Ank2 (ankyrin 2) - Rat Genome Database

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Gene: Ank2 (ankyrin 2) Rattus norvegicus
Analyze
Symbol: Ank2
Name: ankyrin 2
RGD ID: 620156
Description: Enables protein kinase binding activity and transmembrane transporter binding activity. A structural constituent of cytoskeleton. Involved in paranodal junction assembly and response to methylmercury. Predicted to be located in several cellular components, including T-tubule; basolateral plasma membrane; and myofibril. Predicted to be active in paranodal junction. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in ankyrin-B-related cardiac arrhythmia; atrial fibrillation; long QT syndrome; and sick sinus syndrome. Orthologous to human ANK2 (ankyrin 2); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ank3; ankyrin 2 brain; ankyrin 2, brain; ankyrin 2, neuronal; ankyrin 3, epithelial; ankyrin-2; LOC103691695; LOC310885; LOC362036; uncharacterized LOC103691695
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82218,052,555 - 218,628,414 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2218,052,555 - 218,537,259 (-)EnsemblGRCr8
mRatBN7.22215,378,028 - 215,954,015 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2215,379,680 - 215,862,923 (-)EnsemblmRatBN7.2
Rnor_6.02231,224,643 - 231,522,655 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2231,226,949 - 231,648,122 (-)Ensemblrn6Rnor6.0
Rnor_5.02250,573,979 - 250,869,144 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42224,182,431 - 224,501,751 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2207,699,846 - 207,902,141 (-)NCBICelera
RGSC_v3.12224,228,885 - 224,376,051 (-)NCBI
Cytogenetic Map2q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-carotene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cantharidin  (ISO)
carmustine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lovastatin  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
quercetin  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
temozolomide  (ISO)
thimerosal  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zaragozic acid A  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
atrial cardiac muscle cell action potential  (IEA,ISO)
atrial cardiac muscle cell to AV node cell communication  (ISO)
atrial septum development  (IEA,ISO)
cardiac muscle contraction  (ISO)
cytoskeleton organization  (IEA)
intracellular calcium ion homeostasis  (ISO)
intracellular protein localization  (IEA,ISO)
nervous system development  (IEP)
paranodal junction assembly  (IEP)
positive regulation of calcium ion transport  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of potassium ion import across plasma membrane  (ISO)
protein localization to cell surface  (ISO)
protein localization to endoplasmic reticulum  (IEA,ISO)
protein localization to M-band  (ISO)
protein localization to plasma membrane  (IEA,ISO)
protein localization to T-tubule  (ISO)
protein stabilization  (ISO)
regulation of atrial cardiac muscle cell action potential  (IEA,ISO)
regulation of AV node cell action potential  (ISO)
regulation of calcium ion transport  (IEA,ISO)
regulation of cardiac muscle cell contraction  (IEA,ISO)
regulation of cardiac muscle cell membrane potential  (ISO)
regulation of cardiac muscle contraction  (IEA,ISO)
regulation of cardiac muscle contraction by calcium ion signaling  (IEA,ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (IEA,ISO)
regulation of heart rate  (IEA,ISO)
regulation of heart rate by cardiac conduction  (IEA,ISO)
regulation of release of sequestered calcium ion into cytosol  (IEA,ISO)
regulation of SA node cell action potential  (IEA,ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (IEA,ISO)
response to methylmercury  (IEP)
SA node cell action potential  (ISO)
SA node cell to atrial cardiac muscle cell communication  (IEA,ISO)
signal transduction  (IEA)
T-tubule organization  (ISO)
ventricular cardiac muscle cell action potential  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Obscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-line. Cunha SR and Mohler PJ, J Biol Chem. 2008 Nov 14;283(46):31968-80. doi: 10.1074/jbc.M806050200. Epub 2008 Sep 9.
2. Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Cunha SR, etal., Circulation. 2011 Sep 13;124(11):1212-22. Epub 2011 Aug 22.
