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Gene: Gabrr1 (gamma-aminobutyric acid type A receptor subunit rho 1) Rattus norvegicus

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Symbol:

Gabrr1

Name:

gamma-aminobutyric acid type A receptor subunit rho 1

RGD ID:

61900

Description:

Enables several functions, including GABA-A receptor activity; GABA-gated chloride ion channel activity; and identical protein binding activity. Predicted to be involved in GABAergic synaptic transmission; chloride transmembrane transport; and modulation of chemical synaptic transmission. Predicted to be located in plasma membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and presynaptic membrane. Orthologous to human GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1); INTERACTS WITH ammonium chloride; bisphenol A; bleomycin A2.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

GABA(A) receptor subunit rho-1; GABA(C) receptor; GABAAR subunit rho-1; gamma-aminobutyric acid (GABA) A receptor, rho 1; gamma-aminobutyric acid (GABA) receptor, rho 1; gamma-aminobutyric acid (GABA-A) receptor subunit rho 1; gamma-aminobutyric acid (GABA-A) receptor, subunit rho 1; gamma-aminobutyric acid (GABA-C) receptor, subunit rho 1; gamma-aminobutyric acid A receptor, rho 1; gamma-aminobutyric acid receptor subunit rho-1; gamma-aminobutyric acid type A receptor rho 1 subunit

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	52,320,475 - 52,357,549 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	52,320,475 - 52,357,549 (+)	Ensembl				GRCr8
mRatBN7.2	5	47,524,151 - 47,561,228 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	47,524,151 - 47,561,228 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	49,670,090 - 49,707,269 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	51,269,275 - 51,306,457 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	51,212,706 - 51,250,049 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	48,374,048 - 48,411,170 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	48,374,096 - 48,411,170 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	52,956,762 - 52,993,836 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	49,421,463 - 49,458,535 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	46,281,021 - 46,318,155 (+)	NCBI		Celera
RGSC_v3.1	5	49,421,641 - 49,458,714 (+)	NCBI
Cytogenetic Map	5	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-Methoxyflavanone (ISO)

6-Methoxyflavone (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bleomycin A2 (EXP)

cadmium dichloride (EXP)

CGP 52608 (ISO)

diarsenic trioxide (ISO)

diazepam (ISO)

dicyclanil (ISO)

dieldrin (ISO)

endosulfan (ISO)

folic acid (ISO)

gaboxadol (ISO)

gamma-aminobutyric acid (ISO)

gamma-hexachlorocyclohexane (ISO)

genistein (ISO)

lead diacetate (EXP)

methapyrilene (ISO)

paracetamol (ISO)

raloxifene (ISO)

sarin (ISO)

silicon dioxide (EXP)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

streptozocin (ISO)

Theaflavin 3,3'-digallate (ISO)

thimerosal (ISO)

triadimefon (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chloride transmembrane transport (IBA,IEA)

chloride transport (IEA)

modulation of chemical synaptic transmission (IEA,ISO)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

regulation of presynaptic membrane potential (IEA)

synaptic transmission, GABAergic (IBA)

Cellular Component

chloride channel complex (IEA)

GABA-A receptor complex (IBA)

GABA-ergic synapse (IEA,ISO)

glutamatergic synapse (IEA,ISO)

intracellular vesicle (IEA,ISO)

membrane (IEA)

plasma membrane (IEA,ISO,ISS)

postsynaptic membrane (IEA)

presynaptic membrane (IEA,ISO)

Molecular Function

chloride channel activity (IBA,IEA)

extracellular ligand-gated monoatomic ion channel activity (IEA)

GABA receptor activity (IDA)

GABA-A receptor activity (IBA,IDA,IEA)

GABA-gated chloride ion channel activity (IDA,IEA)

identical protein binding (IPI)

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (IEA,ISO)

monoatomic ion channel activity (IEA)

protein binding (IPI,ISO)

protein domain specific binding (IPI)

protein-containing complex binding (IDA)

transmembrane signaling receptor activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2.	Croci C, etal., J Biol Chem 2003 Feb 21;278(8):6128-35.
2.	gamma-Aminobutyric acidA rho receptor subunits in the developing rat hippocampus.	Didelon F, etal., J Neurosci Res 2002 Mar 15;67(6):739-44.
3.	Interaction of GABA receptor/channel rho(1) and gamma(2) subunit.	Ekema GM, etal., Invest Ophthalmol Vis Sci. 2002 Jul;43(7):2326-33.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	The rho 1 GABA receptor cloned from rat retina is down-modulated by protons.	Wegelius K, etal., Neuroreport 1996 Aug 12;7(12):2005-9.
10.	Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block.	Zhang D, etal., Proc Natl Acad Sci U S A 1995 Dec 5;92(25):11756-60.

