Axl (Axl receptor tyrosine kinase) - Rat Genome Database

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Gene: Axl (Axl receptor tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Axl
Name: Axl receptor tyrosine kinase
RGD ID: 620028
Description: Enables myosin heavy chain binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including animal organ regeneration; cellular response to hydrogen peroxide; and response to axon injury. Predicted to be located in cell surface and extracellular space. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Used to study glomerulonephritis. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AXL (AXL receptor tyrosine kinase); PARTICIPATES IN Gas6 - Axl signaling axis; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC308444; tyrosine-protein kinase receptor UFO
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Axlem1Mcwi ; Axlem2Mcwi
Genetic Models: SS-Axlem1Mcwi ; SS-Axlem2Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,392,864 - 90,424,123 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl190,392,864 - 90,424,009 (-)EnsemblGRCr8
mRatBN7.2181,265,088 - 81,296,278 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,265,088 - 81,296,265 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx186,658,736 - 86,688,215 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0195,209,987 - 95,239,417 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,414,540 - 88,444,021 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,550,892 - 82,580,761 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,549,420 - 82,580,761 (-)Ensemblrn6Rnor6.0
Rnor_5.0183,812,118 - 83,840,542 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,964,751 - 80,994,300 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,705,827 - 75,734,332 (-)NCBICelera
RGSC_v3.1181,045,570 - 81,045,733 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
ADP  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
capecitabine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDE  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
fenamidone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gemcitabine  (ISO)
glyphosate  (EXP)
hydrogen peroxide  (EXP,ISO)
ifosfamide  (ISO)
Lasiocarpine  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
menaquinone  (EXP)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
mithramycin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
nimesulide  (EXP)
nitric oxide  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phylloquinone  (EXP)
pinostrobin  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
toluene 2,4-diisocyanate  (ISO)
Tributyltin oxide  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vitamin K  (ISO)
warfarin  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
apoptotic cell clearance  (ISO)
blood vessel remodeling  (ISO)
cell differentiation  (IEA,IMP)
cell maturation  (ISO)
cell migration  (IBA)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA)
cellular response to hydrogen peroxide  (IDA)
cellular response to interferon-alpha  (ISO)
cellular response to lipopolysaccharide  (ISO)
dendritic cell differentiation  (ISO)
enzyme-linked receptor protein signaling pathway  (IEA,ISO)
erythrocyte homeostasis  (ISO)
forebrain cell migration  (ISO)
immune system process  (IEA)
inflammatory response  (ISO)
innate immune response  (IEA)
mononuclear cell differentiation  (IEA)
natural killer cell differentiation  (IBA,ISO)
negative regulation of apoptotic process  (IBA,IEA,IMP,ISO)
negative regulation of cytokine production  (IEA,ISO)
negative regulation of dendritic cell apoptotic process  (ISO)
negative regulation of lymphocyte activation  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of type II interferon production  (ISO)
nervous system development  (IBA)
neuron migration  (ISO)
neutrophil clearance  (ISO)
ovulation cycle  (ISO)
phagocytosis  (IBA,IEA,ISO)
platelet activation  (IBA,ISO)
positive regulation of cytokine-mediated signaling pathway  (ISO)
positive regulation of natural killer cell differentiation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,ISO)
positive regulation of pinocytosis  (ISO)
positive regulation of signal transduction  (IEA)
positive regulation of viral life cycle  (ISO)
regulation of lymphocyte activation  (IEA)
response to axon injury  (IEP)
secretion by cell  (ISO)
spermatogenesis  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
symbiont entry into host cell  (ISO)
tissue regeneration  (TAS)
tissue remodeling  (TAS)
vagina development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Noninsulin-dependent diabetes mellitus occurs in mice ectopically expressing the human Axl tyrosine kinase receptor. Augustine KA, etal., J Cell Physiol. 1999 Dec;181(3):433-47.
2. Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells. Cavet ME, etal., Arterioscler Thromb Vasc Biol. 2008 May;28(5):886-91. Epub 2008 Feb 21.
3. Gas6-Axl Pathway. The Role of Redox-Dependent Association of Axl With Nonmuscle Myosin IIB. Cavet ME, etal., Hypertension. 2010 May 17.
4. Expression and role of Gas6 protein and of its receptor Axl in hepatic regeneration from oval cells in the rat. Couchie D, etal., Gastroenterology. 2005 Nov;129(5):1633-42.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target. Koorstra JB, etal., Cancer Biol Ther. 2009 Apr;8(7):618-26. Epub 2009 Apr 22.
7. Multiple receptor tyrosine kinases are expressed in adult rat retinal ganglion cells as revealed by single-cell degenerate primer polymerase chain reaction. Lindqvist N, etal., Ups J Med Sci. 2010 Feb;115(1):65-80. doi: 10.3109/03009731003597119.
8. Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats. Melaragno MG, etal., Circ Res 1998 Oct 5;83(7):697-704.
9. Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. Melaragno MG, etal., J Mol Cell Cardiol. 2004 Oct;37(4):881-7.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Structural basis for Gas6-Axl signalling. Sasaki T, etal., EMBO J. 2006 Jan 11;25(1):80-7. Epub 2005 Dec 15.
15. Identification of hypertension-related genes through an integrated genomic-transcriptomic approach. Yagil C, etal., Circ Res. 2005 Apr 1;96(6):617-25. Epub 2005 Feb 24.
16. Gas6, warfarin, and kidney diseases. Yanagita M Clin Exp Nephrol. 2004 Dec;8(4):304-9.
17. Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis. Yanagita M, etal., Am J Pathol. 2001 Apr;158(4):1423-32.
Additional References at PubMed
PMID:9395235   PMID:10227296   PMID:10322635   PMID:11452127   PMID:15650770   PMID:16627783   PMID:16723520   PMID:16751775   PMID:16831897   PMID:17442946   PMID:18159085   PMID:18188450  
PMID:18393392   PMID:18787040   PMID:18804096   PMID:18840707   PMID:19027714   PMID:19463168   PMID:19581412   PMID:19602523   PMID:19657094   PMID:20088931   PMID:21047970   PMID:21270900  
PMID:21501828   PMID:21529875   PMID:22327215   PMID:22606290   PMID:23376485   PMID:23533145   PMID:23878224   PMID:27927649   PMID:28386842   PMID:29196212   PMID:31181097   PMID:31884887  
PMID:34678434  