3. Distribution of ankyrin isoforms and their proteolysis after ischemia and reperfusion in rat brain. Harada K, etal., J Neurochem. 1997 Jul;69(1):371-6.
4. Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation. Kline CF, etal., Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16669-74. doi: 10.1073/pnas.0907138106. Epub 2009 Sep 15.
5. Expression and localization of brain ankyrin isoforms and related proteins during early developmental stages of rat nervous system. Kunimoto M, etal., J Neurochem. 1998 Dec;71(6):2585-92.
6. Plasma membrane-cytoskeleton-endoplasmic reticulum complexes in neurons and astrocytes. Lencesova L, etal., J Biol Chem. 2004 Jan 23;279(4):2885-93. Epub 2003 Oct 30.
7. Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. Mohler PJ, etal., J Biol Chem. 2004 Sep 17;279(38):40185-93. Epub 2004 Jul 19.
8. Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Mohler PJ, etal., Nature 2003 Feb 6;421(6923):634-9.
9. A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. Mohler PJ, etal., Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9137-42. Epub 2004 Jun 3.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton. Ogawa Y, etal., J Neurosci. 2006 May 10;26(19):5230-9.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Selective disappearance of an axonal protein, 440-kDa ankyrinB, associated with neuronal degeneration induced by methylmercury. Sakaue M, etal., J Neurosci Res. 2003 Sep 15;73(6):831-9.
18. Proteolysis of erythrocyte-type and brain-type ankyrins in rat heart after postischemic reperfusion. Yoshida K and Harada K, J Biochem (Tokyo). 1997 Aug;122(2):279-85.
Additional References at PubMed
PMID:7961622   PMID:9151675   PMID:11781319   PMID:12070130   PMID:15611082   PMID:16292983   PMID:17114649   PMID:17178715   PMID:17242276   PMID:17416611   PMID:17884088   PMID:18832177  
PMID:19007774   PMID:20489164   PMID:20610380   PMID:21177872   PMID:21700703   PMID:22886464   PMID:25950943   PMID:26109584   PMID:30949686   PMID:32640013  


Genomics

Comparative Map Data
Ank2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82218,052,555 - 218,628,414 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2218,052,555 - 218,537,259 (-)EnsemblGRCr8
mRatBN7.22215,378,028 - 215,954,015 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2215,379,680 - 215,862,923 (-)EnsemblmRatBN7.2
Rnor_6.02231,224,643 - 231,522,655 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2231,226,949 - 231,648,122 (-)Ensemblrn6Rnor6.0
Rnor_5.02250,573,979 - 250,869,144 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42224,182,431 - 224,501,751 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2207,699,846 - 207,902,141 (-)NCBICelera
RGSC_v3.12224,228,885 - 224,376,051 (-)NCBI
Cytogenetic Map2q42NCBI
ANK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384112,705,622 - 113,383,736 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4112,818,032 - 113,384,231 (+)Ensemblhg38GRCh38
GRCh374113,626,778 - 114,304,892 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364114,190,319 - 114,524,337 (+)NCBIBuild 36Build 36hg18NCBI36
Celera4111,031,065 - 111,596,545 (+)NCBICelera
Cytogenetic Map4q25-q26NCBI
HuRef4109,467,190 - 110,033,212 (+)NCBIHuRef
CHM1_14113,715,710 - 114,281,305 (+)NCBICHM1_1
T2T-CHM13v2.04116,013,980 - 116,692,458 (+)NCBIT2T-CHM13v2.0
Ank2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393126,715,256 - 127,293,996 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3126,715,261 - 127,292,999 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383126,921,607 - 127,500,347 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3126,921,612 - 127,499,350 (-)Ensemblmm10GRCm38
MGSCv373126,624,525 - 126,701,370 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363126,913,629 - 126,990,474 (-)NCBIMGSCv36mm8
Celera3133,394,159 - 133,470,953 (-)NCBICelera
Cytogenetic Map3G2NCBI
cM Map356.07NCBI
Ank2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545713,624,413 - 14,076,261 (-)Ensembl
ChiLan1.0NW_00495545713,624,590 - 13,938,427 (-)NCBIChiLan1.0ChiLan1.0