Additional References at PubMed

PMID:8889548	PMID:12019334	PMID:12706246	PMID:15617751	PMID:16999686	PMID:18201822	PMID:18385542	PMID:19198818	PMID:19902194	PMID:23935098	PMID:29253887

Genomics

Comparative Map Data

Gabrr1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	52,320,475 - 52,357,549 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	52,320,475 - 52,357,549 (+)	Ensembl				GRCr8
mRatBN7.2	5	47,524,151 - 47,561,228 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	47,524,151 - 47,561,228 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	49,670,090 - 49,707,269 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	51,269,275 - 51,306,457 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	51,212,706 - 51,250,049 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	48,374,048 - 48,411,170 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	48,374,096 - 48,411,170 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	52,956,762 - 52,993,836 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	49,421,463 - 49,458,535 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	46,281,021 - 46,318,155 (+)	NCBI		Celera
RGSC_v3.1	5	49,421,641 - 49,458,714 (+)	NCBI
Cytogenetic Map	5	q21	NCBI

GABRR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	89,177,504 - 89,231,288 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	89,177,504 - 89,231,278 (-)	Ensembl			hg38	GRCh38
GRCh37	6	89,887,223 - 89,941,007 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	89,944,691 - 89,983,779 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	89,944,690 - 89,983,779	NCBI
Celera	6	90,305,117 - 90,345,991 (-)	NCBI		Celera
Cytogenetic Map	6	q15	ENTREZGENE
HuRef	6	87,103,304 - 87,157,675 (-)	NCBI		HuRef
CHM1_1	6	89,985,186 - 90,038,978 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	90,386,177 - 90,440,555 (-)	NCBI		T2T-CHM13v2.0

Gabrr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	33,132,556 - 33,163,606 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	33,132,521 - 33,163,588 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	33,132,556 - 33,163,588 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	33,132,521 - 33,163,588 (+)	Ensembl			mm10	GRCm38
MGSCv37	4	33,219,531 - 33,250,563 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	33,461,169 - 33,492,200 (+)	NCBI		MGSCv36	mm8
Celera	4	32,883,762 - 32,914,628 (+)	NCBI		Celera
Cytogenetic Map	4	A5	NCBI
cM Map	4	14.68	NCBI

Gabrr1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	15,967,610 - 16,002,303 (-)	Ensembl
ChiLan1.0	NW_004955411	15,967,857 - 16,002,199 (-)	NCBI	ChiLan1.0	ChiLan1.0

GABRR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	109,257,328 - 109,297,706 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	107,157,505 - 107,197,896 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	87,052,479 - 87,092,665 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	90,327,562 - 90,371,612 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	90,327,562 - 90,367,938 (-)	Ensembl			panPan2	panpan1.1

