Uts2 (urotensin 2) - Rat Genome Database

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Gene: Uts2 (urotensin 2) Rattus norvegicus
Analyze
Symbol: Uts2
Name: urotensin 2
RGD ID: 3930
Description: Predicted to enable hormone activity. Involved in several processes, including regulation of blood pressure; regulation of circadian sleep/wake cycle; and regulation of heart rate. Located in extracellular space. Used to study hypertension. Biomarker of asthma; cardiomyopathy; endomyocardial fibrosis; myocardial infarction; and pulmonary hypertension. Human ortholog(s) of this gene implicated in gestational diabetes and type 2 diabetes mellitus. Orthologous to human UTS2 (urotensin 2); INTERACTS WITH 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: U-II; Ucn2; UII; urocortin 2; urotensin II; urotensin-2; urotensin-II
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85166,725,471 - 166,739,063 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5166,733,671 - 166,739,059 (+)EnsemblGRCr8
mRatBN7.25161,450,846 - 161,456,235 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5161,450,846 - 161,456,237 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5164,167,730 - 164,173,039 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,984,293 - 165,989,452 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,946,373 - 165,951,683 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05168,078,748 - 168,084,133 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5168,078,748 - 168,084,145 (+)Ensemblrn6Rnor6.0
Rnor_5.05171,655,843 - 171,661,228 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45168,143,315 - 168,148,700 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5159,703,053 - 159,708,438 (+)NCBICelera
RGSC_v3.15168,153,502 - 168,158,888 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Increased plasma levels of Urotensin-II in preeclampsia-eclampsia: a new mediator in pathogenesis? Balat O, etal., Eur J Obstet Gynecol Reprod Biol. 2005 May 1;120(1):33-8.
2. Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta. Bousette N, etal., Atherosclerosis. 2004 Sep;176(1):117-23.
3. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases Cheng DY, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Jun;29(6):381-4.
4. Plasma concentration of urotensin II is raised in hypertension. Cheung BM, etal., J Hypertens. 2004 Jul;22(7):1341-4.
5. Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors. Coulouarn Y, etal., FEBS Lett 1999 Aug 20;457(1):28-32.
6. Elevated expression of urotensin II and its receptor in diabetic cardiomyopathy. Dai HY, etal., J Diabetes Complications. 2008 Mar-Apr;22(2):137-43.
7. URP acts as a pure antagonist of urotensinergic receptors in rat cortical astrocytes. Diallo M, etal., Peptides. 2008 May;29(5):813-9. Epub 2007 Nov 6.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Circulating urotensin II levels in moderate to severe congestive heart failure: its relations with myocardial function and well established neurohormonal markers. Gruson D, etal., Peptides. 2006 Jun;27(6):1527-31. Epub 2005 Dec 20.
11. Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons. Huitron-Resendiz S, etal., J Neurosci. 2005 Jun 8;25(23):5465-74.
12. Urotensin-II-mediated cardiomyocyte hypertrophy: effect of receptor antagonism and role of inflammatory mediators. Johns DG, etal., Naunyn Schmiedebergs Arch Pharmacol. 2004 Oct;370(4):238-50. Epub 2004 Sep 30.
13. Increased expression of urotensin II and urotensin II receptor in human diabetic nephropathy. Langham RG, etal., Am J Kidney Dis. 2004 Nov;44(5):826-31.
14. Central cardiovascular action of urotensin II in spontaneously hypertensive rats. Lin Y, etal., Hypertens Res. 2003 Oct;26(10):839-45.
15. Magnolol Depresses Urotensin II-Induced Cell Proliferation in Rat Cardiac Fibroblasts. Liou JY, etal., Clin Exp Pharmacol Physiol. 2009 Jan 17.
16. Cardiovascular effects of urotensin II in different brain areas. Lu Y, etal., Peptides. 2002 Sep;23(9):1631-5.
17. Evidence for endogenous urotensin-II as an inhibitor of insulin secretion. Study in the perfused rat pancreas. Marco J, etal., Peptides. 2008 May;29(5):852-8. Epub 2007 Sep 4.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Role of androgens in the regulation of urotensin II precursor mRNA expression in the rat brainstem and spinal cord. Pelletier G, etal., Neuroscience. 2002;115(2):525-32.
