Kcnj2 (potassium inwardly-rectifying channel, subfamily J, member 2) - Rat Genome Database

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Gene: Kcnj2 (potassium inwardly-rectifying channel, subfamily J, member 2) Rattus norvegicus
Analyze
Symbol: Kcnj2
Name: potassium inwardly-rectifying channel, subfamily J, member 2
RGD ID: 61968
Description: Enables inward rectifier potassium channel activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in cellular response to mechanical stimulus; positive regulation of potassium ion transmembrane transport; and regulation of cardiac muscle cell contraction. Located in several cellular components, including T-tubule; dendritic spine; and intercalated disc. Is active in glutamatergic synapse and postsynaptic membrane. Used to study myocardial infarction. Human ortholog(s) of this gene implicated in Andersen-Tawil syndrome; familial atrial fibrillation; familial periodic paralysis; and short QT syndrome. Orthologous to human KCNJ2 (potassium inwardly rectifying channel subfamily J member 2); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inward rectifier K(+) channel Kir2.1; inward rectifier potassium channel 2; IRK-1; Kir2.1; potassium channel, inwardly rectifying subfamily J member 2; potassium channel, inwardly rectifying subfamily J, member 2; potassium voltage-gated channel subfamily J member 2; RBL-IRK1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Kcnj2em2Mcwi ; Kcnj2em4Mcwi
Genetic Models: SS-Kcnj2em4Mcwi ; SS-Kcnj2em2Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81096,560,225 - 96,570,788 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1096,565,600 - 96,570,901 (+)EnsemblGRCr8
mRatBN7.21096,060,834 - 96,071,397 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1096,060,821 - 96,071,445 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10101,129,119 - 101,130,402 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010100,592,089 - 100,593,372 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01096,000,266 - 96,001,549 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01099,429,337 - 99,442,520 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1099,437,436 - 99,439,114 (+)Ensemblrn6Rnor6.0
Rnor_5.01099,125,234 - 99,134,077 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410100,574,985 - 100,576,268 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1094,712,069 - 94,713,352 (+)NCBICelera
RGSC_v3.110100,589,354 - 100,590,638 (+)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atenolol  (ISO)
barium chloride  (EXP)
barium(0)  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
clofibrate  (ISO)
crocidolite asbestos  (ISO)
daunorubicin  (ISO)
diallyl disulfide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
halothane  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitroprusside  (EXP)
paracetamol  (EXP,ISO)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
potassium atom  (EXP,ISO)
propranolol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tribromoethanol  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
neuron-to-neuron signaling pathway via the chemical synapse  (IEP)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Novel KCNJ2 mutation in familial periodic paralysis with ventricular dysrhythmia. Ai T, etal., Circulation. 2002 Jun 4;105(22):2592-4.
2. Kir2.6 regulates the surface expression of Kir2.x inward rectifier potassium channels. Dassau L, etal., J Biol Chem. 2011 Mar 18;286(11):9526-41. doi: 10.1074/jbc.M110.170597. Epub 2011 Jan 5.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Cellular and subcellular localization of Kir2.1 subunits in neurons and glia in piriform cortex with implications for K+ spatial buffering. Howe MW, etal., J Comp Neurol. 2008 Feb 10;506(5):877-93.
5. Experimental study on inhibition of rat ventricular Ik1 by RNA interference targeting the KCNJ2 gene. Hu B, etal., Biosci Trends. 2012 Feb;6(1):26-32. doi: 10.5582/bst.2012.v6.1.26.
6. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Huang CL, etal., Nature. 1998 Feb 19;391(6669):803-6. doi: 10.1038/35882.
7. Mesenchymal stem cell transplantation mitigates electrophysiological remodeling in a rat model of myocardial infarction. Lai PF, etal., J Cardiovasc Electrophysiol. 2013 Jul;24(7):813-21. doi: 10.1111/jce.12162. Epub 2013 May 3.
8. A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. Leonoudakis D, etal., J Biol Chem 2004 Apr 30;279(18):19051-63. Epub 2004 Feb 11.
9. MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation. Luo X, etal., J Clin Invest. 2013 May 1;123(5):1939-51. doi: 10.1172/JCI62185. Epub 2013 Apr 1.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia. Milstein ML, etal., Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):E2134-43. doi: 10.1073/pnas.1109370109. Epub 2012 Apr 16.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function. Pruss H, etal., Brain Res Mol Brain Res. 2003 Feb 20;110(2):203-19.
16. Differential distribution of individual subunits of strongly inwardly rectifying potassium channels (Kir2 family) in rat brain. Pruss H, etal., Brain Res Mol Brain Res. 2005 Sep 13;139(1):63-79.
17. Inwardly rectifying potassium channels in lens epithelium are from the IRK1 (Kir 2.1) family. Rae JL and Shepard AR, Exp Eye Res 1998 Mar;66(3):347-59.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Losartan prevents stretch-induced electrical remodeling in cultured atrial neonatal myocytes. Saygili E, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2898-905. Epub 2007 Feb 9.
22. The Interaction of Caveolin 3 Protein with the Potassium Inward Rectifier Channel Kir2.1: PHYSIOLOGY AND PATHOLOGY RELATED TO LONG QT SYNDROME 9 (LQT9). Vaidyanathan R, etal., J Biol Chem. 2013 Jun 14;288(24):17472-80. doi: 10.1074/jbc.M112.435370. Epub 2013 May 2.
23. Physiological and molecular characterization of an IRK-type inward rectifier K+ channel in a tumour mast cell line. Wischmeyer E, etal., Pflugers Arch 1995 Apr;429(6):809-19.
Additional References at PubMed
PMID:8189383   PMID:11371347   PMID:12086641   PMID:14993195   PMID:15284349   PMID:15304517   PMID:15581370   PMID:15761194   PMID:15775962   PMID:16330144   PMID:16834334   PMID:17401374  
PMID:17670900   PMID:17675572   PMID:18063660   PMID:20921230   PMID:21703452   PMID:23426663   PMID:26566151   PMID:26786162   PMID:26854211   PMID:27387235   PMID:28331977   PMID:29184507  
PMID:29514831   PMID:31391240   PMID:32449050   PMID:32554946   PMID:34592781   PMID:35856410  