GABRR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	48,431,273 - 48,465,426 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	48,431,379 - 48,538,037 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	48,235,244 - 48,293,320 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	49,236,551 - 49,295,241 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	49,236,816 - 49,346,733 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	48,553,505 - 48,611,791 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	48,451,979 - 48,510,383 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	48,644,241 - 48,702,924 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gabrr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	83,454,447 - 83,492,207 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936510	2,978,521 - 3,018,690 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936510	2,978,565 - 3,016,421 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GABRR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	57,222,585 - 57,254,563 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	57,222,027 - 57,285,918 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	63,999,927 - 64,063,579 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GABRR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	13,934,772 - 13,975,142 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	13,936,016 - 13,974,519 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	190,251,724 - 190,291,857 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gabrr1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624799	4,946,102 - 4,985,242 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624799	4,946,085 - 4,985,450 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gabrr1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	109,874,820 - 109,912,314 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gabrr1
222 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	412
Count of miRNA genes:	235
Interacting mature miRNAs:	273
Transcripts:	ENSRNOT00000010172
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	38011670	83011670	Rat
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	32751649	77751649	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
6907115	Mcs29	Mammary carcinoma susceptibility QTL 29			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	38004331	83004331	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	23671493	79046465	Rat
1300117	Hrtrt8	Heart rate QTL 8	3.49		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	8627230	52665523	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	17576633	62576633	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	48523123	134369373	Rat
1578774	Tcas8	Tongue tumor susceptibility QTL 8	3.47		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	15707451	60707451	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	38011670	83011670	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	38011670	83011670	Rat
1331782	Rf36	Renal function QTL 36	3.296		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	39019942	102105896	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	33311673	78311673	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	32751649	77751649	Rat
1641922	Alcrsp8	Alcohol response QTL 8			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	5	17486080	62486080	Rat
2313085	Bss59	Bone structure and strength QTL 59	2.9	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	5	8627230	53627230	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	39985948	84985948	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	6922282	81330203	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33311673	78311673	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	39526924	84526924	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	14606078	59606078	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	48523123	91770353	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	91770353	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	7065535	74335773	Rat
1641903	Alcrsp3	Alcohol response QTL 3			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	17486080	62486080	Rat
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	87027358	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	26023211	71023211	Rat
2303577	Gluco47	Glucose level QTL 47	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	16520019	61520019	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	23671493	68671493	Rat

Markers in Region

AU048617

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	47,550,473 - 47,550,743 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	48,400,416 - 48,400,685	NCBI	Rnor6.0
Rnor_5.0	5	52,983,082 - 52,983,351	UniSTS	Rnor5.0
RGSC_v3.4	5	49,447,783 - 49,448,052	UniSTS	RGSC3.4
Celera	5	46,307,436 - 46,307,705	UniSTS
Cytogenetic Map	5	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
11	12	22	141	68	73	44	62	44	6	216	111	11	119	42	75	29	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AW532797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U21070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X95579	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Z48737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000010172 ⟹ ENSRNOP00000010172

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	52,320,475 - 52,357,549 (+)	Ensembl
mRatBN7.2 Ensembl	5	47,524,151 - 47,561,228 (+)	Ensembl
Rnor_6.0 Ensembl	5	48,374,096 - 48,411,170 (+)	Ensembl

RefSeq Acc Id:

NM_017291 ⟹ NP_058987

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	52,320,475 - 52,357,549 (+)	NCBI
mRatBN7.2	5	47,524,151 - 47,561,228 (+)	NCBI
Rnor_6.0	5	48,374,096 - 48,411,170 (+)	NCBI
Rnor_5.0	5	52,956,762 - 52,993,836 (+)	NCBI
RGSC_v3.4	5	49,421,463 - 49,458,535 (+)	RGD
Celera	5	46,281,021 - 46,318,155 (+)	NCBI

Sequence:

show sequence

CCTTCTAATAACAAACACAGCAATGGTGCCTTAAGAGAGGACGGTCGGACGGCAGCTCCTCACC
GGCTCCTTCTCACGGCTTCTCGGGAGAACTGTTTGATTTGGAAATCTATGTTGGCTGTCCGGAA
TATGAAATTTGGCATATTCCTTTTGTGGTGGGGATGGGTTCTGGCTGCTGAGAGCACAGTGCAC
TGGCCAGGAAGAGAAGTTCATGAGCCCTCTAAGAAAGGCAGCAGACCTCAGAGACAGAGACGAG
GTGCACATGACGATGCCCACAAGCAAGGCAGCCCCATTCTGAAACGAAGCTCTGACATAACCAA
GTCGCCTCTCACCAAGTCAGAGCAGCTGCTCAGGATAGATGACCACGACTTCAGCATGAGGCCT
GGCTTTGGAGGTCCCGCCATCCCTGTGGGTGTGGATGTGCAGGTGGAGAGTCTGGACAGCATCT
CCGAGGTGGACATGGACTTCACCATGACCCTCTATCTGAGGCACTACTGGAAGGACGAGAGGCT
GTCTTTTCCCAGTACCAACAACCTCAGCATGACGTTTGACGGCCGACTTGTAAAGAAGATATGG
GTTCCCGACATGTTCTTTGTGCACTCCAAACGCTCCTTCATCCATGACACCACCACAGACAACG
TCATGTTGCGGGTACAGCCAGATGGGAAAGTGCTGTACAGCCTCAGAGTTACAGTGACAGCGAT
GTGCAACATGGACTTCAGCCGGTTTCCCCTGGACACACAGACCTGCTCCCTCGAAATCGAAAGC
TATGCCTACACAGAAGACGACCTCATGCTGTACTGGAAAAAAGGCAATGACTCCTTAAAGACAG
ATGAGAGGATCTCCCTCTCTCAGTTCCTCATTCAAGAATTCCACACCACCACAAAACTAGCCTT
CTACAGCAGTACAGGCTGGTACAACCGTCTGTACATCAACTTCACTCTACGTCGTCACATCTTC
TTCTTCTTGCTCCAAACCTACTTTCCTGCCACCCTCATGGTCATGCTGTCCTGGGTGTCCTTCT
GGATCGACCGCAGAGCTGTGCCTGCCAGAGTCCCCTTAGGCATCACCACGGTGCTGACCATGTC
CACCATCATCACGGGCGTGAACGCCTCCATGCCTCGAGTGTCCTACATCAAAGCCGTGGACATC
TACCTCTGGGTCAGCTTTGTGTTCGTGTTTCTCTCGGTGTTGGAGTACGCAGCTGTCAACTACC
TGACCACAGTGCAGGAGCGGAAGGAACGGAAGCTTCGGGAGAAGATCTCCTGCACCTGTGGGCT
GCCCCAGCCTCGAGGGGTGATGCTGGACAGCAGCTACAGTGACGGGGAGGTGAACGACCTGGGT
GGCTACATGCCTGAGAACGGAGAGAAACCCGACCGGATGATGGTGCAGCTGACCCCGGCCTCCG
AGAGGGGCTCCCCACAGAGGAAAAGCCAGAGAGGCAGCTATGTGAGCATGAGGATCAACACCCA
CGCCATTGACAAATACTCAAGGATCATTTTCCCAGCTGCTTACATTTTATTCAATCTGATATAC
TGGTCAATTTTCTCTTAGATAGATGTGATTGTGTAAATCTTGGCAGGCACCACAGAAGTTGCTG
TAAAAATGAGAATGACAGTTTAAAGCCATTCCTACCTGGGTTTTCTCTGTCCCCTGTTCAGCTC
TCCAAAGCTGCACCAACAAGACACCTTGTTTTTGCACTTATTAAGTATCAGTTGTCTGCACAGC
AGTATACTAGGCGTTGCAGGACGTTGCCATGATAGTAACTGATGTTAGCGGCTCCCAGATCCCA
GGAAGAGCACAGAGGCCACATGTGGACATGCTGCGGTCCAGGGCCAGGGCTCTGGATGCTTTTC
ACATCGAGGGGTTTCTACGTCGGTGGACCATGTTCTTTAGACTACGTAGATCTGGGAAGGACCT
AAATAAAACTCATCTGCATTGGGCTCACAGGTACATAAACCCCCTCGGCTGAAAGGGCAGGCTT
CGTCTGTCTCCGCACCTGCTCCACATCCCCATACTTAATGGAAGGCAGTGGCGCTCACAGGGTT
CTTTTCCACAAGCTGCATGGCTCTCTCCTTCTAAGAAATGCCCTTTACATGGCTGAAATGTCCC
TAGTAGACTTTGAAGATAGAGATACATGGATCATTTCATCTGTTTTGAGGGGGCAACAAAGCTA
GAAAACCGTGTCCCTTTCCACGCCTTCTAGTCACCGTTTCCCTCCTCTCTACCACAGAGCAGGT
GCTTTCTTCAAAATAAAATCTTTTCTCAGTCGCATGACAGCATCACTGACTGAGGCGCTTGAAG
AGGTATTCATTTCTTCTGCATAGTCAGCATTTCAAGAAAACTCGAGGCTGTTTCTAACTCATGG
GAATGAGAAGCAAACTGTTTCTTAAGAGAAAGATAACATTGAAAAACAAAAGAAACAGACAGAC
ATCTTCATTTCCGTTCAGCAAGTGCTGTCTGGGAACTAGAAAGCAATTATCTTCTAGATTGAGC
ATCCCATAGACCAGATAAGCTGGCCCATAGCAACTGATGTCAGCCATGGGTTGTAATTTGATGT
