Cyp2b12 (cytochrome P450, family 2, subfamily b, polypeptide 12) - Rat Genome Database

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Gene: Cyp2b12 (cytochrome P450, family 2, subfamily b, polypeptide 12) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp2b12
Name: cytochrome P450, family 2, subfamily b, polypeptide 12
RGD ID: 620088
Description: Enables arachidonate epoxygenase activity. Involved in epoxygenase P450 pathway. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6); PARTICIPATES IN cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism; arachidonic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH benzo[a]pyrene; copper atom; copper(0).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cyp2b15; CYPIIB12; cytochrome P-450b type b; cytochrome P450 2B12; cytochrome P450, 2b19; cytochrome P450, family 2, subfamily b, polypeptide 15
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,135,294 - 91,147,094 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl191,135,294 - 91,208,159 (+)EnsemblGRCr8
mRatBN7.2182,007,609 - 82,019,409 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,007,609 - 82,080,480 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx187,431,512 - 87,443,301 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0195,917,812 - 95,929,573 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,187,357 - 89,199,139 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,511,167 - 83,522,965 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,511,167 - 83,584,589 (+)Ensemblrn6Rnor6.0
Rnor_5.0184,763,724 - 84,775,524 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4181,780,088 - 81,791,887 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera176,437,032 - 76,444,656 (+)NCBICelera
RGSC_v3.1181,858,198 - 81,931,360 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Segmental homologies in the coding and 3' non-coding sequences of rat liver cytochrome P-450e and P-450b cDNAs and cytochrome P-450e-like genes. Affolter M and Anderson A, Biochem Biophys Res Commun 1984 Jan 30;118(2):655-62.
2. Sequence of a novel cytochrome CYP2B cDNA coding for a protein which is expressed in a sebaceous gland, but not in the liver. Friedberg T, etal., Biochem J 1992 Nov 1;287 ( Pt 3):775-83.
3. Molecular cloning and coding nucleotide sequence of complementary DNA of cytochrome P-450 involved in metabolic activation of carcinogenic substances. Fujii-Kuriyama Y, etal., Princess Takamatsu Symp 1982;12:31-40.
4. Primary structure of a cytochrome P-450: coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 cDNA from rat liver. Fujii-Kuriyama Y, etal., Proc Natl Acad Sci U S A 1982 May;79(9):2793-7.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. A keratinocyte-specific epoxygenase, CYP2B12, metabolizes arachidonic acid with unusual selectivity, producing a single major epoxyeicosatrienoic acid. Keeney DS, etal., J Biol Chem. 1998 Apr 10;273(15):9279-84.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Alternative splicing of mRNA encoding rat liver cytochrome P450e (P450IIB2). Lacroix D, etal., Gene 1990 Feb 14;86(2):201-7.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:109438   PMID:2539047   PMID:2583091   PMID:2989270   PMID:3928374   PMID:6306654   PMID:8142377   PMID:8294026   PMID:12477932  


Genomics

Variants

.
Variants in Cyp2b12
105 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:77
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000041580
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat


Expression

RNA-SEQ Expression

appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 11 19 22 13 4 13 6 20 5 4 1 17 9

Sequence


Ensembl Acc Id: ENSRNOT00000034845   ⟹   ENSRNOP00000030069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl191,135,294 - 91,146,215 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000041580   ⟹   ENSRNOP00000048784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl191,135,294 - 91,208,159 (+)Ensembl
mRatBN7.2 Ensembl182,007,609 - 82,080,480 (+)Ensembl
Rnor_6.0 Ensembl183,511,167 - 83,584,589 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084936   ⟹   ENSRNOP00000071570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,511,198 - 83,523,310 (+)Ensembl
RefSeq Acc Id: NM_017156   ⟹   NP_058852
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,135,294 - 91,147,094 (+)NCBI
mRatBN7.2182,007,609 - 82,019,409 (+)NCBI
Rnor_6.0183,511,167 - 83,522,965 (+)NCBI
Rnor_5.0184,763,724 - 84,775,524 (+)NCBI
RGSC_v3.4181,780,088 - 81,791,887 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058852 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA45107 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048784
GenBank Protein P33272 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058852   ⟸   NM_017156
- UniProtKB: P33272 (UniProtKB/Swiss-Prot),   F1LMN1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071570   ⟸   ENSRNOT00000084936
Ensembl Acc Id: ENSRNOP00000048784   ⟸   ENSRNOT00000041580
Ensembl Acc Id: ENSRNOP00000030069   ⟸   ENSRNOT00000034845

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33272-F1-model_v2 AlphaFold P33272 1-492 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689838
Promoter ID:EPDNEW_R363
Type:single initiation site
Name:Cyp2b12_1
Description:cytochrome P450, family 2, subfamily b, polypeptide 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0183,511,181 - 83,511,241EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620088 AgrOrtholog
BioCyc Gene G2FUF-60340 BioCyc
Ensembl Genes ENSRNOG00000031529 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000041580 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7122207 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I_CYP2B-like UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
KEGG Report rno:29295 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188065 IMAGE-MGC_LOAD
NCBI Gene 29295 ENTREZGENE
PANTHER CYTOCHROME P450 2B19-RELATED UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp2b12 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450ICYP2B UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031529 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt CP2BC_RAT UniProtKB/Swiss-Prot
  F1LMN1 ENTREZGENE, UniProtKB/TrEMBL
  P33272 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-07-06 Cyp2b12  cytochrome P450, family 2, subfamily b, polypeptide 12  Cyp2b15  cytochrome P450, family 2, subfamily b, polypeptide 15  Name updated 1299863 APPROVED
2005-01-20 Cyp2b15  cytochrome P450, family 2, subfamily b, polypeptide 15    cytochrome P450, 2b19  Name updated 1299863 APPROVED
2002-08-07 Cyp2b15  cytochrome P450, 2b19      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a signal sequence for insertion into the endoplasmic reticulum and a haem-binding site characteristic of cytochromes P-450 632642
gene_expression expressed only in the preputial gland 632642
gene_product member of the CYP2B subfamily of cytochrome P-450 gene 632642