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Gene: Fut4 (fucosyltransferase 4) Rattus norvegicus

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Symbol:

Fut4

Name:

fucosyltransferase 4

RGD ID:

619954

Description:

Enables alpha-(1->3)-fucosyltransferase activity. Predicted to be involved in several processes, including Lewis x epitope biosynthetic process; glycoprotein biosynthetic process; and regulation of leukocyte migration. Predicted to be located in cell periphery; cell surface; and trans-Golgi network. Orthologous to human FUT4 (fucosyltransferase 4); PARTICIPATES IN lacto-series glycosphingolipid metabolic pathway; O-linked glycan biosynthetic pathway; INTERACTS WITH (S)-amphetamine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase; alpha 1,3-fucosyltransferase Fuc-T (similar to mouse Fut4); alpha 13-fucosyltransferase Fuc-T (similar to mouse Fut4); alpha-(1,3)-fucosyltransferase; alpha-(1,3)-fucosyltransferase 4; fuc-TIV; fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific); fucosyltransferase IV; Fuct; fucT-IV; galactoside 3-L-fucosyltransferase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FUT4 (fucosyltransferase 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Fut4 (fucosyltransferase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fut4 (fucosyltransferase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FUT4 (fucosyltransferase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FUT4 (fucosyltransferase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fut4 (fucosyltransferase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FUT4 (fucosyltransferase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FUT4 (fucosyltransferase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fut4 (fucosyltransferase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Fut4 (fucosyltransferase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PCGF6 (polycomb group ring finger 6)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Fut4 (fucosyltransferase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	FUT4 (fucosyltransferase 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	fut-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	fut-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|SonicParanoid)
Drosophila melanogaster (fruit fly):	FucTC	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	FucTC	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	FucTA	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	fut-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	fut-6	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	fut-6	Alliance	DIOPT (OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	fut4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Related Pseudogenes:

Fut4-ps1

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	19,868,178 - 19,872,139 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	19,868,079 - 19,872,436 (-)	Ensembl				GRCr8
mRatBN7.2	8	11,586,721 - 11,590,682 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	11,586,721 - 11,590,682 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	15,571,456 - 15,575,419 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	13,869,199 - 13,873,162 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	11,844,759 - 11,848,737 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	13,258,768 - 13,262,729 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	13,258,768 - 13,262,729 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	13,199,560 - 13,203,521 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	11,541,524 - 11,545,485 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	13,056,457 - 13,060,418 (-)	NCBI		Celera
RGSC_v3.1	8	11,541,524 - 11,545,485 (-)	NCBI
Cytogenetic Map	8	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

thrombosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(20S)-ginsenoside Rg3 (ISO)

(S)-amphetamine (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-Ethylhexanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acrolein (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amiodarone (EXP)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

choline (ISO)

cobalt dichloride (EXP)

cordycepin (ISO)

Cuprizon (EXP)

cycloheximide (ISO)

decabromodiphenyl ether (EXP)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fipronil (EXP)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

gentamycin (EXP)

glycidol (EXP)

L-methionine (ISO)

lead diacetate (ISO)

metformin (ISO)

methyl methanesulfonate (ISO)

nickel atom (ISO)

okadaic acid (ISO)

oligomycin A (ISO)

ozone (ISO)

panobinostat (ISO)

paracetamol (EXP)

perfluorooctanoic acid (EXP)

Phenelzine (ISO)

phorbol 13-acetate 12-myristate (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

tamibarotene (ISO)

testosterone (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

zinc protoporphyrin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glycoprotein biosynthetic process (IEA)

glycosphingolipid biosynthetic process (ISO,ISS)

inflammatory response (IEA)

Lewis x epitope biosynthetic process (ISO,ISS)

lymphocyte migration into lymph node (IEA,ISO,ISS)

oligosaccharide metabolic process (IEA,ISO,ISS)

positive regulation of leukocyte tethering or rolling (IEA,ISO,ISS)

positive regulation of neutrophil migration (IEA,ISO,ISS)

protein N-linked glycosylation (ISO,ISS)

protein O-linked glycosylation (ISO,ISS)

regulation of leukocyte cell-cell adhesion (IEA,ISO,ISS)

