Lgmn (legumain) - Rat Genome Database

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Gene: Lgmn (legumain) Heterocephalus glaber
Analyze
Symbol: Lgmn
Name: legumain
RGD ID: 18922222
Description: ENCODES a protein that exhibits endopeptidase activator activity (ortholog); peptidase activity (ortholog); INVOLVED IN antigen processing and presentation of exogenous peptide antigen via MHC class II (ortholog); associative learning (ortholog); cellular response to amyloid-beta (ortholog); ASSOCIATED WITH achondrogenesis type IA (ortholog); Experimental Liver Cirrhosis (ortholog); High Myopia (ortholog); FOUND IN apical part of cell (ortholog); cytoplasm (ortholog); extracellular region (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: legumain preproprotein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247349,204,790 - 9,240,309 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247349,207,496 - 9,240,026 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Lgmn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247349,204,790 - 9,240,309 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247349,207,496 - 9,240,026 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
LGMN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381492,703,809 - 92,748,627 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1492,703,807 - 92,748,679 (-)EnsemblGRCh38hg38GRCh38
GRCh371493,170,154 - 93,214,972 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361492,239,907 - 92,284,765 (-)NCBINCBI36Build 36hg18NCBI36
Build 341492,239,909 - 92,284,765NCBI
Celera1473,224,285 - 73,269,160 (-)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1473,353,202 - 73,398,165 (-)NCBIHuRef
CHM1_11493,108,397 - 93,153,238 (-)NCBICHM1_1
T2T-CHM13v2.01486,935,604 - 86,980,392 (-)NCBIT2T-CHM13v2.0
Lgmn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912102,360,341 - 102,405,987 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12102,360,343 - 102,406,072 (-)EnsemblGRCm39 Ensembl
GRCm3812102,394,082 - 102,439,728 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12102,394,084 - 102,439,813 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712103,632,308 - 103,677,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612102,795,148 - 102,840,747 (-)NCBIMGSCv36mm8
Celera12103,611,726 - 103,647,892 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1251.45NCBI
Lgmn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86127,308,913 - 127,347,355 (-)NCBIGRCr8
mRatBN7.26121,544,048 - 121,582,495 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,544,053 - 121,582,480 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6121,684,520 - 121,722,056 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,979,783 - 122,017,312 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06121,315,105 - 121,353,227 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06126,282,246 - 126,308,207 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,282,233 - 126,320,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,492,943 - 135,518,916 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46126,668,905 - 126,694,866 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16126,672,651 - 126,698,616 (-)NCBI
Celera6119,032,612 - 119,058,582 (-)NCBICelera
Cytogenetic Map6q32NCBI
Lgmn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543814,905,856 - 14,939,256 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543814,905,856 - 14,938,722 (-)NCBIChiLan1.0ChiLan1.0
LGMN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21593,861,233 - 93,907,416 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11493,077,738 - 93,123,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01473,337,607 - 73,383,462 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11492,677,608 - 92,723,051 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1492,677,608 - 92,723,051 (-)Ensemblpanpan1.1panPan2
LGMN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.181,810,263 - 1,843,116 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl81,728,273 - 1,843,050 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha81,834,051 - 1,866,767 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.081,864,425 - 1,878,822 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl81,782,672 - 1,889,344 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.181,802,050 - 1,834,797 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.081,752,395 - 1,785,146 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.081,879,451 - 1,912,213 (-)NCBIUU_Cfam_GSD_1.0
Lgmn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864012,674,224 - 12,694,251 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936733772,708 - 792,995 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936733772,764 - 792,792 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGMN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7114,173,693 - 114,217,102 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17114,176,217 - 114,210,096 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27120,780,926 - 120,811,668 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LGMN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12470,456,463 - 70,500,345 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2470,456,095 - 70,486,087 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605357,705,088 - 57,748,692 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000014323   ⟹   ENSHGLP00000014180
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247349,204,790 - 9,240,309 (-)Ensembl
RefSeq Acc Id: XM_004837027   ⟹   XP_004837084
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247349,207,496 - 9,240,026 (-)NCBI
RefSeq Acc Id: XM_021244852   ⟹   XP_021100511
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247349,207,496 - 9,239,789 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004837084 (Get FASTA)   NCBI Sequence Viewer  
  XP_021100511 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB03642 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000014180
  ENSHGLP00000029609
  ENSHGLP00100050576
GenBank Protein JAO03505 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004837084   ⟸   XM_004837027
- UniProtKB: G5B2X4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100511   ⟸   XM_021244852
- UniProtKB: G5B2X4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000014180   ⟸   ENSHGLT00000014323


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010132 Ensembl, ENTREZGENE
  ENSHGLG00000048497 UniProtKB/TrEMBL
  ENSHGLG00100044301 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000014323 ENTREZGENE
  ENSHGLT00000078581 UniProtKB/TrEMBL
  ENSHGLT00100054052 UniProtKB/TrEMBL
Gene3D-CATH 1.10.132.130 UniProtKB/TrEMBL
  3.40.50.1460 UniProtKB/TrEMBL
InterPro IPR043577 UniProtKB/TrEMBL
  Legum_prodom UniProtKB/TrEMBL
  Legumain_prodom_sf UniProtKB/TrEMBL
  Peptidase_C13 UniProtKB/TrEMBL
KEGG Report hgl:101698288 UniProtKB/TrEMBL
NCBI Gene Lgmn ENTREZGENE
PANTHER LEGUMAIN UniProtKB/TrEMBL
  PTHR12000 UniProtKB/TrEMBL
Pfam Legum_prodom UniProtKB/TrEMBL
  Peptidase_C13 UniProtKB/TrEMBL
PIRSF Legumain UniProtKB/TrEMBL
  PIRSF500139 UniProtKB/TrEMBL
PRINTS HEMOGLOBNASE UniProtKB/TrEMBL
UniProt G5B2X4 ENTREZGENE, UniProtKB/TrEMBL