MARK1 (microtubule affinity regulating kinase 1) - Rat Genome Database

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Gene: MARK1 (microtubule affinity regulating kinase 1) Chlorocebus sabaeus
Analyze
Symbol: MARK1
Name: microtubule affinity regulating kinase 1
RGD ID: 18533224
Description: ENCODES a protein that exhibits protein kinase activity (ortholog); INVOLVED IN cytoskeleton organization (ortholog); negative regulation of gene expression (ortholog); neuron migration (ortholog); ASSOCIATED WITH autistic disorder (ortholog); gastrointestinal stromal tumor (ortholog); Loeys-Dietz syndrome 4 (ortholog); FOUND IN cytoskeleton (ortholog); glutamatergic synapse (ortholog); postsynapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase MARK1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1258,876,945 - 9,019,780 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl258,879,201 - 9,019,598 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660559,155,904 - 9,298,871 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MARK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1258,876,945 - 9,019,780 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl258,879,201 - 9,019,598 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660559,155,904 - 9,298,871 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MARK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381220,528,136 - 220,664,461 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1220,528,136 - 220,664,461 (+)EnsemblGRCh38hg38GRCh38
GRCh371220,701,478 - 220,837,803 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361218,768,191 - 218,904,422 (+)NCBINCBI36Build 36hg18NCBI36
Build 341217,089,962 - 217,225,667NCBI
Celera1193,920,723 - 194,057,269 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1191,375,808 - 191,512,424 (+)NCBIHuRef
CHM1_11221,974,021 - 222,110,252 (+)NCBICHM1_1
T2T-CHM13v2.01219,767,527 - 219,904,166 (+)NCBIT2T-CHM13v2.0
Mark1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391184,628,621 - 184,732,152 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1184,628,986 - 184,731,767 (-)EnsemblGRCm39 Ensembl
GRCm381184,896,424 - 184,999,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1184,896,789 - 184,999,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv371186,720,303 - 186,823,428 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361186,598,391 - 186,700,267 (-)NCBIMGSCv36mm8
Celera1191,860,242 - 191,963,269 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map189.26NCBI
Mark1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81398,981,727 - 99,086,998 (-)NCBIGRCr8
mRatBN7.21396,450,189 - 96,555,304 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1396,451,487 - 96,555,173 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1398,957,791 - 99,061,914 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013100,356,587 - 100,460,278 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01397,540,024 - 97,644,155 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013102,808,254 - 102,942,863 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13102,808,253 - 102,942,863 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013107,485,344 - 107,589,704 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413100,905,369 - 101,009,161 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113101,094,411 - 101,198,263 (-)NCBI
Celera1395,968,489 - 96,018,212 (-)NCBICelera
Cytogenetic Map13q26NCBI
Mark1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555203,086,887 - 3,205,525 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555203,087,581 - 3,205,525 (-)NCBIChiLan1.0ChiLan1.0
MARK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2128,735,310 - 28,871,788 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1128,697,135 - 28,833,583 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01196,114,714 - 196,251,166 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11201,150,316 - 201,286,201 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1201,150,310 - 201,286,201 (+)Ensemblpanpan1.1panPan2
MARK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13815,270,523 - 15,341,934 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3815,273,004 - 15,340,448 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3815,268,336 - 15,385,001 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03815,263,226 - 15,379,605 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3815,262,280 - 15,379,579 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13815,270,806 - 15,387,062 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03815,625,161 - 15,741,308 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03815,905,948 - 16,022,402 (+)NCBIUU_Cfam_GSD_1.0
Mark1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934456,357,812 - 56,419,056 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366501,605,487 - 1,667,297 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366501,607,480 - 1,672,591 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl109,980,383 - 10,104,867 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1109,980,277 - 10,106,507 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Mark1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248353,986,642 - 4,101,388 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248353,987,023 - 4,101,428 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 20 60
Low 16 16
Below cutoff 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000013952   ⟹   ENSCSAP00000011934
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl258,879,201 - 9,019,598 (-)Ensembl
RefSeq Acc Id: XM_007988393   ⟹   XP_007986584
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1258,876,945 - 9,019,780 (-)NCBI
Vero_WHO_p1.0NW_0236660559,155,904 - 9,298,824 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988394   ⟹   XP_007986585
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1258,876,945 - 9,019,780 (-)NCBI
Vero_WHO_p1.0NW_0236660559,156,158 - 9,298,824 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988395   ⟹   XP_007986586
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1258,876,945 - 9,019,222 (-)NCBI
Vero_WHO_p1.0NW_0236660559,155,904 - 9,298,871 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988396   ⟹   XP_007986587
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1258,876,945 - 9,019,780 (-)NCBI
Vero_WHO_p1.0NW_0236660559,156,158 - 9,298,824 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037985549   ⟹   XP_037841477
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660559,155,904 - 9,298,869 (-)NCBI
RefSeq Acc Id: XM_037985550   ⟹   XP_037841478
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660559,155,904 - 9,298,389 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_007986587   ⟸   XM_007988396
- Peptide Label: isoform X4
RefSeq Acc Id: XP_007986585   ⟸   XM_007988394
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RTJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007986584   ⟸   XM_007988393
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007986586   ⟸   XM_007988395
- Peptide Label: isoform X3
RefSeq Acc Id: ENSCSAP00000011934   ⟸   ENSCSAT00000013952
RefSeq Acc Id: XP_037841477   ⟸   XM_037985549
- Peptide Label: isoform X5
RefSeq Acc Id: XP_037841478   ⟸   XM_037985550
- Peptide Label: isoform X6


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015860 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013952.1 UniProtKB/TrEMBL
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
  Kinase associated domain 1, KA1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro KA1/Ssp2_C UniProtKB/TrEMBL
  KA1_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  MARK1-4_cat UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
NCBI Gene MARK1 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  PTHR24346:SF21 UniProtKB/TrEMBL
Pfam KA1 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
PROSITE KA1 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
Superfamily-SCOP SSF103243 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9RTJ5 ENTREZGENE, UniProtKB/TrEMBL