Dcxr (dicarbonyl and L-xylulose reductase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Dcxr (dicarbonyl and L-xylulose reductase) Rattus norvegicus
Analyze
Symbol: Dcxr
Name: dicarbonyl and L-xylulose reductase
RGD ID: 620031
Description: Enables L-xylulose reductase (NADPH) activity. Involved in glucose metabolic process and xylulose metabolic process. Predicted to be located in brush border; cytoplasmic microtubule; and microvillus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in pentosuria. Orthologous to human DCXR (dicarbonyl and L-xylulose reductase); PARTICIPATES IN pentose and glucuronate interconversion pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: diacetyl/L-xylulose reductase; dicarbonyl L-xylulose reductase; glb; L-xylulose reductase; XR
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,504,730 - 106,506,619 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.210106,006,404 - 106,008,293 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx10111,110,399 - 111,112,288 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,573,434 - 110,575,323 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,926,854 - 105,928,743 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,906,119 - 109,909,696 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,906,815 - 109,909,715 (-)Ensemblrn6Rnor6.0
Rnor_5.010109,499,388 - 109,501,278 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera10104,550,346 - 104,552,236 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(R)-acetoin  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1,4-naphthoquinone  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
9,10-phenanthroquinone  (ISO)
acetamide  (EXP)
acetoin  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
beauvericin  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butane-2,3-dione  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
hexanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
lead diacetate  (ISO)
Licochalcone B  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
metformin  (EXP)
monosodium L-glutamate  (ISO)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalenes  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
omeprazole  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
superoxide  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichloroethene  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
xylitol  (ISO)
xylulose  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney. Nakagawa J, etal., J Biol Chem 2002 May 17;277(20):17883-91.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12604240   PMID:19056867   PMID:19442656   PMID:21630459   PMID:23264731   PMID:23376485   PMID:23533145   PMID:25416956   PMID:31515488   PMID:34800366  


Genomics

Comparative Map Data
Dcxr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,504,730 - 106,506,619 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.210106,006,404 - 106,008,293 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx10111,110,399 - 111,112,288 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,573,434 - 110,575,323 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,926,854 - 105,928,743 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,906,119 - 109,909,696 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,906,815 - 109,909,715 (-)Ensemblrn6Rnor6.0
Rnor_5.010109,499,388 - 109,501,278 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera10104,550,346 - 104,552,236 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
DCXR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381782,035,858 - 82,037,697 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1782,035,136 - 82,037,776 (-)Ensemblhg38GRCh38
GRCh371779,993,734 - 79,995,573 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,587,046 - 77,588,862 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341777,587,045 - 77,588,862NCBI
Celera1776,587,448 - 76,589,264 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,393,877 - 75,395,693 (-)NCBIHuRef
CHM1_11780,079,960 - 80,081,776 (-)NCBICHM1_1
T2T-CHM13v2.01782,903,016 - 82,904,855 (-)NCBIT2T-CHM13v2.0
Dcxr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,615,372 - 120,618,110 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,616,225 - 120,618,107 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811120,724,546 - 120,727,284 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,725,399 - 120,727,281 (-)Ensemblmm10GRCm38
MGSCv3711120,586,687 - 120,588,595 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611120,541,491 - 120,543,370 (-)NCBIMGSCv36mm8
Celera11132,460,832 - 132,462,740 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.47NCBI
DCXR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,570,108 - 98,572,755 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,470,818 - 103,473,450 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,439,645 - 76,442,282 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11782,145,224 - 82,147,257 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1782,145,224 - 82,147,257 (-)EnsemblpanPan2panpan1.1
