Paics (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase)

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Gene: Paics (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase) Rattus norvegicus

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Symbol:

Paics

Name:

phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase

RGD ID:

620066

Description:

Predicted to enable identical protein binding activity; phosphoribosylaminoimidazole carboxylase activity; and phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Involved in G1/S transition of mitotic cell cycle. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Ade2h1; AIR carboxylase-SAICAR synthetase; Airc; bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase; LOC100910308; MGC93240; multifunctional protein ADE2; multifunctional protein ADE2-like; phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase; phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase; phosphoribosylaminoimidazolesuccinocarboxamide synthase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	31,553,355 - 31,586,843 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	31,553,357 - 31,587,027 (-)	Ensembl				GRCr8
mRatBN7.2	14	31,199,086 - 31,232,731 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	31,173,541 - 31,232,635 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	31,576,746 - 31,593,097 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	32,885,078 - 32,901,428 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	31,369,751 - 31,386,102 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	33,563,884 - 33,580,944 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	33,563,886 - 33,580,566 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	33,354,797 - 33,371,784 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	33,492,707 - 33,509,389 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	30,512,320 - 30,529,517 (-)	NCBI		Celera
RGSC_v3.1	14	33,492,708 - 33,509,389 (-)	NCBI
Cytogenetic Map	14	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE DEFICIENCY (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-butoxyethanol (ISO)

2-methylcholine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

5-fluorouracil (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrolein (ISO)

actinomycin D (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amiodarone (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

choline (ISO)

chromium(6+) (ISO)

clofibrate (EXP)

clofibric acid (EXP)

cobalt dichloride (ISO)

coumarin (ISO)

coumestrol (ISO)

DDE (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

enzyme inhibitor (ISO)

ethyl methanesulfonate (ISO)

eugenol (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

GSK-J4 (ISO)

hexadecanoic acid (ISO)

hydroquinone (ISO)

indometacin (ISO)

ivermectin (ISO)

L-ethionine (EXP)

L-methionine (ISO)

lead(0) (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

menadione (ISO)

methyl methanesulfonate (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosomorpholine (EXP)

nefazodone (EXP)

nickel atom (ISO)

nimesulide (EXP)

nitrates (ISO)

nitroglycerin (EXP)

Nutlin-3 (ISO)

ochratoxin A (ISO)

omeprazole (EXP)

oxaliplatin (EXP,ISO)

ozone (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (EXP)

pregnenolone 16alpha-carbonitrile (EXP)

propiconazole (ISO)

quinoline (ISO)

resveratrol (ISO)

rotenone (ISO)

sodium arsenite (ISO)

thapsigargin (EXP)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

troglitazone (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

'de novo' AMP biosynthetic process (ISO)

'de novo' IMP biosynthetic process (IBA,IEA,ISO)

'de novo' XMP biosynthetic process (ISO)

G1/S transition of mitotic cell cycle (IEP)

GMP biosynthetic process (ISO)

purine nucleobase biosynthetic process (ISO,ISS)

purine nucleotide biosynthetic process (IEA)

Cellular Component

cytoplasm (ISO)

cytosol (IBA)

Molecular Function

ATP binding (IEA)

carboxy-lyase activity (IEA)

catalytic activity (IEA)

identical protein binding (ISO)

ligase activity (IEA)

lyase activity (IEA)

nucleotide binding (IEA)

phosphoribosylaminoimidazole carboxylase activity (IEA,ISO,ISS)

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity (IBA,IEA,ISO,ISS)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

adenine phoshoribosyltransferase deficiency pathway (ISO)

adenosine monophosphate deaminase deficiency pathway (ISO)

adenylosuccinate lyase deficiency pathway (ISO)

AICA-ribosuria pathway (ISO)

azathioprine pharmacodynamics pathway (ISO)

de novo purine biosynthetic pathway (TAS)

Kelley-Seegmiller syndrome pathway (ISO)

Lesch-Nyhan syndrome pathway (ISO)

mercaptopurine pharmacodynamics pathway (ISO)

molybdenum cofactor deficiency pathway (ISO)

purine metabolic pathway (IEA,ISO)

purine nucleoside phosphorylase deficiency pathway (ISO)

tioguanine pharmacodynamics pathway (ISO)

xanthinuria type I pathway (ISO)

xanthinuria pathway (ISO)

xanthinuria type II pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Nucleotide sequence of a nearly full-length cDNA coding for pepsinogen of rat gastric mucosa.	Ichihara Y, etal., Eur J Biochem 1986 Nov 17;161(1):7-12.
3.	Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.	Ikeda M, etal., Biol Psychiatry. 2010 Feb 1;67(3):263-9. Epub 2009 Oct 22.
4.	Rat genomic structure of amidophosphoribosyltransferase, cDNA sequence of aminoimidazole ribonucleotide carboxylase, and cell cycle-dependent expression of these two physically linked genes.	Iwahana H, etal., Biochim Biophys Acta 1995 Apr 26;1261(3):369-80.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:16169070	PMID:16189514	PMID:19946888	PMID:20458337	PMID:21988832	PMID:23376485	PMID:23533145	PMID:25416956	PMID:25468996	PMID:28131823