ANK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23110,785,514 - 111,471,268 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14111,078,901 - 111,762,687 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04105,315,776 - 105,882,506 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14115,760,071 - 116,446,170 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4115,967,106 - 116,443,905 (+)EnsemblpanPan2panpan1.1
ANK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13232,484,196 - 33,143,295 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3232,671,281 - 33,141,036 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha328,888,883 - 9,218,786 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03233,040,789 - 33,371,120 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3232,898,398 - 33,370,466 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13233,020,952 - 33,349,123 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03232,787,755 - 33,117,694 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0326,746,226 - 7,076,960 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ank2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053017,738,663 - 8,389,184 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365633,520,193 - 4,171,362 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365633,520,195 - 4,170,716 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8109,306,797 - 109,912,908 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18109,306,793 - 109,661,970 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28117,345,572 - 117,559,478 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1760,487,776 - 61,174,351 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl760,938,523 - 61,175,519 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603739,246,221 - 39,938,996 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ank2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248386,548,159 - 7,023,945 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248386,490,434 - 7,023,945 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ank2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1331,846,968 - 32,432,241 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ank2
5991 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:235
Count of miRNA genes:143
Interacting mature miRNAs:159
Transcripts:ENSRNOT00000014962, ENSRNOT00000015386, ENSRNOT00000037255, ENSRNOT00000055615, ENSRNOT00000068415, ENSRNOT00000074002
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2212145502231732847Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
1302789Stl26Serum triglyceride level QTL 263.10.0035blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)2206613059226891081Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2209350500221678003Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2205135267225627153Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat

Markers in Region
D2Rat360  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82218,316,106 - 218,316,320 (+)Marker Load Pipeline
mRatBN7.22215,641,574 - 215,641,788 (+)MAPPERmRatBN7.2
Rnor_6.02231,488,516 - 231,488,731NCBIRnor6.0
Rnor_5.02250,836,498 - 250,836,713UniSTSRnor5.0
RGSC_v3.42224,468,436 - 224,468,649UniSTSRGSC3.4
Celera2207,962,059 - 207,962,274UniSTS
RH 3.4 Map21546.8UniSTS
RH 3.4 Map21546.8RGD
RH 2.0 Map21142.2RGD
SHRSP x BN Map286.3798RGD
Cytogenetic Map2q42UniSTS
AW491075  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22215,378,422 - 215,378,515 (+)MAPPERmRatBN7.2
Rnor_6.02231,225,038 - 231,225,130NCBIRnor6.0
Rnor_5.02250,574,369 - 250,574,461UniSTSRnor5.0
RGSC_v3.42224,181,007 - 224,181,099UniSTSRGSC3.4
Celera2207,700,241 - 207,700,333UniSTS
Cytogenetic Map2q42UniSTS
BF390514  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22215,430,667 - 215,430,822 (+)MAPPERmRatBN7.2
Rnor_6.02231,277,280 - 231,277,434NCBIRnor6.0
Rnor_5.02250,626,611 - 250,626,765UniSTSRnor5.0
RGSC_v3.42224,233,249 - 224,233,403UniSTSRGSC3.4
Celera2207,752,482 - 207,752,636UniSTS
RH 3.4 Map21546.3UniSTS
Cytogenetic Map2q42UniSTS
RH132931  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22215,585,818 - 215,586,020 (+)MAPPERmRatBN7.2
Rnor_6.02231,432,766 - 231,432,967NCBIRnor6.0
Rnor_5.02250,780,748 - 250,780,949UniSTSRnor5.0
RGSC_v3.42224,412,666 - 224,412,867UniSTSRGSC3.4
Celera2207,906,163 - 207,906,364UniSTS
RH 3.4 Map21546.5UniSTS
Cytogenetic Map2q42UniSTS
