Atn1 (atrophin 1) - Rat Genome Database

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Gene: Atn1 (atrophin 1) Rattus norvegicus
Analyze
Symbol: Atn1
Name: atrophin 1
RGD ID: 61832
Description: Enables JUN kinase binding activity. Involved in regulation of neuron differentiation. Located in cell leading edge; nucleus; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in dentatorubral-pallidoluysian atrophy and schizophrenia. Orthologous to human ATN1 (atrophin 1); INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; allethrin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: atrophin-1; atrophin-1-like; dentatorubral pallidoluysian atrophy; dentatorubral-pallidoluysian atrophy protein homolog; Drpla; LOC100911672
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,240,573 - 159,254,378 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4159,237,562 - 159,254,418 (-)EnsemblGRCr8
mRatBN7.24157,554,287 - 157,568,092 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,551,276 - 157,568,132 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,776,523 - 163,790,330 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,559,429 - 159,573,234 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,201,011 - 158,214,821 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,267,394 - 157,281,199 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,264,418 - 20,278,261 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl4157,267,901 - 157,274,755 (-)Ensemblrn6Rnor6.0
Rnor_5.04224,284,990 - 224,298,835 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44160,872,360 - 160,886,205 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4146,292,553 - 146,300,062 (-)NCBICelera
RGSC_v3.14161,117,300 - 161,131,141 (-)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells. Hou R and Sibinga NE, J Biol Chem. 2009 Mar 13;284(11):6955-65. doi: 10.1074/jbc.M809333200. Epub 2009 Jan 7.
3. Cloning and expression of the rat atrophin-I (DRPLA disease gene) homologue. Loev SJ, etal., Neurobiol Dis 1995 Jun;2(3):129-38.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Analysis of the CAG repeats in the SCA1 and B37 genes in schizophrenic and bipolar I disorder patients: tentative association between B37 and schizophrenia. Morris-Rosendahl DJ, etal., Am J Med Genet 1997 May 31;74(3):324-30.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity. Nucifora FC Jr, etal., J Biol Chem 2003 Apr 11;278(15):13047-55. Epub 2002 Dec 2.
8. Dentatorubral-pallidoluysian atrophy protein is phosphorylated by c-Jun NH2-terminal kinase. Okamura-Oho Y, etal., Hum Mol Genet 2003 Jul 1;12(13):1535-42.
9. Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate. Okamura-Oho Y, etal., Hum Mol Genet. 1999 Jun;8(6):947-57.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Secretory granules of hypophyseal and pancreatic endocrine cells contain proteins of the neuronal postsynaptic density. Redecker P, etal., Cell Tissue Res. 2007 Apr;328(1):49-55. Epub 2006 Nov 22.
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8541849   PMID:8889548   PMID:10085113   PMID:10973986   PMID:11984006   PMID:15784964   PMID:16702404   PMID:17150957   PMID:19681162   PMID:22082260   PMID:25519973  