Genomics

Comparative Map Data
Axl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,392,864 - 90,424,123 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl190,392,864 - 90,424,009 (-)EnsemblGRCr8
mRatBN7.2181,265,088 - 81,296,278 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,265,088 - 81,296,265 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx186,658,736 - 86,688,215 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0195,209,987 - 95,239,417 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,414,540 - 88,444,021 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,550,892 - 82,580,761 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,549,420 - 82,580,761 (-)Ensemblrn6Rnor6.0
Rnor_5.0183,812,118 - 83,840,542 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,964,751 - 80,994,300 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,705,827 - 75,734,332 (-)NCBICelera
RGSC_v3.1181,045,570 - 81,045,733 (-)NCBI
Cytogenetic Map1q21NCBI
AXL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,219,223 - 41,261,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,219,174 - 41,261,766 (+)Ensemblhg38GRCh38
GRCh371941,725,128 - 41,767,671 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,416,948 - 46,459,511 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341946,416,662 - 46,459,510NCBI
Celera1938,525,268 - 38,567,818 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,157,135 - 38,200,127 (+)NCBIHuRef
CHM1_11941,724,837 - 41,767,370 (+)NCBICHM1_1
T2T-CHM13v2.01944,040,107 - 44,082,625 (+)NCBIT2T-CHM13v2.0
Axl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,455,925 - 25,488,502 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,456,698 - 25,488,130 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38725,756,500 - 25,788,924 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,757,273 - 25,788,705 (-)Ensemblmm10GRCm38
MGSCv37726,542,292 - 26,573,560 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36725,466,033 - 25,497,301 (-)NCBIMGSCv36mm8
Celera720,366,185 - 20,397,512 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.02NCBI
Axl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555189,174 - 218,565 (+)Ensembl
ChiLan1.0NW_004955555189,445 - 218,509 (+)NCBIChiLan1.0ChiLan1.0
AXL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22047,428,901 - 47,471,877 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11949,297,139 - 49,340,132 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,211,555 - 38,254,464 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11946,719,615 - 46,761,747 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,719,615 - 46,761,747 (+)EnsemblpanPan2panpan1.1
AXL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,699,679 - 112,727,434 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,700,365 - 112,726,960 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1112,104,006 - 112,130,669 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01113,298,102 - 113,324,981 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,297,567 - 113,324,929 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,859,212 - 112,885,893 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,491,561 - 112,518,264 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,484,923 - 113,511,641 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Axl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,229,833 - 15,259,221 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366613,657,831 - 3,687,816 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366613,658,140 - 3,687,290 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AXL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,245,673 - 49,277,914 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1649,245,802 - 49,277,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,979,820 - 45,009,909 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2645,072,278 - 45,073,025 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AXL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,537,718 - 35,580,143 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl635,537,773 - 35,580,716 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607313,772,922 - 13,815,487 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Axl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462490777,806 - 106,228 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462490776,236 - 106,765 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Axl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12169,008,685 - 169,039,051 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Axl
126 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:74
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000028131, ENSRNOT00000028132
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat

Markers in Region
Axl  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8190,396,439 - 90,397,100 (+)Marker Load Pipeline
mRatBN7.2181,268,663 - 81,269,324 (+)MAPPERmRatBN7.2
Rnor_6.0182,553,005 - 82,553,665NCBIRnor6.0
Rnor_5.0183,814,231 - 83,814,891UniSTSRnor5.0
RGSC_v3.4180,966,864 - 80,967,524UniSTSRGSC3.4
Celera175,707,940 - 75,708,600UniSTS
Cytogenetic Map1q21UniSTS


