Mark1 (microtubule affinity regulating kinase 1) - Rat Genome Database

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Gene: Mark1 (microtubule affinity regulating kinase 1) Rattus norvegicus
Analyze
Symbol: Mark1
Name: microtubule affinity regulating kinase 1
RGD ID: 619882
Description: Enables ATP binding activity; magnesium ion binding activity; and tau-protein kinase activity. Involved in several processes, including microtubule cytoskeleton organization; neuron migration; and protein phosphorylation. Located in cytoplasm and cytoskeleton. Orthologous to human MARK1 (microtubule affinity regulating kinase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MAP/microtubule affinity-regulating kinase 1; serine/threonine-protein kinase MARK1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81398,981,727 - 99,086,998 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1398,983,020 - 99,086,701 (-)EnsemblGRCr8
mRatBN7.21396,450,189 - 96,555,304 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1396,451,487 - 96,555,173 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1398,957,791 - 99,061,914 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013100,356,587 - 100,460,278 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01397,540,024 - 97,644,155 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.013102,808,254 - 102,942,863 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13102,808,253 - 102,942,863 (-)Ensemblrn6Rnor6.0
Rnor_5.013107,485,344 - 107,589,704 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.413100,905,369 - 101,009,161 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1395,968,489 - 96,018,212 (-)NCBICelera
RGSC_v3.113101,094,411 - 101,198,263 (-)NCBI
Cytogenetic Map13q26NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
allethrin  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dibutyl phthalate  (EXP,ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
folic acid  (ISO)
FR900359  (ISO)
glyphosate  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
phenylarsine oxide  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium chromate  (ISO)
pyrethrins  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
staurosporine  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell projection  (IEA)
cytoplasm  (IBA,IDA,IEA,ISO)
cytoskeleton  (IDA,IEA)
dendrite  (IEA,ISO,ISS)
glutamatergic synapse  (IEA,ISO)
plasma membrane  (IEA,ISO,ISS)
postsynapse  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Drewes G, etal., Cell 1997 Apr 18;89(2):297-308.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons. Schaar BT, etal., Neuron. 2004 Jan 22;41(2):203-13.
Additional References at PubMed
PMID:14976552   PMID:16238695   PMID:17728463   PMID:18492799   PMID:21145462   PMID:23666762   PMID:25931508   PMID:25932647  


