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Gene: Klrg1 (killer cell lectin like receptor G1) Rattus norvegicus

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Symbol:

Klrg1

Name:

killer cell lectin like receptor G1

RGD ID:

61978

Description:

Enables carbohydrate binding activity. Predicted to be involved in innate immune response. Predicted to be located in plasma membrane. Orthologous to human KLRG1 (killer cell lectin like receptor G1); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

killer cell lectin-like receptor subfamily G member 1; killer cell lectin-like receptor subfamily G, member 1; MAFA; mast cell function-associated antigen

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	157,127,571 - 157,139,372 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	157,127,571 - 157,139,372 (-)	Ensembl				GRCr8
mRatBN7.2	4	155,455,465 - 155,467,301 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	155,455,495 - 155,467,424 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	161,720,032 - 161,731,009 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	157,503,490 - 157,514,467 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	156,147,473 - 156,158,452 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	155,038,936 - 155,051,449 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	155,039,628 - 155,051,429 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	222,068,701 - 222,080,449 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	158,673,698 - 158,684,674 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	144,276,745 - 144,287,819 (-)	NCBI		Celera
RGSC_v3.1	4	158,917,862 - 158,929,749 (-)	NCBI
Cytogenetic Map	4	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

17beta-estradiol (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,6-trinitrotoluene (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-methylcholine (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

benzene-1,2,4-triol (ISO)

benzo[a]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

beta-naphthoflavone (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

D-glucose (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

Didecyldimethylammonium (ISO)

esketamine (ISO)

fentin chloride (EXP)

formaldehyde (EXP)

fructose (ISO)

furan (EXP)

gentamycin (EXP)

glucose (ISO)

glufosinate (ISO)

glyphosate (ISO)

GSK-J4 (ISO)

indometacin (ISO)

leflunomide (EXP)

lipopolysaccharide (ISO)

nickel atom (ISO)

okadaic acid (ISO)

paracetamol (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

propanal (ISO)

propiconazole (EXP)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

triadimefon (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

tunicamycin (ISO)

valdecoxib (EXP)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

immune system process (IEA)

innate immune response (IEA)

Cellular Component

plasma membrane (IEA)

Molecular Function

carbohydrate binding (IDA,IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	An unusual inhibitory receptor--the mast cell function-associated antigen (MAFA).	Abramson J, etal., Mol Immunol 2002 Sep;38(16-18):1307-13.
2.	Analysis of the genes encoding the mast cell function-associated antigen and its alternatively spliced transcripts.	Bocek P Jr, etal., J Immunol 1997 Apr 1;158(7):3235-43.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	A secretion inhibitory signal transduction molecule on mast cells is another C-type lectin.	Guthmann MD, etal., Proc Natl Acad Sci U S A 1995 Sep 26;92(20):9397-401.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Interactions of the mast cell function-associated antigen with the type I Fcepsilon receptor.	Song J, etal., Mol Immunol 2002 Sep;38(16-18):1315-21.

Additional References at PubMed

PMID:12008030	PMID:15944145	PMID:16407976	PMID:16797115	PMID:16934222	PMID:17149590	PMID:23424659

Genomics

Comparative Map Data

Klrg1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	157,127,571 - 157,139,372 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	157,127,571 - 157,139,372 (-)	Ensembl				GRCr8
mRatBN7.2	4	155,455,465 - 155,467,301 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	155,455,495 - 155,467,424 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	161,720,032 - 161,731,009 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	157,503,490 - 157,514,467 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	156,147,473 - 156,158,452 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	155,038,936 - 155,051,449 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	155,039,628 - 155,051,429 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	222,068,701 - 222,080,449 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	158,673,698 - 158,684,674 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	144,276,745 - 144,287,819 (-)	NCBI		Celera
RGSC_v3.1	4	158,917,862 - 158,929,749 (-)	NCBI
Cytogenetic Map	4	q42	NCBI