Cellular Component

cell periphery (IEA,ISO)

cell surface (IEA,ISO)

Golgi apparatus (IEA)

Golgi cisterna membrane (IEA)

membrane (IEA)

trans-Golgi network (IEA,ISO,ISS)

Molecular Function

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity (IBA,IEA,ISO,ISS)

alpha-(1->3)-fucosyltransferase activity (IDA,IEA,ISO)

fucosyltransferase activity (IEA)

glycosyltransferase activity (IEA)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

lacto-series glycosphingolipid metabolic pathway (IEA)

O-linked glycan biosynthetic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Cloning of a rat alpha1,3-fucosyltransferase gene: a member of the fucosyltransferase IV family.	Sajdel-Sulkowska EM, etal., Glycoconj J 1997 Feb;14(2):249-58.
10.	Pax6 controls the expression of Lewis x epitope in the embryonic forebrain by regulating alpha 1,3-fucosyltransferase IX expression.	Shimoda Y, etal., J Biol Chem 2002 Jan 18;277(3):2033-9.
11.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:1740457	PMID:10894166	PMID:11278338	PMID:15063176	PMID:15632090	PMID:16099728	PMID:19576189	PMID:23192350	PMID:28325116

Genomics

Comparative Map Data

Fut4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	19,868,178 - 19,872,139 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	19,868,079 - 19,872,436 (-)	Ensembl				GRCr8
mRatBN7.2	8	11,586,721 - 11,590,682 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	11,586,721 - 11,590,682 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	15,571,456 - 15,575,419 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	13,869,199 - 13,873,162 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	11,844,759 - 11,848,737 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	13,258,768 - 13,262,729 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	13,258,768 - 13,262,729 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	13,199,560 - 13,203,521 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	11,541,524 - 11,545,485 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	13,056,457 - 13,060,418 (-)	NCBI		Celera
RGSC_v3.1	8	11,541,524 - 11,545,485 (-)	NCBI
Cytogenetic Map	8	q12	NCBI

FUT4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	94,543,921 - 94,549,895 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	94,543,921 - 94,549,895 (+)	Ensembl			hg38	GRCh38
GRCh37	11	94,277,087 - 94,283,061 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	93,916,775 - 93,922,712 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	93,916,774 - 93,922,712	NCBI
Celera	11	91,564,827 - 91,570,875 (+)	NCBI		Celera
Cytogenetic Map	11	q21	NCBI
HuRef	11	90,342,221 - 90,348,273 (+)	NCBI		HuRef
CHM1_1	11	94,160,008 - 94,166,060 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	94,550,967 - 94,556,942 (+)	NCBI		T2T-CHM13v2.0

Fut4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	14,659,755 - 14,663,418 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	14,659,616 - 14,663,689 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	14,748,459 - 14,752,122 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	14,748,320 - 14,752,393 (-)	Ensembl			mm10	GRCm38
MGSCv37	9	14,552,903 - 14,556,566 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	14,498,852 - 14,502,515 (-)	NCBI		MGSCv36	mm8
Celera	9	12,028,933 - 12,032,596 (-)	NCBI		Celera
Cytogenetic Map	9	A2	NCBI
cM Map	9	4.3	NCBI

Fut4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955605	331,638 - 398,528 (-)	Ensembl
ChiLan1.0	NW_004955605	397,721 - 398,470 (-)	NCBI	ChiLan1.0	ChiLan1.0

FUT4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	95,379,390 - 95,413,344 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	96,470,878 - 96,507,402 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	89,550,637 - 89,566,111 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	93,034,946 - 93,041,893 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	93,036,119 - 93,037,711 (+)	Ensembl			panPan2	panpan1.1

