Tacr1 (tachykinin receptor 1) - Rat Genome Database

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Gene: Tacr1 (tachykinin receptor 1) Rattus norvegicus
Analyze
Symbol: Tacr1
Name: tachykinin receptor 1
RGD ID: 3811
Description: Enables substance P receptor activity. Involved in several processes, including learning or memory; positive regulation of cell communication; and regulation of cell migration. Located in cell body; cell surface; and dendrite. Is active in postsynaptic membrane. Used to study central sleep apnea; cystitis; pancreatitis; and pulmonary hypertension. Biomarker of acute necrotizing pancreatitis; allergic rhinitis; asthma; colitis; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in developmental disorder of mental health and exercise-induced bronchoconstriction. Orthologous to human TACR1 (tachykinin receptor 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; measles pathway; INTERACTS WITH (S)-amphetamine; (S)-nicotine; 1,2-naphthoquinone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: neurokinin 1 receptor; NK-1 receptor; NK-1R; SPR; substance p receptor; substance-P receptor; Tac1r; Tachykinin 1 receptor; Tachykinin 1 receptor (substance P receptor neurokinin 1 receptor); Tachykinin 1 receptor (substance P receptor neurokinin 1 receptor) see also D4Mgh17 D4Wox19 and D4Mit23
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   BB.SHR-(D4Got41-Tacr1)/K
QTLs:   Bw52  
Candidate Gene For: Anxrr16
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84116,478,617 - 116,647,492 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4116,478,617 - 116,647,492 (+)EnsemblGRCr8
mRatBN7.24114,920,844 - 115,089,733 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4114,920,844 - 115,089,733 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4120,383,645 - 120,552,243 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,158,843 - 116,327,453 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04114,778,790 - 114,948,892 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,247,236 - 113,416,139 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,247,795 - 113,414,504 (+)Ensemblrn6Rnor6.0
Rnor_5.04177,926,094 - 178,095,041 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44116,610,595 - 116,780,394 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4103,918,032 - 104,086,347 (+)NCBICelera
RGSC_v3.14116,855,058 - 117,024,964 (+)NCBI
Cytogenetic Map4q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
alpha-amyrin  (ISO)
ammonium chloride  (EXP)
aprepitant  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-amyrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
casopitant  (ISO)
CGP 52608  (ISO)
clothianidin  (ISO)
cocaine  (ISO)
CP-96345(1+)  (EXP)
cyclophosphamide  (EXP,ISO)
dextran sulfate  (ISO)
dioxygen  (ISO)
dobutamine  (ISO)
dydrogesterone  (ISO)
ethylparaben  (ISO)
famotidine  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydrogen chloride  (EXP)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
Mecamylamine  (EXP)
methyllycaconitine  (EXP)
morphine  (EXP)
nicotine  (EXP)
nitroprusside  (EXP)
okadaic acid  (ISO)
omeprazole  (ISO)
phenyl biguanide  (EXP)
phenylarsine oxide  (EXP)
phenylephrine  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
sodium cyanide  (EXP)
sucrose  (EXP)
suramin  (EXP)
taurine  (ISO)
testosterone  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
VX nerve agent  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IDA,IEA,ISO)
aggressive behavior  (IMP)
angiotensin-mediated drinking behavior  (IMP)
associative learning  (IMP)
behavioral response to pain  (IMP)
eating behavior  (IMP)
G protein-coupled receptor signaling pathway  (IEA)
learning or memory  (IMP)
long-term memory  (IMP)
neuropeptide signaling pathway  (TAS)
operant conditioning  (IMP)
phospholipase C-activating tachykinin receptor signaling pathway  (IDA,IEA,ISO)
