Mpst (mercaptopyruvate sulfurtransferase) - Rat Genome Database

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Gene: Mpst (mercaptopyruvate sulfurtransferase) Rattus norvegicus
Analyze
Symbol: Mpst
Name: mercaptopyruvate sulfurtransferase
RGD ID: 620065
Description: Enables identical protein binding activity and thiosulfate-cyanide sulfurtransferase activity. Involved in several processes, including liver development; spinal cord development; and transsulfuration. Located in mitochondrion. Biomarker of type 2 diabetes mellitus. Orthologous to human MPST (mercaptopyruvate sulfurtransferase); PARTICIPATES IN cysteine metabolic pathway; mercaptolactate-cysteine disulfiduria pathway; ocular nonnephropathic cystinosis pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-mercaptopyruvate sulfurtransferase; Mst
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,836,079 - 111,843,651 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7111,835,587 - 111,843,650 (+)EnsemblGRCr8
mRatBN7.27109,955,581 - 109,963,155 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,955,675 - 109,963,141 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7111,705,344 - 111,712,997 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,928,877 - 113,936,530 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,897,575 - 113,905,031 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,626,636 - 119,631,317 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,626,637 - 119,631,425 (+)Ensemblrn6Rnor6.0
Rnor_5.07119,617,311 - 119,621,992 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47116,359,466 - 116,364,146 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7106,296,353 - 106,301,034 (+)NCBICelera
RGSC_v3.17116,393,694 - 116,398,377 (+)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-tribromophenol  (ISO)
2,6-dimethoxyphenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acrolein  (ISO)
acrylonitrile  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
Evodiamine  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fructose  (EXP)
furan  (EXP)
furfural  (ISO)
gentamycin  (EXP)
glucose  (EXP)
hexachlorobenzene  (EXP)
hydralazine  (ISO)
hydrogen cyanide  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
mercury dichloride  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
Nutlin-3  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IDA,IEA)
mitochondrion  (IBA,IDA,IEA)
neuron projection  (IEA,ISO,ISS)
synapse  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Developmental pattern, tissue distribution, and subcellular distribution of cysteine: alpha-ketoglutarate aminotransferase and 3-mercaptopyruvate sulfurtransferase activities in the rat. Kuo SM, etal., Biol Neonate. 1983;43(1-2):23-32.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Contribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neurons. Miyamoto R, etal., J Neurochem. 2014 Jul;130(1):29-40. doi: 10.1111/jnc.12698. Epub 2014 Mar 27.
6. Proteomic profiling of non-obese type 2 diabetic skeletal muscle. Mullen E and Ohlendieck K, Int J Mol Med. 2010 Mar;25(3):445-58.
7. Role of amino acid residues in the active site of rat liver mercaptopyruvate sulfurtransferase. CDNA cloning, overexpression, and site-directed mutagenesis. Nagahara N and Nishino T, J Biol Chem 1996 Nov 1;271(44):27395-401.
8. Tissue and subcellular distribution of mercaptopyruvate sulfurtransferase in the rat: confocal laser fluorescence and immunoelectron microscopic studies combined with biochemical analysis. Nagahara N, etal., Histochem Cell Biol. 1998 Sep;110(3):243-50.
9. Cytosolic mercaptopyruvate sulfurtransferase is evolutionarily related to mitochondrial rhodanese. Striking similarity in active site amino acid sequence and the increase in the mercaptopyruvate sulfurtransferase activity of rhodanese by site-directed mutagenesis. Nagahara N, etal., J Biol Chem. 1995 Jul 7;270(27):16230-5.
10. Thioredoxin-dependent enzymatic activation of mercaptopyruvate sulfurtransferase. An intersubunit disulfide bond serves as a redox switch for activation. Nagahara N, etal., J Biol Chem. 2007 Jan 19;282(3):1561-9. Epub 2006 Nov 27.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Regulation of myelin oligodendrocyte glycoprotein in different species throughout development. Slavin AJ, etal., Dev Neurosci. 1997;19(1):69-78.
