Gabra2 (gamma-aminobutyric acid type A receptor subunit alpha 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Gabra2 (gamma-aminobutyric acid type A receptor subunit alpha 2) Rattus norvegicus
Analyze
Symbol: Gabra2
Name: gamma-aminobutyric acid type A receptor subunit alpha 2
RGD ID: 61856
Description: Predicted to enable GABA-gated chloride ion channel activity; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and inhibitory synapse assembly. Located in dendrite membrane. Is active in GABA-ergic synapse; postsynaptic specialization membrane; and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; autistic disorder; and developmental and epileptic encephalopathy 78. Orthologous to human GABRA2 (gamma-aminobutyric acid type A receptor subunit alpha2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alcohol; Alphaxolone.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GABA(A) receptor subunit alpha-2; GABAAR subunit alpha-2; gamma-aminobutyric acid (GABA) A receptor, alpha 2; gamma-aminobutyric acid (GABA-A) receptor subunit alpha 2; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2; gamma-aminobutyric acid A receptor, alpha 2; gamma-aminobutyric acid receptor A2 subunit; gamma-aminobutyric acid receptor subunit alpha-2; gamma-aminobutyric acid type A receptor alpha2 subunit; similar to Gamma-aminobutyric-acid receptor alpha-2 subunit precursor (GABA(A) receptor)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81437,451,218 - 37,587,458 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1437,450,683 - 37,587,457 (+)EnsemblGRCr8
mRatBN7.21437,097,251 - 37,230,030 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1437,097,279 - 37,228,944 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1437,456,948 - 37,589,716 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01438,761,706 - 38,894,495 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01437,242,647 - 37,375,425 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01439,662,411 - 39,801,082 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1439,661,968 - 39,798,302 (+)Ensemblrn6Rnor6.0
Rnor_5.01439,473,078 - 39,610,209 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41439,568,677 - 39,705,897 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1436,313,034 - 36,444,629 (+)NCBICelera
RGSC_v3.11439,574,531 - 39,707,830 (+)NCBI
Cytogenetic Map14p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
2,2,2-trifluoroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3',5'-cyclic AMP  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
6-Methoxyflavanone  (ISO)
6-Methoxyflavone  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alcohol  (EXP)
Alphaxolone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
atrazine  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bicuculline  (ISO)
bisphenol A  (EXP,ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chaetocin  (EXP)
chloral hydrate  (ISO)
Chloralose  (ISO)
chlorobutanol  (ISO)
chlorpyrifos  (EXP,ISO)
cocaine hydrochloride  (EXP)
Cuprizon  (EXP)
dextran sulfate  (ISO)
diazepam  (EXP,ISO)
dieldrin  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
enflurane  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ether  (ISO)
Etizolam  (EXP)
felbamate  (ISO)
fipronil  (ISO)
flunitrazepam  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (EXP)
gamma-aminobutyric acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
isoflurane  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP)
Lorazepam  (EXP)
maneb  (ISO)
methoxyflurane  (ISO)
oxcarbazepine  (EXP)
paraquat  (ISO)
parathion  (ISO)
pentetrazol  (ISO)
pentobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
picrotoxin  (ISO)
picrotoxinin  (ISO)
progesterone  (ISO)
propofol  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butanol  (ISO)
tert-Butylbicyclophosphorothionate  (ISO)
Testosterone propionate  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topiramate  (EXP)
triadimefon  (ISO)
tribromoethanol  (ISO)
triclosan  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Edenberg HJ, etal., Am J Hum Genet. 2004 Apr;74(4):705-14. Epub 2004 Mar 12.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Graf ER, etal., Cell. 2004 Dec 29;119(7):1013-26.
5. Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling. Kasugai Y, etal., Eur J Neurosci. 2010 Dec;32(11):1868-88. doi: 10.1111/j.1460-9568.2010.07473.x. Epub 2010 Nov 14.
6. Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. Ma DQ, etal., Am J Hum Genet. 2005 Sep;77(3):377-88. Epub 2005 Jul 15.
7. The interactions of alcohol and cocaine regulate the expression of genes involved in the GABAergic, glutamatergic and endocannabinoid systems of male and female rats. Marcos A, etal., Neuropharmacology. 2022 Mar 15;206:108937. doi: 10.1016/j.neuropharm.2021.108937. Epub 2021 Dec 26.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells. Nusser Z, etal., Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11939-44.
10. Input-dependent synaptic targeting of alpha(2)-subunit-containing GABA(A) receptors in synapses of hippocampal pyramidal cells of the rat. Nyíri G, etal., Eur J Neurosci. 2001 Feb;13(3):428-42. doi: 10.1046/j.1460-9568.2001.01407.x.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Gamma-aminobutyric acid receptor (GABA(A)) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry.PG - 241-57 Saha S, etal., Mol Cell Neurosci 2001 Jan;17(1):241-57.
