Tmod2 (tropomodulin 2) - Rat Genome Database

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Gene: Tmod2 (tropomodulin 2) Rattus norvegicus
Analyze
Symbol: Tmod2
Name: tropomodulin 2
RGD ID: 61948
Description: Enables actin binding activity and tropomyosin binding activity. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Predicted to act upstream of or within learning or memory; neuron-neuron synaptic transmission; and positive regulation of G protein-coupled receptor signaling pathway. Located in growth cone. Orthologous to human TMOD2 (tropomodulin 2); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: N-Tmod; neuronal tropomodulin; tropomodulin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8885,197,222 - 85,250,627 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl885,196,226 - 85,246,371 (-)EnsemblGRCr8
mRatBN7.2876,316,736 - 76,366,003 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl876,325,667 - 76,365,720 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx881,833,194 - 81,859,701 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0880,098,086 - 80,124,579 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0877,932,534 - 77,959,043 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0882,505,947 - 82,547,450 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl882,506,934 - 82,533,689 (-)Ensemblrn6Rnor6.0
Rnor_5.0882,108,631 - 82,148,859 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4880,392,806 - 80,419,315 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera876,115,302 - 76,142,235 (-)NCBICelera
RGSC_v3.1880,411,859 - 80,438,369 (-)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-lariciresinol  (ISO)
(-)-lariciresinol  (ISO)
1,2-dichloroethane  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
butyric acid  (ISO)
camptothecin  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
corosolic acid  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
indometacin  (ISO)
lead(0)  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
testosterone undecanoate  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
actin binding  (IDA,IEA)
protein binding  (ISO)
tropomyosin binding  (IBA,IDA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
7. N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin. Watakabe A, etal., J Cell Sci 1996 Sep;109 ( Pt 9)(2):2299-310.
Additional References at PubMed
PMID:12799133   PMID:20131911   PMID:22871113   PMID:24625528   PMID:27126680   PMID:28131823   PMID:29476059   PMID:30301754  


Genomics

Comparative Map Data
Tmod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8885,197,222 - 85,250,627 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl885,196,226 - 85,246,371 (-)EnsemblGRCr8
mRatBN7.2876,316,736 - 76,366,003 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl876,325,667 - 76,365,720 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx881,833,194 - 81,859,701 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0880,098,086 - 80,124,579 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0877,932,534 - 77,959,043 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0882,505,947 - 82,547,450 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl882,506,934 - 82,533,689 (-)Ensemblrn6Rnor6.0
Rnor_5.0882,108,631 - 82,148,859 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4880,392,806 - 80,419,315 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera876,115,302 - 76,142,235 (-)NCBICelera
RGSC_v3.1880,411,859 - 80,438,369 (-)NCBI
Cytogenetic Map8q24NCBI
TMOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381551,751,597 - 51,816,363 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1551,751,564 - 51,816,363 (+)Ensemblhg38GRCh38
GRCh371552,043,794 - 52,108,560 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361549,831,102 - 49,889,635 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341549,831,101 - 49,889,634NCBI
Celera1528,937,177 - 29,001,954 (+)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1528,874,266 - 28,939,046 (+)NCBIHuRef
CHM1_11552,161,794 - 52,226,629 (+)NCBICHM1_1
T2T-CHM13v2.01549,559,103 - 49,623,854 (+)NCBIT2T-CHM13v2.0
Tmod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39975,472,903 - 75,518,620 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl975,472,903 - 75,518,607 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38975,565,621 - 75,611,342 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl975,565,621 - 75,611,325 (-)Ensemblmm10GRCm38
MGSCv37975,413,428 - 75,459,132 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36975,351,530 - 75,397,234 (-)NCBIMGSCv36mm8
Celera972,726,546 - 72,775,171 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map942.31NCBI
Tmod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554092,808,543 - 2,842,844 (-)Ensembl
ChiLan1.0NW_0049554092,801,173 - 2,842,717 (-)NCBIChiLan1.0ChiLan1.0
TMOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21640,985,905 - 41,053,274 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11545,166,348 - 45,233,756 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01530,690,641 - 30,757,960 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11549,035,929 - 49,087,467 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1549,035,929 - 49,079,570 (+)EnsemblpanPan2panpan1.1
TMOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13017,425,216 - 17,501,484 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3017,455,987 - 17,592,580 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3017,351,455 - 17,420,147 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03017,571,419 - 17,646,819 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3017,588,331 - 17,740,756 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13017,492,670 - 17,561,539 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03017,611,072 - 17,686,398 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03017,717,590 - 17,785,938 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864095,742,038 - 95,794,177 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647113,602,732 - 13,729,228 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647113,602,769 - 13,636,258 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,956,588 - 120,009,372 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11119,956,583 - 120,009,372 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21133,216,996 - 133,269,777 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMOD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12631,560,112 - 31,624,967 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2631,568,024 - 31,624,905 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048109,589,912 - 109,655,378 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247318,583,352 - 8,605,826 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247318,575,955 - 8,612,553 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmod2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1869,854,476 - 69,892,671 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmod2
499 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:27
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000014124
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat

Markers in Region
AW535177  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2876,325,756 - 76,325,912 (+)MAPPERmRatBN7.2
Rnor_6.0882,507,145 - 82,507,300NCBIRnor6.0
Rnor_5.0882,109,829 - 82,109,984UniSTSRnor5.0
RGSC_v3.4880,392,896 - 80,393,051UniSTSRGSC3.4
Celera876,115,392 - 76,115,547UniSTS
RH 3.4 Map8925.69UniSTS
Cytogenetic Map8q24UniSTS
RH138018  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2876,344,654 - 76,344,827 (+)MAPPERmRatBN7.2
Rnor_6.0882,526,081 - 82,526,253NCBIRnor6.0
Rnor_5.0882,127,490 - 82,127,662UniSTSRnor5.0
RGSC_v3.4880,411,717 - 80,411,889UniSTSRGSC3.4
Celera876,134,637 - 76,134,809UniSTS
RH 3.4 Map8925.59UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 76 75 44 39 44 6 286 139 11 144 79 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014124   ⟹   ENSRNOP00000014124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl885,207,606 - 85,232,736 (-)Ensembl
mRatBN7.2 Ensembl876,325,667 - 76,352,253 (-)Ensembl
Rnor_6.0 Ensembl882,506,934 - 82,533,689 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118239   ⟹   ENSRNOP00000079258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl885,196,226 - 85,232,736 (-)Ensembl
mRatBN7.2 Ensembl876,327,796 - 76,365,720 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000124895   ⟹   ENSRNOP00000110033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl885,206,153 - 85,246,371 (-)Ensembl
RefSeq Acc Id: NM_031613   ⟹   NP_113801
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8885,206,153 - 85,232,736 (-)NCBI
mRatBN7.2876,325,667 - 76,352,253 (-)NCBI
Rnor_6.0882,507,055 - 82,533,679 (-)NCBI
Rnor_5.0882,108,631 - 82,148,859 (-)NCBI
RGSC_v3.4880,392,806 - 80,419,315 (-)RGD
Celera876,115,302 - 76,142,235 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243407   ⟹   XP_006243469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8885,197,222 - 85,250,627 (-)NCBI
mRatBN7.2876,316,736 - 76,366,003 (-)NCBI
Rnor_6.0882,505,947 - 82,547,450 (-)NCBI
Rnor_5.0882,108,631 - 82,148,859 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006243408   ⟹   XP_006243470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8885,197,222 - 85,233,300 (-)NCBI
mRatBN7.2876,316,736 - 76,352,805 (-)NCBI
Rnor_6.0882,505,947 - 82,537,445 (-)NCBI
Rnor_5.0882,108,631 - 82,148,859 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008766331   ⟹   XP_008764553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8885,197,222 - 85,245,899 (-)NCBI
mRatBN7.2876,316,736 - 76,365,405 (-)NCBI
Rnor_6.0882,505,947 - 82,546,679 (-)NCBI
Sequence:
RefSeq Acc Id: NP_113801   ⟸   NM_031613
- UniProtKB: P70566 (UniProtKB/Swiss-Prot),   A6I1E0 (UniProtKB/TrEMBL),   A0A8I5ZMG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243469   ⟸   XM_006243407
- Peptide Label: isoform X1
- UniProtKB: P70566 (UniProtKB/Swiss-Prot),   A6I1E0 (UniProtKB/TrEMBL),   A0A8I5ZMG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243470   ⟸   XM_006243408
- Peptide Label: isoform X1
- UniProtKB: P70566 (UniProtKB/Swiss-Prot),   A6I1E0 (UniProtKB/TrEMBL),   A0A8I5ZMG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764553   ⟸   XM_008766331
- Peptide Label: isoform X1
- UniProtKB: P70566 (UniProtKB/Swiss-Prot),   A6I1E0 (UniProtKB/TrEMBL),   A0A8I5ZMG0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014124   ⟸   ENSRNOT00000014124
Ensembl Acc Id: ENSRNOP00000079258   ⟸   ENSRNOT00000118239
Ensembl Acc Id: ENSRNOP00000110033   ⟸   ENSRNOT00000124895

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70566-F1-model_v2 AlphaFold P70566 1-351 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61948 AgrOrtholog
BioCyc Gene G2FUF-29812 BioCyc
Ensembl Genes ENSRNOG00000010447 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014124 ENTREZGENE
  ENSRNOT00000014124.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
InterPro LRR_dom_sf UniProtKB/Swiss-Prot
  TMOD UniProtKB/Swiss-Prot
KEGG Report rno:58814 UniProtKB/Swiss-Prot
NCBI Gene 58814 ENTREZGENE
PANTHER PTHR10901 UniProtKB/Swiss-Prot
  PTHR10901:SF15 UniProtKB/Swiss-Prot
Pfam Tropomodulin UniProtKB/Swiss-Prot
PhenoGen Tmod2 PhenoGen
RatGTEx ENSRNOG00000010447 RatGTEx
Superfamily-SCOP RNI-like UniProtKB/Swiss-Prot
TIGR TC223086
UniProt A0A8I5ZMG0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M4B7_RAT UniProtKB/TrEMBL
  A6I1E0 ENTREZGENE, UniProtKB/TrEMBL
  A6I1E3_RAT UniProtKB/TrEMBL
  A6I1E4_RAT UniProtKB/TrEMBL
  P70566 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tmod2  tropomodulin 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA and protein expressed predominantly in brain 61770
gene_physical_interaction protein binds to the neuron-specific isoform of tropomyosin (Tmbr3) 61770