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Gene: Camkk2 (calcium/calmodulin-dependent protein kinase kinase 2) Rattus norvegicus

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Symbol:

Camkk2

Name:

calcium/calmodulin-dependent protein kinase kinase 2

RGD ID:

620092

Description:

Enables calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Predicted to be involved in CAMKK-AMPK signaling cascade; positive regulation of autophagy of mitochondrion; and protein autophosphorylation. Predicted to be located in cytosol. Orthologous to human CAMKK2 (calcium/calmodulin dependent protein kinase kinase 2); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Ca+/Calmodulin-dependent protein kinase kinase beta (CaM-kinase kinase beta); calcium/calmodulin-dependent protein kinase 2 beta; calcium/calmodulin-dependent protein kinase kinase 2, beta; calcium/calmodulin-dependent protein kinase kinase beta; caM-kinase kinase 2; CaM-kinase kinase beta; caM-KK 2; caM-KK beta; caMKK 2; caMKK beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	39,451,828 - 39,505,719 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	39,451,834 - 39,514,964 (+)	Ensembl				GRCr8
mRatBN7.2	12	33,791,023 - 33,845,000 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	33,791,052 - 33,843,279 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	34,968,796 - 35,019,553 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	35,580,228 - 35,630,988 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	34,632,361 - 34,683,280 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	39,253,409 - 39,302,601 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	39,253,409 - 39,302,601 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	41,155,785 - 41,191,356 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	34,907,317 - 34,938,479 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	35,469,700 - 35,516,023 (+)	NCBI		Celera
RGSC_v3.1	12	34,635,881 - 34,801,867 (+)	NCBI
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

high grade glioma (ISO)

Ovarian Neoplasms (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,4'-trichlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide (EXP)

3-chloropropane-1,2-diol (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-phenylbutyric acid (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

Ampullosporin (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

calcium atom (ISO)

calcium(0) (ISO)

carbon disulfide (EXP)

carboplatin (ISO)

chloroacetaldehyde (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

cidofovir anhydrous (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

clodronic acid (ISO)

clopidogrel (ISO)

clozapine (EXP)

cobalt dichloride (ISO)

colforsin daropate hydrochloride (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

Cuprizon (EXP)

desipramine (ISO)

dioxygen (ISO)

doxorubicin (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fenvalerate (EXP)

FR900359 (ISO)

genistein (ISO)

gentamycin (EXP)

Geraniin (ISO)

haloperidol (EXP)

ifosfamide (ISO)

imidacloprid (ISO)

ionomycin (ISO)

isoflavones (ISO)

isoprenaline (EXP)

ketamine (EXP)

lead diacetate (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

lithium atom (EXP)

lithium hydride (EXP)

manganese(II) chloride (ISO)

methotrexate (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

microcystin-LR (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

propiconazole (ISO)

PX-866 (ISO)

risperidone (EXP)

rotenone (ISO)

scopolamine (EXP)

sodium arsenate (ISO)

sodium arsenite (EXP,ISO)

Soman (EXP)

testosterone (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

trovafloxacin (ISO)

valproic acid (EXP,ISO)

vanadium atom (ISO)

vanadium(0) (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of protein kinase activity (IDA)

CAMKK-AMPK signaling cascade (IBA,IEA,ISO)

positive regulation of autophagy of mitochondrion (IEA,ISO)

protein autophosphorylation (ISO,ISS)

protein phosphorylation (ISO,ISS,TAS)

Cellular Component

cytoplasm (IEA)

cytosol (IEA,ISO)

neuron projection (IEA)

nucleoplasm (IEA,TAS)

nucleus (IEA)