16. Ethanol concentration-dependent alterations in gene expression during acute binge drinking in the HIV-1 transgenic rat. Sarkar S and Chang SL, Alcohol Clin Exp Res. 2013 Jul;37(7):1082-90. doi: 10.1111/acer.12077. Epub 2013 Feb 15.
17. The GABAA receptor family: molecular and functional diversity. Seeburg PH, etal., Cold Spring Harb Symp Quant Biol 1990;55(48):29-40.
Additional References at PubMed
PMID:1312131   PMID:1312132   PMID:1379501   PMID:1849552   PMID:8391122   PMID:9039914   PMID:9682826   PMID:11389177   PMID:12354299   PMID:12763608   PMID:14627650   PMID:14729731  
PMID:17113954   PMID:17483577   PMID:18256255   PMID:18292084   PMID:18360306   PMID:20833253   PMID:21219474   PMID:21368176   PMID:22044189   PMID:22215379   PMID:22666188   PMID:22871113  
PMID:23916758   PMID:23962649   PMID:24554721   PMID:25896802   PMID:26164299   PMID:26469128   PMID:27129275   PMID:32620552   PMID:38858171  


Genomics

Comparative Map Data
Gabra2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81437,451,218 - 37,587,458 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1437,450,683 - 37,587,457 (+)EnsemblGRCr8
mRatBN7.21437,097,251 - 37,230,030 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1437,097,279 - 37,228,944 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1437,456,948 - 37,589,716 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01438,761,706 - 38,894,495 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01437,242,647 - 37,375,425 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01439,662,411 - 39,801,082 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1439,661,968 - 39,798,302 (+)Ensemblrn6Rnor6.0
Rnor_5.01439,473,078 - 39,610,209 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41439,568,677 - 39,705,897 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1436,313,034 - 36,444,629 (+)NCBICelera
RGSC_v3.11439,574,531 - 39,707,830 (+)NCBI
Cytogenetic Map14p11NCBI
GABRA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38446,243,548 - 46,390,300 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl446,243,548 - 46,475,230 (-)Ensemblhg38GRCh38
GRCh37446,245,565 - 46,392,317 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36445,946,463 - 46,086,702 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34446,092,633 - 46,232,873NCBI
Celera446,700,624 - 46,841,051 (-)NCBICelera
Cytogenetic Map4p12NCBI
HuRef445,569,699 - 45,710,166 (-)NCBIHuRef
CHM1_1446,248,463 - 46,389,517 (-)NCBICHM1_1
T2T-CHM13v2.0446,210,399 - 46,357,479 (-)NCBIT2T-CHM13v2.0
Gabra2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39571,115,735 - 71,253,192 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl571,114,940 - 71,253,192 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38570,958,392 - 71,095,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl570,957,597 - 71,095,849 (-)Ensemblmm10GRCm38
MGSCv37571,352,296 - 71,487,088 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36571,240,192 - 71,374,984 (-)NCBIMGSCv36mm8
Celera568,229,777 - 68,364,499 (-)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map537.59NCBI
Gabra2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554432,042,151 - 2,179,174 (+)Ensembl
ChiLan1.0NW_0049554432,042,202 - 2,176,589 (+)NCBIChiLan1.0ChiLan1.0
GABRA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2381,473,905 - 81,625,212 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1481,735,556 - 81,886,702 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0475,762,568 - 75,913,708 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1486,491,841 - 86,641,878 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl486,491,837 - 86,638,166 (+)EnsemblpanPan2panpan1.1
GABRA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11342,367,988 - 42,488,069 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1342,368,949 - 42,488,075 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1342,260,942 - 42,439,688 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01342,916,600 - 43,095,420 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1342,973,212 - 43,094,323 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11342,594,633 - 42,773,515 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01342,656,291 - 42,835,136 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01343,007,629 - 43,186,860 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gabra2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528533,613,559 - 33,748,243 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648212,556,585 - 12,682,948 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648212,555,222 - 12,685,122 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl836,347,040 - 36,474,627 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1836,344,633 - 36,474,840 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2838,215,163 - 38,344,937 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GABRA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1273,858,741 - 4,013,385 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl273,858,910 - 4,006,582 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604749,925,823 - 50,088,704 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabra2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476120,688,838 - 20,819,568 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476120,688,819 - 20,819,487 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gabra2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11127,872,514 - 28,007,739 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gabra2
1054 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:26
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000003197, ENSRNOT00000064779