positive regulation of action potential  (IMP)
positive regulation of blood pressure  (IMP)
positive regulation of cytosolic calcium ion concentration  (IEA,IMP,ISO)
positive regulation of epithelial cell migration  (IMP)
positive regulation of epithelial cell proliferation  (IMP)
positive regulation of flagellated sperm motility  (IBA,IEA,ISO)
positive regulation of hormone secretion  (IMP)
positive regulation of leukocyte migration  (IMP)
positive regulation of lymphocyte proliferation  (IMP)
positive regulation of ossification  (IMP)
positive regulation of stress fiber assembly  (IMP)
positive regulation of synaptic transmission, cholinergic  (IMP)
positive regulation of synaptic transmission, GABAergic  (IMP)
positive regulation of uterine smooth muscle contraction  (IDA,IEA)
positive regulation of vascular permeability  (IMP)
positive regulation of vasoconstriction  (IMP)
regulation of blood pressure  (IMP)
regulation of smooth muscle cell migration  (IMP)
regulation of smooth muscle cell proliferation  (IMP)
regulation of uterine smooth muscle contraction  (IEA,ISO)
response to auditory stimulus  (IDA)
response to electrical stimulus  (IEP)
response to estradiol  (IEP)
response to ethanol  (IMP)
response to hormone  (IMP)
response to nicotine  (IMP)
response to ozone  (IMP)
response to pain  (ISO)
response to progesterone  (IEP)
signal transduction  (IEA)
smooth muscle contraction involved in micturition  (IMP)
sperm ejaculation  (IMP)
tachykinin receptor signaling pathway  (IEA,ISO)

Cellular Component
cell body  (IDA)
cell periphery  (IEA,ISO)
cell surface  (IDA)
dendrite  (IDA)
early endosome  (IDA,IEA)
membrane  (IEA)
plasma membrane  (IBA,IDA,IEA,ISO)
postsynaptic membrane  (IDA)
sperm flagellum  (IEA,ISO)
sperm head  (IEA,ISO)
sperm midpiece  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids. Adcock IM, etal., J Mol Endocrinol. 1993 Aug;11(1):1-7.
2. Thiorphan-induced survival and proliferation of rat thymocytes by activation of Akt/survivin pathway and inhibition of caspase-3 activity. Amantini C, etal., J Pharmacol Exp Ther. 2008 Oct;327(1):215-25. Epub 2008 Jul 11.
3. Neurokinin-1 receptor antagonism in a rat model of subarachnoid hemorrhage: prevention of upregulation of contractile ETB and 5-HT1B receptors and cerebral blood flow reduction. Ansar S, etal., J Neurosurg. 2007 May;106(5):881-6.
4. Intrathecal administration of neurokinin 1 and neurokinin 2 receptor antagonists undermines the savings effect in spinal rats seen in an instrumental learning paradigm. Baumbauer KM, etal., Behav Neurosci. 2007 Feb;121(1):186-99.
5. Role of Spinal Microglia in Visceral Hyperalgesia and NK1R Up-regulation in a Rat Model of Chronic Stress. Bradesi S, etal., Gastroenterology. 2008 Dec 24.
6. Substance P receptor blockade decreases stretch-induced lung cytokines and lung injury in rats. Bregeon F, etal., J Physiol. 2010 Apr 15;588(Pt 8):1309-19. Epub 2010 Feb 22.
7. Direct evidence for the interaction of neurokinin A with the tachykinin NK(1) receptor in tissue. Bremer AA, etal., Eur J Pharmacol. 2001 Jul 6;423(2-3):143-7.
8. Ablation of primary afferent neurons by neonatal capsaicin treatment reduces the susceptibility of the portal hypertensive gastric mucosa to ethanol-induced injury in cirrhotic rats. Camara PR, etal., Eur J Pharmacol. 2008 Jul 28;589(1-3):245-50. Epub 2008 May 16.
9. Role of substance P and bradykinin in acute pancreatitis induced by secretory phospholipase A2. Camargo EA, etal., Pancreas. 2008 Jul;37(1):50-5.
10. Hemodynamic effects of substance P and its receptor antagonist RP67580 in anesthetized rats with carbon tetrachloride-induced cirrhosis. Cardenas A, etal., Scand J Gastroenterol. 2008 Mar;43(3):328-33.
11. Exercise reduces GABA synaptic input onto nucleus tractus solitarii baroreceptor second-order neurons via NK1 receptor internalization in spontaneously hypertensive rats. Chen CY, etal., J Neurosci. 2009 Mar 4;29(9):2754-61.