FUT4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	6,386,665 - 6,390,109 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	6,389,021 - 6,390,793 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	6,397,366 - 6,401,819 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	6,567,061 - 6,570,571 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	21	6,354,240 - 6,358,357 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	6,419,443 - 6,420,749 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	6,466,083 - 6,470,537 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Fut4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	79,461,440 - 79,474,084 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936674	419,808 - 421,925 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936674	418,751 - 428,998 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FUT4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	26,679,868 - 26,681,541 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	26,679,540 - 26,686,217 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	30,433,511 - 30,436,409 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FUT4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	85,747,612 - 85,752,557 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	85,748,886 - 85,750,481 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666043	40,024,888 - 40,028,623 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fut4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624735	39,220,525 - 39,224,289 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Fut4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	10,535,940 - 10,539,938 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Fut4
29 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	33
Count of miRNA genes:	30
Interacting mature miRNAs:	33
Transcripts:	ENSRNOT00000012176
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	16994642	61994642	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	10382540	55382540	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	12964165	57964165	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	15952279	60952279	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	12964165	57964165	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	17993862	62252873	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	10382540	55382540	Rat
9590084	Insglur5	Insulin/glucose ratio QTL 5	18.54	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	8	1	32882639	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	10382540	55382540	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	16994642	61994642	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	12964165	57964165	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	10382540	55382540	Rat

Markers in Region

BF412716

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	11,588,101 - 11,588,312 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	13,260,149 - 13,260,359	NCBI	Rnor6.0
Rnor_5.0	8	13,200,941 - 13,201,151	UniSTS	Rnor5.0
RGSC_v3.4	8	11,542,905 - 11,543,115	UniSTS	RGSC3.4
Celera	8	13,057,838 - 13,058,048	UniSTS
RH 3.4 Map	8	109.2	UniSTS
Cytogenetic Map	8	q11	UniSTS

AI237192

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	11,586,833 - 11,587,030 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	13,258,881 - 13,259,077	NCBI	Rnor6.0
Rnor_5.0	8	13,199,673 - 13,199,869	UniSTS	Rnor5.0
RGSC_v3.4	8	11,541,637 - 11,541,833	UniSTS	RGSC3.4
Celera	8	13,056,570 - 13,056,766	UniSTS
RH 3.4 Map	8	119.2	UniSTS
Cytogenetic Map	8	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	355	192	11	143	80	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB049938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC097778	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061776	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U58860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012176 ⟹ ENSRNOP00000012176

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	19,868,079 - 19,872,436 (-)	Ensembl
mRatBN7.2 Ensembl	8	11,586,721 - 11,590,682 (-)	Ensembl
Rnor_6.0 Ensembl	8	13,258,768 - 13,262,729 (-)	Ensembl

RefSeq Acc Id:

NM_022219 ⟹ NP_071555

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	19,868,178 - 19,872,139 (-)	NCBI
mRatBN7.2	8	11,586,721 - 11,590,682 (-)	NCBI
Rnor_6.0	8	13,258,768 - 13,262,729 (-)	NCBI
Rnor_5.0	8	13,199,560 - 13,203,521 (-)	NCBI
RGSC_v3.4	8	11,541,524 - 11,545,485 (-)	RGD
Celera	8	13,056,457 - 13,060,418 (-)	RGD

Sequence:

