Ywhab (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ywhab (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta) Rattus norvegicus
Analyze
Symbol: Ywhab
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
RGD ID: 61998
Description: Predicted to enable several functions, including enzyme inhibitor activity; histone deacetylase binding activity; and phosphoserine residue binding activity. Involved in negative regulation of DNA-templated transcription. Part of transcription repressor complex. Biomarker of brain ischemia. Orthologous to human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 14-3-3 protein beta-subtype; 14-3-3 protein beta/alpha; 14-3-3proteinbeta-subtype; 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide; 3-monooxygenase/tryptophan5monooxygenaseactivationproteinbetapolypeptide; KCIP-1; prepronerve growth factor RNH-1; protein kinase C inhibitor protein 1; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,078,904 - 173,101,508 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3173,079,041 - 173,101,854 (+)EnsemblGRCr8
mRatBN7.23152,659,663 - 152,682,105 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,659,651 - 152,682,105 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3156,467,118 - 156,489,555 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03164,966,056 - 164,988,493 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,710,239 - 162,732,648 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,391,108 - 160,399,931 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,391,106 - 160,399,931 (+)Ensemblrn6Rnor6.0
Rnor_5.03166,577,934 - 166,586,801 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43154,926,025 - 154,948,297 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3151,308,216 - 151,330,624 (+)NCBICelera
RGSC_v3.13154,832,060 - 154,854,385 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bleomycin A2  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
finasteride  (EXP)
flucloxacillin  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
ketanserin  (ISO)
lead(0)  (ISO)
melatonin  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
ochratoxin A  (EXP)
paracetamol  (ISO)
PCB138  (EXP)
phencyclidine  (ISO)
phenethyl isothiocyanate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
pyrimidifen  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
sarin  (ISO)
saxitoxin  (ISO)
serotonin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenylstannane  (ISO)
triptonide  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
wortmannin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. Aoki H, etal., J Virol. 2000 Feb;74(4):1736-41.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. CaM kinase IIdeltaC phosphorylation of 14-3-3beta in vascular smooth muscle cells: activation of class II HDAC repression. Ellis JJ, etal., Mol Cell Biochem 2003 Jan;242(1-2):153-61.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. 14-3-3 beta in the healthy and diseased male reproductive system. Graf M, etal., Hum Reprod. 2011 Jan;26(1):59-66. doi: 10.1093/humrep/deq319. Epub 2010 Nov 26.
7. A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis. Komiya Y, etal., J Biol Chem. 2008 Jul 4;283(27):18753-64. Epub 2008 May 5.
8. AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane. Koumanov F, etal., J Biol Chem. 2011 May 13;286(19):16574-82. doi: 10.1074/jbc.M111.226092. Epub 2011 Mar 17.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals. O'Kelly I, etal., Cell. 2002 Nov 15;111(4):577-88.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Shinoda S, etal., Eur J Neurosci. 2003 May;17(10):2065-76.
16. Interaction of 14-3-3 with Bid during seizure-induced neuronal death. Shinoda S, etal., J Neurochem. 2003 Jul;86(2):460-9.
17. Novel surrogate markers for acute brain damage: cerebrospinal fluid levels corrrelate with severity of ischemic neurodegeneration in the rat. Siman R, etal., J Cereb Blood Flow Metab. 2005 Nov;25(11):1433-44.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation. Takai R, etal., J Biochem (Tokyo) 1995 Nov;118(5):1045-53.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Implication of Akt-dependent Prp19 alpha/14-3-3beta/Cdc5L complex formation in neuronal differentiation. Urano-Tashiro Y, etal., J Neurosci Res. 2010 Oct;88(13):2787-97. doi: 10.1002/jnr.22455.
22. Molecular cloning of rat cDNAs for beta and gamma subtypes of 14-3-3 protein and developmental changes in expression of their mRNAs in the nervous system. Watanabe M, etal., Brain Res Mol Brain Res 1993 Jan;17(1-2):135-46.
23. Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain. Watanabe M, etal., Brain Res Mol Brain Res 1994 Aug;25(1-2):113-21.