Genomics

Comparative Map Data
Atn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,240,573 - 159,254,378 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4159,237,562 - 159,254,418 (-)EnsemblGRCr8
mRatBN7.24157,554,287 - 157,568,092 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,551,276 - 157,568,132 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,776,523 - 163,790,330 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,559,429 - 159,573,234 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,201,011 - 158,214,821 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,267,394 - 157,281,199 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,264,418 - 20,278,261 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl4157,267,901 - 157,274,755 (-)Ensemblrn6Rnor6.0
Rnor_5.04224,284,990 - 224,298,835 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44160,872,360 - 160,886,205 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4146,292,553 - 146,300,062 (-)NCBICelera
RGSC_v3.14161,117,300 - 161,131,141 (-)NCBI
Cytogenetic Map4q42NCBI
ATN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,924,459 - 6,942,321 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,924,463 - 6,942,322 (+)Ensemblhg38GRCh38
GRCh37127,033,622 - 7,051,484 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,903,887 - 6,921,745 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34126,907,740 - 6,921,743NCBI
Celera128,652,242 - 8,670,105 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,889,640 - 6,907,586 (+)NCBIHuRef
CHM1_1127,032,499 - 7,050,471 (+)NCBICHM1_1
T2T-CHM13v2.0126,935,640 - 6,953,487 (+)NCBIT2T-CHM13v2.0
Atn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,719,507 - 124,733,450 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,719,507 - 124,733,487 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl6124,716,152 - 124,732,984 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386124,742,544 - 124,756,487 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,742,544 - 124,756,524 (-)Ensemblmm10GRCm38
GRCm38.p6 Ensembl6124,739,189 - 124,756,021 (-)Ensemblmm10GRCm38
MGSCv376124,692,562 - 124,706,505 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366124,708,163 - 124,722,106 (-)NCBIMGSCv36mm8
Celera6126,424,276 - 126,438,219 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Atn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,516,532 - 4,522,831 (+)Ensembl
ChiLan1.0NW_0049554134,511,251 - 4,524,037 (+)NCBIChiLan1.0ChiLan1.0
ATN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,491,675 - 12,506,034 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,488,434 - 12,502,793 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,057,430 - 7,071,767 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,978,414 - 6,986,944 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,978,576 - 6,990,580 (+)EnsemblpanPan2panpan1.1
ATN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,104,683 - 38,118,957 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,104,842 - 38,111,462 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha278,497,826 - 8,512,450 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02738,457,244 - 38,471,505 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,456,843 - 38,464,161 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,331,302 - 38,345,906 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,372,276 - 38,386,882 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,976,546 - 7,990,812 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Atn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,219,906 - 102,227,203 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709887,455 - 894,727 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936709886,571 - 894,746 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,782,162 - 63,795,648 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1563,782,159 - 63,795,648 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,218,992 - 66,232,264 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,959,568 - 6,973,341 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,964,784 - 6,972,801 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660631,244,409 - 1,258,202 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,571,254 - 3,577,400 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248603,564,741 - 3,577,889 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Atn1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1623,127,526 - 23,141,645 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Atn1
137 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:277
Count of miRNA genes:143
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000019865, ENSRNOT00000051841
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4150095743159267220Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
BF402758  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,564,318 - 157,564,561 (-)MAPPERmRatBN7.2
mRatBN7.24157,564,318 - 157,564,561 (+)MAPPERmRatBN7.2
Rnor_6.04157,277,426 - 157,277,668NCBIRnor6.0
Rnor_6.0920,267,989 - 20,268,231NCBIRnor6.0
Rnor_5.04224,295,022 - 224,295,264UniSTSRnor5.0
Rnor_5.0919,143,965 - 19,144,207UniSTSRnor5.0
RGSC_v3.44160,882,392 - 160,882,634UniSTSRGSC3.4
Celera4146,302,585 - 146,302,827UniSTS
RH 3.4 Map41004.1UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 2 32 99 1 131 268 183 22 97 70 65 1 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000051841   ⟹   ENSRNOP00000045475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4159,237,562 - 159,254,418 (-)Ensembl
mRatBN7.2 Ensembl4157,551,276 - 157,568,132 (-)Ensembl
Rnor_6.0 Ensembl920,264,418 - 20,278,261 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088895   ⟹   ENSRNOP00000070945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4159,240,578 - 159,254,418 (-)Ensembl
mRatBN7.2 Ensembl4157,554,292 - 157,568,132 (-)Ensembl
Rnor_6.0 Ensembl4157,267,901 - 157,274,755 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123781   ⟹   ENSRNOP00000110187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4159,237,562 - 159,254,418 (-)Ensembl
RefSeq Acc Id: NM_001394346   ⟹   NP_001381275
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,240,573 - 159,254,080 (-)NCBI
mRatBN7.24157,554,287 - 157,567,794 (-)NCBI
RefSeq Acc Id: NM_017228   ⟹   NP_058924
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,240,573 - 159,254,378 (-)NCBI
mRatBN7.24157,554,287 - 157,568,092 (-)NCBI
Rnor_6.04157,267,394 - 157,281,199 (-)NCBI
Rnor_5.04224,284,990 - 224,298,835 (-)NCBI
RGSC_v3.44160,872,360 - 160,886,205 (-)RGD
Celera4146,292,553 - 146,300,062 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001381275 (Get FASTA)   NCBI Sequence Viewer  
  NP_058924 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA80337 (Get FASTA)   NCBI Sequence Viewer  
  CAA61623 (Get FASTA)   NCBI Sequence Viewer  
  EDM01940 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070945
GenBank Protein P54258 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058924   ⟸   NM_017228
- UniProtKB: P54258 (UniProtKB/Swiss-Prot),   A0A0G2JZ81 (UniProtKB/TrEMBL),   A6ILJ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070945   ⟸   ENSRNOT00000088895
Ensembl Acc Id: ENSRNOP00000045475   ⟸   ENSRNOT00000051841
RefSeq Acc Id: NP_001381275   ⟸   NM_001394346
- UniProtKB: P54258 (UniProtKB/Swiss-Prot),   A0A0G2JZ81 (UniProtKB/TrEMBL),   A6ILJ9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110187   ⟸   ENSRNOT00000123781

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54258-F1-model_v2 AlphaFold P54258 1-1183 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61832 AgrOrtholog
BioCyc Gene G2FUF-43074 BioCyc
Ensembl Genes ENSRNOG00000049575 Ensembl
  ENSRNOG00000060594 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000088895 ENTREZGENE
InterPro Atrophin-1 UniProtKB/Swiss-Prot
  Atrophin-like UniProtKB/Swiss-Prot
NCBI Gene 29515 ENTREZGENE
PANTHER ATROPHIN-1 UniProtKB/Swiss-Prot
  ATROPHIN-RELATED UniProtKB/Swiss-Prot
Pfam Atrophin-1 UniProtKB/Swiss-Prot
PhenoGen Atn1 PhenoGen
PRINTS ATROPHIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000049575 RatGTEx
  ENSRNOG00000060594 RatGTEx
UniProt A0A0G2JZ81 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M558_RAT UniProtKB/TrEMBL
  A6ILJ9 ENTREZGENE, UniProtKB/TrEMBL
  ATN1_RAT UniProtKB/Swiss-Prot
  G3V7W3_RAT UniProtKB/TrEMBL
  P54258 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Atn1  atrophin 1  LOC100911672  atrophin-1-like  Data merged from RGD:6491795 737654 PROVISIONAL
2012-07-05 LOC100911672  atrophin-1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Atn1  atrophin 1  Drpla  dentatorubral pallidoluysian atrophy  Symbol and Name updated 1299863 APPROVED
2002-06-10 Drpla  dentatorubral pallidoluysian atrophy      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease expansion of CAG trinucleotide repeat in human homolog causes dentatorubral pallidoluysian atrophy, a degenerative neurological disorder similar to Huntington disease 632619
gene_domains contains a polymorphic proline repeat, a serine repeat, and a region of alternating acidic and basic residues 632619
gene_expression widely expressed in many tissues 632619