Genomics

Comparative Map Data

Paics
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	31,553,355 - 31,586,843 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	31,553,357 - 31,587,027 (-)	Ensembl				GRCr8
mRatBN7.2	14	31,199,086 - 31,232,731 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	31,173,541 - 31,232,635 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	31,576,746 - 31,593,097 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	32,885,078 - 32,901,428 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	31,369,751 - 31,386,102 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	33,563,884 - 33,580,944 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	33,563,886 - 33,580,566 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	33,354,797 - 33,371,784 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	33,492,707 - 33,509,389 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	30,512,320 - 30,529,517 (-)	NCBI		Celera
RGSC_v3.1	14	33,492,708 - 33,509,389 (-)	NCBI
Cytogenetic Map	14	p11	NCBI

PAICS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	56,410,507 - 56,464,578 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	56,435,058 - 56,464,578 (+)	Ensembl			hg38	GRCh38
GRCh37	4	57,276,673 - 57,330,744 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	56,996,672 - 57,022,291 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	4	57,142,868 - 57,168,453	NCBI
Celera	4	54,808,286 - 54,833,908 (+)	NCBI		Celera
Cytogenetic Map	4	q12	NCBI
HuRef	4	53,256,050 - 53,281,675 (+)	NCBI		HuRef
CHM1_1	4	57,337,028 - 57,362,670 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	59,898,501 - 59,952,584 (+)	NCBI		T2T-CHM13v2.0

Paics
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	77,099,149 - 77,115,356 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	77,099,154 - 77,115,356 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	76,951,302 - 76,967,509 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	76,951,307 - 76,967,509 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	77,380,436 - 77,396,530 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	78,026,186 - 78,042,280 (+)	NCBI		MGSCv36	mm8
Celera	5	74,219,278 - 74,235,370 (+)	NCBI		Celera
Cytogenetic Map	5	C3.3	NCBI
cM Map	5	41.45	NCBI

Paics
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955447	14,558,468 - 14,574,052 (-)	Ensembl
ChiLan1.0	NW_004955447	14,558,468 - 14,571,081 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100993147
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	73,318,512 - 73,374,750 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	73,524,030 - 73,578,412 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	67,461,799 - 67,491,300 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	74,031,397 - 74,059,868 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	74,031,397 - 74,059,857 (-)	Ensembl			panPan2	panpan1.1

PAICS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	48,296,232 - 48,682,650 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	48,502,631 - 48,572,598 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	49,226,506 - 49,296,327 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	49,226,501 - 49,298,373 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	48,898,441 - 48,968,392 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	48,427,408 - 48,497,095 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	49,373,530 - 49,443,304 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LOC101961407
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	27,633,677 - 27,672,235 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936482	18,626,015 - 18,667,164 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936482	18,649,093 - 18,664,629 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PAICS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	55,700,956 - 55,722,979 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	55,700,700 - 55,722,982 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	57,827,127 - 57,849,464 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PAICS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	12,178,588 - 12,205,554 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666066	12,843,637 - 12,894,717 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Paics
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624761	12,954,309 - 12,980,381 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624761	12,954,309 - 12,980,352 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Paics
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	33,698,623 - 33,714,474 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Paics
102 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	57
Count of miRNA genes:	53
Interacting mature miRNAs:	55
Transcripts:	ENSRNOT00000063942
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631528	Scl11	Serum cholesterol level QTL 11	4.9		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	14	17875645	36079022	Rat
7411573	Bw139	Body weight QTL 139	4.7	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	14	1	40068101	Rat
9589814	Gluco67	Glucose level QTL 67	4.54	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	40068101	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9393298	39411170	Rat
1300154	Bp189	Blood pressure QTL 189	3.04		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	14	31238080	72970315	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30674469	85041098	Rat
2324617	Coatc2	Coat color QTL 2		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	14	31121333	39507682	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8621398	53621398	Rat
61420	Pia6	Pristane induced arthritis QTL 6	4.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	14	18915454	42433608	Rat
7387267	Uae42	Urinary albumin excretion QTL 42		0.61	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	14	22521517	67521517	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11334716	100078267	Rat
2313397	Coatc1	Coat color QTL1			coat/hair pigmentation trait (VT:0010463)	coat/hair color measurement (CMO:0001808)	14	18895192	63895192	Rat
631262	Tcas4	Tongue tumor susceptibility QTL 4	7.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	14	17906726	54251504	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41415516	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1	31893212	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8621398	53621398	Rat

Markers in Region

RH127888

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	31,199,203 - 31,199,390 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	33,564,002 - 33,564,188	NCBI	Rnor6.0
Rnor_6.0	14	33,968,284 - 33,968,470	NCBI	Rnor6.0
Rnor_5.0	14	33,354,915 - 33,355,101	UniSTS	Rnor5.0
Rnor_5.0	14	33,752,801 - 33,752,987	UniSTS	Rnor5.0
RGSC_v3.4	14	33,492,825 - 33,493,011	UniSTS	RGSC3.4
Celera	14	30,512,438 - 30,512,624	UniSTS
Cytogenetic Map	14	p11	UniSTS