Molecular Function

ATP binding (IEA)

calcium ion binding (IEA,ISO,ISS)

calcium/calmodulin-dependent protein kinase activity (IDA,IEA,TAS)

calmodulin binding (IDA,IEA)

kinase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activator activity (TAS)

protein kinase activity (IEA,TAS)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IEA)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

adenosine monophosphate-activated protein kinase (AMPK) signaling pathway (IDA)

vascular endothelial growth factor signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.	Hawley SA, etal., Cell Metab. 2005 Jul;2(1):9-19.
3.	Molecular cloning of Ca2+/calmodulin-dependent protein kinase kinase beta.	Kitani T, etal., J Biochem (Tokyo) 1997 Jul;122(1):243-50.
4.	CAMKK2, Regulated by Promoter Methylation, is a Prognostic Marker in Diffuse Gliomas.	Liu DM, etal., CNS Neurosci Ther. 2016 Jun;22(6):518-24. doi: 10.1111/cns.12531. Epub 2016 Mar 25.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8631893	PMID:9822657	PMID:10651863	PMID:11264466	PMID:11395482	PMID:16054096	PMID:19292454	PMID:21669867	PMID:21725312	PMID:21859090	PMID:21957496	PMID:22019086
PMID:25089838	PMID:26050738	PMID:26103054	PMID:27151216	PMID:27791458	PMID:37338678

Genomics

Comparative Map Data

Camkk2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	39,451,828 - 39,505,719 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	39,451,834 - 39,514,964 (+)	Ensembl				GRCr8
mRatBN7.2	12	33,791,023 - 33,845,000 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	33,791,052 - 33,843,279 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	34,968,796 - 35,019,553 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	35,580,228 - 35,630,988 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	34,632,361 - 34,683,280 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	39,253,409 - 39,302,601 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	39,253,409 - 39,302,601 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	41,155,785 - 41,191,356 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	34,907,317 - 34,938,479 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	35,469,700 - 35,516,023 (+)	NCBI		Celera
RGSC_v3.1	12	34,635,881 - 34,801,867 (+)	NCBI
Cytogenetic Map	12	q16	NCBI

CAMKK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	121,237,692 - 121,297,819 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	121,237,675 - 121,298,308 (-)	Ensembl			hg38	GRCh38
GRCh37	12	121,675,495 - 121,735,622 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	120,159,878 - 120,220,494 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	120,138,216 - 120,197,225	NCBI
Celera	12	121,313,250 - 121,374,183 (-)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	118,685,098 - 118,755,528 (-)	NCBI		HuRef
CHM1_1	12	121,644,332 - 121,704,907 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	121,228,458 - 121,289,212 (-)	NCBI		T2T-CHM13v2.0

Camkk2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	122,856,064 - 122,918,295 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	122,869,233 - 122,917,472 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	122,718,380 - 122,779,522 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	122,731,170 - 122,779,409 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	123,183,197 - 123,214,303 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	122,993,805 - 123,024,911 (-)	NCBI		MGSCv36	mm8
Celera	5	119,811,042 - 119,842,555 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	62.55	NCBI

Camkk2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	7,000,010 - 7,029,623 (+)	Ensembl
ChiLan1.0	NW_004955482	7,000,010 - 7,029,623 (+)	NCBI	ChiLan1.0	ChiLan1.0

CAMKK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	129,322,640 - 129,383,236 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	129,319,014 - 129,379,567 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	118,835,862 - 118,896,918 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	122,206,552 - 122,267,631 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	122,206,552 - 122,267,631 (-)	Ensembl			panPan2	panpan1.1

CAMKK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	7,848,191 - 7,895,317 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	7,847,466 - 7,893,410 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	8,012,962 - 8,060,085 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	8,105,183 - 8,153,475 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	8,105,181 - 8,153,475 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	8,064,970 - 8,113,415 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	8,123,749 - 8,171,998 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	8,079,881 - 8,128,342 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Camkk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	156,416,414 - 156,449,106 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936558	3,030,289 - 3,061,227 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936558	3,030,343 - 3,060,191 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CAMKK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	31,312,049 - 31,366,499 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	31,307,418 - 31,366,504 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	33,169,763 - 33,229,746 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CAMKK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	116,613,003 - 116,648,389 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	116,615,996 - 116,653,261 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	128,411,296 - 128,468,994 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Camkk2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	21,801,590 - 21,842,860 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	21,799,152 - 21,842,898 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Camkk2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	31,045,537 - 31,093,391 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Camkk2
316 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	242
Count of miRNA genes:	155
Interacting mature miRNAs:	175
Transcripts:	ENSRNOT00000001774
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	29775522	42298555	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
631829	Alc6	Alcohol consumption QTL 6	4.7		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	34243475	43352593	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat

Markers in Region

DXMgh7

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	33,819,167 - 33,819,400 (+)	MAPPER	mRatBN7.2
mRatBN7.2	X	112,124,540 - 112,124,758 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	119,394,326 - 119,394,543	NCBI	Rnor6.0
Rnor_6.0	12	39,282,339 - 39,282,571	NCBI	Rnor6.0
Rnor_5.0	12	41,171,094 - 41,171,326	UniSTS	Rnor5.0
Rnor_5.0	X	119,539,148 - 119,539,365	UniSTS	Rnor5.0
RGSC_v3.4	12	34,918,461 - 34,918,693	UniSTS	RGSC3.4
Celera	X	111,378,557 - 111,378,785	UniSTS
Celera	12	35,496,132 - 35,496,364	UniSTS
SHRSP x BN Map	X	33.1599	RGD
SHRSP x BN Map	X	33.1599	UniSTS
FHH x ACI Map	X	34.6	RGD
Cytogenetic Map	X	q34	UniSTS
Cytogenetic Map	12	q16	UniSTS

RH144353

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	33,793,171 - 33,793,286 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	39,255,495 - 39,255,609	NCBI	Rnor6.0
Rnor_5.0	12	41,145,422 - 41,145,536	UniSTS	Rnor5.0
RGSC_v3.4	12	34,895,902 - 34,896,016	UniSTS	RGSC3.4
Celera	12	35,471,782 - 35,471,896	UniSTS
RH 3.4 Map	12	598.7	UniSTS
Cytogenetic Map	12	q16	UniSTS

BE106902

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	33,839,020 - 33,839,182 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	39,302,433 - 39,302,594	NCBI	Rnor6.0
Rnor_5.0	12	41,191,188 - 41,191,349	UniSTS	Rnor5.0
RGSC_v3.4	12	34,938,311 - 34,938,472	UniSTS	RGSC3.4
Celera	12	35,515,855 - 35,516,016	UniSTS
RH 3.4 Map	12	603.0	UniSTS
Cytogenetic Map	12	q16	UniSTS

BE116442

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	33,834,935 - 33,835,110 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	39,298,347 - 39,298,521	NCBI	Rnor6.0
Rnor_5.0	12	41,187,102 - 41,187,276	UniSTS	Rnor5.0
RGSC_v3.4	12	34,934,226 - 34,934,400	UniSTS	RGSC3.4
Celera	12	35,511,770 - 35,511,944	UniSTS
RH 3.4 Map	12	597.2	UniSTS
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001395661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_031338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089810	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089811	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089813	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089814	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089816	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089817	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB018081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001774 ⟹ ENSRNOP00000001774

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,451,834 - 39,514,964 (+)	Ensembl
mRatBN7.2 Ensembl	12	33,791,090 - 33,839,189 (+)	Ensembl
Rnor_6.0 Ensembl	12	39,253,409 - 39,302,601 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097411 ⟹ ENSRNOP00000081396

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,451,834 - 39,502,574 (+)	Ensembl
mRatBN7.2 Ensembl	12	33,791,052 - 33,843,279 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109897 ⟹ ENSRNOP00000093619

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,451,893 - 39,502,651 (+)	Ensembl
mRatBN7.2 Ensembl	12	33,791,052 - 33,841,835 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117141 ⟹ ENSRNOP00000085154

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,451,893 - 39,502,651 (+)	Ensembl
mRatBN7.2 Ensembl	12	33,791,090 - 33,839,189 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000157012 ⟹ ENSRNOP00000106609

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,451,893 - 39,502,651 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000172213 ⟹ ENSRNOP00000099222

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,451,893 - 39,502,651 (+)	Ensembl

RefSeq Acc Id:

NM_001395661 ⟹ NP_001382590

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,451,896 - 39,475,937 (+)	NCBI
mRatBN7.2	12	33,791,090 - 33,815,106 (+)	NCBI

RefSeq Acc Id:

NM_031338 ⟹ NP_112628

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,451,896 - 39,502,653 (+)	NCBI
mRatBN7.2	12	33,791,090 - 33,841,826 (+)	NCBI
Rnor_6.0	12	39,253,409 - 39,302,601 (+)	NCBI
Rnor_5.0	12	41,155,785 - 41,191,356 (+)	NCBI
RGSC_v3.4	12	34,907,317 - 34,938,479 (+)	RGD
Celera	12	35,469,700 - 35,516,023 (+)	RGD

