Ugt8 (UDP glycosyltransferase 8) - Rat Genome Database

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Gene: Ugt8 (UDP glycosyltransferase 8) Rattus norvegicus
Analyze
Symbol: Ugt8
Name: UDP glycosyltransferase 8
RGD ID: 3938
Description: Enables N-acylsphingosine galactosyltransferase activity and UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity. Involved in galactosylceramide biosynthetic process and response to immobilization stress. Located in endoplasmic reticulum. Orthologous to human UGT8 (UDP glycosyltransferase 8); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; ceramide UDP-galactosyltransferase; cerebroside synthase; CGalT; UDP galactosyltransferase 8; UDP galactosyltransferase 8A; UDP-galactose-ceramide galactosyltransferase 8; UDP-glucuronosyltransferase 8; Ugt8a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82216,938,884 - 217,007,167 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2216,938,990 - 217,007,167 (-)EnsemblGRCr8
mRatBN7.22214,264,483 - 214,332,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2214,264,483 - 214,332,660 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2221,935,494 - 222,003,681 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02219,835,423 - 219,903,608 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02214,689,623 - 214,757,812 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02229,644,373 - 229,718,678 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2229,644,382 - 229,718,659 (-)Ensemblrn6Rnor6.0
Rnor_5.02248,998,871 - 249,072,741 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42222,977,966 - 223,048,277 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2206,609,425 - 206,656,289 (-)NCBICelera
RGSC_v3.1436,844,752 - 36,845,448 (+)NCBI
Cytogenetic Map2q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
endoplasmic reticulum  (IBA,IDA,IEA)
membrane  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Coetzee T, etal., Cell 1996 Jul 26;86(2):209-19.
2. Myelin galactolipids are essential for proper node of Ranvier formation in the CNS. Dupree JL, etal., J Neurosci 1998 Mar 1;18(5):1642-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Ceramide UDPgalactosyltransferase from myelinating rat brain: purification, cloning, and expression. Schulte S and Stoffel W, Proc Natl Acad Sci U S A 1993 Nov 1;90(21):10265-9.
13. Isolation, characterization, and expression of cDNA clones that encode rat UDP-galactose: ceramide galactosyltransferase. Stahl N, etal., J Neurosci Res 1994 Jun 1;38(2):234-42.
14. Enriched Environment Enhances the Myelin Regulatory Factor by mTOR Signaling and Protects the Myelin Membrane Against Oxidative Damage in Rats Exposed to Chronic Immobilization Stress. Thamizhoviya G and Vanisree AJ, Neurochem Res. 2021 Dec;46(12):3314-3324. doi: 10.1007/s11064-021-03433-8. Epub 2021 Aug 27.
15. Synthesis of non-hydroxy-galactosylceramides and galactosyldiglycerides by hydroxy-ceramide galactosyltransferase. van der Bijl P, etal., Biochem J. 1996 Jul 15;317 ( Pt 2):589-97. doi: 10.1042/bj3170589.
