIWWEDV GKTYFFKGDRYWRYSEEMKTMDPGYPKPITIWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNN QILKVEPGYPRSILKDFMGCDGPTDRDKEGLSPPP hide sequence

Ensembl Acc Id:

ENSRNOP00000040229 ⟸ ENSRNOT00000050137

RefSeq Acc Id:	XP_038966660 ⟸ XM_039110732
- Peptide Label:	isoform X1

Protein Domains

Peptidase metallopeptidase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35548-F1-model_v2	AlphaFold	O35548	1-607	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693583

Promoter ID:

EPDNEW_R4108

Type:

initiation region

Name:

Mmp16_1

Description:

matrix metallopeptidase 16

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	31,568,431 - 31,568,491	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620199	AgrOrtholog
BioCyc Gene	G2FUF-41847	BioCyc
Ensembl Genes	ENSRNOG00000005708	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000050137	ENTREZGENE
Gene3D-CATH	2.110.10.10	UniProtKB/Swiss-Prot
	3.40.390.10	UniProtKB/Swiss-Prot
InterPro	Hemopexin-like_dom	UniProtKB/Swiss-Prot
	Hemopexin-like_dom_sf	UniProtKB/Swiss-Prot
	Hemopexin-like_repeat	UniProtKB/Swiss-Prot
	Hemopexin_CS	UniProtKB/Swiss-Prot
	M10A_MMP	UniProtKB/Swiss-Prot
	MetalloPept_cat_dom_sf	UniProtKB/Swiss-Prot
	Pept_M10_metallopeptidase	UniProtKB/Swiss-Prot
	Pept_M10A	UniProtKB/Swiss-Prot
	Pept_M10A_metallopeptidase_C	UniProtKB/Swiss-Prot
	Pept_M10A_Zn_BS	UniProtKB/Swiss-Prot
	Peptidase_Metallo	UniProtKB/Swiss-Prot
	Peptidoglycan-bd-like	UniProtKB/Swiss-Prot
	PGBD-like_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:65205	UniProtKB/Swiss-Prot
NCBI Gene	65205	ENTREZGENE
PANTHER	MATRIX METALLOPROTEINASE	UniProtKB/Swiss-Prot
	PTHR10201:SF26	UniProtKB/Swiss-Prot
Pfam	DUF3377	UniProtKB/Swiss-Prot
	Hemopexin	UniProtKB/Swiss-Prot
	Peptidase_M10	UniProtKB/Swiss-Prot
	PG_binding_1	UniProtKB/Swiss-Prot
PhenoGen	Mmp16	PhenoGen
PIRSF	Peptidase_M10A_matrix	UniProtKB/Swiss-Prot
PRINTS	MATRIXIN	UniProtKB/Swiss-Prot
PROSITE	CYSTEINE_SWITCH	UniProtKB/Swiss-Prot
	HEMOPEXIN	UniProtKB/Swiss-Prot
	HEMOPEXIN_2	UniProtKB/Swiss-Prot
	ZINC_PROTEASE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000005708	RatGTEx
SMART	SM00120	UniProtKB/Swiss-Prot
	ZnMc	UniProtKB/Swiss-Prot
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/Swiss-Prot
	SSF47090	UniProtKB/Swiss-Prot
	SSF50923	UniProtKB/Swiss-Prot
UniProt	A6IIB9	ENTREZGENE, UniProtKB/TrEMBL
	F1M7F5	ENTREZGENE, UniProtKB/TrEMBL
	MMP16_RAT	UniProtKB/Swiss-Prot
	O35541	ENTREZGENE
	O35548	ENTREZGENE
UniProt Secondary	O35541	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-22	Mmp16	matrix metallopeptidase 16	Mmp16	matrix metalloproteinase 16	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-26	Mmp16	matrix metalloproteinase 16			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Mmp16				Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_function	cleaves endogenous progelatinase A to its mature form	729074
gene_protein	607 amino acids	729074

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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