21. Cardiovascular effects of native and non-native urotensin II and urotensin II-related peptide on rat and salmon hearts. Prosser HC, etal., Peptides. 2006 Dec;27(12):3261-8. Epub 2006 Nov 9.
22. Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury. Prosser HC, etal., Peptides. 2008 May;29(5):770-7. Epub 2007 Aug 21.
23. The upregulation of endothelial nitric oxide synthase and urotensin-II is associated with pulmonary hypertension and vascular diseases in rats produced by aortocaval shunting. Qi J, etal., Heart Vessels. 2004 Mar;19(2):81-8.
24. GOA pipeline RGD automated data pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure. Russell FD, etal., Am J Physiol Heart Circ Physiol. 2003 Oct;285(4):H1576-81. Epub 2003 Jun 5.
27. Urotensin II and renal function in the rat. Song W, etal., Kidney Int. 2006 Apr;69(8):1360-8.
28. Urotensin-II and its receptor (UT-R) are expressed in rat brain endothelial cells, and urotensin-II via UT-R stimulates angiogenesis in vivo and in vitro. Spinazzi R, etal., Int J Mol Med. 2006 Dec;18(6):1107-12.
29. Increased plasma urotensin-II levels are associated with diabetic retinopathy and carotid atherosclerosis in Type 2 diabetes. Suguro T, etal., Clin Sci (Lond). 2008 Dec;115(11):327-34.
30. [The expression and significance of urotensin II, nitric oxide, and C-type natriuretic peptide in hypoxia-induced pulmonary hypertension in rats] Sun DJ, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Mar;29(3):185-8.
31. Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese. Suzuki S, etal., Peptides. 2004 Oct;25(10):1803-8.
32. [Role of urotensin II gene in the genetic susceptibility to gestational diabetes mellitus in northern Chinese women]. Tan YJ, etal., Zhonghua Fu Chan Ke Za Zhi. 2006 Nov;41(11):732-5.
33. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
34. Diabetes-induced upregulation of urotensin II and its receptor plays an important role in TGF-beta1-mediated renal fibrosis and dysfunction. Tian L, etal., Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1234-42. Epub 2008 Sep 16.
35. Elevated plasma levels of immunoreactive urotensin II and its increased urinary excretion in patients with Type 2 diabetes mellitus: association with progress of diabetic nephropathy. Totsune K, etal., Peptides. 2004 Oct;25(10):1809-14.
36. Urotensin II-induced endothelin-1 expression and cell proliferation via epidermal growth factor receptor transactivation in rat aortic smooth muscle cells. Tsai CS, etal., Atherosclerosis. 2009 Feb 20.
37. Elevated expression of urotensin II and its receptor in skeletal muscle of diabetic mouse. Wang HX, etal., Regul Pept. 2009 Apr 10;154(1-3):85-90. doi: 10.1016/j.regpep.2009.01.004. Epub 2009 Jan 27.
38. Effect of central urotensin II on heart rate, blood pressure and brain Fos immunoreactivity in conscious rats. Watson AM, etal., Neuroscience. 2008 Jul 31;155(1):241-9. Epub 2008 Jul 1.
39. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics Wu XJ, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Dec;24(6):656-9.
40. Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol. Zhang YG, etal., Acta Pharmacol Sin. 2007 Jan;28(1):36-43.
41. Urotensin II induces phenotypic differentiation, migration, and collagen synthesis of adventitial fibroblasts from rat aorta. Zhang YG, etal., J Hypertens. 2008 Jun;26(6):1119-26.
42. Urotensin II is an inverse predictor of incident cardiovascular events in end-stage renal disease. Zoccali C, etal., Kidney Int. 2006 Apr;69(7):1253-8.
Additional References at PubMed
PMID:15097239   PMID:16171813   PMID:16685423   PMID:16807543   PMID:18318439   PMID:18355946   PMID:18955090   PMID:19463745   PMID:19797237   PMID:19906507   PMID:19930425   PMID:20025629  
PMID:20422157   PMID:21056072   PMID:21186587   PMID:22044114   PMID:22166643   PMID:22244812   PMID:22270542   PMID:23053343   PMID:23403244   PMID:23933501   PMID:24478001   PMID:24481965  
PMID:24521102   PMID:24878476   PMID:25803040   PMID:26323194   PMID:26453012   PMID:27208703   PMID:27448985   PMID:27613164   PMID:28656205   PMID:29257277   PMID:31473519  