Genomics

Comparative Map Data
Kcnj2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81096,560,225 - 96,570,788 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1096,565,600 - 96,570,901 (+)EnsemblGRCr8
mRatBN7.21096,060,834 - 96,071,397 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1096,060,821 - 96,071,445 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10101,129,119 - 101,130,402 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010100,592,089 - 100,593,372 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01096,000,266 - 96,001,549 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01099,429,337 - 99,442,520 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1099,437,436 - 99,439,114 (+)Ensemblrn6Rnor6.0
Rnor_5.01099,125,234 - 99,134,077 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410100,574,985 - 100,576,268 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1094,712,069 - 94,713,352 (+)NCBICelera
RGSC_v3.110100,589,354 - 100,590,638 (+)NCBI
Cytogenetic Map10q32.1NCBI
KCNJ2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381770,169,532 - 70,180,044 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1770,168,302 - 70,180,044 (+)Ensemblhg38GRCh38
GRCh371768,165,673 - 68,176,185 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361765,677,271 - 65,687,780 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341765,677,270 - 65,687,776NCBI
Celera1764,737,556 - 64,748,065 (+)NCBICelera
Cytogenetic Map17q24.3NCBI
HuRef1763,551,441 - 63,561,946 (+)NCBIHuRef
CHM1_11768,231,773 - 68,242,282 (+)NCBICHM1_1
T2T-CHM13v2.01771,047,853 - 71,058,363 (+)NCBIT2T-CHM13v2.0
Kcnj2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911110,956,990 - 110,967,651 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11110,956,990 - 110,967,647 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811111,066,164 - 111,076,825 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11111,066,164 - 111,076,821 (+)Ensemblmm10GRCm38
MGSCv3711110,927,478 - 110,938,139 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611110,882,254 - 110,891,741 (+)NCBIMGSCv36mm8
Celera11122,816,654 - 122,827,315 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1175.23NCBI
Kcnj2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554782,734,795 - 2,745,217 (-)Ensembl
ChiLan1.0NW_0049554782,734,795 - 2,745,217 (-)NCBIChiLan1.0ChiLan1.0
KCNJ2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21986,190,439 - 86,213,932 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11791,011,394 - 91,039,851 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01764,097,908 - 64,112,914 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11769,482,344 - 69,492,838 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1769,487,846 - 69,489,129 (+)EnsemblpanPan2panpan1.1
KCNJ2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1916,468,938 - 16,475,722 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl916,468,938 - 16,475,722 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha917,360,013 - 17,366,796 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0918,122,955 - 18,129,749 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl918,122,955 - 18,129,749 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1917,067,115 - 17,073,888 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0910,461,025 - 10,467,799 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0910,426,806 - 10,433,589 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnj2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056029,949,176 - 9,968,112 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366553,447,321 - 3,458,312 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366553,447,026 - 3,459,569 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1210,351,699 - 10,362,244 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11210,351,959 - 10,380,631 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNJ2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11651,448,821 - 51,461,801 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1651,452,567 - 51,453,850 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607722,340,093 - 22,354,971 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624801365,361 - 374,487 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624801365,393 - 375,802 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcnj2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1978,225,598 - 78,236,467 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcnj2
43 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1rno-miR-1-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI19775284