KLRG1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	8,950,044 - 9,215,570 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	8,950,044 - 9,010,760 (+)	Ensembl			hg38	GRCh38
GRCh37	12	9,102,640 - 9,163,347 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	9,033,488 - 9,054,610 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	9,033,487 - 9,054,605	NCBI
Celera	12	10,679,601 - 10,700,699 (+)	NCBI		Celera
Cytogenetic Map	12	p13.31	NCBI
HuRef	12	8,922,782 - 8,943,883 (+)	NCBI		HuRef
CHM1_1	12	9,111,184 - 9,132,306 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	8,932,277 - 9,198,833 (+)	NCBI		T2T-CHM13v2.0

Klrg1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	122,247,555 - 122,259,792 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	122,247,555 - 122,259,841 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	122,270,596 - 122,282,833 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	122,270,596 - 122,282,882 (-)	Ensembl			mm10	GRCm38
MGSCv37	6	122,220,614 - 122,232,851 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	122,236,215 - 122,248,452 (-)	NCBI		MGSCv36	mm8
Celera	6	124,065,284 - 124,077,222 (-)	NCBI		Celera
Cytogenetic Map	6	F1	NCBI
cM Map	6	57.52	NCBI

Klrg1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	6,118,611 - 6,129,441 (-)	Ensembl
ChiLan1.0	NW_004955413	6,119,299 - 6,131,907 (-)	NCBI	ChiLan1.0	ChiLan1.0

KLRG1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	14,476,812 - 14,548,917 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	14,473,385 - 14,545,676 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	9,034,918 - 9,288,351 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	9,266,365 - 9,326,522 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	9,305,401 - 9,326,513 (+)	Ensembl			panPan2	panpan1.1

KLRG1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	36,741,379 - 36,781,049 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	36,741,767 - 36,766,637 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	9,836,039 - 9,875,380 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	37,089,990 - 37,129,244 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	37,089,607 - 37,135,745 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	36,970,671 - 36,999,130 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	37,005,930 - 37,044,896 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	9,367,567 - 9,406,590 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Klrg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	98,418,251 - 98,460,460 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936870	339,521 - 353,207 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936870	339,526 - 352,807 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KLRG1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	62,507,507 - 62,523,810 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	62,506,001 - 62,523,969 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	65,412,861 - 65,431,926 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KLRG1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	8,808,676 - 8,829,406 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	8,808,943 - 8,828,685 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666089	905,432 - 925,974 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Klrg1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624860	4,687,306 - 4,695,627 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624860	4,686,589 - 4,696,738 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Klrg1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	24,823,233 - 24,834,106 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Klrg1
49 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	72
Count of miRNA genes:	69
Interacting mature miRNAs:	70
Transcripts:	ENSRNOT00000020094
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	146370897	184426481	Rat
724558	Plsm2	Polydactyly-luxate syndrome (PLS) morphotypes QTL 2		0.0003	hindlimb integrity trait (VT:0010563)	hind foot phalanges count (CMO:0001949)	4	134095016	179095016	Rat
1582237	Kidm34	Kidney mass QTL 34	4	0.0001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	4	149763204	169799698	Rat
61446	Coreg2	Compensatory renal growth QTL 2	3.5		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	4	150095743	159267220	Rat
6478757	Anxrr44	Anxiety related response QTL 44		0.01087	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	146370897	184426481	Rat
1358364	Sradr4	Stress Responsive Adrenal Weight QTL 4	4.92		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	131384565	176384565	Rat
6478763	Anxrr46	Anxiety related response QTL 46		0.07428	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
6478760	Anxrr45	Anxiety related response QTL 45		0.06717	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
61451	Ciaa4	CIA Autoantibody QTL 4	3.1		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	4	123870974	168870974	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	140059299	181024663	Rat
1331802	Srn5	Serum renin concentration QTL 5	3.045		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	4	117559384	162559384	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	106848959	168870974	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	94638356	168870820	Rat
7411558	Bw133	Body weight QTL 133	13.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	127263297	172263297	Rat
6478778	Anxrr51	Anxiety related response QTL 51		0.25384	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	126334185	171334185	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	147299608	184426481	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
6478782	Anxrr52	Anxiety related response QTL 52		0.02091	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
631511	Pia7	Pristane induced arthritis QTL 7	4.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
634347	Hcar8	Hepatocarcinoma resistance QTL 8	5.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	124700988	169700988	Rat
6478720	Alc23	Alcohol consumption QTL 23		0.00509	drinking behavior trait (VT:0001422)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	155834926	184426481	Rat
6478785	Anxrr53	Anxiety related response QTL 53		0.01397	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	100752691	179366077	Rat
1581566	Eae21	Experimental allergic encephalomyelitis QTL 21	6.2		body mass (VT:0001259)	maximum body weight loss to initial body weight ratio (CMO:0001400)	4	137447185	182447185	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	45429709	157555683	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	137430611	182430611	Rat
6478728	Anxrr36	Anxiety related response QTL 36		0.01061	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	86709649	168870974	Rat
61422	Cia13	Collagen induced arthritis QTL 13	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	134199006	168870974	Rat
634342	Cia24	Collagen induced arthritis QTL 24	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	148121375	176967367	Rat
6478733	Anxrr37	Anxiety related response QTL 37		0.00095	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
737978	Pia23	Pristane induced arthritis QTL 23	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	65495851	159259805	Rat
6478737	Anxrr38	Anxiety related response QTL 38		0.00159	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	116184844	161184844	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
12798525	Anxrr57	Anxiety related response QTL 57	3.21	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	148834094	168870974	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
7	9	32	44	77	80	50	91	50	4	254	150	11	21	42	56	30	1	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031649	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC127013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X79812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X97191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X97192	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X97194	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X97195	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000020094 ⟹ ENSRNOP00000020094