Sequence:

show sequence

CCGGACCGAGTCGAGCCGAGCCAAGCCGAGCCGGGGGCGCAGAGCGCGGGAGGCGGCGGCGCGG
AGCCCAGGCAGCTCTACTGCTGATGGAAGTGCTCCGGCCTGGCCGATGAAGTTGGTACACACAC
CATGTCATCATGTGTCTCTAGCCAGCCCACCAGCGACCGGGCGGCCCCCCAGGATGAGCTGGGA
AGCGGGGGTGTCAGCCGGGAAAGCCAGAAGCCCTGCGAGGCACTGCGGGGACTCTCATCCTTAA
GCATCCACTTGGGCATGGAATCCTTCATCGTGGTCACCGAGTGTGAACCAGGCCGGGGCGTGGA
CCTCAGCCTGGCCAGAGACCAACCTCTGGAGGCCGATGGCCAGGAACTCCCTCTGGATGCCTCG
GAACCTGAGTCACGGTCCCTGCTTTCTGGTGGCAAGATGTCCCTCCAGGAGCGGTCCCAGGGCG
GGCCGGCGTCCAGCAGCAGCCTGGACATGAATGGACGCTGCATCTGCCCATCCCTGTCCTACTC
ACCAGCCAGCTCCCCACAGTCCTCTCCCCGGATGCCCCGGCGGCCCACAGTGGAGTCGCACCAC
GTCTCCATCACGGGTTTGCAGGACTGTGTGCAGCTGAATCAGTACACGCTGAAGGATGAAATTG
GAAAGGGCTCCTATGGCGTTGTCAAGCTGGCCTACAATGAAAATGACAATACTTATTATGCAAT
GAAAGTGCTGTCCAAAAAGAAGCTGATCCGACAGGCCGGCTTTCCACGTCGCCCCCCACCTCGA
GGTACTCGCCCAGCTCCAGGGGGCTGCATCCAGCCCAGGGGCCCCATCGAGCAGGTGTATCAGG
AAATTGCCATCCTCAAGAAGCTGGATCACCCCAACGTGGTGAAGCTGGTGGAGGTCCTGGATGA
CCCTAACGAGGACCATCTGTACATGGTGTTTGAACTGGTCAACCAAGGGCCTGTGATGGAAGTT
CCCACCCTCAAGCCACTGTCTGAAGACCAGGCCCGGTTCTACTTCCAAGATCTGATCAAAGGCA
TTGAGTACTTACACTACCAGAAGATCATTCACCGGGACATCAAACCCTCCAACCTCCTAGTGGG
GGAGGACGGGCACATCAAGATAGCCGACTTCGGCGTGAGCAATGAGTTCAAGGGCAGCGACGCC
TTGCTGTCTAACACCGTGGGCACGCCTGCCTTCATGGCGCCCGAGTCGCTCTCAGAGACCCGGA
AGATCTTCTCCGGAAAGGCCTTGGATGTTTGGGCCATGGGTGTGACACTATACTGCTTTGTTTT
TGGCCAGTGCCCTTTCATGGATGAACGAATCATGTGTTTGCACAGTAAGATCAAGAGTCAGGCC
CTGGAGTTTCCAGACCAGCCTGACATAGCCGAAGACTTGAAAGATCTGATCACCCGGATGTTGG
ACAAGAACCCAGAGTCCAGGATTGTGGTGCCTGAAATCAAGCTGCACCCTTGGGTCACGAGGCA
CGGGGCCGAGCCACTGCCGTCGGAGGACGAGAACTGCACACTGGTCGAGGTGACCGAAGAGGAG
GTCGAGAATTCAGTCAAACACATTCCCAGCCTGGCAACTGTGATCCTAGTGAAGACCATGATTC
GGAAACGGTCTTTTGGGAACCCATTTGAAGGTAGCCGGCGGGAGGAGCGTTCCTTGTCAGCACC
CGGAAACCTGCTCACCAAAAAACCAACCAGGGAGTGGGAGCCCTTGTCTGAGCCCAAGGAAGCA
AGGCAGCGAAGACAGCCTCCGGGGCCCAGAGCCAGCCCCTGTGGGGGAGGAGGAAGTGCTCTTG
TGAAAGGTGGTCCCTGCGTGGAAAGTTGCGGGGCTCCGGCCCCTGGCTCCCCGCCACGCACGCC
TCCACAGCAGCCCGAGGAGGCCATGGAGCCGGAGTAGCTGCGCGGACCACCTGACCTCGCATGC
CTGGCTGTGTGGCCCTGCACGGGGCTGCTGCACCCTGCGTTTCCATAGCAGCATGTCCTACGGA
AACCAAGCACGTGTGTAGAGCCTTGACTGTCATCTCTGGTTATCAGTTTTTTGTTTTTGTTTTT
GTTTCTTTTTGTTGTTGCTGTTGTTTTTCTTGTGGTTTTTCTTTTCTTTTTTTTTCTCTCCCTT
TGTTGTCTAAGGGGACAAAG