RH129425

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	31,199,203 - 31,199,360 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	33,564,002 - 33,564,158	NCBI	Rnor6.0
Rnor_6.0	14	33,968,284 - 33,968,440	NCBI	Rnor6.0
Rnor_5.0	14	33,752,801 - 33,752,957	UniSTS	Rnor5.0
Rnor_5.0	14	33,354,915 - 33,355,071	UniSTS	Rnor5.0
RGSC_v3.4	14	33,492,825 - 33,492,981	UniSTS	RGSC3.4
Celera	14	30,512,438 - 30,512,594	UniSTS
RH 3.4 Map	14	427.39	UniSTS
Cytogenetic Map	14	p11	UniSTS

RH143742

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	14	33,360,622 - 33,360,963	NCBI	Rnor5.0
Rnor_5.0	14	33,758,508 - 33,758,849	NCBI	Rnor5.0
Rnor_5.0	X	5,076,828 - 5,076,944	NCBI	Rnor5.0
RGSC_v3.4	X	15,625,492 - 15,625,607	UniSTS	RGSC3.4
RGSC_v3.4	14	33,498,533 - 33,498,873	UniSTS	RGSC3.4
Celera	X	4,574,774 - 4,574,889	UniSTS
Celera	14	30,517,945 - 30,518,285	UniSTS
RH 3.4 Map	14	423.4	UniSTS
Cytogenetic Map	14	p11	UniSTS

RH140904

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	31,199,115 - 31,199,335 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	33,968,196 - 33,968,415	NCBI	Rnor6.0
Rnor_6.0	14	33,563,914 - 33,564,133	NCBI	Rnor6.0
Rnor_5.0	14	33,752,713 - 33,752,932	UniSTS	Rnor5.0
Rnor_5.0	14	33,354,827 - 33,355,046	UniSTS	Rnor5.0
RGSC_v3.4	14	33,492,737 - 33,492,956	UniSTS	RGSC3.4
Celera	14	30,512,350 - 30,512,569	UniSTS
RH 3.4 Map	14	428.59	UniSTS
Cytogenetic Map	14	p11	UniSTS

PMC312758P2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	31,216,183 - 31,216,360 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	33,580,984 - 33,581,160	NCBI	Rnor6.0
Rnor_5.0	14	33,371,897 - 33,372,073	UniSTS	Rnor5.0
RGSC_v3.4	14	33,509,807 - 33,509,983	UniSTS	RGSC3.4
Celera	14	30,529,935 - 30,530,111	UniSTS
Cytogenetic Map	14	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001433942	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001433943	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_080910	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250852	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250854	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272816	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC072508	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085711	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D37978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D37979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000002890 ⟹ ENSRNOP00000002890

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	31,553,357 - 31,587,027 (-)	Ensembl
mRatBN7.2 Ensembl	14	31,173,541 - 31,232,635 (-)	Ensembl
Rnor_6.0 Ensembl	14	33,968,759 - 33,977,277 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000063942 ⟹ ENSRNOP00000061495

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	31,553,357 - 31,566,301 (-)	Ensembl
mRatBN7.2 Ensembl	14	31,199,086 - 31,216,112 (-)	Ensembl
Rnor_6.0 Ensembl	14	33,563,886 - 33,580,566 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096789 ⟹ ENSRNOP00000089961

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	31,553,357 - 31,587,027 (-)	Ensembl
mRatBN7.2 Ensembl	14	31,173,541 - 31,232,635 (-)	Ensembl

RefSeq Acc Id:

NM_080910 ⟹ NP_543186

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	31,553,355 - 31,570,035 (-)	NCBI
mRatBN7.2	14	31,199,086 - 31,215,766 (-)	NCBI
Rnor_6.0	14	33,563,884 - 33,580,566 (-)	NCBI
Rnor_5.0	14	33,354,797 - 33,371,784 (-)	NCBI
RGSC_v3.4	14	33,492,707 - 33,509,389 (-)	RGD
Celera	14	30,512,320 - 30,529,517 (-)	RGD