Additional References at PubMed
PMID:8889548   PMID:12060780   PMID:16551741  


Genomics

Comparative Map Data
Ugt8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82216,938,884 - 217,007,167 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2216,938,990 - 217,007,167 (-)EnsemblGRCr8
mRatBN7.22214,264,483 - 214,332,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2214,264,483 - 214,332,660 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2221,935,494 - 222,003,681 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02219,835,423 - 219,903,608 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02214,689,623 - 214,757,812 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02229,644,373 - 229,718,678 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2229,644,382 - 229,718,659 (-)Ensemblrn6Rnor6.0
Rnor_5.02248,998,871 - 249,072,741 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42222,977,966 - 223,048,277 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2206,609,425 - 206,656,289 (-)NCBICelera
RGSC_v3.1436,844,752 - 36,845,448 (+)NCBI
Cytogenetic Map2q42NCBI
UGT8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384114,598,402 - 114,678,225 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4114,598,374 - 114,678,588 (+)Ensemblhg38GRCh38
GRCh374115,519,558 - 115,599,381 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364115,762,972 - 115,817,201 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344115,901,126 - 115,955,356NCBI
Celera4112,813,079 - 112,891,640 (+)NCBICelera
Cytogenetic Map4q26NCBI
HuRef4111,253,852 - 111,332,365 (+)NCBIHuRef
CHM1_14115,496,077 - 115,574,635 (+)NCBICHM1_1
T2T-CHM13v2.04117,901,444 - 117,981,528 (+)NCBIT2T-CHM13v2.0
Ugt8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393125,655,071 - 125,732,301 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3125,658,920 - 125,732,268 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383125,865,272 - 125,938,682 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3125,865,271 - 125,938,619 (-)Ensemblmm10GRCm38
MGSCv373125,568,261 - 125,641,468 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363125,857,534 - 125,907,483 (-)NCBIMGSCv36mm8
Celera3132,313,587 - 132,366,589 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map354.68NCBI
Ugt8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542824,800,854 - 24,865,378 (-)Ensembl
ChiLan1.0NW_00495542824,800,854 - 24,864,904 (-)NCBIChiLan1.0ChiLan1.0
UGT8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23112,702,522 - 112,788,302 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14112,993,894 - 113,079,701 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04107,113,476 - 107,199,272 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14117,676,804 - 117,762,363 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4117,676,810 - 117,762,729 (+)EnsemblpanPan2panpan1.1
UGT8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13234,148,874 - 34,250,891 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3234,179,247 - 34,233,116 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha327,771,814 - 7,877,424 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03234,375,940 - 34,480,809 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3234,194,392 - 34,547,378 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13234,352,188 - 34,479,955 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03234,121,751 - 34,227,483 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0325,634,135 - 5,739,686 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ugt8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053016,603,659 - 6,685,574 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365635,224,173 - 5,306,120 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365635,251,451 - 5,305,683 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UGT8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8108,233,143 - 108,314,921 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18108,233,134 - 108,315,284 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28115,965,708 - 115,974,792 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UGT8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1762,380,506 - 62,465,695 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl762,381,223 - 62,466,401 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603741,154,173 - 41,238,937 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ugt8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248671,182,589 - 1,255,796 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248671,182,674 - 1,255,714 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ugt8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1333,484,203 - 33,552,936 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ugt8
459 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:520
Count of miRNA genes:275
Interacting mature miRNAs:338
Transcripts:ENSRNOT00000012676
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2212145502231732847Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1302789Stl26Serum triglyceride level QTL 263.10.0035blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)2206613059226891081Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2209350500221678003Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2205135267225627153Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat

Markers in Region
X92122  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22214,266,036 - 214,266,184 (+)MAPPERmRatBN7.2
Rnor_6.02229,646,033 - 229,646,180NCBIRnor6.0
Rnor_5.02249,000,425 - 249,000,572UniSTSRnor5.0
RGSC_v3.42222,979,520 - 222,979,667UniSTSRGSC3.4
Celera2206,610,979 - 206,611,126UniSTS
Cytogenetic Map2q42UniSTS
RH136801  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22214,264,648 - 214,264,768 (+)MAPPERmRatBN7.2
Rnor_6.02229,644,645 - 229,644,764NCBIRnor6.0
Rnor_5.02248,999,037 - 248,999,156UniSTSRnor5.0
RGSC_v3.42222,978,132 - 222,978,251UniSTSRGSC3.4
Celera2206,609,591 - 206,609,710UniSTS
RH 3.4 Map21546.6UniSTS
Cytogenetic Map2q42UniSTS
Ugt8a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22214,266,341 - 214,266,603 (+)MAPPERmRatBN7.2
Rnor_6.02229,646,338 - 229,646,599NCBIRnor6.0
Rnor_5.02249,000,730 - 249,000,991UniSTSRnor5.0
RGSC_v3.42222,979,825 - 222,980,086UniSTSRGSC3.4
Celera2206,611,284 - 206,611,545UniSTS
Cytogenetic Map2q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 55 156 72 71 40 59 40 6 292 147 11 135 81 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000012676   ⟹   ENSRNOP00000012676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2216,938,990 - 217,007,167 (-)Ensembl
mRatBN7.2 Ensembl2214,264,483 - 214,332,660 (-)Ensembl
Rnor_6.0 Ensembl2229,644,382 - 229,718,659 (-)Ensembl
RefSeq Acc Id: NM_019276   ⟹   NP_062149
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82216,938,990 - 217,007,167 (-)NCBI
mRatBN7.22214,264,483 - 214,332,660 (-)NCBI
Rnor_6.02229,644,479 - 229,718,672 (-)NCBI
Rnor_5.02248,998,871 - 249,072,741 (-)NCBI
RGSC_v3.42222,977,966 - 223,048,277 (-)RGD
Celera2206,609,425 - 206,656,289 (-)RGD
Sequence:
RefSeq Acc Id: XM_017591052   ⟹   XP_017446541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82216,938,884 - 217,007,155 (-)NCBI
mRatBN7.22214,266,268 - 214,332,769 (-)NCBI
Rnor_6.02229,644,373 - 229,718,678 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063282414   ⟹   XP_063138484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82216,938,884 - 217,004,826 (-)NCBI
Protein Sequences
Protein RefSeqs NP_062149 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446541 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138484 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA16108 (Get FASTA)   NCBI Sequence Viewer  
  EDL82139 (Get FASTA)   NCBI Sequence Viewer  
  EDL82140 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012676
  ENSRNOP00000012676.2
GenBank Protein Q09426 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062149   ⟸   NM_019276
- Peptide Label: precursor
- UniProtKB: Q09426 (UniProtKB/Swiss-Prot),   A6HVK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446541   ⟸   XM_017591052
- Peptide Label: isoform X1
- UniProtKB: Q09426 (UniProtKB/Swiss-Prot),   A6HVK3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012676   ⟸   ENSRNOT00000012676
RefSeq Acc Id: XP_063138484   ⟸   XM_063282414
- Peptide Label: isoform X1
- UniProtKB: Q09426 (UniProtKB/Swiss-Prot),   A6HVK3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q09426-F1-model_v2 AlphaFold Q09426 1-541 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691736
Promoter ID:EPDNEW_R2261
Type:single initiation site
Name:Ugt8_1
Description:UDP glycosyltransferase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02229,718,746 - 229,718,806EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3938 AgrOrtholog
BioCyc Gene G2FUF-51291 BioCyc
BioCyc Pathway PWY-7840 [gala-series glycosphingolipids biosynthesis] BioCyc
BioCyc Pathway Image PWY-7840 BioCyc
Ensembl Genes ENSRNOG00000009345 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012676 ENTREZGENE
  ENSRNOT00000012676.5 UniProtKB/Swiss-Prot
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot
InterPro UDP-glycosyltransferase UniProtKB/Swiss-Prot
  UDP_glucos_trans UniProtKB/Swiss-Prot
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot
KEGG Report rno:50555 UniProtKB/Swiss-Prot
NCBI Gene 50555 ENTREZGENE
PANTHER 2-HYDROXYACYLSPHINGOSINE 1-BETA-GALACTOSYLTRANSFERASE UniProtKB/Swiss-Prot
  EG:EG0003.4 PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam UDPGT UniProtKB/Swiss-Prot
PhenoGen Ugt8 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009345 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot
UniProt A6HVK3 ENTREZGENE, UniProtKB/TrEMBL
  A6HVK4_RAT UniProtKB/TrEMBL
  CGT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-08-29 Ugt8  UDP glycosyltransferase 8  Ugt8a  UDP galactosyltransferase 8A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Ugt8a  UDP galactosyltransferase 8A  Ugt8  UDP galactosyltransferase 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Ugt8  UDP galactosyltransferase 8      Name updated 1299863 APPROVED
2002-06-10 Ugt8  UDP-glucuronosyltransferase 8       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression developmental expression of mRNA similar to the myelination profile 70050
gene_protein predicted protein masses 61 kDa 70050
gene_transcript open reading frame of 1623 bp 70050