Trpv2 (transient receptor potential cation channel, subfamily V, member 2) - Rat Genome Database

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Gene: Trpv2 (transient receptor potential cation channel, subfamily V, member 2) Rattus norvegicus
Analyze
Symbol: Trpv2
Name: transient receptor potential cation channel, subfamily V, member 2
RGD ID: 3965
Description: Enables calcium channel activity and identical protein binding activity. Involved in negative regulation of cell population proliferation. Located in endomembrane system; lamellipodium; and plasma membrane. Orthologous to human TRPV2 (transient receptor potential cation channel subfamily V member 2); INTERACTS WITH 11-hydroxy-Delta(9)-tetrahydrocannabinol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC105451; osm-9-like TRP channel 2; OTRPC2; stretch-activated channel 2B; transient receptor potential cation channel subfamily V member 2; vanilloid receptor-like protein 1; VRL-1; Vrl1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Trpv2em1Mcwi
Genetic Models: WKY-Trpv2em1Mcwi
Candidate Gene For: Pia26
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81047,772,223 - 47,797,956 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1047,764,839 - 47,793,533 (+)EnsemblGRCr8
mRatBN7.21047,265,524 - 47,294,263 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1047,272,931 - 47,294,260 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1051,975,970 - 51,997,253 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01051,466,516 - 51,487,799 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01046,969,925 - 46,991,212 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01048,903,540 - 48,925,036 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1048,903,540 - 48,925,030 (+)Ensemblrn6Rnor6.0
Rnor_5.01048,686,500 - 48,707,996 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41048,764,894 - 48,786,150 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1046,520,118 - 46,541,280 (+)NCBICelera
RGSC_v3.11048,778,506 - 48,799,767 (+)NCBI
Cytogenetic Map10q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dibromoethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
11-hydroxy-Delta(9)-tetrahydrocannabinol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
Cannabichromene  (ISO)
cannabidiol  (EXP,ISO)
cannabidiolic acid  (ISO)
Cannabidivarin  (ISO)
Cannabinol  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
endosulfan  (EXP)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glycidol  (ISO)
indometacin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nabilone  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sotorasib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
tranilast  (ISO)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
vincristine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IEA,ISO)
axonal growth cone  (IEA,ISO)
cell body  (IEA,ISO)
cell surface  (IEA,ISO)
cytoplasm  (IEA)
endomembrane system  (IDA)
growth cone membrane  (IEA,ISO)
lamellipodium  (IDA)
melanosome  (IEA)
membrane  (IEA)
neuronal cell body  (IDA)
plasma membrane  (IBA,IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. RGA protein associates with a TRPV ion channel during biosynthesis and trafficking. Barnhill JC, etal., J Cell Biochem. 2004 Mar 1;91(4):808-20.
2. A capsaicin-receptor homologue with a high threshold for noxious heat. Caterina MJ, etal., Nature 1999 Apr 1;398(6726):436-41.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Structural insight into the assembly of TRPV channels. Huynh KW, etal., Structure. 2014 Feb 4;22(2):260-8. doi: 10.1016/j.str.2013.11.008. Epub 2013 Dec 26.
5. Agonist recognition sites in the cytosolic tails of vanilloid receptor 1. Jung J, etal., J Biol Chem 2002 Nov 15;277(46):44448-54.
6. Efficacy of nifedipine therapy in patients with sphincter of Oddi dysfunction: a prospective, double-blind, randomized, placebo-controlled, cross over trial. Khuroo MS, etal., Br J Clin Pharmacol. 1992 May;33(5):477-85. doi: 10.1111/j.1365-2125.1992.tb04074.x.
7. The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion. Laragione T, etal., Clin Immunol. 2015 Apr 11. pii: S1521-6616(15)00131-X. doi: 10.1016/j.clim.2015.04.001.
8. Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex. Liapi A and Wood JN, Eur J Neurosci. 2005 Aug;22(4):825-34. doi: 10.1111/j.1460-9568.2005.04270.x.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue. Sun W, etal., EMBO Rep. 2016 Mar;17(3):383-99. doi: 10.15252/embr.201540819. Epub 2016 Feb 11.
Additional References at PubMed
PMID:10559903   PMID:12062441   PMID:12477932   PMID:12829722   PMID:12867271   PMID:14622291   PMID:14625457   PMID:14725976   PMID:14961565   PMID:15174083   PMID:15249591   PMID:15254097  
PMID:15489334   PMID:15547947   PMID:15620571   PMID:15653710   PMID:16533525   PMID:17287441   PMID:17517374   PMID:17712480   PMID:19579031   PMID:19619635   PMID:20357111   PMID:21998141  
PMID:22188460   PMID:22190268   PMID:22750329   PMID:23584686   PMID:24392006   PMID:25136832   PMID:25956061   PMID:27021073   PMID:27074678   PMID:27468746   PMID:27784066   PMID:28007781  
PMID:29505690   PMID:30764505   PMID:31062423   PMID:31566564   PMID:31719194   PMID:31724952   PMID:33763489   PMID:34605028   PMID:35406761   PMID:35686730   PMID:36134661   PMID:36470868  
PMID:37608122   PMID:38728789   PMID:38776831  