Additional References at PubMed
PMID:12477932   PMID:12865426   PMID:14651853   PMID:15489334   PMID:16107337   PMID:18614015   PMID:18855522   PMID:19056867   PMID:19605461   PMID:22149235   PMID:23104984   PMID:23376485  
PMID:23533145   PMID:23759691   PMID:23805308   PMID:24051007   PMID:26519030   PMID:28079151   PMID:29331374   PMID:31893496   PMID:32813542  


Genomics

Comparative Map Data
Mpst
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,836,079 - 111,843,651 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7111,835,587 - 111,843,650 (+)EnsemblGRCr8
mRatBN7.27109,955,581 - 109,963,155 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,955,675 - 109,963,141 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7111,705,344 - 111,712,997 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,928,877 - 113,936,530 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,897,575 - 113,905,031 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,626,636 - 119,631,317 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,626,637 - 119,631,425 (+)Ensemblrn6Rnor6.0
Rnor_5.07119,617,311 - 119,621,992 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47116,359,466 - 116,364,146 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7106,296,353 - 106,301,034 (+)NCBICelera
RGSC_v3.17116,393,694 - 116,398,377 (+)NCBI
Cytogenetic Map7q34NCBI
MPST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,019,742 - 37,029,815 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,019,635 - 37,029,822 (+)Ensemblhg38GRCh38
GRCh372237,415,783 - 37,425,856 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,745,648 - 35,755,809 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342235,740,290 - 35,750,363NCBI
Celera2221,217,038 - 21,227,199 (+)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2220,380,914 - 20,391,094 (+)NCBIHuRef
CHM1_12237,375,175 - 37,385,355 (+)NCBICHM1_1
T2T-CHM13v2.02237,479,341 - 37,489,414 (+)NCBIT2T-CHM13v2.0
Mpst
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391578,290,918 - 78,298,213 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1578,290,616 - 78,298,213 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381578,406,712 - 78,414,015 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1578,406,416 - 78,414,013 (+)Ensemblmm10GRCm38
MGSCv371578,237,142 - 78,244,445 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361578,234,359 - 78,241,268 (+)NCBIMGSCv36mm8
Celera1579,869,406 - 79,876,711 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.47NCBI
Mpst
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541323,538,648 - 23,547,120 (+)Ensembl
ChiLan1.0NW_00495541323,538,648 - 23,543,132 (+)NCBIChiLan1.0ChiLan1.0
MPST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22346,876,544 - 46,886,778 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12249,565,112 - 49,575,337 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02217,933,995 - 17,944,196 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12235,770,203 - 35,780,250 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2235,770,209 - 35,780,250 (+)EnsemblpanPan2panpan1.1
MPST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,465,007 - 27,469,788 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,443,865 - 27,469,554 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1027,419,572 - 27,427,730 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01028,257,080 - 28,265,242 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1028,254,100 - 28,265,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,978,667 - 27,986,827 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01028,287,244 - 28,295,406 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01028,465,170 - 28,473,346 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mpst
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,862,881 - 10,866,510 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,873,176 - 3,876,706 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364923,873,295 - 3,876,895 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl510,739,197 - 10,749,731 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1510,739,179 - 10,749,826 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.258,338,529 - 8,345,210 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MPST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11919,724,780 - 19,735,503 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1919,724,809 - 19,735,194 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045106,127,100 - 106,137,854 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mpst
