Ywhaz (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Ywhaz (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta) Rattus norvegicus
Analyze
Symbol: Ywhaz
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
RGD ID: 3980
Description: Predicted to enable several functions, including enzyme binding activity; phosphoserine residue binding activity; and transmembrane transporter binding activity. Involved in histamine secretion by mast cell; protein targeting to mitochondrion; and response to xenobiotic stimulus. Located in cell leading edge and perinuclear region of cytoplasm. Part of protein-containing complex. Is active in postsynaptic specialization. Biomarker of absence epilepsy and hypertension. Orthologous to human YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; histone modification pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 14-3-3 protein zeta/delta; 14-3-3z; KCIP-1; mitochondrial import stimulation factor S1 subunit; protein kinase C inhibitor protein 1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8769,826,404 - 69,848,702 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl769,826,404 - 69,849,007 (-)EnsemblGRCr8
mRatBN7.2767,941,353 - 67,963,651 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl767,940,017 - 67,963,668 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx769,829,731 - 69,852,029 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0772,032,344 - 72,054,642 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0771,900,221 - 71,922,519 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0775,573,553 - 75,598,295 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl775,574,967 - 75,597,276 (-)Ensemblrn6Rnor6.0
Rnor_5.0775,719,688 - 75,744,428 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4772,283,825 - 72,306,126 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera765,020,398 - 65,042,696 (-)NCBICelera
RGSC_v3.1772,304,554 - 72,327,161 (-)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
Evodiamine  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furfural  (ISO)
glucose  (ISO)
hypochlorous acid  (ISO)
ivermectin  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
microcystin-LR  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nitrates  (ISO)
nitroglycerin  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
prostaglandin F2alpha  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sodium nitrate  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
triacsin C  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. cDNA cloning and characterization of mitochondrial import stimulation factor (MSF) purified from rat liver cytosol. Alam R, etal., J Biochem (Tokyo) 1994 Aug;116(2):416-25.
2. Fluoxetine-induced up-regulation of 14-3-3zeta and tryptophan hydroxylase levels in RBL-2H3 cells. Baik SY, etal., Neurosci Lett. 2005 Feb 1;374(1):53-7.
3. Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins. Birkenfeld J, etal., Biochem Biophys Res Commun 2003 Mar 14;302(3):526-33.
4. Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta. Birkenfeld J, etal., Biochem J. 2003 Jan 1;369(Pt 1):45-54.
5. miR-22 targets YWHAZ to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival. Chen M, etal., Oncotarget. 2016 Dec 6;7(49):80751-80764. doi: 10.18632/oncotarget.13037.
6. Association of GABA(B) receptors and members of the 14-3-3 family of signaling proteins. Couve A, etal., Mol Cell Neurosci. 2001 Feb;17(2):317-28.
7. Changes in intracellular protein expression in cortex, thalamus and hippocampus in a genetic rat model of absence epilepsy. Danis O, etal., Brain Res Bull. 2011 Apr 5;84(6):381-8. doi: 10.1016/j.brainresbull.2011.02.002. Epub 2011 Feb 15.
8. Stimulation of 14-3-3 protein and its isoform on histamine secretion from permeabilized rat peritoneal mast cells. Fujii T and Ueeda T, Biol Pharm Bull. 2002 Dec;25(12):1524-7.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. 14-3-3 proteins within the hypothalamic-neurohypophyseal system of the osmotically stressed rat: transcriptomic and proteomic studies. Gouraud SS, etal., J Neuroendocrinol. 2007 Nov;19(11):913-22.
11. Proteomic response to acupuncture treatment in spontaneously hypertensive rats. Lai X, etal., PLoS One. 2012;7(9):e44216. doi: 10.1371/journal.pone.0044216. Epub 2012 Sep 12.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Readout of epigenetic modifications. Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Cloning and characterization of the epsilon and zeta isoforms of the 14-3-3 proteins. Roseboom PH, etal., DNA Cell Biol 1994 Jun;13(6):629-40.
20. Isoform- and subcellular fraction-specific differences in hippocampal 14-3-3 levels following experimentally evoked seizures and in human temporal lobe epilepsy. Schindler CK, etal., J Neurochem. 2006 Oct;99(2):561-9. Epub 2006 Sep 18.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms. Suginta W, etal., Biochem J. 2001 Oct 1;359(Pt 1):55-64.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. Thompson S, etal., J Biol Chem. 2011 Jun 3;286(22):19331-9. doi: 10.1074/jbc.M110.197707. Epub 2011 Apr 8.
25. Kainic acid induces 14-3-3 zeta expression in distinct regions of rat brain. van der Brug MP, etal., Brain Res 2002 Nov 22;956(1):110-5.
26. Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain. Watanabe M, etal., Brain Res Mol Brain Res 1994 Aug;25(1-2):113-21.
Additional References at PubMed
PMID:8972907   PMID:10102273   PMID:12176995   PMID:12446771   PMID:12650640   PMID:14651853   PMID:15073173   PMID:15489334   PMID:15615787   PMID:16114898   PMID:16376338   PMID:16502470  
PMID:16854843   PMID:16959763   PMID:17455326   PMID:18029012   PMID:19014373   PMID:19056867   PMID:19190083   PMID:19199708   PMID:19289463   PMID:19451227   PMID:19725078   PMID:20332113  
PMID:20458337   PMID:20618440   PMID:21423176   PMID:21630459   PMID:22069327   PMID:22124272   PMID:22516433   PMID:22588126   PMID:22658674   PMID:22692127   PMID:22871113   PMID:23106098  
PMID:23533145   PMID:23580065   PMID:23936434   PMID:24206074   PMID:24367683   PMID:25468996   PMID:27401462   PMID:28131823   PMID:28259758   PMID:29118970   PMID:29476059   PMID:31024343  
PMID:31904090   PMID:32357304   PMID:35352799  


Genomics

Comparative Map Data
Ywhaz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8769,826,404 - 69,848,702 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl769,826,404 - 69,849,007 (-)EnsemblGRCr8
mRatBN7.2767,941,353 - 67,963,651 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl767,940,017 - 67,963,668 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx769,829,731 - 69,852,029 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0772,032,344 - 72,054,642 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0771,900,221 - 71,922,519 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0775,573,553 - 75,598,295 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl775,574,967 - 75,597,276 (-)Ensemblrn6Rnor6.0
Rnor_5.0775,719,688 - 75,744,428 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4772,283,825 - 72,306,126 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera765,020,398 - 65,042,696 (-)NCBICelera
RGSC_v3.1772,304,554 - 72,327,161 (-)NCBI
Cytogenetic Map7q22NCBI
YWHAZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388100,916,523 - 100,953,382 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8100,916,523 - 100,953,388 (-)Ensemblhg38GRCh38
GRCh378101,928,751 - 101,965,610 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368102,000,090 - 102,034,745 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348102,000,089 - 102,033,447NCBI
Celera898,115,836 - 98,150,667 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef897,128,746 - 97,163,575 (-)NCBIHuRef
CHM1_18101,971,677 - 102,006,519 (-)NCBICHM1_1
T2T-CHM13v2.08102,042,222 - 102,079,082 (-)NCBIT2T-CHM13v2.0
Ywhaz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391536,770,505 - 36,803,228 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1536,771,014 - 36,797,173 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381536,770,261 - 36,802,984 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1536,770,770 - 36,796,929 (-)Ensemblmm10GRCm38
MGSCv371536,700,016 - 36,724,293 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361536,715,359 - 36,738,833 (-)NCBIMGSCv36mm8
Celera1537,392,750 - 37,416,932 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1514.56NCBI
Ywhaz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541716,047,263 - 16,072,854 (-)Ensembl
ChiLan1.0NW_00495541716,047,263 - 16,070,506 (-)NCBIChiLan1.0ChiLan1.0
YWHAZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27118,270,716 - 118,309,855 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1893,806,633 - 93,841,368 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0897,560,251 - 97,595,117 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1899,730,393 - 99,765,559 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl899,730,393 - 99,762,990 (-)EnsemblpanPan2panpan1.1
YWHAZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1132,729,404 - 2,764,422 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha132,728,046 - 2,764,406 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0132,885,028 - 2,921,415 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl132,884,653 - 2,921,431 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1132,728,699 - 2,765,052 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0132,841,194 - 2,877,738 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0132,857,979 - 2,894,557 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ywhaz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530335,018,527 - 35,044,806 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647042,445,412 - 42,470,900 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647042,444,671 - 42,470,548 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YWHAZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl435,975,508 - 36,009,887 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1435,975,513 - 36,009,909 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2438,914,372 - 38,942,695 (+)NCBISscrofa10.2Sscrofa10.2susScr3
YWHAZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1895,786,197 - 95,821,270 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl895,788,305 - 95,819,197 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603944,861,087 - 44,896,463 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ywhaz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247637,722,275 - 7,723,482 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ywhaz
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11210,289,055 - 210,313,838 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ywhaz
189 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:404
Count of miRNA genes:232
Interacting mature miRNAs:268
Transcripts:ENSRNOT00000035628
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
RH144540  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2767,965,448 - 67,965,585 (+)MAPPERmRatBN7.2
Rnor_6.0775,599,074 - 75,599,210NCBIRnor6.0
Rnor_5.0775,745,207 - 75,745,343UniSTSRnor5.0
RGSC_v3.4772,307,924 - 72,308,060UniSTSRGSC3.4
Celera765,044,494 - 65,044,630UniSTS
RH 3.4 Map7639.9UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000035628   ⟹   ENSRNOP00000030885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl769,826,404 - 69,847,434 (-)Ensembl
mRatBN7.2 Ensembl767,941,393 - 67,963,668 (-)Ensembl
Rnor_6.0 Ensembl775,574,967 - 75,597,276 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080676   ⟹   ENSRNOP00000069366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl769,826,404 - 69,848,122 (-)Ensembl
mRatBN7.2 Ensembl767,940,017 - 67,961,970 (-)Ensembl
Rnor_6.0 Ensembl775,575,763 - 75,597,087 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096774   ⟹   ENSRNOP00000082109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl769,826,565 - 69,849,007 (-)Ensembl
mRatBN7.2 Ensembl767,940,017 - 67,963,622 (-)Ensembl
RefSeq Acc Id: NM_013011   ⟹   NP_037143
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8769,826,404 - 69,848,702 (-)NCBI
mRatBN7.2767,941,353 - 67,963,651 (-)NCBI
Rnor_6.0775,574,966 - 75,597,276 (-)NCBI
Rnor_5.0775,719,688 - 75,744,428 (-)NCBI
RGSC_v3.4772,283,825 - 72,306,126 (-)RGD
Celera765,020,398 - 65,042,696 (-)RGD
Sequence:
RefSeq Acc Id: NP_037143   ⟸   NM_013011
- UniProtKB: Q52KK1 (UniProtKB/Swiss-Prot),   Q6IRF4 (UniProtKB/Swiss-Prot),   P63102 (UniProtKB/Swiss-Prot),   A6HR34 (UniProtKB/TrEMBL),   A0A0G2JV65 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069366   ⟸   ENSRNOT00000080676
Ensembl Acc Id: ENSRNOP00000030885   ⟸   ENSRNOT00000035628
Ensembl Acc Id: ENSRNOP00000082109   ⟸   ENSRNOT00000096774
Protein Domains
14-3-3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63102-F1-model_v2 AlphaFold P63102 1-245 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695294
Promoter ID:EPDNEW_R5819
Type:initiation region
Name:Ywhaz_1
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activationprotein, zeta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0775,597,310 - 75,597,370EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3980 AgrOrtholog
BioCyc Gene G2FUF-33637 BioCyc
Ensembl Genes ENSRNOG00000008195 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000096774 ENTREZGENE
  ENSRNOT00000096774.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.190.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7099670 IMAGE-MGC_LOAD
  IMAGE:7313193 IMAGE-MGC_LOAD
InterPro 14-3-3 UniProtKB/Swiss-Prot
  14-3-3_CS UniProtKB/Swiss-Prot
  14-3-3_dom_sf UniProtKB/Swiss-Prot
  14-3-3_domain UniProtKB/Swiss-Prot
KEGG Report rno:25578 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105417 IMAGE-MGC_LOAD
  MGC:91665 IMAGE-MGC_LOAD
NCBI Gene 25578 ENTREZGENE
PANTHER PTHR18860 UniProtKB/Swiss-Prot
Pfam 14-3-3 UniProtKB/Swiss-Prot
PhenoGen Ywhaz PhenoGen
PIRSF 14-3-3 UniProtKB/Swiss-Prot
PRINTS 1433ZETA UniProtKB/Swiss-Prot
PROSITE 1433_1 UniProtKB/Swiss-Prot
  1433_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008195 RatGTEx
SMART 14_3_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48445 UniProtKB/Swiss-Prot
TIGR TC204183
UniProt 1433Z_RAT UniProtKB/Swiss-Prot
  A0A0G2JV65 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QI32_RAT UniProtKB/TrEMBL
  A6HR33_RAT UniProtKB/TrEMBL
  A6HR34 ENTREZGENE, UniProtKB/TrEMBL
  P63102 ENTREZGENE
  Q52KK1 ENTREZGENE
  Q6IRF4 ENTREZGENE
UniProt Secondary P35215 UniProtKB/Swiss-Prot
  P70197 UniProtKB/Swiss-Prot
  P97286 UniProtKB/Swiss-Prot
  Q52KK1 UniProtKB/Swiss-Prot
  Q6IRF4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-12-11 Ywhaz  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta  Ywhaz  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ywhaz  Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may play a role in ATP-dependent protein depolymerization and unfolding 727986
gene_product member of the 14-3-3 protein family 727986