Genomics

Comparative Map Data
Trpv2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81047,772,223 - 47,797,956 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1047,764,839 - 47,793,533 (+)EnsemblGRCr8
mRatBN7.21047,265,524 - 47,294,263 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1047,272,931 - 47,294,260 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1051,975,970 - 51,997,253 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01051,466,516 - 51,487,799 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01046,969,925 - 46,991,212 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01048,903,540 - 48,925,036 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1048,903,540 - 48,925,030 (+)Ensemblrn6Rnor6.0
Rnor_5.01048,686,500 - 48,707,996 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41048,764,894 - 48,786,150 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1046,520,118 - 46,541,280 (+)NCBICelera
RGSC_v3.11048,778,506 - 48,799,767 (+)NCBI
Cytogenetic Map10q23NCBI
TRPV2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381716,415,571 - 16,437,003 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1716,415,571 - 16,437,003 (+)Ensemblhg38GRCh38
GRCh371716,318,885 - 16,340,317 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361716,259,613 - 16,281,042 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341716,259,612 - 16,281,040NCBI
Celera1716,221,759 - 16,243,216 (+)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1716,185,329 - 16,206,779 (+)NCBIHuRef
CHM1_11716,328,475 - 16,349,923 (+)NCBICHM1_1
T2T-CHM13v2.01716,317,872 - 16,339,304 (+)NCBIT2T-CHM13v2.0
Trpv2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,465,312 - 62,491,131 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,465,312 - 62,491,341 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381162,574,486 - 62,600,305 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,574,486 - 62,600,515 (+)Ensemblmm10GRCm38
MGSCv371162,387,988 - 62,413,807 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361162,390,733 - 62,416,491 (+)NCBIMGSCv36mm8
Celera1169,494,115 - 69,519,933 (+)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1138.48NCBI
TRPV2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21956,184,883 - 56,211,452 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11761,001,608 - 61,023,202 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01735,329,283 - 35,350,729 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A110,620,793 - 110,642,926 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A110,620,793 - 110,642,926 (+)EnsemblpanPan2panpan1.1
TRPV2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1539,488,155 - 39,512,454 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl539,491,484 - 39,509,902 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha539,632,760 - 39,656,359 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0539,596,549 - 39,620,384 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl539,600,757 - 39,620,349 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1539,568,532 - 39,592,119 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0539,513,796 - 39,537,381 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0539,705,961 - 39,729,555 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Trpv2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560259,586,614 - 59,613,898 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936821198,098 - 226,025 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936821198,622 - 225,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPV2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1259,135,329 - 59,152,228 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11259,132,529 - 59,152,633 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21262,259,257 - 62,278,900 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRPV2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11615,226,276 - 15,246,488 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1615,225,554 - 15,244,364 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660595,726,313 - 5,748,264 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpv2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248774,016,973 - 4,034,495 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248774,016,964 - 4,034,522 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Trpv2
187 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:113
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000004248
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
Trpv2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21047,289,885 - 47,291,406 (+)MAPPERmRatBN7.2
Rnor_6.01048,920,659 - 48,922,179NCBIRnor6.0
Rnor_5.01048,703,619 - 48,705,139UniSTSRnor5.0
Celera1046,536,903 - 46,538,423UniSTS
Cytogenetic Map10q23UniSTS