RH144369  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22215,636,683 - 215,636,941 (+)MAPPERmRatBN7.2
Rnor_6.02231,483,625 - 231,483,882NCBIRnor6.0
Rnor_5.02250,831,607 - 250,831,864UniSTSRnor5.0
RGSC_v3.42224,463,545 - 224,463,802UniSTSRGSC3.4
Celera2207,957,168 - 207,957,425UniSTS
RH 3.4 Map21606.4UniSTS
Cytogenetic Map2q42UniSTS
BE101848  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22215,402,476 - 215,402,627 (+)MAPPERmRatBN7.2
Rnor_6.02231,249,089 - 231,249,239NCBIRnor6.0
Rnor_5.02250,598,420 - 250,598,570UniSTSRnor5.0
RGSC_v3.42224,205,058 - 224,205,208UniSTSRGSC3.4
Celera2207,724,293 - 207,724,443UniSTS
RH 3.4 Map21546.4UniSTS
Cytogenetic Map2q42UniSTS
RH141556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22215,487,784 - 215,487,964 (+)MAPPERmRatBN7.2
Rnor_6.02231,334,412 - 231,334,591NCBIRnor6.0
Rnor_5.02250,682,394 - 250,682,573UniSTSRnor5.0
RGSC_v3.42224,314,113 - 224,314,292UniSTSRGSC3.4
Celera2207,808,132 - 207,808,311UniSTS
RH 3.4 Map21556.7UniSTS
Cytogenetic Map2q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 67 165 86 85 54 79 54 6 337 179 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U65916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000014962   ⟹   ENSRNOP00000014962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2231,333,076 - 231,648,122 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000015386   ⟹   ENSRNOP00000015386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2218,052,555 - 218,537,259 (-)Ensembl
mRatBN7.2 Ensembl2215,385,041 - 215,675,402 (-)Ensembl
Rnor_6.0 Ensembl2231,231,827 - 231,409,496 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000037255   ⟹   ENSRNOP00000035307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2218,059,571 - 218,349,298 (-)Ensembl
mRatBN7.2 Ensembl2215,385,041 - 215,563,039 (-)Ensembl
Rnor_6.0 Ensembl2231,231,827 - 231,409,988 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000055615   ⟹   ENSRNOP00000052477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2218,053,863 - 218,537,259 (-)Ensembl
mRatBN7.2 Ensembl2215,379,680 - 215,862,923 (-)Ensembl
Rnor_6.0 Ensembl2231,226,949 - 231,409,496 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000068415   ⟹   ENSRNOP00000060715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2231,329,829 - 231,409,496 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074002   ⟹   ENSRNOP00000064466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2231,335,849 - 231,409,988 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080470   ⟹   ENSRNOP00000073918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2218,059,571 - 218,237,578 (-)Ensembl
mRatBN7.2 Ensembl2215,379,680 - 215,675,402 (-)Ensembl
Rnor_6.0 Ensembl2231,232,925 - 231,521,052 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080637   ⟹   ENSRNOP00000070916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2215,379,680 - 215,614,015 (-)Ensembl
Rnor_6.0 Ensembl2231,226,949 - 231,409,988 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084756   ⟹   ENSRNOP00000075511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2218,052,555 - 218,286,507 (-)Ensembl
mRatBN7.2 Ensembl2215,379,680 - 215,614,015 (-)Ensembl
Rnor_6.0 Ensembl2231,232,925 - 231,521,052 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089534   ⟹   ENSRNOP00000075731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2215,385,041 - 215,674,770 (-)Ensembl
Rnor_6.0 Ensembl2231,231,827 - 231,521,052 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120732   ⟹   ENSRNOP00000098357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2218,052,555 - 218,237,086 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000131299   ⟹   ENSRNOP00000102431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2218,157,749 - 218,537,259 (-)Ensembl
RefSeq Acc Id: NM_001427159   ⟹   NP_001414088
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,555 - 218,628,414 (-)NCBI
RefSeq Acc Id: XM_039103998   ⟹   XP_038959926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
mRatBN7.22215,378,028 - 215,701,707 (-)NCBI
RefSeq Acc Id: XM_039104008   ⟹   XP_038959936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
mRatBN7.22215,378,028 - 215,701,707 (-)NCBI
RefSeq Acc Id: XM_039104019   ⟹   XP_038959947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