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475210,756,634 - 10,764,936 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475210,756,634 - 10,764,950 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Mpst
50 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:50
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000000201
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH133346  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27109,962,874 - 109,963,081 (+)MAPPERmRatBN7.2
Rnor_6.07119,631,148 - 119,631,354NCBIRnor6.0
Rnor_5.07119,621,823 - 119,622,029UniSTSRnor5.0
RGSC_v3.47116,363,978 - 116,364,184UniSTSRGSC3.4
Celera7106,300,865 - 106,301,071UniSTS
RH 3.4 Map7813.1UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000201   ⟹   ENSRNOP00000000201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7111,835,587 - 111,843,650 (+)Ensembl
mRatBN7.2 Ensembl7109,955,675 - 109,963,141 (+)Ensembl
Rnor_6.0 Ensembl7119,626,637 - 119,631,425 (+)Ensembl
RefSeq Acc Id: NM_138843   ⟹   NP_620198
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,836,193 - 111,843,651 (+)NCBI
mRatBN7.27109,955,697 - 109,963,155 (+)NCBI
Rnor_6.07119,626,636 - 119,631,317 (+)NCBI
Rnor_5.07119,617,311 - 119,621,992 (+)NCBI
RGSC_v3.47116,359,466 - 116,364,146 (+)RGD
Celera7106,296,353 - 106,301,034 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078360   ⟹   XP_038934288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,836,079 - 111,843,647 (+)NCBI
mRatBN7.27109,955,581 - 109,963,151 (+)NCBI
RefSeq Acc Id: XM_063262959   ⟹   XP_063119029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,836,243 - 111,843,647 (+)NCBI
RefSeq Acc Id: XM_063262960   ⟹   XP_063119030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,838,575 - 111,843,647 (+)NCBI
RefSeq Acc Id: NP_620198   ⟸   NM_138843
- UniProtKB: P97532 (UniProtKB/Swiss-Prot),   A6HSJ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000201   ⟸   ENSRNOT00000000201
RefSeq Acc Id: XP_038934288   ⟸   XM_039078360
- Peptide Label: isoform X2
- UniProtKB: A6HSJ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119029   ⟸   XM_063262959
- Peptide Label: isoform X1
- UniProtKB: P97532 (UniProtKB/Swiss-Prot),   A6HSJ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119030   ⟸   XM_063262960
- Peptide Label: isoform X1
- UniProtKB: P97532 (UniProtKB/Swiss-Prot),   A6HSJ8 (UniProtKB/TrEMBL)
Protein Domains
Rhodanese

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97532-F1-model_v2 AlphaFold P97532 1-297 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695460
Promoter ID:EPDNEW_R5985
Type:initiation region
Name:Mpst_1
Description:mercaptopyruvate sulfurtransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07119,626,620 - 119,626,680EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620065 AgrOrtholog
BioCyc Gene G2FUF-32827 BioCyc
BioCyc Pathway PWY-5329 [L-cysteine degradation III] BioCyc
BioCyc Pathway Image PWY-5329 BioCyc
Ensembl Genes ENSRNOG00000000185 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000201 ENTREZGENE
  ENSRNOT00000000201.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7306783 IMAGE-MGC_LOAD
InterPro Rhodanese-like_dom UniProtKB/Swiss-Prot
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot
  Thiosulphate_STrfase_CS UniProtKB/Swiss-Prot
  TST/MPST-like UniProtKB/Swiss-Prot
KEGG Report rno:192172 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105317 IMAGE-MGC_LOAD
NCBI Gene 192172 ENTREZGENE
PANTHER 3-MERCAPTOPYRUVATE SULFURTRANSFERASE UniProtKB/Swiss-Prot
  PTHR11364 UniProtKB/Swiss-Prot
Pfam Rhodanese UniProtKB/Swiss-Prot
PhenoGen Mpst PhenoGen
PROSITE RHODANESE_1 UniProtKB/Swiss-Prot
  RHODANESE_2 UniProtKB/Swiss-Prot
  RHODANESE_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000185 RatGTEx
SMART RHOD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52821 UniProtKB/Swiss-Prot
UniProt A6HSJ8 ENTREZGENE, UniProtKB/TrEMBL
  A6HSJ9 ENTREZGENE, UniProtKB/TrEMBL
  P97532 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-08-06 Mpst  mercaptopyruvate sulfurtransferase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 296 amino acid residues 729064
gene_protein Arg187 and Arg196 are important residues in determining substrate specificity for mercaptopyruvate 729064