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143123808072970315Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143112133339507682Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142252151767521517Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat

Markers in Region
M86567  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21437,228,321 - 37,228,442 (+)MAPPERmRatBN7.2
Rnor_6.01439,798,275 - 39,798,395NCBIRnor6.0
Rnor_5.01439,609,556 - 39,609,676UniSTSRnor5.0
RGSC_v3.41439,705,244 - 39,705,364UniSTSRGSC3.4
Celera1436,443,976 - 36,444,096UniSTS
Cytogenetic Map14p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 10 57 154 57 57 26 32 26 6 217 119 11 129 55 89 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003197   ⟹   ENSRNOP00000003197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1437,100,714 - 37,228,944 (+)Ensembl
Rnor_6.0 Ensembl1439,663,421 - 39,798,106 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000064779   ⟹   ENSRNOP00000060621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1437,450,683 - 37,584,001 (+)Ensembl
mRatBN7.2 Ensembl1437,097,279 - 37,228,944 (+)Ensembl
Rnor_6.0 Ensembl1439,661,968 - 39,798,302 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000138569   ⟹   ENSRNOP00000105413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1437,454,681 - 37,587,457 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000171194   ⟹   ENSRNOP00000101170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1437,451,426 - 37,587,457 (+)Ensembl
RefSeq Acc Id: NM_001135779   ⟹   NP_001129251
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81437,451,218 - 37,584,007 (+)NCBI
mRatBN7.21437,097,251 - 37,230,030 (+)NCBI
Rnor_6.01439,662,441 - 39,798,928 (+)NCBI
Rnor_5.01439,473,078 - 39,610,209 (+)NCBI
RGSC_v3.41439,568,677 - 39,705,897 (+)RGD
Celera1436,313,034 - 36,444,629 (+)RGD
Sequence:
RefSeq Acc Id: XM_017599106   ⟹   XP_017454595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81437,451,657 - 37,587,458 (+)NCBI
mRatBN7.21437,097,691 - 37,230,030 (+)NCBI
Rnor_6.01439,662,852 - 39,799,626 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001129251 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454595 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC42030 (Get FASTA)   NCBI Sequence Viewer  
  AAN17788 (Get FASTA)   NCBI Sequence Viewer  
  EDL90008 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060621
  ENSRNOP00000101170
GenBank Protein P23576 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001129251   ⟸   NM_001135779
- Peptide Label: precursor
- UniProtKB: P23576 (UniProtKB/Swiss-Prot),   F1LMU7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454595   ⟸   XM_017599106
- Peptide Label: isoform X1
- UniProtKB: P23576 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003197   ⟸   ENSRNOT00000003197
Ensembl Acc Id: ENSRNOP00000060621   ⟸   ENSRNOT00000064779
Ensembl Acc Id: ENSRNOP00000105413   ⟸   ENSRNOT00000138569
Ensembl Acc Id: ENSRNOP00000101170   ⟸   ENSRNOT00000171194
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23576-F1-model_v2 AlphaFold P23576 1-451 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61856 AgrOrtholog
BioCyc Gene G2FUF-15832 BioCyc
Ensembl Genes ENSRNOG00000002349 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000064779 ENTREZGENE
  ENSRNOT00000171194 ENTREZGENE
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot
  GABAAa_rcpt UniProtKB/Swiss-Prot
  GABBAa2_rcpt UniProtKB/Swiss-Prot
  Gabra-1-6_TM UniProtKB/Swiss-Prot
  Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
NCBI Gene Gabra2 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PhenoGen Gabra2 PhenoGen
PRINTS GABAARALPHA UniProtKB/Swiss-Prot
  GABAARALPHA2 UniProtKB/Swiss-Prot
  GABAARECEPTR UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002349 RatGTEx
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
UniProt A0ABK0LII8_RAT UniProtKB/TrEMBL
  A0ABK0LJS3_RAT UniProtKB/TrEMBL
  A6JD86_RAT UniProtKB/TrEMBL
  F1LMU7 ENTREZGENE, UniProtKB/TrEMBL
  GBRA2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Gabra2  gamma-aminobutyric acid type A receptor subunit alpha 2  Gabra2  gamma-aminobutyric acid type A receptor alpha2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabra2  gamma-aminobutyric acid type A receptor alpha2 subunit  Gabra2  gamma-aminobutyric acid type A receptor alpha2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabra2  gamma-aminobutyric acid type A receptor alpha2 subunit  Gabra2  gamma-aminobutyric acid (GABA) A receptor, alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-20 Gabra2  gamma-aminobutyric acid (GABA) A receptor, alpha 2  Gabra2  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-21 Gabra2  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2  LOC289606  similar to Gamma-aminobutyric-acid receptor alpha-2 subunit precursor (GABA(A) receptor)  Data merged from RGD:1586205 737654 APPROVED
2008-03-11 Gabra2  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2  Gabra2  gamma-aminobutyric acid (GABA) A receptor, alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Gabra2  gamma-aminobutyric acid (GABA) A receptor, alpha 2  Gabra2  gamma-aminobutyric acid A receptor, alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC289606  similar to Gamma-aminobutyric-acid receptor alpha-2 subunit precursor (GABA(A) receptor)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Gabra2  gamma-aminobutyric acid A receptor, alpha 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in low amounts in NTS and protein expression is weak in most areas of the medulla except the olivary, lateral reticular, cuneate, vestibular and spinal trigeminal nuclei 625528
gene_process may mediate inhibitory GABA responses in nucleus tractus solitarii (NTS) in the brain 625528