Additional References at PubMed
PMID:9560161   PMID:9679960   PMID:10407019   PMID:10409742   PMID:10869435   PMID:11984006   PMID:12446771   PMID:12618428   PMID:12650640   PMID:12963375   PMID:15489334   PMID:15543142  
PMID:15677482   PMID:17085597   PMID:17255105   PMID:18436566   PMID:18484353   PMID:18779656   PMID:19199708   PMID:19946888   PMID:20458337   PMID:20598904   PMID:21224381   PMID:21423176  
PMID:21618583   PMID:22846993   PMID:22871113   PMID:23622247   PMID:25468996   PMID:26438180   PMID:28131823   PMID:28684312   PMID:29749466  


Genomics

Comparative Map Data
Ywhab
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,078,904 - 173,101,508 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3173,079,041 - 173,101,854 (+)EnsemblGRCr8
mRatBN7.23152,659,663 - 152,682,105 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,659,651 - 152,682,105 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3156,467,118 - 156,489,555 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03164,966,056 - 164,988,493 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,710,239 - 162,732,648 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,391,108 - 160,399,931 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,391,106 - 160,399,931 (+)Ensemblrn6Rnor6.0
Rnor_5.03166,577,934 - 166,586,801 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43154,926,025 - 154,948,297 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3151,308,216 - 151,330,624 (+)NCBICelera
RGSC_v3.13154,832,060 - 154,854,385 (+)NCBI
Cytogenetic Map3q42NCBI
YWHAB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382044,885,705 - 44,908,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2044,885,676 - 44,908,532 (+)Ensemblhg38GRCh38
GRCh372043,514,346 - 43,537,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362042,947,758 - 42,970,575 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342042,947,757 - 42,970,574NCBI
Celera2040,222,982 - 40,245,799 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,256,131 - 40,279,005 (+)NCBIHuRef
CHM1_12043,417,179 - 43,440,099 (+)NCBICHM1_1
T2T-CHM13v2.02046,621,568 - 46,644,395 (+)NCBIT2T-CHM13v2.0
Ywhab
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392163,837,082 - 163,860,508 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2163,836,880 - 163,860,508 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382163,995,197 - 164,018,588 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2163,994,960 - 164,018,588 (+)Ensemblmm10GRCm38
MGSCv372163,820,933 - 163,844,323 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362163,686,638 - 163,710,028 (+)NCBIMGSCv36mm8
Celera2169,925,360 - 169,948,799 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.59NCBI
Ywhab
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544512,448,760 - 12,474,251 (-)Ensembl
ChiLan1.0NW_00495544512,451,644 - 12,474,251 (-)NCBIChiLan1.0ChiLan1.0
YWHAB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,618,382 - 50,641,330 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,611,587 - 50,634,433 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,216,071 - 41,238,893 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,309,101 - 42,331,705 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,309,155 - 42,331,695 (+)EnsemblpanPan2panpan1.1
YWHAB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,304,808 - 32,325,789 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,304,812 - 32,323,938 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2431,950,457 - 31,971,435 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02433,016,092 - 33,036,942 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2433,016,085 - 33,059,979 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12432,277,256 - 32,298,231 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,392,197 - 32,412,966 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02432,933,875 - 32,954,868 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ywhab
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640192,378,451 - 192,399,435 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365147,830,387 - 7,853,262 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365147,832,094 - 7,853,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YWHAB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,298,044 - 47,319,285 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11747,298,020 - 47,317,826 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21752,794,145 - 52,815,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
YWHAB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,904,588 - 18,927,461 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,906,666 - 18,927,374 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605067,571,578 - 67,594,333 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ywhab
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247909,574,027 - 9,593,825 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247909,574,003 - 9,593,821 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ywhab