Genomics

Comparative Map Data
Uts2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85166,725,471 - 166,739,063 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5166,733,671 - 166,739,059 (+)EnsemblGRCr8
mRatBN7.25161,450,846 - 161,456,235 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5161,450,846 - 161,456,237 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5164,167,730 - 164,173,039 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,984,293 - 165,989,452 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,946,373 - 165,951,683 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05168,078,748 - 168,084,133 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5168,078,748 - 168,084,145 (+)Ensemblrn6Rnor6.0
Rnor_5.05171,655,843 - 171,661,228 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45168,143,315 - 168,148,700 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5159,703,053 - 159,708,438 (+)NCBICelera
RGSC_v3.15168,153,502 - 168,158,888 (+)NCBI
Cytogenetic Map5q36NCBI
UTS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3817,847,612 - 7,913,249 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl17,843,083 - 7,853,512 (-)Ensemblhg38GRCh38
GRCh3717,907,672 - 7,913,551 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3617,830,262 - 7,836,159 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3417,841,940 - 7,847,838NCBI
Celera17,015,352 - 7,021,232 (-)NCBICelera
Cytogenetic Map1p36.23NCBI
HuRef17,055,968 - 7,061,853 (-)NCBIHuRef
CHM1_117,895,413 - 7,901,298 (-)NCBICHM1_1
T2T-CHM13v2.017,378,659 - 7,444,444 (-)NCBIT2T-CHM13v2.0
Uts2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394151,081,554 - 151,086,267 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4151,081,554 - 151,086,267 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384150,997,097 - 151,001,810 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,997,097 - 151,001,810 (+)Ensemblmm10GRCm38
MGSCv374150,371,206 - 150,375,919 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364149,840,897 - 149,845,610 (+)NCBIMGSCv36mm8
Celera4153,272,921 - 153,277,635 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map481.53NCBI
Uts2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554865,052,045 - 5,056,610 (+)Ensembl
ChiLan1.0NW_0049554865,052,045 - 5,056,610 (+)NCBIChiLan1.0ChiLan1.0
UTS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21220,372,481 - 220,378,795 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11219,012,271 - 219,019,892 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016,609,104 - 6,616,966 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.117,853,824 - 7,864,688 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl17,854,687 - 7,864,688 (-)EnsemblpanPan2panpan1.1
UTS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1561,503,268 - 61,508,146 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha561,512,208 - 61,524,420 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0561,720,176 - 61,732,192 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl561,720,240 - 61,722,254 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1561,719,384 - 61,731,402 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0561,583,986 - 61,596,155 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0561,987,535 - 61,999,550 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Uts2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505831,855,288 - 31,860,643 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366232,340,778 - 2,345,700 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366232,339,259 - 2,345,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UTS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl668,552,887 - 68,559,674 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1668,552,889 - 68,560,827 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
UTS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120123,903,137 - 123,910,180 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605427,938,370 - 27,944,781 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uts2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v119,768,059 - 9,773,644 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Uts2
82 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:21
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000024798
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
6 8 7 41 22 9 3 8 3 51 32 1 27 5 32 6

Sequence


Ensembl Acc Id: ENSRNOT00000024798   ⟹   ENSRNOP00000024798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5166,733,671 - 166,739,059 (+)Ensembl
mRatBN7.2 Ensembl5161,450,846 - 161,456,237 (+)Ensembl
Rnor_6.0 Ensembl5168,078,748 - 168,084,145 (+)Ensembl
RefSeq Acc Id: NM_019160   ⟹   NP_062033
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85166,733,671 - 166,739,057 (+)NCBI
mRatBN7.25161,450,846 - 161,456,235 (+)NCBI
Rnor_6.05168,078,748 - 168,084,133 (+)NCBI
Rnor_5.05171,655,843 - 171,661,228 (+)NCBI
RGSC_v3.45168,143,315 - 168,148,700 (+)RGD
Celera5159,703,053 - 159,708,438 (+)RGD
Sequence:
RefSeq Acc Id: XM_063287245   ⟹   XP_063143315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85166,725,471 - 166,739,063 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001416473 (Get FASTA)   NCBI Sequence Viewer  
  NP_062033 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143315 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD55766 (Get FASTA)   NCBI Sequence Viewer  
  EDL81198 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024798
  ENSRNOP00000024798.3
GenBank Protein Q9QZQ4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062033   ⟸   NM_019160
- Peptide Label: precursor
- UniProtKB: Q9QZQ4 (UniProtKB/Swiss-Prot),   A6IUE7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024798   ⟸   ENSRNOT00000024798
RefSeq Acc Id: XP_063143315   ⟸   XM_063287245
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZQ4-F1-model_v2 AlphaFold Q9QZQ4 1-123 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3930 AgrOrtholog
BioCyc Gene G2FUF-39045 BioCyc
Ensembl Genes ENSRNOG00000018393 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024798 ENTREZGENE
  ENSRNOT00000024798.5 UniProtKB/Swiss-Prot
InterPro Urotensin_II UniProtKB/Swiss-Prot
KEGG Report rno:29180 UniProtKB/Swiss-Prot
NCBI Gene 29180 ENTREZGENE
PANTHER UROTENSIN 2 UniProtKB/Swiss-Prot
  UROTENSIN-2 UniProtKB/Swiss-Prot
Pfam Urotensin_II UniProtKB/Swiss-Prot
PhenoGen Uts2 PhenoGen
PROSITE UROTENSIN_II UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018393 RatGTEx
TIGR TC201608
UniProt A6IUE7 ENTREZGENE, UniProtKB/TrEMBL
  Q9QZQ4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Uts2  urotensin 2      Name updated 70584 APPROVED
2001-12-10 Uts2  urotensin 2      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mainly expressed in motoneurons of the brainstem and spinal cord 70048