mRatBN7.22215,378,028 - 215,701,707 (-)NCBI
RefSeq Acc Id: XM_039104022   ⟹   XP_038959950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,350,903 (-)NCBI
mRatBN7.22215,378,028 - 215,676,331 (-)NCBI
RefSeq Acc Id: XM_039104023   ⟹   XP_038959951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,350,903 (-)NCBI
mRatBN7.22215,378,028 - 215,676,330 (-)NCBI
RefSeq Acc Id: XM_039104025   ⟹   XP_038959953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
mRatBN7.22215,378,028 - 215,701,707 (-)NCBI
RefSeq Acc Id: XM_039104029   ⟹   XP_038959957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,286,314 (-)NCBI
mRatBN7.22215,378,028 - 215,611,773 (-)NCBI
RefSeq Acc Id: XM_039104031   ⟹   XP_038959959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,350,903 (-)NCBI
mRatBN7.22215,378,028 - 215,675,317 (-)NCBI
RefSeq Acc Id: XM_039104034   ⟹   XP_038959962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,286,314 (-)NCBI
mRatBN7.22215,378,028 - 215,611,773 (-)NCBI
RefSeq Acc Id: XM_039104038   ⟹   XP_038959966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,350,903 (-)NCBI
mRatBN7.22215,378,028 - 215,675,311 (-)NCBI
RefSeq Acc Id: XM_039104040   ⟹   XP_038959968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,350,903 (-)NCBI
mRatBN7.22215,378,028 - 215,675,311 (-)NCBI
RefSeq Acc Id: XM_039104042   ⟹   XP_038959970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,350,903 (-)NCBI
mRatBN7.22215,378,028 - 215,675,307 (-)NCBI
RefSeq Acc Id: XM_039104044   ⟹   XP_038959972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,350,903 (-)NCBI
mRatBN7.22215,378,028 - 215,675,310 (-)NCBI
RefSeq Acc Id: XM_039104045   ⟹   XP_038959973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,350,903 (-)NCBI
mRatBN7.22215,378,028 - 215,675,307 (-)NCBI
RefSeq Acc Id: XM_063282182   ⟹   XP_063138252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282183   ⟹   XP_063138253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,286,314 (-)NCBI
RefSeq Acc Id: XM_063282184   ⟹   XP_063138254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282185   ⟹   XP_063138255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,537,235 (-)NCBI
RefSeq Acc Id: XM_063282186   ⟹   XP_063138256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282187   ⟹   XP_063138257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282188   ⟹   XP_063138258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,350,903 (-)NCBI
RefSeq Acc Id: XM_063282189   ⟹   XP_063138259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282190   ⟹   XP_063138260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,286,314 (-)NCBI
RefSeq Acc Id: XM_063282191   ⟹   XP_063138261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282192   ⟹   XP_063138262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282193   ⟹   XP_063138263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282194   ⟹   XP_063138264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,350,903 (-)NCBI
RefSeq Acc Id: XM_063282195   ⟹   XP_063138265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,537,235 (-)NCBI
RefSeq Acc Id: XM_063282196   ⟹   XP_063138266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,286,314 (-)NCBI
RefSeq Acc Id: XM_063282197   ⟹   XP_063138267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282198   ⟹   XP_063138268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282199   ⟹   XP_063138269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,537,257 (-)NCBI
RefSeq Acc Id: XM_063282200   ⟹   XP_063138270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,350,903 (-)NCBI
RefSeq Acc Id: XM_063282201   ⟹   XP_063138271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,286,314 (-)NCBI
RefSeq Acc Id: XM_063282202   ⟹   XP_063138272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282203   ⟹   XP_063138273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,286,314 (-)NCBI
RefSeq Acc Id: XM_063282204   ⟹   XP_063138274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282205   ⟹   XP_063138275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,537,268 (-)NCBI
RefSeq Acc Id: XM_063282206   ⟹   XP_063138276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282207   ⟹   XP_063138277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,350,903 (-)NCBI