hide sequence

RefSeq Acc Id:

XM_039089810 ⟹ XP_038945738

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,452,121 - 39,502,575 (+)	NCBI
mRatBN7.2	12	33,791,260 - 33,841,748 (+)	NCBI

RefSeq Acc Id:

XM_039089811 ⟹ XP_038945739

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,451,828 - 39,502,575 (+)	NCBI
mRatBN7.2	12	33,791,023 - 33,841,748 (+)	NCBI

RefSeq Acc Id:

XM_039089812 ⟹ XP_038945740

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,451,828 - 39,502,575 (+)	NCBI
mRatBN7.2	12	33,791,023 - 33,841,748 (+)	NCBI

RefSeq Acc Id:

XM_039089813 ⟹ XP_038945741

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,451,828 - 39,502,575 (+)	NCBI
mRatBN7.2	12	33,791,023 - 33,841,748 (+)	NCBI

RefSeq Acc Id:

XM_039089814 ⟹ XP_038945742

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,451,828 - 39,505,719 (+)	NCBI
mRatBN7.2	12	33,791,023 - 33,845,000 (+)	NCBI

RefSeq Acc Id:

XM_039089815 ⟹ XP_038945743

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,451,828 - 39,502,575 (+)	NCBI
mRatBN7.2	12	33,791,023 - 33,841,748 (+)	NCBI

RefSeq Acc Id:

XM_039089816 ⟹ XP_038945744

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,451,828 - 39,505,719 (+)	NCBI
mRatBN7.2	12	33,791,023 - 33,845,000 (+)	NCBI

RefSeq Acc Id:

XM_039089817 ⟹ XP_038945745

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,465,070 - 39,502,575 (+)	NCBI
mRatBN7.2	12	33,804,231 - 33,841,748 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001382590	(Get FASTA)	NCBI Sequence Viewer
	NP_112628	(Get FASTA)	NCBI Sequence Viewer
	XP_038945738	(Get FASTA)	NCBI Sequence Viewer
	XP_038945739	(Get FASTA)	NCBI Sequence Viewer
	XP_038945740	(Get FASTA)	NCBI Sequence Viewer
	XP_038945741	(Get FASTA)	NCBI Sequence Viewer
	XP_038945742	(Get FASTA)	NCBI Sequence Viewer
	XP_038945743	(Get FASTA)	NCBI Sequence Viewer
	XP_038945744	(Get FASTA)	NCBI Sequence Viewer
	XP_038945745	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA33524	(Get FASTA)	NCBI Sequence Viewer
	EDM13665	(Get FASTA)	NCBI Sequence Viewer
	EDM13666	(Get FASTA)	NCBI Sequence Viewer
	EDM13667	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001774
	ENSRNOP00000081396
	ENSRNOP00000093619
	ENSRNOP00000099222
GenBank Protein	O88831	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_112628 ⟸ NM_031338
- Peptide Label:	isoform 1
- UniProtKB:	O88831 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MSSCVSSQPTSDRAAPQDELGSGGVSRESQKPCEALRGLSSLSIHLGMESFIVVTECEPGRGVD LSLARDQPLEADGQELPLDASEPESRSLLSGGKMSLQERSQGGPASSSSLDMNGRCICPSLSYS PASSPQSSPRMPRRPTVESHHVSITGLQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAM KVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDD PNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG EDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVF GQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH GAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFEGSRREERSLSAP GNLLTKKPTREWEPLSEPKEARQRRQPPGPRASPCGGGGSALVKGGPCVESCGAPAPGSPPRTP PQQPEEAMEPE hide sequence