ATTGTTTTAAAATAGAAGCCTCTATAGTCTTTATCTAGAAGATATATAGCAGCCCCAACCGAAC
TTGCTCAAACAGTATTGAGCAGTATGTCATTTGCTCTGGGCCACGTCTTTCACTCAGAGAGACA
ACTACTTAGCATCTGCCACATCCCAGCGGCCATTGAAGCATCTTAACCAAGTCCTGGCCCATTT
AGTTGTGGTTGTGTTCAGATTTCAGTGAGAGAATCCCAGGAGAAACATAAATGATAATTTAATA
TTGTGGAACATATGGTTAATAAATATAGAGGAGGTCTAAGAGACCTGTCCAGGGGCAACCATCC
TCTGTGCTGCGAAACCTATCTTCATATATGTCGTTATAGCTCCCATCATTTCAAGGTTAACTTA
AGGGATCAATACTAAATAGTATCATACACATGGCTATTCTTTACTCTGGTCATAAAAAGAGCTA
TTTGCAAATTCCTACTTAGAAGACAGTCTCTCATTTCCCCCAATAAAAGGTCATCAAAAGCTTT
TATCAAACTCAAGTGGTAGACTTAGAGGGATAAATTAAGTAATTATCATTGATTTTCAAAATGA
CCGTTCGTTTTGCCAAGCATGGTTTGCCCATGCACTTGGGAAGTGGAATCAGGAGGGTCTGGAG
TTCAAAGCTAGCTTTGCTTTACGGCATATTGGAGGCAAGCATGGGCTATGTGAGGTTTAAAATG
GTTGGCTTTTCATTTTTATTTTATGAAACATTTACCATCAAAGCCAACAACTTTGCCACTGTCT
TCTTCCTCACCACTAAGGCCACTGAGCTGTCTAGGTTTCCAGAGCTTGTAACTAAGCCCTTTGT
ACTGTTTGGGACACTCCACCATTTGAGCCAGTGTGTAGAATGCTCTCCTAGCCTGCTAACCTGC
TATATTGAAGAGCACAGACTGGATGGCTTAATCAACAGAGATATATTTTCTCACAGTTCTAGAG
ACTGATGTCCAAGGTCAAGGTGCTGGCCGACGCAGTTTCCCCAGAGGCCTGTCTTGCTGTCTTT
CCAATAGCCACTCTCTTGCTGCATCCTTGCCTTCTTTCCTCTGTAGCAACAACCTCTGTCTAGA
TCCCTTTCTCCCTAGTTACATTGTATCAGGGCCCACATCCATGGCCTCATTTAACCTTAGTTAC
TTCTTTAAAAGCCTTGTCTCAAAACCATTTGCTCTTTAGCGATCTCCTCCAATTTGGAATTCTT
CATCTTGGGAAGCTCCTTAGGACTTAGGAGGTACTTAAAGAAGGTGATGCTGTCCATCCCACAG
GGAAGAAGCCTGTTCAGGTTAAGCTCAGGAAACAAATAACAAATTCAGGAAGTCCCTGAAACTG
ATAAGCTATCACCCCCCCCCCCCAAGTATATACAAACAATAAGAACTGCTGAGGTCACTTTTAG
ATAATCCAAAAATTCTGGAAGAGACAAAGACCAGCCAAGCTGCCTAGAAGGGACAGTTCCAACC
CATCTAGCTGCCTGCAAGTCATGCTGTGAGCTCCAGATTTCCAGCTATGGGAGCTGTCACCCAC
GATGGGGCAGGCTTTTGTAATGAAACTGTCTTTGAGTCATTTCTGCACCTCTAAATAACCTCAA
TAAAGCTCATTGGTTCATCCCGTTGGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_058987	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA87730	(Get FASTA)	NCBI Sequence Viewer
	CAA64832	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000010172
	ENSRNOP00000010172.6
GenBank Protein	P50572	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_058987 ⟸ NM_017291
- Peptide Label:	precursor
- UniProtKB:	P50572 (UniProtKB/Swiss-Prot), A6IIL1 (UniProtKB/TrEMBL), F1LPA8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLAVRNMKFGIFLLWWGWVLAAESTVHWPGREVHEPSKKGSRPQRQRRGAHDDAHKQGSPILKR SSDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHY WKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLR VTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHT TTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGIT TVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKI SCTCGLPQPRGVMLDSSYSDGEVNDLGGYMPENGEKPDRMMVQLTPASERGSPQRKSQRGSYVS MRINTHAIDKYSRIIFPAAYILFNLIYWSIFS hide sequence