Genetic Models
This gene Axl is modified in the following models/strains:
SS-Axlem1Mcwi     SS-Axlem2Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 62 59 6 326 162 11 141 81 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000028131   ⟹   ENSRNOP00000028131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl190,392,864 - 90,424,009 (-)Ensembl
mRatBN7.2 Ensembl181,265,088 - 81,296,193 (-)Ensembl
Rnor_6.0 Ensembl182,550,892 - 82,580,761 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000028132   ⟹   ENSRNOP00000028132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl190,392,864 - 90,424,009 (-)Ensembl
mRatBN7.2 Ensembl181,265,088 - 81,296,265 (-)Ensembl
Rnor_6.0 Ensembl182,550,892 - 82,580,761 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078668   ⟹   ENSRNOP00000072240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl190,392,864 - 90,424,009 (-)Ensembl
mRatBN7.2 Ensembl181,265,088 - 81,296,265 (-)Ensembl
Rnor_6.0 Ensembl182,549,420 - 82,580,007 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142629   ⟹   ENSRNOP00000110693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl190,392,864 - 90,423,503 (-)Ensembl
RefSeq Acc Id: NM_001013147   ⟹   NP_001013165
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,392,864 - 90,424,009 (-)NCBI
mRatBN7.2181,265,088 - 81,296,238 (-)NCBI
Rnor_6.0182,550,892 - 82,580,761 (-)NCBI
Rnor_5.0183,812,118 - 83,840,542 (-)NCBI
RGSC_v3.4180,964,751 - 80,994,300 (-)RGD
Celera175,705,827 - 75,734,332 (-)RGD
Sequence:
RefSeq Acc Id: NM_031794   ⟹   NP_113982
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,392,864 - 90,424,009 (-)NCBI
mRatBN7.2181,265,088 - 81,296,238 (-)NCBI
Rnor_6.0182,550,892 - 82,580,761 (-)NCBI
Rnor_5.0183,812,118 - 83,840,542 (-)NCBI
RGSC_v3.4180,964,751 - 80,994,300 (-)RGD
Celera175,705,827 - 75,734,332 (-)RGD
Sequence:
RefSeq Acc Id: XM_039111490   ⟹   XP_038967418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,392,864 - 90,424,123 (-)NCBI
mRatBN7.2181,265,656 - 81,296,278 (-)NCBI
RefSeq Acc Id: NP_001013165   ⟸   NM_001013147
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A0G2K2H0 (UniProtKB/TrEMBL),   Q8VI99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_113982   ⟸   NM_031794
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8VIA0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028132   ⟸   ENSRNOT00000028132
Ensembl Acc Id: ENSRNOP00000028131   ⟸   ENSRNOT00000028131
Ensembl Acc Id: ENSRNOP00000072240   ⟸   ENSRNOT00000078668
RefSeq Acc Id: XP_038967418   ⟸   XM_039111490
- Peptide Label: isoform X1
- UniProtKB: Q8VI99 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110693   ⟸   ENSRNOT00000142629
Protein Domains
Fibronectin type-III   Ig-like   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PSY0-F1-model_v2 AlphaFold E9PSY0 1-888 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689826
Promoter ID:EPDNEW_R351
Type:initiation region
Name:Axl_2
Description:Axl receptor tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R352  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,579,868 - 82,579,928EPDNEW
RGD ID:13689828
Promoter ID:EPDNEW_R352
Type:initiation region
Name:Axl_1
Description:Axl receptor tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R351  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,580,785 - 82,580,845EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620028 AgrOrtholog
BioCyc Gene G2FUF-60366 BioCyc
Ensembl Genes ENSRNOG00000020716 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028131 ENTREZGENE
  ENSRNOT00000028131.8 UniProtKB/TrEMBL
  ENSRNOT00000028132.4 UniProtKB/TrEMBL
  ENSRNOT00000078668 ENTREZGENE
  ENSRNOT00000078668.3 UniProtKB/TrEMBL
  ENSRNOT00000142629.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Fibronectin_type3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RTK UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:308444 UniProtKB/TrEMBL
NCBI Gene Axl ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UFO UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Axl PhenoGen
PIRSF TyrPK_CSF1-R UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020716 RatGTEx
SMART FN3 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2K2H0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M838_RAT UniProtKB/TrEMBL
  A6J989_RAT UniProtKB/TrEMBL
  E9PSX9_RAT UniProtKB/TrEMBL
  E9PSY0_RAT UniProtKB/TrEMBL
  Q8VI99 ENTREZGENE, UniProtKB/TrEMBL
  Q8VIA0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Axl  Axl receptor tyrosine kinase  LOC687188  similar to AXL receptor tyrosine kinase  Data merged from RGD:1588898 1643240 APPROVED
2006-11-19 LOC687188  similar to AXL receptor tyrosine kinase      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-04-27 Axl  Axl receptor tyrosine kinase  Axl_predicted  AXL receptor tyrosine kinase (predicted)  Data merged from RGD:1312008 1299863 APPROVED
2005-01-20 Axl  Axl receptor tyrosine kinase      Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Axl_predicted  AXL receptor tyrosine kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Axl  Axl receptor tyrosine kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease identified as a possible hypertension gene 1559295
gene_regulation expression increases in response to vascular injury 631894