Lgmn (legumain) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Lgmn (legumain) Rattus norvegicus
Analyze
Symbol: Lgmn
Name: legumain
RGD ID: 619832
Description: Enables cysteine-type endopeptidase activity. Predicted to be involved in several processes, including learning or memory; positive regulation of chemotaxis; and proteolysis. Predicted to act upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; negative regulation of neuron apoptotic process; and response to acidic pH. Located in lysosome. Orthologous to human LGMN (legumain); PARTICIPATES IN antigen processing and presentation pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: asparaginyl endopeptidase; MGC105274; protease, cysteine 1; protease, cysteine, 1 (legumain); Prsc1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86127,308,913 - 127,347,355 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6127,308,913 - 127,347,328 (-)EnsemblGRCr8
mRatBN7.26121,544,048 - 121,582,495 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,544,053 - 121,582,480 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6121,684,520 - 121,722,056 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,979,783 - 122,017,312 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06121,315,105 - 121,353,227 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06126,282,246 - 126,308,207 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,282,233 - 126,320,726 (-)Ensemblrn6Rnor6.0
Rnor_5.06135,492,943 - 135,518,916 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46126,668,905 - 126,694,866 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6119,032,612 - 119,058,582 (-)NCBICelera
RGSC_v3.16126,672,651 - 126,698,616 (-)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aconitine  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
curcumin  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
dopamine  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
eugenol  (EXP)
Evodiamine  (ISO)
fenoldopam  (EXP)
folic acid  (ISO)
fonofos  (ISO)
gardiquimod  (ISO)
gentamycin  (EXP)
imiquimod  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nimesulide  (EXP)
nitrogen dioxide  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenacetin  (EXP)
phenylhydrazine  (EXP)
rac-lactic acid  (ISO)
resiquimod  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
temozolomide  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical part of cell  (IEA,ISO)
cytoplasm  (IEA,ISO)
extracellular region  (IEA,ISO)
late endosome  (IEA,ISO)
lysosomal lumen  (IEA,ISO,ISS)
lysosome  (IDA,IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning and expression of mouse legumain, a lysosomal endopeptidase. Chen JM, etal., Biochem J 1998 Oct 1;335 ( Pt 1):111-7.
2. Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase. Chen JM, etal., J Biol Chem. 1997 Mar 21;272(12):8090-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase. Liu Z, etal., Mol Cell. 2008 Mar 28;29(6):665-78. doi: 10.1016/j.molcel.2008.02.017.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:136644   PMID:9821970   PMID:12477932   PMID:12775715   PMID:17350006   PMID:18377911   PMID:20234379   PMID:21237226   PMID:21292981   PMID:21610319   PMID:22718532   PMID:23533145  
PMID:25326800   PMID:30676070   PMID:31521890  


Genomics

Comparative Map Data
Lgmn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86127,308,913 - 127,347,355 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6127,308,913 - 127,347,328 (-)EnsemblGRCr8
mRatBN7.26121,544,048 - 121,582,495 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,544,053 - 121,582,480 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6121,684,520 - 121,722,056 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,979,783 - 122,017,312 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06121,315,105 - 121,353,227 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06126,282,246 - 126,308,207 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,282,233 - 126,320,726 (-)Ensemblrn6Rnor6.0
Rnor_5.06135,492,943 - 135,518,916 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46126,668,905 - 126,694,866 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6119,032,612 - 119,058,582 (-)NCBICelera
RGSC_v3.16126,672,651 - 126,698,616 (-)NCBI
Cytogenetic Map6q32NCBI
LGMN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381492,703,809 - 92,748,627 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1492,703,798 - 92,751,131 (-)Ensemblhg38GRCh38
GRCh371493,170,154 - 93,214,972 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361492,239,907 - 92,284,765 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341492,239,909 - 92,284,765NCBI
Celera1473,224,285 - 73,269,160 (-)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1473,353,202 - 73,398,165 (-)NCBIHuRef
CHM1_11493,108,397 - 93,153,238 (-)NCBICHM1_1
T2T-CHM13v2.01486,935,604 - 86,980,392 (-)NCBIT2T-CHM13v2.0
Lgmn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912102,360,341 - 102,405,987 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12102,360,343 - 102,406,072 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3812102,394,082 - 102,439,728 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12102,394,084 - 102,439,813 (-)Ensemblmm10GRCm38
MGSCv3712103,632,308 - 103,677,907 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612102,795,148 - 102,840,747 (-)NCBIMGSCv36mm8
Celera12103,611,726 - 103,647,892 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1251.45NCBI
Lgmn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543814,905,856 - 14,939,256 (-)Ensembl
ChiLan1.0NW_00495543814,905,856 - 14,938,722 (-)NCBIChiLan1.0ChiLan1.0
LGMN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21593,861,233 - 93,907,416 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11493,077,738 - 93,123,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01473,337,607 - 73,383,462 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11492,677,608 - 92,723,051 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1492,677,608 - 92,723,051 (-)EnsemblpanPan2panpan1.1