Genetic Models
This gene Trpv2 is modified in the following models/strains:
WKY-Trpv2em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000004248   ⟹   ENSRNOP00000004248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1047,764,839 - 47,793,533 (+)Ensembl
mRatBN7.2 Ensembl1047,272,931 - 47,294,260 (+)Ensembl
Rnor_6.0 Ensembl1048,903,540 - 48,925,030 (+)Ensembl
RefSeq Acc Id: NM_001270797   ⟹   NP_001257726
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81047,772,223 - 47,793,543 (+)NCBI
mRatBN7.21047,272,942 - 47,294,263 (+)NCBI
Rnor_6.01048,903,540 - 48,925,036 (+)NCBI
Rnor_5.01048,686,500 - 48,707,996 (+)NCBI
Celera1046,520,118 - 46,541,280 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270798   ⟹   NP_001257727
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81047,772,223 - 47,793,543 (+)NCBI
mRatBN7.21047,272,942 - 47,294,263 (+)NCBI
Rnor_6.01048,903,540 - 48,925,036 (+)NCBI
Rnor_5.01048,686,500 - 48,707,996 (+)NCBI
Celera1046,520,118 - 46,541,280 (+)NCBI
Sequence:
RefSeq Acc Id: NM_017207   ⟹   NP_058903
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81047,772,223 - 47,793,543 (+)NCBI
mRatBN7.21047,272,942 - 47,294,263 (+)NCBI
Rnor_6.01048,903,540 - 48,925,036 (+)NCBI
Rnor_5.01048,686,500 - 48,707,996 (+)NCBI
RGSC_v3.41048,764,894 - 48,786,150 (+)RGD
Celera1046,520,118 - 46,541,280 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063268815   ⟹   XP_063124885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81047,772,375 - 47,797,956 (+)NCBI
RefSeq Acc Id: XM_063268816   ⟹   XP_063124886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81047,772,374 - 47,797,956 (+)NCBI
RefSeq Acc Id: XM_063268817   ⟹   XP_063124887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81047,772,373 - 47,797,956 (+)NCBI
RefSeq Acc Id: NP_058903   ⟸   NM_017207
- UniProtKB: Q9QYH8 (UniProtKB/Swiss-Prot),   Q9JMI8 (UniProtKB/Swiss-Prot),   Q5FWT3 (UniProtKB/Swiss-Prot),   Q9WUD2 (UniProtKB/Swiss-Prot),   A0A0G2JSH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257726   ⟸   NM_001270797
- UniProtKB: Q9QYH8 (UniProtKB/Swiss-Prot),   Q9JMI8 (UniProtKB/Swiss-Prot),   Q5FWT3 (UniProtKB/Swiss-Prot),   Q9WUD2 (UniProtKB/Swiss-Prot),   A0A0G2JSH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257727   ⟸   NM_001270798
- UniProtKB: Q9QYH8 (UniProtKB/Swiss-Prot),   Q9JMI8 (UniProtKB/Swiss-Prot),   Q5FWT3 (UniProtKB/Swiss-Prot),   Q9WUD2 (UniProtKB/Swiss-Prot),   A0A0G2JSH6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004248   ⟸   ENSRNOT00000004248
RefSeq Acc Id: XP_063124887   ⟸   XM_063268817
- Peptide Label: isoform X1
- UniProtKB: Q9WUD2 (UniProtKB/Swiss-Prot),   Q9QYH8 (UniProtKB/Swiss-Prot),   Q9JMI8 (UniProtKB/Swiss-Prot),   Q5FWT3 (UniProtKB/Swiss-Prot),   A0A0G2JSH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124886   ⟸   XM_063268816
- Peptide Label: isoform X1
- UniProtKB: Q9WUD2 (UniProtKB/Swiss-Prot),   Q9QYH8 (UniProtKB/Swiss-Prot),   Q9JMI8 (UniProtKB/Swiss-Prot),   Q5FWT3 (UniProtKB/Swiss-Prot),   A0A0G2JSH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124885   ⟸   XM_063268815
- Peptide Label: isoform X1
- UniProtKB: Q9WUD2 (UniProtKB/Swiss-Prot),   Q9QYH8 (UniProtKB/Swiss-Prot),   Q9JMI8 (UniProtKB/Swiss-Prot),   Q5FWT3 (UniProtKB/Swiss-Prot),   A0A0G2JSH6 (UniProtKB/TrEMBL)
Protein Domains
Ion transport

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUD2-F1-model_v2 AlphaFold Q9WUD2 1-761 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697275
Promoter ID:EPDNEW_R7800
Type:initiation region
Name:Trpv2_1
Description:transient receptor potential cation channel, subfamily V, member2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01048,903,548 - 48,903,608EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3965 AgrOrtholog
BioCyc Gene G2FUF-24770 BioCyc
Ensembl Genes ENSRNOG00000003104 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000004248 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.25.40.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7302251 IMAGE-MGC_LOAD
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  TRPV UniProtKB/Swiss-Prot
  TRPV1-4_channel UniProtKB/Swiss-Prot
KEGG Report rno:29465 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105451 IMAGE-MGC_LOAD
NCBI Gene 29465 ENTREZGENE
PANTHER PTHR10582 UniProtKB/Swiss-Prot
  PTHR10582:SF5 UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
PhenoGen Trpv2 PhenoGen
PRINTS TRPVRECEPTOR UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003104 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
UniProt A0A0G2JSH6 ENTREZGENE, UniProtKB/TrEMBL
  A6HFB1_RAT UniProtKB/TrEMBL
  Q5FWT3 ENTREZGENE
  Q9JMI8 ENTREZGENE
  Q9QYH8 ENTREZGENE
  Q9WUD2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5FWT3 UniProtKB/Swiss-Prot
  Q9JMI8 UniProtKB/Swiss-Prot
  Q9QYH8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Trpv2  transient receptor potential cation channel, subfamily V, member 2  Vrl1  vanilloid receptor-like protein 1  Symbol and Name updated 1299863 APPROVED
2002-06-10 Vrl1  vanilloid receptor-like protein 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation insensitive to capsaicin 70055