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15153,958,612 - 153,981,427 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:298
Count of miRNA genes:189
Interacting mature miRNAs:222
Transcripts:ENSRNOT00000016981
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
RH140223  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83173,099,080 - 173,099,777 (+)Marker Load Pipeline
mRatBN7.23152,679,677 - 152,680,374 (+)MAPPERmRatBN7.2
Rnor_6.03160,397,507 - 160,398,203NCBIRnor6.0
Rnor_5.03166,584,377 - 166,585,073UniSTSRnor5.0
RGSC_v3.43154,946,030 - 154,946,726UniSTSRGSC3.4
Celera3151,328,197 - 151,328,893UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016981   ⟹   ENSRNOP00000016981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,093,938 - 173,101,854 (+)Ensembl
mRatBN7.2 Ensembl3152,659,651 - 152,682,105 (+)Ensembl
Rnor_6.0 Ensembl3160,391,106 - 160,399,931 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118405   ⟹   ENSRNOP00000097549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,079,041 - 173,099,780 (+)Ensembl
mRatBN7.2 Ensembl3152,674,533 - 152,682,100 (+)Ensembl
RefSeq Acc Id: NM_019377   ⟹   NP_062250
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,079,071 - 173,101,508 (+)NCBI
mRatBN7.23152,659,663 - 152,682,105 (+)NCBI
Rnor_6.03160,391,108 - 160,399,931 (+)NCBI
Rnor_5.03166,577,934 - 166,586,801 (+)NCBI
RGSC_v3.43154,926,025 - 154,948,297 (+)RGD
Celera3151,308,216 - 151,330,624 (+)RGD
Sequence:
RefSeq Acc Id: XM_063284421   ⟹   XP_063140491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,078,904 - 173,101,508 (+)NCBI
RefSeq Acc Id: NP_062250   ⟸   NM_019377
- UniProtKB: P35213 (UniProtKB/Swiss-Prot),   A6JX54 (UniProtKB/TrEMBL),   A0A8I6GMK2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016981   ⟸   ENSRNOT00000016981
Ensembl Acc Id: ENSRNOP00000097549   ⟸   ENSRNOT00000118405
RefSeq Acc Id: XP_063140491   ⟸   XM_063284421
- Peptide Label: isoform X1
Protein Domains
14-3-3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35213-F1-model_v2 AlphaFold P35213 1-246 view protein structure
AF-Q9CQV8-F1-model_v2 AlphaFold Q9CQV8 1-246 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692644
Promoter ID:EPDNEW_R3167
Type:initiation region
Name:Ywhab_1
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activationprotein, beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03160,391,078 - 160,391,138EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61998 AgrOrtholog
BioCyc Gene G2FUF-46886 BioCyc
Ensembl Genes ENSRNOG00000010945 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016981.7 UniProtKB/Swiss-Prot
  ENSRNOT00000118405 ENTREZGENE
Gene3D-CATH 1.20.190.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100393 IMAGE-MGC_LOAD
InterPro 14-3-3 UniProtKB/Swiss-Prot
  14-3-3_CS UniProtKB/Swiss-Prot
  14-3-3_dom_sf UniProtKB/Swiss-Prot
  14-3-3_domain UniProtKB/Swiss-Prot
KEGG Report rno:56011 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91711 IMAGE-MGC_LOAD
NCBI Gene 56011 ENTREZGENE
PANTHER PTHR18860 UniProtKB/Swiss-Prot
Pfam 14-3-3 UniProtKB/Swiss-Prot
PhenoGen Ywhab PhenoGen
PIRSF 14-3-3 UniProtKB/Swiss-Prot
PRINTS 1433ZETA UniProtKB/Swiss-Prot
PROSITE 1433_1 UniProtKB/Swiss-Prot
  1433_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010945 RatGTEx
SMART 14_3_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48445 UniProtKB/Swiss-Prot
TIGR TC216826
UniProt 1433B_RAT UniProtKB/Swiss-Prot
  A0A8I6GMK2 ENTREZGENE, UniProtKB/TrEMBL
  A6JX53_RAT UniProtKB/TrEMBL
  A6JX54 ENTREZGENE, UniProtKB/TrEMBL
  A6JX55_RAT UniProtKB/TrEMBL
  P35213 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-12-11 Ywhab  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta  Ywhab  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ywhab  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide    tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide   Name updated 1299863 APPROVED
2002-06-10 Ywhab  tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide       Name updated 70584 APPROVED
2002-05-14 Ywhab  tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide      spelling corrected 68913 APPROVED
2002-01-14 Ywhab  tryosine 3-monooxgenase/tryptophan 5-momooxgenase activation protein, beta polypeptide      Correction to spelling of name 68926 APPROVED
2001-10-22 Ywhab  tryosine 3-monooxgenase/tryptophan 5-momoozgenase activation protein, gamma      Name updated 68913 WITHDRAWN
2001-10-22 Ywhab  tryosine 3-monooxgenase/tryptophan 5-momoozgenase activation protein, beta polypeptide      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED
2001-07-23 Ywhab  tryosine 3-monooxgenase/tryptophan 5-momoozgenase activation protein, gamma      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Ywhab  3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide      Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed throughout the brain and spinal chord by embryonic day 18 727985
gene_protein protein contains 245 aa residues 727985