LGMN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.181,810,263 - 1,843,116 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl81,728,273 - 1,843,050 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha81,834,051 - 1,866,767 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.081,864,425 - 1,878,822 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl81,782,672 - 1,889,344 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.181,802,050 - 1,834,797 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.081,752,395 - 1,785,146 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.081,879,451 - 1,912,213 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lgmn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864012,674,224 - 12,694,251 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936733772,708 - 792,995 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936733772,764 - 792,792 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGMN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7114,173,693 - 114,217,102 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17114,176,217 - 114,210,096 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27120,780,926 - 120,811,668 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LGMN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12470,456,463 - 70,500,345 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2470,456,095 - 70,486,087 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605357,705,088 - 57,748,692 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgmn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247349,204,790 - 9,240,309 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247349,207,496 - 9,240,026 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lgmn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17113,679,420 - 113,717,580 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lgmn
191 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:198
Count of miRNA genes:149
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000010101
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
D6Hmgc6  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86127,335,269 - 127,335,620 (+)Marker Load Pipeline
mRatBN7.26121,570,409 - 121,570,760 (+)MAPPERmRatBN7.2
Rnor_6.06126,308,599 - 126,308,949NCBIRnor6.0
Rnor_5.06135,519,308 - 135,519,658UniSTSRnor5.0
Celera6119,058,974 - 119,059,323UniSTS
Cytogenetic Map6q32UniSTS
RH140587  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26121,546,683 - 121,546,892 (+)MAPPERmRatBN7.2
Rnor_6.06126,284,877 - 126,285,085NCBIRnor6.0
Rnor_5.06135,495,574 - 135,495,782UniSTSRnor5.0
RGSC_v3.46126,671,536 - 126,671,744UniSTSRGSC3.4
Celera6119,035,243 - 119,035,451UniSTS
RH 3.4 Map6852.2UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010101   ⟹   ENSRNOP00000010101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6127,308,913 - 127,347,328 (-)Ensembl
mRatBN7.2 Ensembl6121,544,053 - 121,582,480 (-)Ensembl
Rnor_6.0 Ensembl6126,282,233 - 126,320,726 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103783   ⟹   ENSRNOP00000084412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6127,308,913 - 127,347,328 (-)Ensembl
mRatBN7.2 Ensembl6121,544,053 - 121,582,480 (-)Ensembl
RefSeq Acc Id: NM_022226   ⟹   NP_071562
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86127,308,913 - 127,347,328 (-)NCBI
mRatBN7.26121,544,048 - 121,582,468 (-)NCBI
Rnor_6.06126,282,246 - 126,308,207 (-)NCBI
Rnor_5.06135,492,943 - 135,518,916 (-)NCBI
RGSC_v3.46126,668,905 - 126,694,866 (-)RGD
Celera6119,032,612 - 119,058,582 (-)RGD
Sequence:
RefSeq Acc Id: XM_039112870   ⟹   XP_038968798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86127,308,918 - 127,347,355 (-)NCBI
mRatBN7.26121,544,053 - 121,582,495 (-)NCBI
RefSeq Acc Id: NP_071562   ⟸   NM_022226
- Peptide Label: precursor
- UniProtKB: Q9R0J8 (UniProtKB/Swiss-Prot),   Q9JLN3 (UniProtKB/Swiss-Prot),   Q5PPG2 (UniProtKB/TrEMBL),   A6JEK1 (UniProtKB/TrEMBL),   F7EX67 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010101   ⟸   ENSRNOT00000010101
RefSeq Acc Id: XP_038968798   ⟸   XM_039112870
- Peptide Label: isoform X1
- UniProtKB: Q9R0J8 (UniProtKB/Swiss-Prot),   Q9JLN3 (UniProtKB/Swiss-Prot),   Q5PPG2 (UniProtKB/TrEMBL),   A6JEK1 (UniProtKB/TrEMBL),   F7EX67 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084412   ⟸   ENSRNOT00000103783
Protein Domains
Legumain prodomain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R0J8-F1-model_v2 AlphaFold Q9R0J8 1-435 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619832 AgrOrtholog
BioCyc Gene G2FUF-36453 BioCyc
Ensembl Genes ENSRNOG00000007089 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000010101 ENTREZGENE
Gene3D-CATH 1.10.132.130 UniProtKB/Swiss-Prot
  3.40.50.1460 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7315308 IMAGE-MGC_LOAD
InterPro IPR043577 UniProtKB/Swiss-Prot
  Legum_prodom UniProtKB/Swiss-Prot
  Legumain_prodom_sf UniProtKB/Swiss-Prot
  Peptidase_C13 UniProtKB/Swiss-Prot
KEGG Report rno:63865 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105274 IMAGE-MGC_LOAD
NCBI Gene 63865 ENTREZGENE
PANTHER LEGUMAIN UniProtKB/Swiss-Prot
  PTHR12000 UniProtKB/Swiss-Prot
Pfam Legum_prodom UniProtKB/Swiss-Prot
  Peptidase_C13 UniProtKB/Swiss-Prot
PhenoGen Lgmn PhenoGen
PIRSF Legumain UniProtKB/Swiss-Prot
  PIRSF500139 UniProtKB/Swiss-Prot
PRINTS HEMOGLOBNASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007089 RatGTEx
UniProt A0A8I6A185_RAT UniProtKB/TrEMBL
  A6JEK0_RAT UniProtKB/TrEMBL
  A6JEK1 ENTREZGENE, UniProtKB/TrEMBL
  F7EX67 ENTREZGENE, UniProtKB/TrEMBL
  LGMN_RAT UniProtKB/Swiss-Prot
  Q5PPG2 ENTREZGENE
  Q9JLN3 ENTREZGENE
  Q9R0J8 ENTREZGENE
UniProt Secondary Q9JLN3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-04-22 Lgmn  legumain  Prsc1  protease, cysteine, 1 (legumain)  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 Prsc1  protease, cysteine, 1 (legumain)      Symbol and Name status set to provisional 70820 PROVISIONAL