Tpi1 (triosephosphate isomerase 1) - Rat Genome Database

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Gene: Tpi1 (triosephosphate isomerase 1) Rattus norvegicus
Analyze
Symbol: Tpi1
Name: triosephosphate isomerase 1
RGD ID: 3896
Description: Enables triose-phosphate isomerase activity. Predicted to be involved in several processes, including glucose metabolic process; glyceraldehyde-3-phosphate biosynthetic process; and methylglyoxal biosynthetic process. Predicted to act upstream of or within glucose metabolic process. Predicted to be active in cytosol. Biomarker of ocular hypertension. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1); PARTICIPATES IN Fanconi syndrome pathway; fructose and mannose metabolic pathway; fructose-1,6-bisphosphatase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100911515; methylglyoxal synthase; MGC156639; TIM; Tpi; triose-phosphate isomerase; triosephosphate isomerase; triosephosphate isomerase-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: LOC681129  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,301,558 - 159,305,088 (-)NCBIGRCr8
mRatBN7.24157,615,283 - 157,618,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,615,386 - 157,619,541 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,843,450 - 163,846,958 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,626,360 - 159,629,868 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,261,966 - 158,265,490 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,328,375 - 157,331,905 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,345,971 - 224,349,501 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,933,341 - 160,936,871 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,178,382 - 161,181,807 (-)NCBI
Celera4146,353,273 - 146,356,791 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-bromopropane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azaspiracid  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
bufalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon dioxide  (EXP)
carbon nanotube  (ISO)
casticin  (ISO)
ceruletide  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clozapine  (EXP)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dihydroartemisinin  (ISO)
dihydroxyacetone phosphate  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (EXP)
haloperidol  (EXP)
hydralazine  (ISO)
ibuprofen  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
mancozeb  (ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP,ISO)
niclosamide  (ISO)
nimesulide  (EXP)
olomoucine  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP)
phenylpropanolamine  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
quartz  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
sarin  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thiram  (ISO)
toosendanin  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Evidence for founder effect of the Glu104Asp substitution and identification of new mutations in triosephosphate isomerase deficiency. Arya R, etal., Hum Mutat. 1997;10(4):290-4.
2. Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa Zn(2+)-binding protein (parathymosin). Brand IA and Heinickel A, J Biol Chem. 1991 Nov 5;266(31):20984-9.
3. The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function. Dhar-Chowdhury P, etal., J Biol Chem. 2005 Nov 18;280(46):38464-70. Epub 2005 Sep 16.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Differences in expression of retinal proteins between diabetic and normal rats. Liu SQ, etal., World J Gastroenterol. 2007 Apr 14;13(14):2118-24.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Proteomic analysis of rat retina in a steroid-induced ocular hypertension model: potential vulnerability to oxidative stress. Miyara N, etal., Jpn J Ophthalmol. 2008 Mar-Apr;52(2):84-90. Epub 2008 Apr 30.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Information Derived from GenBank Report RGD, Sept. 2003
17. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:204065   PMID:566475   PMID:566476   PMID:2693209   PMID:3796661   PMID:6434534   PMID:8417789   PMID:15155459   PMID:15489334   PMID:15632090   PMID:16502470   PMID:16854843  
PMID:17023274   PMID:18562316   PMID:19056867   PMID:19182904   PMID:19725078   PMID:21630459   PMID:22420779   PMID:22664934   PMID:22871113   PMID:23376485   PMID:23533145   PMID:23580065  
PMID:26316108   PMID:26945066   PMID:29476059   PMID:33450132   PMID:35111160   PMID:35352799   PMID:36755387  


Genomics

Comparative Map Data
Tpi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,301,558 - 159,305,088 (-)NCBIGRCr8
mRatBN7.24157,615,283 - 157,618,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,615,386 - 157,619,541 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,843,450 - 163,846,958 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,626,360 - 159,629,868 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,261,966 - 158,265,490 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,328,375 - 157,331,905 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,345,971 - 224,349,501 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,933,341 - 160,936,871 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,178,382 - 161,181,807 (-)NCBI
Celera4146,353,273 - 146,356,791 (-)NCBICelera
Cytogenetic Map4q42NCBI
TPI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,867,420 - 6,870,948 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,867,119 - 6,870,948 (+)EnsemblGRCh38hg38GRCh38
GRCh37126,976,584 - 6,980,112 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,846,967 - 6,850,253 (+)NCBINCBI36Build 36hg18NCBI36
Build 34126,846,966 - 6,850,253NCBI
Celera128,593,870 - 8,597,397 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,830,312 - 6,833,839 (+)NCBIHuRef
CHM1_1126,975,582 - 6,979,109 (+)NCBICHM1_1
T2T-CHM13v2.0126,876,717 - 6,880,246 (+)NCBIT2T-CHM13v2.0
Tpi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,787,549 - 124,791,121 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,787,549 - 124,791,259 (-)EnsemblGRCm39 Ensembl
GRCm386124,810,586 - 124,814,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,810,586 - 124,814,296 (-)EnsemblGRCm38mm10GRCm38
MGSCv376124,760,610 - 124,764,314 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,776,334 - 124,780,031 (-)NCBIMGSCv36mm8
Celera6126,486,721 - 126,490,425 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Tpi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,467,566 - 4,471,177 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,467,615 - 4,471,594 (+)NCBIChiLan1.0ChiLan1.0
TPI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,430,570 - 12,434,002 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,427,328 - 12,430,760 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,999,275 - 7,002,678 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,910,819 - 6,914,056 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,910,813 - 6,913,612 (+)Ensemblpanpan1.1panPan2
TPI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,154,519 - 38,157,900 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,154,519 - 38,158,137 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,458,847 - 8,462,228 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,507,407 - 38,510,797 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,507,407 - 38,510,859 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,381,481 - 38,384,861 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,422,508 - 38,425,888 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,937,580 - 7,940,961 (+)NCBIUU_Cfam_GSD_1.0
Tpi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,280,602 - 102,283,888 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709945,201 - 951,441 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936709948,151 - 951,430 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,838,506 - 63,843,134 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,839,473 - 63,842,853 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,274,980 - 66,278,361 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,900,762 - 6,904,188 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,900,787 - 6,906,787 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,319,371 - 1,323,379 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,533,320 - 3,539,755 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,533,226 - 3,536,786 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tpi1
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:107
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000020647
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat

Markers in Region
RH94523  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q42UniSTS
RH129184  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q42UniSTS
AI411387  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,619,843 - 157,620,056 (-)MAPPERmRatBN7.2
mRatBN7.24157,619,843 - 157,620,056 (+)MAPPERmRatBN7.2
Rnor_6.04157,332,936 - 157,333,148NCBIRnor6.0
Rnor_6.0920,212,509 - 20,212,721NCBIRnor6.0
Rnor_5.04224,350,532 - 224,350,744UniSTSRnor5.0
Rnor_5.0919,088,485 - 19,088,697UniSTSRnor5.0
RGSC_v3.44160,937,902 - 160,938,114UniSTSRGSC3.4
Celera4146,357,822 - 146,358,034UniSTS
RH 3.4 Map41005.8UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
18 22 98 221 173 174 113 46 113 12 423 186 185 90 115 61

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L36250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000020647   ⟹   ENSRNOP00000020647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,615,386 - 157,619,050 (-)Ensembl
Rnor_6.0 Ensembl4157,328,379 - 157,331,905 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000071439   ⟹   ENSRNOP00000067409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,615,386 - 157,618,825 (-)Ensembl
Rnor_6.0 Ensembl920,213,776 - 20,216,608 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089341   ⟹   ENSRNOP00000069904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl920,213,588 - 20,217,176 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117284   ⟹   ENSRNOP00000088185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,615,386 - 157,619,541 (-)Ensembl
RefSeq Acc Id: NM_022922   ⟹   NP_075211
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,301,558 - 159,305,088 (-)NCBI
mRatBN7.24157,615,283 - 157,618,813 (-)NCBI
Rnor_6.04157,328,375 - 157,331,905 (-)NCBI
Rnor_5.04224,345,971 - 224,349,501 (-)NCBI
RGSC_v3.44160,933,341 - 160,936,871 (-)RGD
Celera4146,353,273 - 146,356,791 (-)RGD
Sequence:
RefSeq Acc Id: NP_075211   ⟸   NM_022922
- UniProtKB: A0JN18 (UniProtKB/Swiss-Prot),   Q6P793 (UniProtKB/Swiss-Prot),   P48500 (UniProtKB/Swiss-Prot),   A0A8L2R053 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020647   ⟸   ENSRNOT00000020647
Ensembl Acc Id: ENSRNOP00000067409   ⟸   ENSRNOT00000071439
Ensembl Acc Id: ENSRNOP00000069904   ⟸   ENSRNOT00000089341
Ensembl Acc Id: ENSRNOP00000088185   ⟸   ENSRNOT00000117284

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48500-F1-model_v2 AlphaFold P48500 1-249 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693390
Promoter ID:EPDNEW_R3915
Type:multiple initiation site
Name:Tpi1_1
Description:triosephosphate isomerase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04157,331,917 - 157,331,977EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3896 AgrOrtholog
BioCyc Gene G2FUF-43066 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
  PWY66-373 [sucrose degradation V (sucrose alpha-glucosidase)] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image ANAGLYCOLYSIS-PWY BioCyc
  PWY66-373 BioCyc
  PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000015290 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000050669 Ensembl
Ensembl Transcript ENSRNOT00000020647.7 UniProtKB/TrEMBL
  ENSRNOT00000071439.2 UniProtKB/TrEMBL
  ENSRNOT00000117284.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623367 IMAGE-MGC_LOAD
  IMAGE:8368624 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TrioseP_Isoase_bac/euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Triosephosphate_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Triosephosphate_isomerase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24849 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156639 IMAGE-MGC_LOAD
  MGC:72436 IMAGE-MGC_LOAD
NCBI Gene 24849 ENTREZGENE
PANTHER PTHR21139 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRIOSEPHOSPHATE ISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tpi1 PhenoGen
PROSITE TIM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015290 RatGTEx
  ENSRNOG00000050669 RatGTEx
Superfamily-SCOP SSF51351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A997_RAT UniProtKB/TrEMBL
  A0A8L2QAQ2_RAT UniProtKB/TrEMBL
  A0A8L2R053 ENTREZGENE, UniProtKB/TrEMBL
  A0JN18 ENTREZGENE
  P48500 ENTREZGENE
  Q6P793 ENTREZGENE
  TPIS_RAT UniProtKB/Swiss-Prot
UniProt Secondary A0JN18 UniProtKB/Swiss-Prot
  Q6P793 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Tpi1  triosephosphate isomerase 1  LOC100911515  triosephosphate isomerase-like  Data merged from RGD:6492323 737654 PROVISIONAL
2012-07-05 LOC100911515  triosephosphate isomerase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Tpi1  triosephosphate isomerase 1    Triosephosphate isomerase 1  Name updated 629478 APPROVED
2002-06-10 Tpi1  Triosephosphate isomerase 1      Symbol and Name status set to approved 70586 APPROVED