Axl (AXL receptor tyrosine kinase) - Rat Genome Database

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Gene: Axl (AXL receptor tyrosine kinase) Ictidomys tridecemlineatus
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Symbol: Axl
Name: AXL receptor tyrosine kinase
RGD ID: 12708726
Description: ENCODES a protein that exhibits myosin heavy chain binding (ortholog); phosphatidylinositol 3-kinase binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); apoptotic process (ortholog); PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WITH amenorrhea (ortholog); Carpenter Syndrome 2 (ortholog); congenital hypoplastic anemia (ortholog); FOUND IN cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AXL receptor tyrosine kinase, transcript variant X1; AXL receptor tyrosine kinase, transcript variant X2; tyrosine-protein kinase receptor UFO
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,229,833 - 15,259,221 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366613,657,831 - 3,687,816 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366613,658,140 - 3,687,290 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
apoptotic cell clearance  (IEA,ISO)
apoptotic process  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
cell differentiation  (ISO)
cell maturation  (IEA)
cell migration  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to extracellular stimulus  (IEA,ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interferon-alpha  (IEA)
cellular response to lipopolysaccharide  (IEA)
dendritic cell differentiation  (IEA)
enzyme-linked receptor protein signaling pathway  (IEA,ISO)
erythrocyte homeostasis  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
forebrain cell migration  (IEA,ISO)
inflammatory response  (IEA,ISO)
lymphocyte activation  (IEA,ISO)
natural killer cell differentiation  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of cytokine production  (IEA,ISO)
negative regulation of dendritic cell apoptotic process  (IEA)
negative regulation of lymphocyte activation  (IEA,ISO)
negative regulation of macrophage cytokine production  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
negative regulation of type II interferon production  (IEA)
nervous system development  (IEA)
neuron apoptotic process  (IEA,ISO)
neuron migration  (IEA,ISO)
neutrophil clearance  (IEA,ISO)
ovulation cycle  (IEA,ISO)
phagocytosis  (IEA,ISO)
platelet activation  (IEA,ISO)
positive regulation of cytokine-mediated signaling pathway  (IEA)
positive regulation of natural killer cell differentiation  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of pinocytosis  (IEA)
positive regulation of viral life cycle  (IEA)
response to axon injury  (ISO)
secretion by cell  (IEA,ISO)
spermatogenesis  (IEA,ISO)
substrate adhesion-dependent cell spreading  (IEA,ISO)
symbiont entry into host cell  (IEA)
vagina development  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Axl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,229,833 - 15,259,221 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366613,657,831 - 3,687,816 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366613,658,140 - 3,687,290 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AXL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,219,223 - 41,261,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,219,223 - 41,261,766 (+)EnsemblGRCh38hg38GRCh38
GRCh371941,725,128 - 41,767,671 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,416,948 - 46,459,511 (+)NCBINCBI36Build 36hg18NCBI36
Build 341946,416,662 - 46,459,510NCBI
Celera1938,525,268 - 38,567,818 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,157,135 - 38,200,127 (+)NCBIHuRef
CHM1_11941,724,837 - 41,767,370 (+)NCBICHM1_1
T2T-CHM13v2.01944,040,107 - 44,082,625 (+)NCBIT2T-CHM13v2.0
Axl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,455,925 - 25,488,502 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,456,698 - 25,488,130 (-)EnsemblGRCm39 Ensembl
GRCm38725,756,500 - 25,788,924 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,757,273 - 25,788,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,542,292 - 26,573,560 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,466,033 - 25,497,301 (-)NCBIMGSCv36mm8
Celera720,366,185 - 20,397,512 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.02NCBI
Axl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,392,864 - 90,424,123 (-)NCBIGRCr8
mRatBN7.2181,265,088 - 81,296,278 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,265,088 - 81,296,265 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,658,736 - 86,688,215 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0195,209,987 - 95,239,417 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,414,540 - 88,444,021 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,550,892 - 82,580,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,549,420 - 82,580,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,812,118 - 83,840,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,964,751 - 80,994,300 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1181,045,570 - 81,045,733 (-)NCBI
Celera175,705,827 - 75,734,332 (-)NCBICelera
Cytogenetic Map1q21NCBI
Axl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555189,174 - 218,565 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555189,445 - 218,509 (+)NCBIChiLan1.0ChiLan1.0
AXL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22047,428,901 - 47,471,877 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11949,297,139 - 49,340,132 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,211,555 - 38,254,464 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11946,719,615 - 46,761,747 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,719,615 - 46,761,747 (+)Ensemblpanpan1.1panPan2
AXL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,699,679 - 112,727,434 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,700,365 - 112,726,960 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,104,006 - 112,130,669 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01113,298,102 - 113,324,981 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,297,567 - 113,324,929 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,859,212 - 112,885,893 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,491,561 - 112,518,264 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,484,923 - 113,511,641 (-)NCBIUU_Cfam_GSD_1.0
AXL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,245,673 - 49,277,914 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,245,802 - 49,277,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,979,820 - 45,009,909 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2645,072,278 - 45,073,025 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AXL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,537,718 - 35,580,143 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl635,537,773 - 35,580,716 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607313,772,922 - 13,815,487 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Axl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462490777,806 - 106,228 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462490776,236 - 106,765 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSSTOT00000001599   ⟹   ENSSTOP00000001430
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366613,658,367 - 3,685,820 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000038063   ⟹   ENSSTOP00000029063
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366613,657,831 - 3,687,816 (+)Ensembl
RefSeq Acc Id: XM_005336452   ⟹   XP_005336509
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934915,229,833 - 15,259,221 (+)NCBI
SpeTri2.0NW_0049366613,658,140 - 3,687,290 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021734008   ⟹   XP_021589683
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934915,229,833 - 15,259,221 (+)NCBI
SpeTri2.0NW_0049366613,658,140 - 3,687,290 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005336509 (Get FASTA)   NCBI Sequence Viewer  
  XP_021589683 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000001430.3
  ENSSTOP00000029063.1
GenBank Protein KAG3256096 (Get FASTA)   NCBI Sequence Viewer  
  KAG3256097 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005336509   ⟸   XM_005336452
- Peptide Label: isoform X1
- UniProtKB: A0A287D6A2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021589683   ⟸   XM_021734008
- Peptide Label: isoform X2
- UniProtKB: I3LYV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000029063   ⟸   ENSSTOT00000038063
RefSeq Acc Id: ENSSTOP00000001430   ⟸   ENSSTOT00000001599

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000001595 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000001599.3 UniProtKB/TrEMBL
  ENSSTOT00000038063.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
NCBI Gene Axl ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UFO UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PIRSF TyrPK_CSF1-R UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A287D6A2 ENTREZGENE, UniProtKB/TrEMBL
  I3LYV8 ENTREZGENE, UniProtKB/TrEMBL