Sequence:

show sequence

CGGTTCCTGCCCTGAGCAGCCAGCCGAGTGCTTTGGGTTCGCTGATCGCTGCTTCTTTTTCCCG
CGCGGTCTGCTCCTCTAGTTCACCTAGGATAATGGCGACAGCTGAAGTACTGAACATCGGGAGA
AAGCTGTATGAGGGTAAAACAAAGGAAGTCTATGAATTGTTAGACAGTCCAGGAAGAGTCCTCC
TGCAGTCCAAGGACCAGATTACAGCAGGAAATGCAGCTAGAAAGAACCACCTGGAAGGCAAAGC
CGCCATCTCCAATAAGATCACCAGCTGCATATTTCAGTTGTTACAGGAAGCTGGTATAAAAACT
GCTTTCACCAAGAAATGTGGGGAGACTGCTTTCATTGCACCCCAGTGTGAAATGATTCCAATTG
AGTGGGTATGCCGAAGAATCGCCACTGGATCTTTTCTCAAAAGGAACCCTGGTGTGAAGGAGGG
GTATAGGTTTTATCCACCAAAAGTAGAGATGTTCTTCAAGGATGATGCCAATAACGACCCACAA
TGGTCTGAGGAGCAACTCATCGCTGCAAAATTTTGTTTTGCTGGACTCGTTATAGGGCAAACTG
AAGTGGATATCATGAGTCATGCCACACAAGCTATTTTTGAAATTCTGGAGAAATCCTGGCTGCC
CCAAAACTGTACGCTGGTTGATATGAAGATTGAGTTTGGCGTTGATGTAACCACCAAAGAGATT
GTTCTTGCTGATGTCATAGATAATGATTCCTGGAGACTATGGCCATCAGGAGATCGGAGCCAGC
AGAAAGACAAACAGTCTTATCGGGATCTCAAAGAAGTAACTCCGGAAGGACTCCAGATGGTAAA
GAAGAACTTTGAGTGGGTTGCAGACCGAGTGGAGTTGCTTCTCAAGTCAAACAGTCAGTGCAGG
GTGGTAGTGCTGATGGGGTCGACCTCTGACCTTGGTCACTGTGAAAAAATTAAGAAGGCTTGTG
GAAACTTTGGGATTCCATGTGAACTTAGAGTAACATCTGCACATAAAGGACCAGATGAAACTTT
GAGGATTAAAGCAGAATATGAAGGGGATGGCATACCTACTGTATTTGTCGCAGTGGCGGGCAGG
AGCAATGGACTGGGCCCAGTGATGTCTGGTAATACTGCATACCCGGTTATCAGCTGTCCCCCAA
TCACAGCAGACTGGGGTGCTCAGGATGTGTGGTCATCTCTGCGACTGCCCAGTGGTATTGGCTG
TTCAACTATACTTTCTCCAGAAGGATCAGCCCAGTTTGCTGCTCAGATATTTGGGTTAAACAAC
CATTTGGTGTGGGCCAAACTTCGAGCGAGCAAACTGAACACGTGGATATCCTTAAAGCAGGCTG
ATAAGAAAATCAGAGAGTGCAATTTGTAATAAAGCAATTTAATTTGTAGGAGAAAAGTTACATA
TTCCTAGTTTGGATTTAAAAAAAAAATCAAGCAAAATGATTTCACATCAGAGAAAACAATTCAG
TTTATTTTCTGGCTCTATGTAGTGATATGTCCCTGTAGCCTGAGCACTCTAGAGGATCACTAAA
TTCAAGGCCAGCCTGAATTGTGTATTGAGACCCTGTATTTGCTGGGGAGGGGATCTTGGCACAA
CGCTGCTAAATTACATCTCGCTTTCTATATAGTCATTGTTGGGTAAATATGTAATTATGGAACT
GGAGCAATGTGTCTGTGGTTCAAGAACCAGTATGGCTCTCCTGCAGATGCCCTGAGTTTGGCTC
CCAGCATCCATGTAGACTGCCTCACAATAAATAACCTTTAACCCGGGATCTGACCCCGTGGCTT
CCTTATGCACCTGCTCTCAGATTCTGTTACATTCCTCCACCCAACACACACAATTTTAAAAAAT
AAACGTTTTCAAAGAGTATTATTTCTAAGTGGTAATAACATTTATAAATCAATAGTATTGCTTG
ACATTTGGAGTTGACACTTTAAAAATTAAAATATTGTGCGTGTTAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006250852 ⟹ XP_006250914

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	31,553,447 - 31,570,386 (-)	NCBI
mRatBN7.2	14	31,199,178 - 31,216,117 (-)	NCBI
Rnor_6.0	14	33,564,416 - 33,580,893 (-)	NCBI
Rnor_5.0	14	33,354,797 - 33,371,784 (-)	NCBI

Sequence:

show sequence

CAAGGGACTGGGGTTAATTCTCCGCGGCAGAGGTCAGGATCGCTGCTTTTCCCTGCACGTGGGA
GACTCCGTTATTTTCCCGCTCCCAAGGCATCGCTGCTTCTTTTTCCCGCGCGGTCTGCTCCTCT
AGTTCACCTAGGATAATGGCGACAGCTGAAGTACTGAACATCGGGAGAAAGCTGTATGAGGGTA
AAACAAAGGAAGTCTATGAATTGTTAGACAGTCCAGGAAGAGTCCTCCTGCAGTCCAAGGACCA
GATTACAGCAGGAAATGCAGCTAGAAAGAACCACCTGGAAGGCAAAGCCGCCATCTCCAATAAG
ATCACCAGCTGCATATTTCAGTTGTTACAGGAAGCTGGTATAAAAACTGCTTTCACCAAGAAAT
GTGGGGAGACTGCTTTCATTGCACCCCAGTGTGAAATGATTCCAATTGAGTGGGTATGCCGAAG
AATCGCCACTGGATCTTTTCTCAAAAGGAACCCTGGTGTGAAGGAGGGGTATAGGTTTTATCCA
CCAAAAGTAGAGATGTTCTTCAAGGATGATGCCAATAACGACCCACAATGGTCTGAGGAGCAAC
TCATCGCTGCAAAATTTTGTTTTGCTGGACTCGTTATAGGGCAAACTGAAGTGGATATCATGAG
TCATGCCACACAAGCTATTTTTGAAATTCTGGAGAAATCCTGGCTGCCCCAAAACTGTACGCTG
GTTGATATGAAGATTGAGTTTGGCGTTGATGTAACCACCAAAGAGATTGTTCTTGCTGATGTCA
TAGATAATGATTCCTGGAGACTATGGCCATCAGGAGATCGGAGCCAGCAGAAAGACAAACAGTC
TTATCGGGATCTCAAAGAAGTAACTCCGGAAGGACTCCAGATGGTAAAGAAGAACTTTGAGTGG
GTTGCAGACCGAGTGGAGTTGCTTCTCAAGTCAAACAGTCAGTGCAGGGTGGTAGTGCTGATGG
GGTCGACCTCTGACCTTGGTCACTGTGAAAAAATTAAGAAGGCTTGTGGAAACTTTGGGATTCC
ATGTGAACTTAGAGTAACATCTGCACATAAAGGACCAGATGAAACTTTGAGGATTAAAGCAGAA
TATGAAGGGGATGGCATACCTACTGTATTTGTCGCAGTGGCGGGCAGGAGCAATGGACTGGGCC
CAGTGATGTCTGGTAATACTGCATACCCGGTTATCAGCTGTCCCCCAATCACAGCAGACTGGGG
TGCTCAGGATGTGTGGTCATCTCTGCGACTGCCCAGTGGTATTGGCTGTTCAACTATACTTTCT
CCAGAAGGATCAGCCCAGTTTGCTGCTCAGATATTTGGGTTAAACAACCATTTGGTGTGGGCCA
AACTTCGAGCGAGCAAACTGAACACGTGGATATCCTTAAAGCAGGCTGATAAGAAAATCAGAGA
GTGCAATTTGTAATAAAGCAATTTAATTTGTAGGAGAAAAGTTACATATTCCTAGTTTGGATTT
AAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006250853 ⟹ XP_006250915

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	31,553,447 - 31,570,469 (-)	NCBI
mRatBN7.2	14	31,199,178 - 31,216,196 (-)	NCBI
Rnor_6.0	14	33,563,976 - 33,580,944 (-)	NCBI
Rnor_5.0	14	33,354,797 - 33,371,784 (-)	NCBI

Sequence:

show sequence

CAGCTCCGGGCCAATCAGCTAGGACACGGGACGGGGGCGGAGCTATGGAGTCAAGGGACTGGGG
TTAATTCTCCGCGGCAGAGATCGCTGCTTCTTTTTCCCGCGCGGTCTGCTCCTCTAGTTCACCT
AGGATAATGGCGACAGCTGAAGTACTGAACATCGGGAGAAAGCTGTATGAGGGTAAAACAAAGG
AAGTCTATGAATTGTTAGACAGTCCAGGAAGAGTCCTCCTGCAGTCCAAGGACCAGATTACAGC
AGGAAATGCAGCTAGAAAGAACCACCTGGAAGGCAAAGCCGCCATCTCCAATAAGATCACCAGC
TGCATATTTCAGTTGTTACAGGAAGCTGGTATAAAAACTGCTTTCACCAAGAAATGTGGGGAGA
CTGCTTTCATTGCACCCCAGTGTGAAATGATTCCAATTGAGTGGGTATGCCGAAGAATCGCCAC
TGGATCTTTTCTCAAAAGGAACCCTGGTGTGAAGGAGGGGTATAGGTTTTATCCACCAAAAGTA
GAGATGTTCTTCAAGGATGATGCCAATAACGACCCACAATGGTCTGAGGAGCAACTCATCGCTG
CAAAATTTTGTTTTGCTGGACTCGTTATAGGGCAAACTGAAGTGGATATCATGAGTCATGCCAC
ACAAGCTATTTTTGAAATTCTGGAGAAATCCTGGCTGCCCCAAAACTGTACGCTGGTTGATATG
AAGATTGAGTTTGGCGTTGATGTAACCACCAAAGAGATTGTTCTTGCTGATGTCATAGATAATG
ATTCCTGGAGACTATGGCCATCAGGAGATCGGAGCCAGCAGAAAGACAAACAGTCTTATCGGGA
TCTCAAAGAAGTAACTCCGGAAGGACTCCAGATGGTAAAGAAGAACTTTGAGTGGGTTGCAGAC
CGAGTGGAGTTGCTTCTCAAGTCAAACAGTCAGTGCAGGGTGGTAGTGCTGATGGGGTCGACCT
CTGACCTTGGTCACTGTGAAAAAATTAAGAAGGCTTGTGGAAACTTTGGGATTCCATGTGAACT
TAGAGTAACATCTGCACATAAAGGACCAGATGAAACTTTGAGGATTAAAGCAGAATATGAAGGG
GATGGCATACCTACTGTATTTGTCGCAGTGGCGGGCAGGAGCAATGGACTGGGCCCAGTGATGT
CTGGTAATACTGCATACCCGGTTATCAGCTGTCCCCCAATCACAGCAGACTGGGGTGCTCAGGA
TGTGTGGTCATCTCTGCGACTGCCCAGTGGTATTGGCTGTTCAACTATACTTTCTCCAGAAGGA
TCAGCCCAGTTTGCTGCTCAGATATTTGGGTTAAACAACCATTTGGTGTGGGCCAAACTTCGAG
CGAGCAAACTGAACACGTGGATATCCTTAAAGCAGGCTGATAAGAAAATCAGAGAGTGCAATTT
GTAATAAAGCAATTTAATTTGTAGGAGAAAAGTTACATATTCCTAGTTTGGATTTAAAAAAAAA
ATCAAGCAAAATGATTTCACATCAGAGAAAACAATTCAGTTTATTTTCTGGCTCTATGTAGTGA
TATGTCCCTGTAGCCTGAGCACTCTAGAGGATCACTAAATTCAAGGCCAGCCTGAATTGTGTAT
TGAGACCCTGTATTTGCTGGGGAGGGGATCTTGGCACAACGCTGCTAAATTACATCTCGCTTTC
TATATAGTCATTGTTGGGTAAATATGTAATTATGGAACTGGAGCAATGTGTCTGTGGTTCAAGA
ACCAGTATGGCTCTCCTGCAGATGCCCTGAGTTTGGCTCCCAGCATCCATGTAGACTGCCTCAC
AATAAATAACCTTTAACCCGGGATCTGACCCCGTGGCTTCCTTATGCACCTGCTCTCAGATTCT
GTTACATTCCTCCACCCAACACACACAATTTTAAAAAATAAACGTTTTCAAAGAGTA

hide sequence

RefSeq Acc Id:

XM_006250854 ⟹ XP_006250916

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	31,553,447 - 31,570,387 (-)	NCBI
mRatBN7.2	14	31,199,178 - 31,216,118 (-)	NCBI
Rnor_6.0	14	33,563,976 - 33,580,890 (-)	NCBI
Rnor_5.0	14	33,354,797 - 33,371,784 (-)	NCBI

Sequence:

show sequence

GGGACTGGGGTTAATTCTCCGCGGCAGAGGTCAGGATCGCTGCTTTTCCCTGCACGTGGGAGAC
TCCGTTATTTTCCCGCTCCCAAGGCGTAGATCGCTGCTTCTTTTTCCCGCGCGGTCTGCTCCTC
TAGTTCACCTAGGATAATGGCGACAGCTGAAGTACTGAACATCGGGAGAAAGCTGTATGAGGGT
AAAACAAAGGAAGTCTATGAATTGTTAGACAGTCCAGGAAGAGTCCTCCTGCAGTCCAAGGACC
AGATTACAGCAGGAAATGCAGCTAGAAAGAACCACCTGGAAGGCAAAGCCGCCATCTCCAATAA
GATCACCAGCTGCATATTTCAGTTGTTACAGGAAGCTGGTATAAAAACTGCTTTCACCAAGAAA
TGTGGGGAGACTGCTTTCATTGCACCCCAGTGTGAAATGATTCCAATTGAGTGGGTATGCCGAA
GAATCGCCACTGGATCTTTTCTCAAAAGGAACCCTGGTGTGAAGGAGGGGTATAGGTTTTATCC
ACCAAAAGTAGAGATGTTCTTCAAGGATGATGCCAATAACGACCCACAATGGTCTGAGGAGCAA
CTCATCGCTGCAAAATTTTGTTTTGCTGGACTCGTTATAGGGCAAACTGAAGTGGATATCATGA
GTCATGCCACACAAGCTATTTTTGAAATTCTGGAGAAATCCTGGCTGCCCCAAAACTGTACGCT
GGTTGATATGAAGATTGAGTTTGGCGTTGATGTAACCACCAAAGAGATTGTTCTTGCTGATGTC
ATAGATAATGATTCCTGGAGACTATGGCCATCAGGAGATCGGAGCCAGCAGAAAGACAAACAGT
CTTATCGGGATCTCAAAGAAGTAACTCCGGAAGGACTCCAGATGGTAAAGAAGAACTTTGAGTG
GGTTGCAGACCGAGTGGAGTTGCTTCTCAAGTCAAACAGTCAGTGCAGGGTGGTAGTGCTGATG
GGGTCGACCTCTGACCTTGGTCACTGTGAAAAAATTAAGAAGGCTTGTGGAAACTTTGGGATTC
CATGTGAACTTAGAGTAACATCTGCACATAAAGGACCAGATGAAACTTTGAGGATTAAAGCAGA
ATATGAAGGGGATGGCATACCTACTGTATTTGTCGCAGTGGCGGGCAGGAGCAATGGACTGGGC
CCAGTGATGTCTGGTAATACTGCATACCCGGTTATCAGCTGTCCCCCAATCACAGCAGACTGGG
GTGCTCAGGATGTGTGGTCATCTCTGCGACTGCCCAGTGGTATTGGCTGTTCAACTATACTTTC
TCCAGAAGGATCAGCCCAGTTTGCTGCTCAGATATTTGGGTTAAACAACCATTTGGTGTGGGCC
AAACTTCGAGCGAGCAAACTGAACACGTGGATATCCTTAAAGCAGGCTGATAAGAAAATCAGAG
AGTGCAATTTGTAATAAAGCAATTTAATTTGTAGGAGAAAAGTTACATATTCCTAGTTTGGATT
TAAAAAAAAAATCAAGCAAAATGATTTCACATCAGAGAAAACAATTCAGTTTATTTTCTGGCTC
TATGTAGTGATATGTCCCTGTAGCCTGAGCACTCTAGAGGATCACTAAATTCAAGGCCAGCCTG
AATTGTGTATTGAGACCCTGTATTTGCTGGGGAGGGGATCTTGGCACAACGCTGCTAAATTACA
TCTCGCTTTCTATATAGTCATTGTTGGGTAAATATGTAATTATGGAACTGGAGCAATGTGTCTG
TGGTTCAAGAACCAGTATGGCTCTCCTGCAGATGCCCTGAGTTTGGCTCCCAGCATCCATGTAG
ACTGCCTCACAATAAATAACCTTTAACCCGGGATCTGACCCCGTGGCTTCCTTATGCACCTGCT
CTCAGATTCTGTTACATTCCTCCACCCAACACACACAATTTTAAAAAATAAACGTTTTCAAAGA
GTA