DCXR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19289,864 - 291,518 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9289,889 - 291,480 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha9891,671 - 893,706 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.09882,891 - 884,926 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl9882,938 - 884,888 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.19908,059 - 910,094 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,034,747 - 1,036,782 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,113,334 - 1,115,369 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101967786
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602877,786 - 879,695 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,531,560 - 5,538,105 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,532,264 - 5,534,129 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12973,760 - 976,017 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.112973,780 - 976,017 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DCXR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,923,170 - 73,925,025 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,919,463 - 73,925,277 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607745,390,184 - 45,392,044 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dcxr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,865,219 - 10,868,060 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480110,866,264 - 10,868,064 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dcxr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1963,291,288 - 63,293,170 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dcxr
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:28
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000074362
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 90 59 6 354 190 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000074362   ⟹   ENSRNOP00000064161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl10109,907,759 - 109,909,646 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088907   ⟹   ENSRNOP00000068544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl10109,906,815 - 109,909,715 (-)Ensembl
RefSeq Acc Id: NM_134387   ⟹   NP_599214
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,504,730 - 106,506,619 (-)NCBI
mRatBN7.210106,006,404 - 106,008,293 (-)NCBI
Rnor_6.010109,907,756 - 109,909,646 (-)NCBI
Rnor_5.010109,499,388 - 109,501,278 (-)NCBI
Celera10104,550,346 - 104,552,236 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085156   ⟹   XP_038941084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,504,730 - 106,506,375 (-)NCBI
mRatBN7.210106,006,404 - 106,008,087 (-)NCBI
Protein Sequences
Protein RefSeqs NP_599214 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941084 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB64340 (Get FASTA)   NCBI Sequence Viewer  
  EDM06892 (Get FASTA)   NCBI Sequence Viewer  
  EDM06893 (Get FASTA)   NCBI Sequence Viewer  
  EDM06894 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000108490
GenBank Protein Q920P0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_599214   ⟸   NM_134387
- UniProtKB: Q920P0 (UniProtKB/Swiss-Prot),   A6HLI8 (UniProtKB/TrEMBL),   A6HLI7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064161   ⟸   ENSRNOT00000074362
Ensembl Acc Id: ENSRNOP00000068544   ⟸   ENSRNOT00000088907
RefSeq Acc Id: XP_038941084   ⟸   XM_039085156
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q920P0-F1-model_v2 AlphaFold Q920P0 1-244 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697976
Promoter ID:EPDNEW_R8500
Type:initiation region
Name:Dcxr_1
Description:dicarbonyl and L-xylulose reductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010109,909,648 - 109,909,708EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620031 AgrOrtholog
BioCyc Gene G2FUF-22390 BioCyc
BioCyc Pathway PWY-5525 [D-glucuronate degradation I] BioCyc
BioCyc Pathway Image PWY-5525 BioCyc
Ensembl Genes ENSRNOG00000050315 Ensembl
  ENSRNOG00000081885 ENTREZGENE
Ensembl Transcript ENSRNOT00000168618 ENTREZGENE
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
InterPro L-xylulose/Carbonyl_redctase UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot
  SDR_fam UniProtKB/Swiss-Prot
KEGG Report rno:171408 UniProtKB/Swiss-Prot
NCBI Gene 171408 ENTREZGENE
PANTHER D-ERYTHRULOSE REDUCTASE UniProtKB/Swiss-Prot
  L-XYLULOSE REDUCTASE UniProtKB/Swiss-Prot
Pfam adh_short_C2 UniProtKB/Swiss-Prot
PhenoGen Dcxr PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot
  SDRFAMILY UniProtKB/Swiss-Prot
PROSITE ADH_SHORT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000050315 RatGTEx
  ENSRNOG00000081885 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
UniProt A0ABK0M239_RAT UniProtKB/TrEMBL
  A6HLI7 ENTREZGENE, UniProtKB/TrEMBL
  A6HLI8 ENTREZGENE, UniProtKB/TrEMBL
  A6HLI9_RAT UniProtKB/TrEMBL
  DCXR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Dcxr  dicarbonyl and L-xylulose reductase  Dcxr  dicarbonyl L-xylulose reductase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Dcxr  dicarbonyl L-xylulose reductase  glb  diacetyl/L-xylulose reductase  Symbol and Name updated 1299863 APPROVED
2002-08-07 glb  diacetyl/L-xylulose reductase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized in the inner membranes of the proximal renal tubules 632676
gene_expression mRNA expressed in kidney and liver 632676
gene_homology 85% identical to human, rat hamster, and guinea pig protein 632676
gene_protein 100 kDa homotetramer protein which has NADPH-linked reductase activity for alpha-dicarbonyl compounds 632676