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	157,127,571 - 157,139,372 (-)	Ensembl
mRatBN7.2 Ensembl	4	155,455,495 - 155,467,424 (-)	Ensembl
Rnor_6.0 Ensembl	4	155,039,628 - 155,051,429 (-)	Ensembl

RefSeq Acc Id:

NM_031649 ⟹ NP_113837

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	157,127,571 - 157,139,372 (-)	NCBI
mRatBN7.2	4	155,455,494 - 155,467,294 (-)	NCBI
Rnor_6.0	4	155,040,400 - 155,051,376 (-)	NCBI
Rnor_5.0	4	222,068,701 - 222,080,449 (-)	NCBI
RGSC_v3.4	4	158,673,698 - 158,684,674 (-)	RGD
Celera	4	144,276,745 - 144,287,819 (-)	RGD

Sequence:

show sequence

ATGGCCGACAACTCTATCTACTCAACATTAGAGCTGCCTGCTGCACCTCGAGTCCAAGATGACT
CCAGATGGAAGGTCAAAGCTGTCTTACACCGACCCTGTGTTTCCTACCTTGTGATGGTGGCTTT
GGGGCTTTTGACTGTGATTCTCATGAGTCTACTGTTGTACCAACGGACTCTGTGCTGTGGCTCC
AAGGGCTTTATGTGTTCCCAGTGCTCCAGGTGCCCCAACCTCTGGATGAGGAACGGGAGCCACT
GTTACTACTTCTCAATGGAGAAAAGGGACTGGAACTCTAGTCTGAAGTTCTGTGCAGACAAAGG
CTCGCATCTCCTTACATTTCCGGACAACCAGGGAGTGAACCTGTTCCAGGAGTATGTGGGCGAG
GACTTTTACTGGATTGGCTTGAGGGACATCGATGGCTGGAGGTGGGAAGATGGCCCAGCTCTCA
GCTTAAGCATTCTCTCTAACAGCGTGGTACAGAAGTGTGGCACCATCCACAGGTGTGGCCTCCA
CGCCTCCAGTTGTGAGGTTGCTTTGCAGTGGATCTGTGAGAAGGTCCTGCCCTGA

hide sequence

RefSeq Acc Id:

XM_006237313 ⟹ XP_006237375

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	157,127,571 - 157,139,364 (-)	NCBI
mRatBN7.2	4	155,455,465 - 155,467,301 (-)	NCBI
Rnor_6.0	4	155,038,936 - 155,051,449 (-)	NCBI
Rnor_5.0	4	222,068,701 - 222,080,449 (-)	NCBI