show sequence

CGCACCCCTACCCCGCCACCCCTTCGAGGTGCAGGTCTCCAGTGCAAGACTCTCTCTGCAAGGC
GAGGACTCAGGTCACCTAGTCGCGGGACCAGCGAACGCATCAAGAGGCCACGACCCCCGGTGAG
GCGCCATCCGGGCGCAGTTTCGGAGCCCAGGATCCTTGGCTGGGCAGGGGAACCAGCGCAGGCG
CAGCAGGAAACGCCCCAGGCCGGGCCCGCAGGGCTTGGAGAGCAGTGTCTGGGAAGGCCAGCGT
GGCGCCGCGCCAGGGCCACCGGCCCGGTTCACCTCGTCCTGGACTTGGGAGGGGCGAGGCACCG
CCCGTGGGCCCGCCGATGCCCCGCCCGCCCCCTCTATGGCCCCGGCCGGGCGAAAGCTACAGCA
TGAGAGCCGGTGCCGCCCCTCACGGCCCGTGGACGCGTGGCGAGCCGCGGCGACCACTCGTGGG
CGCTGCATGGGGACCCCAGGGGCCCGGCGACGCGCACGGCGCGGAGGCTGGGGATTACCCCGGA
CCTCCTCTGGGCTGGCAGCAGCGGGACTACTATGCACCGCGTTGACTGCCTGCCTCTGTTGGGG
ACAGCTGCCGCCGCTGCCCTGGGCGTCCCCAGCCCCGCAACGCCCGGTGAGTGTGCTGCTCTGG
TGGGAACCCTTTGGGGGGCGCGGCGGCCACTCCAAGCCTCCCCCCGATTGCAGCCTGCGCTTCA
ACATCAGCGGCTGCCGCTTGCTCACCGACCGCGCGGCCTACGGGGAGGCTCAAGCAGTGCTGTT
CCACCACCGCGACCTGGTGAAGGGACCCCCCGACTGGCCCCCGCCCTGGGGCGCCCAAGAACGC
ACCGATGAGGCTCCGGAGCTACGCGTGTTCGACGACCAGGAGGGAGCGGTGATGCTAGCTAGAG
AAGCCCTGGAGACCACAGGCTCTCGTCCCCCGGGTCAGCGGTGGGTGTGGATGAACTTCGAATC
ACCCTCCCACACTCCAGGGCTGCGGGGCTTGGCTAAGGACCTCTTCAATTGGACACTATCCTAC
CGGACCGATTCGGATATCTTCGTGCCCTATGGCTTCCTCTATCCCAGGAGCCATCCAGCCGAAC
AGCCTTCAGGTCTGGGCCCCCCGCTGGCCCGCAAGCGGGGACTGGTGGCCTGGGTTGTGAGCCA
CTGGAACGAGCGCCAGGCACGGGTCCGTTACTACCATCAGCTGAGGCGGCACGTGTCTGTGGAC
GTGTTTGGCCGGGCGGGACCCGGACAACCAGTGCCAGCCGTCGGGTTGCTGCACACGGTGGCCC
GCTACAAGTTTTACCTGGCGTTTGAGAACTCACAGCACGTGGATTACATCACTGAGAAGCTGTG
GCGGAATGCCTTCCTGGCTGGGGCCGTGCCAGTGGTACTTGGTCCCGATCGTGCCAACTATGAG
CGCTTCGTGCCTCGTGGTTCCTTCATCCATGTGGATGATTTCCCTAGTGCTGCCTCCCTGGCTG
CCTACCTGCTCTTTCTGGACCGAAACGTGGCTGTCTATCGCCGCTACTTCCACTGGCGTCGGAG
CTATGCGGTGCACATCACTTCTTTCTGGGATGAGCCATGGTGCCAGACATGCAGGGCCGTCCAG
ACCTCTGGGGACCAGCCCAAGAGTATCCACAACTTGGCAGACTGGTTCCAGCGATGAGGCTATT
CTGCTGTGAATTGATGACATCTCCTTGACTGTTTTTCTAAATACCCAATTTTGCTTTATGGGAA
GAAGATGAGTTACCAGTTAATATTATTTAGCACAAGGATGGGGAAATTGCCAGGCCCTCATGGC
TTTTTTACAGAGAGGTGGGCTGGCTCTCTGTTAAAGGGCTATGGTGTCCTGGGTGAAGAAGGAG
GCCCTTCCTTCCCTGTTACCTTTCTTTGGCCATAGGCCTTACCACGACCTATGTGGCCTCTGAA
TTTTAGATGGATTTGTTCTCTGCTCCATGATTGGTTGGACCAATGAGGAGCAGACCACAGGTTT
TTGAAAGGCAGTGGGTGTGAGATAGTGGAAGGCTTGTCCCCTCGGGTGGTGTTTTCTTTGGTGG
TTGGAGTCCTCAATCCCTCTGAACCTGGAAAAGATAAGAAGCCATTGAGTTCCTTCACCAGCCG
CTGTGTTCCCAGCCCTGCGAATAGAAACGAGAGGCGAGATTATCCTCAAAGGGAAATTCAGATG