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:37
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000006254
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
631558Bp137Blood pressure QTL 1370.013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)109522434497335592Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108780775896620484Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)108890050196620484Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
Kcnj2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21096,067,750 - 96,067,946 (+)MAPPERmRatBN7.2
Rnor_6.01099,439,111 - 99,439,306NCBIRnor6.0
Rnor_5.01099,132,163 - 99,132,358UniSTSRnor5.0
RGSC_v3.410100,576,461 - 100,576,656UniSTSRGSC3.4
Celera1094,713,545 - 94,713,740UniSTS
Cytogenetic Map10q32.1UniSTS


Genetic Models
This gene Kcnj2 is modified in the following models/strains:
SS-Kcnj2em4Mcwi     SS-Kcnj2em2Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 89 59 6 352 189 11 144 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000006254   ⟹   ENSRNOP00000006254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1099,437,436 - 99,439,114 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102334   ⟹   ENSRNOP00000079758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1096,565,600 - 96,570,901 (+)Ensembl
mRatBN7.2 Ensembl1096,060,821 - 96,071,445 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133616   ⟹   ENSRNOP00000110101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1096,565,600 - 96,568,128 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000135330   ⟹   ENSRNOP00000111037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1096,565,600 - 96,567,516 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136217   ⟹   ENSRNOP00000109976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1096,565,600 - 96,567,049 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000144045   ⟹   ENSRNOP00000108601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1096,565,600 - 96,568,109 (+)Ensembl
RefSeq Acc Id: NM_017296   ⟹   NP_058992
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81096,560,225 - 96,570,788 (+)NCBI
mRatBN7.21096,060,834 - 96,071,397 (+)NCBI
Rnor_6.01099,437,635 - 99,438,918 (+)NCBI
Rnor_5.01099,125,234 - 99,134,077 (+)NCBI
RGSC_v3.410100,574,985 - 100,576,268 (+)RGD
Celera1094,712,069 - 94,713,352 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058992 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB03890 (Get FASTA)   NCBI Sequence Viewer  
  AAB88795 (Get FASTA)   NCBI Sequence Viewer  
  EDM06499 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000079758
  ENSRNOP00000079758.1
GenBank Protein Q64273 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058992   ⟸   NM_017296
- UniProtKB: Q64273 (UniProtKB/Swiss-Prot),   A6HKE4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006254   ⟸   ENSRNOT00000006254
Ensembl Acc Id: ENSRNOP00000079758   ⟸   ENSRNOT00000102334
Ensembl Acc Id: ENSRNOP00000108601   ⟸   ENSRNOT00000144045
Ensembl Acc Id: ENSRNOP00000109976   ⟸   ENSRNOT00000136217
Ensembl Acc Id: ENSRNOP00000110101   ⟸   ENSRNOT00000133616
Ensembl Acc Id: ENSRNOP00000111037   ⟸   ENSRNOT00000135330
Protein Domains
Inward rectifier potassium channel C-terminal   Potassium channel inwardly rectifying Kir N-   Potassium channel inwardly rectifying transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64273-F1-model_v2 AlphaFold Q64273 1-427 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61968 AgrOrtholog
BioCyc Gene G2FUF-22804 BioCyc
Ensembl Genes ENSRNOG00000004720 Ensembl
  ENSRNOG00000064933 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000102334 ENTREZGENE
  ENSRNOT00000102334.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  2.60.40.1400 UniProtKB/Swiss-Prot
InterPro Ig_E-set UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir2.1 UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir_N UniProtKB/Swiss-Prot
  Kir_TM UniProtKB/Swiss-Prot
KEGG Report rno:29712 UniProtKB/Swiss-Prot
NCBI Gene 29712 ENTREZGENE
PANTHER PTHR11767 UniProtKB/Swiss-Prot
  PTHR11767:SF43 UniProtKB/Swiss-Prot
Pfam IRK UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
  IRK_N UniProtKB/Swiss-Prot
PharmGKB KCNJ2 RGD
PhenoGen Kcnj2 PhenoGen
PIRSF GIRK_kir UniProtKB/Swiss-Prot
PRINTS KIR21CHANNEL UniProtKB/Swiss-Prot
  KIRCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004720 RatGTEx
  ENSRNOG00000064933 RatGTEx
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A6HKE4 ENTREZGENE, UniProtKB/TrEMBL
  KCNJ2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnj2  potassium voltage-gated channel subfamily J member 2  Kcnj2  potassium channel, inwardly rectifying subfamily J, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnj2  potassium channel, inwardly rectifying subfamily J, member 2  Kcnj2  potassium inwardly-rectifying channel, subfamily J, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcnj2  potassium inwardly-rectifying channel, subfamily J, member 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in lens 61645
gene_other channel is blocked by extracellular Na+, Cs+ and Ba2+ 729170