Sequence:

show sequence

TTCCTCACGGGTGCTGATCTCACCCTGCTTACTGTCGTCACTCCCTGCTGAGTGTGAAGGGCGT
TGGGTGGAGATGGCCGACAACTCTATCTACTCAACATTAGAGCTGCCTGCTGCACCTCGAGTCC
AAGATGACTCCAGATGGAAGGTCAAAGGCTCCAAGGGCTTTATGTGTTCCCAGTGCTCCAGGTG
CCCCAACCTCTGGATGAGGAACGGGAGCCACTGTTACTACTTCTCAATGGAGAAAAGGGACTGG
AACTCTAGTCTGAAGTTCTGTGCAGACAAAGGCTCGCATCTCCTTACATTTCCGGACAACCAGG
GAGTGAACCTGTTCCAGGAGTATGTGGGCGAGGACTTTTACTGGATTGGCTTGAGGGACATCGA
TGGCTGGAGGTGGGAAGATGGCCCAGCTCTCAGCTTAAGCATTCTCTCTAACAGCGTGGTACAG
AAGTGTGGCACCATCCACAGGTGTGGCCTCCACGCCTCCAGTTGTGAGGTTGCTTTGCAGTGGA
TCTGTGAGAAGGTCCTGCCCTGAAGGATTCCACTGTGTCCCAAGCCTCAGATCTGCCACATGTC
TTCAAAAAGAGGGAATGGGCATGGGGAACCTCTGTTCACAAAGGTGTCTTTAGCAAATGCCAAA
CCTGTTATGATATGCCATTAGACAGGCGTTAGCATTCCTTCCTGGGAGCTGGCATTTTTCAACT
GGGCTTTCTCAGTCATGTTAGCCATTTAAAGCCTAAATCTGGGCAAATGAAATAGATAAAATTT
ATTTTGATGGCTCTTACTGCACAAACTCACCCTGGCTTTCTCATCCCATACTCTGCCATATCTA
TCAAAGATATGTGCAAAACTATTCATCTGCAGAAGAACCCCCACCACGGTCAATAACACATTAC
ATAGACATCGAGTAGAGACAGAAAAGCAAACACCTCCTGTTCTCACTCCTGCTTGGAAGCTGAA
GTAGCTCAAGCCTGAGGTGTAGGGAGAAGTGCAGTGGTTACCAGAGTCCAGGAGACTGAAGGGA
TGGTAGAGGTTGGTTAATGGTTTGGCTGGTGTGGGGTGACCATCATGATTAATGATTGTTGTAT
GTTTGCCAATATGTTGTGAACTTCCGGATAGCGAGGTGGAAGGACCGTGGGTGTTACCAAATGC
CTGCAGGAGAGATGTGCTGAGAACCCTGACTGGATGATTTCCACACACATTGAAATATCACACT
GTGCCCCATAAATGTGTACAATCATTATCTATCCCTAATTTCCCTAAAAATTAAAGAAGTCCCA
ATTAAAATAAAAAATACCTTTCTGCTACATGTCTATTTTATATCTGGAATTAATCTGAAGAAGT
GTGTGCATGTAGCATTGGTGAGACCCTTTCCTGTGCACTGTTATGAAGAACATAAACTATGCCA
GCTAATGGTACCTGCCTCCCCCCACCCCACTGCGTATCGTGTGCTAACAGTGGCTTGTGGTGTG
TGGAGTTTTATGCTGAAACACTGCTTGCTGCGAGAAGGCATGGCTCTACAGTGTGGGAAGCAGA
TGACGACAGGATGAAGCTTTCTACTGATTCAGCTGTTCACACTTACCCAGTGACCTGCCCTTAA
TGTAGTTTCTTCAGATACTCCTGCCTGGGTGTGGTTGAAGGAGCCAGTGTGTGACAACAGATTC
TGTTCTACTGGGTGAGTGTGTGATTGTCTTTAGTCTGAGACTGGGCTTCTACAGAGGAAACTTT
ACAGAGGTCATTTATGGGGCTGACTCCTGCCCCGATGCCTCAGAAGTGAGGAGAGACCTCACTA
TTTCTTCTTAGTAGACTTTGGGCACAGGCGAGGAGAGAGCGTATCCTTTGGGTCTACACACAAC
ACAACAGAAGGAAATCTCTGTCTTTTGAGGATGCTGACTGCCATGTTACCCTTCACAGTCATTC
TTCTACCTGTCTATCTCAGCATCTAAGAAAATGCTGACACTTAGCAAACGCTTAATAGACAGAC
TGGTGAATAAAATAA

hide sequence

RefSeq Acc Id:

XM_039108299 ⟹ XP_038964227

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	157,127,571 - 157,139,341 (-)	NCBI
mRatBN7.2	4	155,455,465 - 155,467,263 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_113837	(Get FASTA)	NCBI Sequence Viewer
	XP_006237375	(Get FASTA)	NCBI Sequence Viewer
	XP_038964227	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAA56208	(Get FASTA)	NCBI Sequence Viewer
	CAA65829	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020094
GenBank Protein	Q64335	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_113837 ⟸ NM_031649
- UniProtKB:	Q64335 (UniProtKB/Swiss-Prot), A0A8L2QB90 (UniProtKB/TrEMBL)
- Sequence:	show sequence MADNSIYSTLELPAAPRVQDDSRWKVKAVLHRPCVSYLVMVALGLLTVILMSLLLYQRTLCCGS KGFMCSQCSRCPNLWMRNGSHCYYFSMEKRDWNSSLKFCADKGSHLLTFPDNQGVNLFQEYVGE DFYWIGLRDIDGWRWEDGPALSLSILSNSVVQKCGTIHRCGLHASSCEVALQWICEKVLP hide sequence

RefSeq Acc Id:	XP_006237375 ⟸ XM_006237313
- Peptide Label:	isoform X1
- Sequence:	show sequence MADNSIYSTLELPAAPRVQDDSRWKVKGSKGFMCSQCSRCPNLWMRNGSHCYYFSMEKRDWNSS LKFCADKGSHLLTFPDNQGVNLFQEYVGEDFYWIGLRDIDGWRWEDGPALSLSILSNSVVQKCG TIHRCGLHASSCEVALQWICEKVLP hide sequence

Ensembl Acc Id:

ENSRNOP00000020094 ⟸ ENSRNOT00000020094

RefSeq Acc Id:	XP_038964227 ⟸ XM_039108299
- Peptide Label:	isoform X2

Protein Domains

C-type lectin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q64335-F1-model_v2	AlphaFold	Q64335	1-188	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61978	AgrOrtholog
BioCyc Gene	G2FUF-43160	BioCyc
Ensembl Genes	ENSRNOG00000014918	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000020094	ENTREZGENE
Gene3D-CATH	3.10.100.10	UniProtKB/Swiss-Prot
InterPro	C-type_lectin-like	UniProtKB/Swiss-Prot
	C-type_lectin-like/link_sf	UniProtKB/Swiss-Prot
	CTDL_fold	UniProtKB/Swiss-Prot
	KLRG1	UniProtKB/Swiss-Prot
	NKR-like_CTLD	UniProtKB/Swiss-Prot
KEGG Report	rno:58975	UniProtKB/Swiss-Prot
NCBI Gene	58975	ENTREZGENE
PANTHER	KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY G MEMBER 1	UniProtKB/Swiss-Prot
	PTHR47648	UniProtKB/Swiss-Prot
Pfam	Lectin_C	UniProtKB/Swiss-Prot
PhenoGen	Klrg1	PhenoGen
PROSITE	C_TYPE_LECTIN_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000014918	RatGTEx
SMART	CLECT	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56436	UniProtKB/Swiss-Prot
UniProt	A0A8L2QB90	ENTREZGENE, UniProtKB/TrEMBL
	KLRG1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-20	Klrg1	killer cell lectin like receptor G1	Klrg1	killer cell lectin-like receptor subfamily G, member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Klrg1	killer cell lectin-like receptor subfamily G, member 1			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expression is restricted to mast cells	633098
gene_transcript	single-copy gene that spans 13 kb and consists of five exons	633098

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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