Genomics

Comparative Map Data
Mark1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81398,981,727 - 99,086,998 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1398,983,020 - 99,086,701 (-)EnsemblGRCr8
mRatBN7.21396,450,189 - 96,555,304 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1396,451,487 - 96,555,173 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1398,957,791 - 99,061,914 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013100,356,587 - 100,460,278 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01397,540,024 - 97,644,155 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.013102,808,254 - 102,942,863 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13102,808,253 - 102,942,863 (-)Ensemblrn6Rnor6.0
Rnor_5.013107,485,344 - 107,589,704 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.413100,905,369 - 101,009,161 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1395,968,489 - 96,018,212 (-)NCBICelera
RGSC_v3.113101,094,411 - 101,198,263 (-)NCBI
Cytogenetic Map13q26NCBI
MARK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381220,528,136 - 220,664,461 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1220,528,086 - 220,664,461 (+)Ensemblhg38GRCh38
GRCh371220,701,478 - 220,837,803 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361218,768,191 - 218,904,422 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341217,089,962 - 217,225,667NCBI
Celera1193,920,723 - 194,057,269 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1191,375,808 - 191,512,424 (+)NCBIHuRef
CHM1_11221,974,021 - 222,110,252 (+)NCBICHM1_1
T2T-CHM13v2.01219,767,527 - 219,904,166 (+)NCBIT2T-CHM13v2.0
Mark1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391184,628,621 - 184,732,152 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1184,628,986 - 184,731,767 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381184,896,424 - 184,999,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1184,896,789 - 184,999,570 (-)Ensemblmm10GRCm38
MGSCv371186,720,303 - 186,823,428 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361186,598,391 - 186,700,267 (-)NCBIMGSCv36mm8
Celera1191,860,242 - 191,963,269 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map189.26NCBI
Mark1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555203,086,887 - 3,205,525 (-)Ensembl
ChiLan1.0NW_0049555203,087,581 - 3,205,525 (-)NCBIChiLan1.0ChiLan1.0
MARK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2128,735,310 - 28,871,788 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1128,697,135 - 28,833,583 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01196,114,714 - 196,251,166 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11201,150,316 - 201,286,201 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1201,150,310 - 201,286,201 (+)EnsemblpanPan2panpan1.1
MARK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13815,270,523 - 15,341,934 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3815,273,004 - 15,340,448 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3815,268,336 - 15,385,001 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03815,263,226 - 15,379,605 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3815,262,280 - 15,379,579 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13815,270,806 - 15,387,062 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03815,625,161 - 15,741,308 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03815,905,948 - 16,022,402 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mark1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934456,357,812 - 56,419,056 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366501,605,487 - 1,667,297 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366501,607,480 - 1,672,591 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl109,980,383 - 10,104,867 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1109,980,277 - 10,106,507 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MARK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1258,876,945 - 9,019,780 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl258,879,201 - 9,019,598 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660559,155,904 - 9,298,871 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mark1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248353,986,642 - 4,101,388 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248353,987,023 - 4,101,428 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mark1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11063,070,581 - 63,176,519 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mark1
616 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:159
Interacting mature miRNAs:184
Transcripts:ENSRNOT00000003198
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
D13Mit15  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81399,044,112 - 99,044,320 (+)Marker Load Pipeline
mRatBN7.21396,512,579 - 96,512,789 (+)MAPPERmRatBN7.2
Rnor_6.013102,870,610 - 102,870,817NCBIRnor6.0
Rnor_5.013107,546,551 - 107,546,758UniSTSRnor5.0
RGSC_v3.413100,966,403 - 100,966,610UniSTSRGSC3.4
RGSC_v3.413100,966,402 - 100,966,609RGDRGSC3.4
Celera1396,029,857 - 96,030,064UniSTS
RGSC_v3.113101,155,416 - 101,155,877RGD
RH 3.4 Map13656.1UniSTS
RH 3.4 Map13656.1RGD
Cytogenetic Map13q26UniSTS
RH138446  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21396,459,086 - 96,459,209 (+)MAPPERmRatBN7.2
Rnor_6.013102,817,149 - 102,817,271NCBIRnor6.0
Rnor_5.013107,492,944 - 107,493,066UniSTSRnor5.0
RGSC_v3.413100,912,969 - 100,913,091UniSTSRGSC3.4
Celera1395,976,089 - 95,976,211UniSTS
RH 3.4 Map13654.1UniSTS
Cytogenetic Map13q26UniSTS
BF418092  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21396,520,436 - 96,520,545 (+)MAPPERmRatBN7.2
Rnor_6.013102,878,465 - 102,878,573NCBIRnor6.0
Rnor_5.013107,554,406 - 107,554,514UniSTSRnor5.0
RGSC_v3.413100,974,258 - 100,974,366UniSTSRGSC3.4
Celera1396,037,712 - 96,037,820UniSTS
RH 3.4 Map13654.1UniSTS
Cytogenetic Map13q26UniSTS
AI176765  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21396,451,780 - 96,451,953 (+)MAPPERmRatBN7.2
Rnor_6.013102,809,843 - 102,810,015NCBIRnor6.0
Rnor_5.013107,485,638 - 107,485,810UniSTSRnor5.0
RGSC_v3.413100,905,663 - 100,905,835UniSTSRGSC3.4
Celera1395,968,783 - 95,968,955UniSTS
RH 3.4 Map13654.8UniSTS
Cytogenetic Map13q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 354 191 11 144 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003198   ⟹   ENSRNOP00000003198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1398,983,020 - 99,086,701 (-)Ensembl
mRatBN7.2 Ensembl1396,451,487 - 96,555,173 (-)Ensembl
Rnor_6.0 Ensembl13102,809,549 - 102,942,863 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080309   ⟹   ENSRNOP00000074213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1398,983,020 - 99,033,505 (-)Ensembl
mRatBN7.2 Ensembl1396,451,487 - 96,501,971 (-)Ensembl
Rnor_6.0 Ensembl13102,808,253 - 102,857,551 (-)Ensembl
RefSeq Acc Id: NM_053947   ⟹   NP_446399
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81398,983,020 - 99,086,701 (-)NCBI
mRatBN7.21396,451,487 - 96,555,173 (-)NCBI
Rnor_6.013102,809,549 - 102,942,863 (-)NCBI
Rnor_5.013107,485,344 - 107,589,704 (-)NCBI
RGSC_v3.413100,905,369 - 101,009,161 (-)RGD
Celera1395,968,489 - 96,018,212 (-)RGD
Sequence:
RefSeq Acc Id: XM_039090282   ⟹   XP_038946210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81398,981,727 - 99,086,998 (-)NCBI
mRatBN7.21396,450,194 - 96,555,304 (-)NCBI
RefSeq Acc Id: XM_039090284   ⟹   XP_038946212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81398,981,727 - 99,021,180 (-)NCBI
mRatBN7.21396,450,189 - 96,489,634 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446399 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946210 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946212 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAB06294 (Get FASTA)   NCBI Sequence Viewer  
  EDL94906 (Get FASTA)   NCBI Sequence Viewer  
  EDL94907 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003198
  ENSRNOP00000074213
GenBank Protein O08678 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446399   ⟸   NM_053947
- UniProtKB: O08678 (UniProtKB/Swiss-Prot),   A0A0G2K7H9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074213   ⟸   ENSRNOT00000080309
Ensembl Acc Id: ENSRNOP00000003198   ⟸   ENSRNOT00000003198
RefSeq Acc Id: XP_038946212   ⟸   XM_039090284
- Peptide Label: isoform X2
- UniProtKB: A6JGQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946210   ⟸   XM_039090282
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q1K3 (UniProtKB/TrEMBL),   A0A0G2K7H9 (UniProtKB/TrEMBL)
Protein Domains
KA1   Protein kinase   UBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08678-F1-model_v2 AlphaFold O08678 1-793 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619882 AgrOrtholog
BioCyc Gene G2FUF-16995 BioCyc
Ensembl Genes ENSRNOG00000002339 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000003198 ENTREZGENE
  ENSRNOT00000080309 ENTREZGENE
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot
  Kinase associated domain 1, KA1 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro KA1/Ssp2_C UniProtKB/Swiss-Prot
  KA1_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MARK1-4_cat UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
KEGG Report rno:117016 UniProtKB/Swiss-Prot
NCBI Gene 117016 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/Swiss-Prot
  PTHR24346:SF21 UniProtKB/Swiss-Prot
Pfam KA1 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
PhenoGen Mark1 PhenoGen
PROSITE KA1 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002339 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103243 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0G2K7H9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q1K3 ENTREZGENE, UniProtKB/TrEMBL
  A6JGQ0_RAT UniProtKB/TrEMBL
  A6JGQ1 ENTREZGENE, UniProtKB/TrEMBL
  MARK1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Mark1  microtubule affinity regulating kinase 1  Mark1  MAP/microtubule affinity-regulating kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Mark1  MAP/microtubule affinity-regulating kinase 1      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Mark1  MAP/microtubule affinity-regulating kinase 1      Symbol and Name status set to provisional 70820 PROVISIONAL