AATTCGTGGGGACACCTCACCTCACACTAGAACCCTACTCCCGAGAAGCTGCATTTAAGTGACA
CCCTAAATTCAGGGACCTAAGGGAGTGAGAGTATCTCATAGAAATCAATGAAAAATCCCTTTGC
AATGTGAATTATTTCTCGCCTTTATAGTCCCATAACTGGATCAGGAAAACGTTAAAAATACAGA
TATGAAAGAACCACAAGCAATCGTCTCTCTTTTCCCAGCCAGTGTTTACAAATGGAAGGGACAT
AAATGGTGACCTCTTGTGCACAAATTTGTTTGTTCTGTGTCTCTGATGGACCTGAAATTTAAAC
AGGAACGTTTCGTTAGTCCTTCAGCAGGGTTGGCAGTGCTGTGCAGAGAGAACACTAAAAGATT
CCGGTGAACTATGGGTATGTGCAGAAGCAACACGCTTGTGGTGTCTGTGTACCGTTGTTTGGTT
TCTGTCCAGCTTTTGTTCAATGGAACTGACCTGTGCTTACAGTTAGTTTCTGTCCTTTGTCCTC
CCGTTGCTCTCTGCTCCTAGGTACACTCATTCACTCCAGTGCCTTGGACCCTGCGCTGTGGGAC
TAATCTTGAAAACAGTCATTGATTTTCCACATTCAACAGATGTCAGGGCATGCCTGCTTGTGCC
AAATACTGGCCTTGAGCTCCCAGGGGAAGGAAGGTACAGAAAGGTGTGAGGAATTGCCTCCTCT
TTGGGGCTCCTACACTCTACTACTGCCGCAGGGGAATAGGGATTTTTGGTTACACAAAGTATTG
TTCATGAATCAGTTGGTTGACTAGAGGCCTCGAGTTATTAAACTAGGACCCTCAGATCAACGTG
CTGTATACCAAGTTCTACCCATTTTGGGTCAGGACAGTTATTTGAATCTTATATCAGATTTATA
TCTAAGATTCTTCATTACACAGAAGCTTGCAAAACTACTTAGGCCCAGGTGCTTCTAGTCCCCA
TCTTCCATAAAAAGGAGTAATTAAAAGCTGTGAATAACATTGCCTCATTAAAGTGTTAAGGTGT
GGGCAGAGCCACAGTTGAAGAATTAAAAGAAAACAAAAGTTCGGGGGGCGGGGGAGCGTTTGTT
TGCTTACTTTGGTTTTCAGACAGGGTTTCTCTGTAATAGTCCTGGAACTCTCTTTGTAGACCAG
GCTGGCCTTGAACTCCAGAGGATCCACCTGCCTCTGGCTTCCTAGGGCTGGGATTAAAGGTGTG
TGCCACGATGCCCAGCTTGAAAATTCTGTTTTTAAGACAAATATCAATGGAATGTTGGCCAGGG
GTCTCAGTGTTGTCGGAATCTACAGTGGACATTGGGATTTGGTAATCTGGCTTAGCTTTGCCTT
CCGGCCTGGAGCACTGGGATGAGGAATGAGCCTGAGCACAAAATTCCTCTTCTGTGAAGTGTGG
GGGGAGGGCGCCTGAGGCTCTACTGTGTGACGTAAGAGATGCCGCCTTGTGCTTGGCGGGCAGT
TGGCGGGATATGTGTAGCCATGAGCACATTGGCTACTTTTCTTTGCAGGGATTTTCTGTACTCT
CATATGCATTTTACATCCGAAATTAAATGTCAAGATCTATTACAGAAAAAAATCTAAAAAGAAA
GGAAAGTCAGTCATGTATTGTGTATTTCAAATAAATCCTTAAAACTGAGCCATATCTCAGGATC
AGACAATTTCTATGAAGCTTGTATTTTCAGACCAGAAGTATGTATGTTTTGATAAAGCTACGTA
ATTAAAATTGTTTGGATTGTTTCACCTATGTCTTCTGCATTAAATCCATGTAAAACTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_071555	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB97609	(Get FASTA)	NCBI Sequence Viewer
	AAH61776	(Get FASTA)	NCBI Sequence Viewer
	BAB40992	(Get FASTA)	NCBI Sequence Viewer
	EDL78468	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012176
GenBank Protein	Q62994	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_071555 ⟸ NM_022219