Ensembl Acc Id:

ENSRNOP00000001774 ⟸ ENSRNOT00000001774

RefSeq Acc Id:	XP_038945742 ⟸ XM_039089814
- Peptide Label:	isoform X5
- UniProtKB:	O88831 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038945744 ⟸ XM_039089816
- Peptide Label:	isoform X7
- UniProtKB:	O88831 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038945740 ⟸ XM_039089812
- Peptide Label:	isoform X3
- UniProtKB:	O88831 (UniProtKB/Swiss-Prot), A0A8I6GKR3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038945741 ⟸ XM_039089813
- Peptide Label:	isoform X4
- UniProtKB:	O88831 (UniProtKB/Swiss-Prot), A0A8I5ZSP8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038945739 ⟸ XM_039089811
- Peptide Label:	isoform X2
- UniProtKB:	O88831 (UniProtKB/Swiss-Prot), F1LPT4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038945743 ⟸ XM_039089815
- Peptide Label:	isoform X6
- UniProtKB:	O88831 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038945738 ⟸ XM_039089810
- Peptide Label:	isoform X1
- UniProtKB:	O88831 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038945745 ⟸ XM_039089817
- Peptide Label:	isoform X8
- UniProtKB:	A6J176 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000085154 ⟸ ENSRNOT00000117141

Ensembl Acc Id:

ENSRNOP00000081396 ⟸ ENSRNOT00000097411

Ensembl Acc Id:

ENSRNOP00000093619 ⟸ ENSRNOT00000109897

RefSeq Acc Id:	NP_001382590 ⟸ NM_001395661
- Peptide Label:	isoform 2

Ensembl Acc Id:

ENSRNOP00000099222 ⟸ ENSRNOT00000172213

Ensembl Acc Id:

ENSRNOP00000106609 ⟸ ENSRNOT00000157012

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O88831-F1-model_v2	AlphaFold	O88831	1-587	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698640

Promoter ID:

EPDNEW_R9163

Type:

multiple initiation site

Name:

Camkk2_1

Description:

calcium/calmodulin-dependent protein kinase kinase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	39,253,421 - 39,253,481	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620092	AgrOrtholog
BioCyc Gene	G2FUF-19271	BioCyc
Ensembl Genes	ENSRNOG00000001309	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000001774	ENTREZGENE
	ENSRNOT00000097411	ENTREZGENE
	ENSRNOT00000109897	ENTREZGENE
	ENSRNOT00000172213	ENTREZGENE
Gene3D-CATH	Phosphorylase Kinase, domain 1	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot
KEGG Report	rno:83506	UniProtKB/Swiss-Prot
NCBI Gene	83506	ENTREZGENE
PANTHER	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 2	UniProtKB/Swiss-Prot
	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED	UniProtKB/Swiss-Prot
Pfam	Pkinase	UniProtKB/Swiss-Prot
PhenoGen	Camkk2	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000001309	RatGTEx
SMART	S_TKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZSP8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GBY8_RAT	UniProtKB/TrEMBL
	A0A8I6GKR3	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0KX72_RAT	UniProtKB/TrEMBL
	A0ABK0L8F2_RAT	UniProtKB/TrEMBL
	A6J176	ENTREZGENE, UniProtKB/TrEMBL
	A6J177_RAT	UniProtKB/TrEMBL
	A6J178_RAT	UniProtKB/TrEMBL
	F1LPT4	ENTREZGENE, UniProtKB/TrEMBL
	KKCC2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-15	Camkk2	calcium/calmodulin-dependent protein kinase kinase 2	Camkk2	calcium/calmodulin-dependent protein kinase kinase 2, beta	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Camkk2	calcium/calmodulin-dependent protein kinase kinase 2, beta		Ca+/Calmodulin-dependent protein kinase kinase beta (CaM-kinase kinase beta)	Name updated	1299863	APPROVED
2002-08-07	Camkk2	Ca+/Calmodulin-dependent protein kinase kinase beta (CaM-kinase kinase beta)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_process	activates calmodulin-dependent protein kinase IV	632354

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)