Ensembl Acc Id:

ENSRNOP00000010172 ⟸ ENSRNOT00000010172

Protein Domains

Neurotransmitter-gated ion-channel ligand-binding Neurotransmitter-gated ion-channel transmembrane

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P50572-F1-model_v2	AlphaFold	P50572	1-480	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61900	AgrOrtholog
BioCyc Gene	G2FUF-41700	BioCyc
Ensembl Genes	ENSRNOG00000007603	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000010172	ENTREZGENE
	ENSRNOT00000010172.7	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.58.390	UniProtKB/Swiss-Prot
	2.70.170.10	UniProtKB/Swiss-Prot
InterPro	GABAA/Glycine_rcpt	UniProtKB/Swiss-Prot
	GABAAa_rho1_rcpt	UniProtKB/Swiss-Prot
	GABAAa_rho_rcpt	UniProtKB/Swiss-Prot
	Neur_chan_lig-bd	UniProtKB/Swiss-Prot
	Neur_chan_lig-bd_sf	UniProtKB/Swiss-Prot
	Neur_channel	UniProtKB/Swiss-Prot
	Neuro-gated_channel_TM_sf	UniProtKB/Swiss-Prot
	Neuro_actylchol_rec	UniProtKB/Swiss-Prot
	Neurotrans-gated_channel_TM	UniProtKB/Swiss-Prot
	Neurotransmitter_ion_chnl_CS	UniProtKB/Swiss-Prot
NCBI Gene	29694	ENTREZGENE
PANTHER	PTHR18945	UniProtKB/Swiss-Prot
Pfam	Neur_chan_LBD	UniProtKB/Swiss-Prot
	Neur_chan_memb	UniProtKB/Swiss-Prot
PhenoGen	Gabrr1	PhenoGen
PRINTS	GABAARECEPTR	UniProtKB/Swiss-Prot
	GABAARRHO	UniProtKB/Swiss-Prot
	GABAARRHO1	UniProtKB/Swiss-Prot
	NRIONCHANNEL	UniProtKB/Swiss-Prot
PROSITE	NEUROTR_ION_CHANNEL	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000007603	RatGTEx
Superfamily-SCOP	SSF63712	UniProtKB/Swiss-Prot
	SSF90112	UniProtKB/Swiss-Prot
UniProt	A6IIL1	ENTREZGENE, UniProtKB/TrEMBL
	F1LPA8	ENTREZGENE, UniProtKB/TrEMBL
	GBRR1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-12-06	Gabrr1	gamma-aminobutyric acid type A receptor subunit rho 1	Gabrr1	gamma-aminobutyric acid type A receptor rho 1 subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-11	Gabrr1	gamma-aminobutyric acid type A receptor rho 1 subunit	Gabrr1	gamma-aminobutyric acid (GABA) A receptor, rho 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-16	Gabrr1	gamma-aminobutyric acid (GABA) A receptor, rho 1	Gabrr1	gamma-aminobutyric acid (GABA) receptor, rho 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-17	Gabrr1	gamma-aminobutyric acid (GABA) receptor, rho 1	Gabrr1	gamma-aminobutyric acid (GABA-C) receptor, subunit rho 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Gabrr1	gamma-aminobutyric acid (GABA-C) receptor, subunit rho 1		gamma-aminobutyric acid A receptor, rho 1	Name updated	1299863	APPROVED
2002-06-10	Gabrr1	gamma-aminobutyric acid A receptor, rho 1			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	channel activity is insensitive to bicuculline, sensitive to picrotoxin block, and is decreased by increased H+ ions	61597

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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