- UniProtKB:

G3V757 (UniProtKB/TrEMBL), A6JN98 (UniProtKB/TrEMBL), Q99N88 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAPAGRKLQHESRCRPSRPVDAWRAAATTRGRCMGTPGARRRARRGGWGLPRTSSGLAAAGLLC
TALTACLCWGQLPPLPWASPAPQRPVSVLLWWEPFGGRGGHSKPPPDCSLRFNISGCRLLTDRA
AYGEAQAVLFHHRDLVKGPPDWPPPWGAQERTDEAPELRVFDDQEGAVMLAREALETTGSRPPG
QRWVWMNFESPSHTPGLRGLAKDLFNWTLSYRTDSDIFVPYGFLYPRSHPAEQPSGLGPPLARK
RGLVAWVVSHWNERQARVRYYHQLRRHVSVDVFGRAGPGQPVPAVGLLHTVARYKFYLAFENSQ
HVDYITEKLWRNAFLAGAVPVVLGPDRANYERFVPRGSFIHVDDFPSAASLAAYLLFLDRNVAV
YRRYFHWRRSYAVHITSFWDEPWCQTCRAVQTSGDQPKSIHNLADWFQR

hide sequence

Ensembl Acc Id:

ENSRNOP00000012176 ⟸ ENSRNOT00000012176

Protein Domains

Fucosyltransferase C-terminal Fucosyltransferase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q62994-F1-model_v2	AlphaFold	Q62994	1-433	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695747

Promoter ID:

EPDNEW_R6270

Type:

initiation region

Name:

Fut4_1

Description:

fucosyltransferase 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	13,262,745 - 13,262,805	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619954	AgrOrtholog
BioCyc Gene	G2FUF-31687	BioCyc
BioCyc Pathway	PWY-7831 [ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide]	BioCyc
BioCyc Pathway Image	PWY-7831	BioCyc
Ensembl Genes	ENSRNOG00000009157	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000012176	ENTREZGENE
Gene3D-CATH	3.40.50.11660	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:5621698	IMAGE-MGC_LOAD
InterPro	Glyco_tran_10_C	UniProtKB/Swiss-Prot
	Glyco_tran_10_N	UniProtKB/Swiss-Prot
	Glyco_trans_10	UniProtKB/Swiss-Prot
	GT10-like_sf	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72456	IMAGE-MGC_LOAD
NCBI Gene	60670	ENTREZGENE
PANTHER	ALPHA-(1,3)-FUCOSYLTRANSFERASE 4	UniProtKB/Swiss-Prot
	PTHR11929	UniProtKB/Swiss-Prot
Pfam	Glyco_tran_10_N	UniProtKB/Swiss-Prot
	Glyco_transf_10	UniProtKB/Swiss-Prot
PhenoGen	Fut4	PhenoGen
RatGTEx	ENSRNOG00000009157	RatGTEx
Superfamily-SCOP	UDP-Glycosyltransferase/glycogen phosphorylase	UniProtKB/Swiss-Prot
UniProt	A6JN98	ENTREZGENE, UniProtKB/TrEMBL
	FUT4_RAT	UniProtKB/Swiss-Prot
	G3V757	ENTREZGENE, UniProtKB/TrEMBL
	Q62994	ENTREZGENE
	Q99N88	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-02	Fut4	fucosyltransferase 4	Fut4	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-18	Fut4	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	Fut4	fucosyltransferase 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-12-14	Fut4	fucosyltransferase 4		alpha 1,3-fucosyltransferase Fuc-T (similar to mouse Fut4)	Name updated	1299863	APPROVED
2002-08-07	Fut4	alpha 1,3-fucosyltransferase Fuc-T (similar to mouse Fut4)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

BioCyc Pathways