RefSeq Acc Id: XM_063282208   ⟹   XP_063138278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282209   ⟹   XP_063138279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282210   ⟹   XP_063138280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,537,257 (-)NCBI
RefSeq Acc Id: XM_063282211   ⟹   XP_063138281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,286,314 (-)NCBI
RefSeq Acc Id: XM_063282212   ⟹   XP_063138282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,537,257 (-)NCBI
RefSeq Acc Id: XM_063282213   ⟹   XP_063138283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,376,235 (-)NCBI
RefSeq Acc Id: XM_063282214   ⟹   XP_063138284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,286,314 (-)NCBI
RefSeq Acc Id: XM_063282215   ⟹   XP_063138285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,350,903 (-)NCBI
RefSeq Acc Id: XM_063282216   ⟹   XP_063138286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,286,314 (-)NCBI
RefSeq Acc Id: XM_063282217   ⟹   XP_063138287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,052,563 - 218,350,903 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414088 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959926 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959936 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959947 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959950 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959951 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959953 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959957 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959959 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959962 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959966 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959968 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959970 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959972 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959973 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138252 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138253 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138254 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138255 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138256 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138257 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138258 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138259 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138260 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138261 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138262 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138263 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138264 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138265 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138266 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138267 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138268 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138269 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138270 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138271 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138272 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138273 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138274 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138275 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138276 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138277 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138278 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138279 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138280 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138281 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138282 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138283 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138284 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138285 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138286 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138287 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB47551 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015386