hide sequence

RefSeq Acc Id:

XM_063272816 ⟹ XP_063128886

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	31,553,447 - 31,586,843 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001420871	(Get FASTA)	NCBI Sequence Viewer
	NP_001420872	(Get FASTA)	NCBI Sequence Viewer
	NP_543186	(Get FASTA)	NCBI Sequence Viewer
	XP_006250914	(Get FASTA)	NCBI Sequence Viewer
	XP_006250915	(Get FASTA)	NCBI Sequence Viewer
	XP_006250916	(Get FASTA)	NCBI Sequence Viewer
	XP_063128886	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH72508	(Get FASTA)	NCBI Sequence Viewer
	AAH85711	(Get FASTA)	NCBI Sequence Viewer
	BAA07196	(Get FASTA)	NCBI Sequence Viewer
	BAA07197	(Get FASTA)	NCBI Sequence Viewer
	EDL89889	(Get FASTA)	NCBI Sequence Viewer
	EDL89890	(Get FASTA)	NCBI Sequence Viewer
	EDL89891	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000061495
	ENSRNOP00000061495.1
	ENSRNOP00000089961
GenBank Protein	P51583	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_543186 ⟸ NM_080910

- UniProtKB:

P51583 (UniProtKB/Swiss-Prot), A6JCW8 (UniProtKB/TrEMBL), A6JCW6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MATAEVLNIGRKLYEGKTKEVYELLDSPGRVLLQSKDQITAGNAARKNHLEGKAAISNKITSCI
FQLLQEAGIKTAFTKKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYRFYPPKVEM
FFKDDANNDPQWSEEQLIAAKFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKI
EFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVADRV
ELLLKSNSQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDG
IPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPITADWGAQDVWSSLRLPSGIGCSTILSPEGSA
QFAAQIFGLNNHLVWAKLRASKLNTWISLKQADKKIRECNL

hide sequence

RefSeq Acc Id:

XP_006250915 ⟸ XM_006250853

- Peptide Label:

isoform X2

- Sequence:

show sequence

MATAEVLNIGRKLYEGKTKEVYELLDSPGRVLLQSKDQITAGNAARKNHLEGKAAISNKITSCI
FQLLQEAGIKTAFTKKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYRFYPPKVEM
FFKDDANNDPQWSEEQLIAAKFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKI
EFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVADRV
ELLLKSNSQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDG
IPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPITADWGAQDVWSSLRLPSGIGCSTILSPEGSA
QFAAQIFGLNNHLVWAKLRASKLNTWISLKQADKKIRECNL

hide sequence

RefSeq Acc Id:

XP_006250914 ⟸ XM_006250852

- Peptide Label:

isoform X2

- Sequence:

show sequence

MATAEVLNIGRKLYEGKTKEVYELLDSPGRVLLQSKDQITAGNAARKNHLEGKAAISNKITSCI
FQLLQEAGIKTAFTKKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYRFYPPKVEM
FFKDDANNDPQWSEEQLIAAKFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKI
EFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVADRV
ELLLKSNSQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDG
IPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPITADWGAQDVWSSLRLPSGIGCSTILSPEGSA
QFAAQIFGLNNHLVWAKLRASKLNTWISLKQADKKIRECNL

hide sequence

RefSeq Acc Id:	XP_006250916 ⟸ XM_006250854
- Peptide Label:	isoform X2
- UniProtKB:	P51583 (UniProtKB/Swiss-Prot), A6JCW8 (UniProtKB/TrEMBL), A6JCW6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MATAEVLNIGRKLYEGKTKEVYELLDSPGRVLLQSKDQITAGNAARKNHLEGKAAISNKITSCI FQLLQEAGIKTAFTKKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYRFYPPKVEM FFKDDANNDPQWSEEQLIAAKFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKI EFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVADRV ELLLKSNSQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDG IPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPITADWGAQDVWSSLRLPSGIGCSTILSPEGSA QFAAQIFGLNNHLVWAKLRASKLNTWISLKQADKKIRECNL hide sequence

Ensembl Acc Id:

ENSRNOP00000061495 ⟸ ENSRNOT00000063942

Ensembl Acc Id:

ENSRNOP00000002890 ⟸ ENSRNOT00000002890

Ensembl Acc Id:

ENSRNOP00000089961 ⟸ ENSRNOT00000096789

RefSeq Acc Id:	XP_063128886 ⟸ XM_063272816
- Peptide Label:	isoform X1

Protein Domains

PurE

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F8WFR8-F1-model_v2	AlphaFold	F8WFR8	1-360	view protein structure
AF-P51583-F1-model_v2	AlphaFold	P51583	1-425	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699270

Promoter ID:

EPDNEW_R9795

Type:

initiation region

Name:

Paics_1

Description:

phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamidesynthase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R9797

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	33,580,399 - 33,580,459	EPDNEW

RGD ID:

13699272

Promoter ID:

EPDNEW_R9797

Type:

initiation region

Name:

Paics_2

Description:

phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamidesynthase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R9795

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	33,580,598 - 33,580,658	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620066	AgrOrtholog
BioCyc Gene	G2FUF-15964	BioCyc
Ensembl Genes	ENSRNOG00000002101	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00000046308	Ensembl
Ensembl Transcript	ENSRNOT00000063942	ENTREZGENE
	ENSRNOT00000063942.2	UniProtKB/Swiss-Prot
	ENSRNOT00000096789	ENTREZGENE
Gene3D-CATH	3.40.50.1970	UniProtKB/Swiss-Prot
	ATP-grasp fold, B domain	UniProtKB/Swiss-Prot
	Phosphorylase Kinase, domain 1	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7103198	IMAGE-MGC_LOAD
	IMAGE:7192781	IMAGE-MGC_LOAD
InterPro	PurE_classII	UniProtKB/Swiss-Prot
	PurE_dom	UniProtKB/Swiss-Prot
	SAICAR_synt/ADE2_N	UniProtKB/Swiss-Prot
	SAICAR_synthetase	UniProtKB/Swiss-Prot
	SAICAR_synthetase_CS	UniProtKB/Swiss-Prot
KEGG Report	rno:140946	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:91523	IMAGE-MGC_LOAD
	MGC:93240	IMAGE-MGC_LOAD
NCBI Gene	140946	ENTREZGENE
PANTHER	BIFUNCTIONAL PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE_PHOSPHORIBOSYLAMINOIMIDAZOLE SUCCINOCARBOXAMIDE SYNTHETASE	UniProtKB/Swiss-Prot
	MULTIFUNCTIONAL PROTEIN ADE2	UniProtKB/Swiss-Prot
Pfam	AIRC	UniProtKB/Swiss-Prot
	SAICAR_synt	UniProtKB/Swiss-Prot
PhenoGen	Paics	PhenoGen
PROSITE	SAICAR_SYNTHETASE_1	UniProtKB/Swiss-Prot
	SAICAR_SYNTHETASE_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000002101	RatGTEx
	ENSRNOG00000046308	RatGTEx
SMART	AIRC	UniProtKB/Swiss-Prot
Superfamily-SCOP	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	UniProtKB/Swiss-Prot
	SAICAR synthase-like	UniProtKB/Swiss-Prot
UniProt	A0A8I6A960_RAT	UniProtKB/TrEMBL
	A6JCW6	ENTREZGENE, UniProtKB/TrEMBL
	A6JCW8	ENTREZGENE, UniProtKB/TrEMBL
	F8WFR8_RAT	UniProtKB/TrEMBL
	P51583	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Paics	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	LOC100910308	multifunctional protein ADE2-like	Data merged from RGD:6499293	737654	PROVISIONAL
2017-01-03	Paics	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	Paics	phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-11-30	Paics	phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase	Paics	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-05	LOC100910308	multifunctional protein ADE2-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-30	Paics	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	Paics	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase	Name updated	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	induced in G1/S phase of the cell cycle	633691

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)