  ENSRNOP00000015386.10
  ENSRNOP00000035307
  ENSRNOP00000035307.7
  ENSRNOP00000052477
  ENSRNOP00000052477.7
  ENSRNOP00000073918
  ENSRNOP00000073918.3
  ENSRNOP00000075511
  ENSRNOP00000075511.3
  ENSRNOP00000098357
  ENSRNOP00000098357.2
  ENSRNOP00000102431.1
Ensembl Acc Id: ENSRNOP00000073918   ⟸   ENSRNOT00000080470
Ensembl Acc Id: ENSRNOP00000070916   ⟸   ENSRNOT00000080637
Ensembl Acc Id: ENSRNOP00000052477   ⟸   ENSRNOT00000055615
Ensembl Acc Id: ENSRNOP00000075511   ⟸   ENSRNOT00000084756
Ensembl Acc Id: ENSRNOP00000014962   ⟸   ENSRNOT00000014962
Ensembl Acc Id: ENSRNOP00000075731   ⟸   ENSRNOT00000089534
Ensembl Acc Id: ENSRNOP00000060715   ⟸   ENSRNOT00000068415
Ensembl Acc Id: ENSRNOP00000035307   ⟸   ENSRNOT00000037255
Ensembl Acc Id: ENSRNOP00000015386   ⟸   ENSRNOT00000015386
Ensembl Acc Id: ENSRNOP00000064466   ⟸   ENSRNOT00000074002
RefSeq Acc Id: XP_038959936   ⟸   XM_039104008
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038959953   ⟸   XM_039104025
- Peptide Label: isoform X34
RefSeq Acc Id: XP_038959947   ⟸   XM_039104019
- Peptide Label: isoform X20
RefSeq Acc Id: XP_038959926   ⟸   XM_039103998
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038959950   ⟸   XM_039104022
- Peptide Label: isoform X27
- UniProtKB: A0A0G2K6R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959951   ⟸   XM_039104023
- Peptide Label: isoform X32
- UniProtKB: A0A0G2K6R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959959   ⟸   XM_039104031
- Peptide Label: isoform X37
RefSeq Acc Id: XP_038959968   ⟸   XM_039104040
- Peptide Label: isoform X40
RefSeq Acc Id: XP_038959966   ⟸   XM_039104038
- Peptide Label: isoform X39
RefSeq Acc Id: XP_038959972   ⟸   XM_039104044
- Peptide Label: isoform X42
RefSeq Acc Id: XP_038959973   ⟸   XM_039104045
- Peptide Label: isoform X43
RefSeq Acc Id: XP_038959970   ⟸   XM_039104042
- Peptide Label: isoform X41
RefSeq Acc Id: XP_038959962   ⟸   XM_039104034
- Peptide Label: isoform X38
RefSeq Acc Id: XP_038959957   ⟸   XM_039104029
- Peptide Label: isoform X36
RefSeq Acc Id: NP_001414088   ⟸   NM_001427159
RefSeq Acc Id: XP_063138275   ⟸   XM_063282205
- Peptide Label: isoform X28
RefSeq Acc Id: XP_063138280   ⟸   XM_063282210
- Peptide Label: isoform X35
RefSeq Acc Id: XP_063138282   ⟸   XM_063282212
- Peptide Label: isoform X45
RefSeq Acc Id: XP_063138269   ⟸   XM_063282199
- Peptide Label: isoform X21
RefSeq Acc Id: XP_063138265   ⟸   XM_063282195
- Peptide Label: isoform X16
RefSeq Acc Id: XP_063138255   ⟸   XM_063282185
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063138283   ⟸   XM_063282213
- Peptide Label: isoform X46
RefSeq Acc Id: XP_063138252   ⟸   XM_063282182
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063138272   ⟸   XM_063282202
- Peptide Label: isoform X24
- UniProtKB: F1M9N9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138268   ⟸   XM_063282198
- Peptide Label: isoform X19
- UniProtKB: F1M9N9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138262   ⟸   XM_063282192
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063138263   ⟸   XM_063282193
- Peptide Label: isoform X14
- UniProtKB: F1M9N9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138256   ⟸   XM_063282186
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063138267   ⟸   XM_063282197
- Peptide Label: isoform X18
RefSeq Acc Id: XP_063138257   ⟸   XM_063282187
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063138261   ⟸   XM_063282191
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063138279   ⟸   XM_063282209
- Peptide Label: isoform X33
RefSeq Acc Id: XP_063138278   ⟸   XM_063282208
- Peptide Label: isoform X31
- UniProtKB: F1M9N9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138259   ⟸   XM_063282189
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063138276   ⟸   XM_063282206
- Peptide Label: isoform X29
RefSeq Acc Id: XP_063138254   ⟸   XM_063282184
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063138274   ⟸   XM_063282204
- Peptide Label: isoform X26
- UniProtKB: F1M9N9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138287   ⟸   XM_063282217
- Peptide Label: isoform X50
RefSeq Acc Id: XP_063138277   ⟸   XM_063282207
- Peptide Label: isoform X30
- UniProtKB: A0A0G2K6R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138270   ⟸   XM_063282200
- Peptide Label: isoform X22
- UniProtKB: A0A0G2K6R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138285   ⟸   XM_063282215
- Peptide Label: isoform X48
RefSeq Acc Id: XP_063138264   ⟸   XM_063282194
- Peptide Label: isoform X15
- UniProtKB: A0A0G2K6R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138258   ⟸   XM_063282188
- Peptide Label: isoform X9
- UniProtKB: A0A0G2K6R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138281   ⟸   XM_063282211
- Peptide Label: isoform X44
RefSeq Acc Id: XP_063138271   ⟸   XM_063282201
- Peptide Label: isoform X23
- UniProtKB: A0A0G2JZ56 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138273   ⟸   XM_063282203
- Peptide Label: isoform X25
- UniProtKB: A0A0G2KAS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138266   ⟸   XM_063282196
- Peptide Label: isoform X17
- UniProtKB: A0A0G2JZ56 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138284   ⟸   XM_063282214
- Peptide Label: isoform X47
RefSeq Acc Id: XP_063138286   ⟸   XM_063282216
- Peptide Label: isoform X49
RefSeq Acc Id: XP_063138260   ⟸   XM_063282190
- Peptide Label: isoform X11
- UniProtKB: A0A0G2JZ56 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138253   ⟸   XM_063282183
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JZ56 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102431   ⟸   ENSRNOT00000131299
Ensembl Acc Id: ENSRNOP00000098357   ⟸   ENSRNOT00000120732

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620156 AgrOrtholog
BioCyc Gene G2FUF-51283 BioCyc
Ensembl Genes ENSRNOG00000011076 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015386 ENTREZGENE
  ENSRNOT00000015386.11 UniProtKB/TrEMBL
  ENSRNOT00000037255 ENTREZGENE
  ENSRNOT00000037255.8 UniProtKB/TrEMBL
  ENSRNOT00000055615 ENTREZGENE
  ENSRNOT00000055615.8 UniProtKB/TrEMBL
  ENSRNOT00000080470 ENTREZGENE
  ENSRNOT00000080470.3 UniProtKB/TrEMBL
  ENSRNOT00000084756 ENTREZGENE
  ENSRNOT00000084756.3 UniProtKB/TrEMBL
  ENSRNOT00000120732 ENTREZGENE
  ENSRNOT00000120732.2 UniProtKB/TrEMBL
  ENSRNOT00000131299.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  2.60.220.30 UniProtKB/TrEMBL
  2.60.40.2660 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Ankyrin_UPA UniProtKB/TrEMBL
  DEATH-like_dom UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  Multifunctional_ANK_Repeat UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
NCBI Gene Ank2 ENTREZGENE
PANTHER ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B UniProtKB/TrEMBL
  ANKYRIN REPEAT-CONTAINING UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  Death UniProtKB/TrEMBL
  UPA_2 UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
PhenoGen Ank2 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  DEATH_DOMAIN UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011076 RatGTEx
SMART ANK UniProtKB/TrEMBL
  DEATH UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  DEATH_like UniProtKB/TrEMBL
UniProt A0A0G2JZ56 ENTREZGENE
  A0A0G2K6R9 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KAS9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L5E7_RAT UniProtKB/TrEMBL
  A0ABK0LKJ6_RAT UniProtKB/TrEMBL
  F1LM42_RAT UniProtKB/TrEMBL
  F1M5N3_RAT UniProtKB/TrEMBL
  F1M9N9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ank2  ankyrin 2  LOC103691695  uncharacterized LOC103691695  Data merged from RGD:9456616 737654 PROVISIONAL
2016-08-18 Ank2  ankyrin 2  Ank2  ankyrin 2, neuronal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103691695  uncharacterized LOC103691695      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-10-14 Ank2  ankyrin 2, neuronal  Ank3_predicted  ankyrin 3, epithelial (predicted)  Data merged from RGD:1308799 737654 APPROVED
2005-01-20 Ank2  ankyrin 2, neuronal    ankyrin 2, brain  Name updated 1299863 APPROVED
2005-01-12 Ank3_predicted  ankyrin 3, epithelial (predicted)      Symbol and Name status set to approved 70820 APPROVED
2005-01-12 Ank2_predicted  ankyrin 2, neuronal (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Ank2  ankyrin 2, brain      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in axons 634625
gene_protein 440 kDa 634625