12. Tachykinin dysfunction attenuates monocrotaline-induced pulmonary hypertension. Chen MJ and Lai YL, Toxicol Appl Pharmacol. 2003 Mar 15;187(3):178-85.
13. Colorectal distension enforce acute urinary bladder distension-induced hepatic vasoconstriction in the rat. Chen SS, etal., Neurosci Lett. 2008 Oct 10;443(3):257-60. Epub 2008 Jun 27.
14. Role of the neurokinin-1 receptors in ejaculation in anesthetized rats. Clement P, etal., J Sex Med. 2009 Jan;6(1):126-34.
15. Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom. Costa SK, etal., Neurosci Lett. 2002 Feb 1;318(3):158-62.
16. Estrogen-dependent regulation of neurokinin 3 receptor-mediated uterine contractility in the rat. Crane LH, etal., Biol Reprod. 2002 Nov;67(5):1480-7.
17. Altered neuropeptide Y and neurokinin messenger RNA expression and receptor binding in stress-sensitised rats. de Lange RP, etal., Brain Res. 2008 May 30;1212:35-47. Epub 2008 Mar 20.
18. Role of the tachykinin NK1 receptor in a murine model of cigarette smoke-induced pulmonary inflammation. De Swert KO, etal., Respir Res. 2009 May 15;10:37.
19. A paradoxical protective role for the proinflammatory peptide substance P receptor (NK1R) in acute hyperoxic lung injury. Dib M, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L687-97. Epub 2009 Jul 24.
20. Spatial and temporal expression of tachykinins and NK1- and NK2-receptor gene during TNB induced colitis in rats. Evangelista S, etal., Neuropeptides. 2008 Oct-Dec;42(5-6):663-70. Epub 2008 Aug 19.
21. Localization of NK1 receptors and roles of substance-P in subepithelial fibroblasts of rat intestinal villi. Furuya S, etal., Cell Tissue Res. 2010 Nov;342(2):243-59. Epub 2010 Oct 22.
22. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
23. Substance P stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptors. Goto T, etal., Neuropeptides. 2007 Feb;41(1):25-31. Epub 2007 Jan 3.
24. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Grady EF, etal., Mol Biol Cell. 1995 May;6(5):509-24. doi: 10.1091/mbc.6.5.509.
25. Neurokinin-1 receptor-expressing cells of the ventral respiratory group are functionally heterogeneous and predominantly glutamatergic. Guyenet PG, etal., J Neurosci 2002 May 1;22(9):3806-16.
26. The effect of neurokinin1 receptor blockade on territorial aggression and in a model of violent aggression. Halasz J, etal., Biol Psychiatry. 2008 Feb 1;63(3):271-8. Epub 2007 Aug 3.
27. Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis. Hegde A, etal., J Leukoc Biol. 2007 Sep;82(3):678-85. Epub 2007 Jun 12.
28. Organization, structure, and expression of the gene encoding the rat substance P receptor. Hershey AD, etal., J Biol Chem 1991 Mar 5;266(7):4366-74.
29. Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs. Hu C, etal., Am J Physiol Lung Cell Mol Physiol 2002 Aug;283(2):L494-502.
30. LIF upregulates expression of NK-1R in NHBE cells. Hu CP, etal., Mediators Inflamm. 2006;2006(5):84829.
31. A neurokinin 1-receptor antagonist improves exercise-induced airway narrowing in asthmatic patients. Ichinose M, etal., Am J Respir Crit Care Med. 1996 Mar;153(3):936-41.
32. Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia. Ikeda H, etal., Science 2003 Feb 21;299(5610):1237-40.
33. Neurokinin-1 receptor mediates stress-exacerbated allergic airway inflammation and airway hyperresponsiveness in mice. Joachim RA, etal., Psychosom Med. 2004 Jul-Aug;66(4):564-71.
34. Role of tachykinin receptors and melatonin in oxitocin secretion from isolated rat hypothalmo-neurohypophysial system. Juszczak M, etal., J Physiol Pharmacol. 2004 Dec;55(4):739-49.
35. Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies. Juszczak M, etal., J Physiol Pharmacol. 2007 Dec;58(4):829-43.
36. Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action. Karagiannides I, etal., Endocrinology. 2011 Jun;152(6):2197-205. Epub 2011 Apr 5.
37. Effects of substance P microinjections into the globus pallidus and central nucleus of amygdala on passive avoidance learning in rats. Kertes E, etal., Behav Brain Res. 2009 Mar 17;198(2):397-403. Epub 2008 Nov 24.
38. Elimination of rat spinal substance P receptor bearing neurons dissociates cardiovascular and nocifensive responses to nicotinic agonists. Khan IM, etal., Neuropharmacology. 2008 Feb;54(2):269-79. Epub 2007 Oct 17.
39. Substance P is involved in the cutaneous blood flow increase response to sympathetic nerve stimulation in persistently inflamed rats. Koeda T, etal., J Physiol Sci. 2007 Dec;57(6):361-6. Epub 2007 Dec 4.
40. The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2. Kwatra MM, etal., J Biol Chem. 1993 May 5;268(13):9161-4.
41. The effect of CP96,345 on the expression of tachykinins and neurokinin receptors in acute pancreatitis. Lau HY and Bhatia M, J Pathol. 2006 Feb;208(3):364-71.
42. The effect of substance P on asthmatic rat airway smooth muscle cell proliferation, migration, and cytoplasmic calcium concentration in vitro. Li M, etal., J Inflamm (Lond). 2011 Jul 21;8(1):18.
43. Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure. Li PC, etal., Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L912-20. Epub 2008 Mar 7.
44. [The relationship between leukemia inhibitory factor and neurokinin receptors in a rat model of asthma]. Lin MJ, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2005 Dec;28(12):820-4.
45. Cyclophosphamide induced cystitis: role of nitric oxide synthase, cyclooxygenase-1 and 2, and NK(1) receptors. Linares-Fernandez BE and Alfieri AB, J Urol. 2007 Apr;177(4):1531-6.
46. Synaptic relationship between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors. Liu H, etal., Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1009-13. doi: 10.1073/pnas.91.3.1009.
47. The Role of Substance P in the Marginal Division of the Neostriatum in Learning and Memory is Mediated Through the Neurokinin 1 Receptor in Rats. Liu XM, etal., Neurochem Res. 2011 May 25.
48. Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing. Liu Y, etal., Hum Mol Genet. 2022 Nov 10;31(22):3769-3776. doi: 10.1093/hmg/ddac129.
49. Differential effects of dexamethasone, ondansetron and a tachykinin NK1 receptor antagonist (GR205171) on cisplatin-induced changes in behaviour, food intake, pica and gastric function in rats. Malik NM, etal., Eur J Pharmacol. 2007 Jan 26;555(2-3):164-73. Epub 2006 Oct 28.
50. Estrogen determines sex differences in airway responsiveness after allergen exposure. Matsubara S, etal., Am J Respir Cell Mol Biol. 2008 May;38(5):501-8. Epub 2007 Dec 6.
51. Central and peripheral expression of neurokinin-1 and neurokinin-3 receptor and substance P-encoding messenger RNAs: peripheral regulation during formalin-induced inflammation and lack of neurokinin receptor expression in primary afferent sensory neurons. McCarson KE Neuroscience. 1999;93(1):361-70.
52. Unilateral ablation of pre-Botzinger complex disrupts breathing during sleep but not wakefulness. McKay LC and Feldman JL, Am J Respir Crit Care Med. 2008 Jul 1;178(1):89-95. Epub 2008 Apr 17.
53. Neurokinin-1 receptors in cholinergic neurons of the rat ventral pallidum have a predominantly dendritic distribution that is affected by apomorphine when combined with startle-evoking auditory stimulation. Mengual E, etal., Neuroscience. 2008 Feb 6;151(3):711-24. Epub 2007 Dec 4.
54. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
55. Physiological and morphological properties of, and effect of substance P on, neurons in the A7 catecholamine cell group in rats. Min MY, etal., Neuroscience. 2008 Jun 2;153(4):1020-33. Epub 2008 Mar 19.
56. Direct linkage of three tachykinin receptors to stimulation of both phosphatidylinositol hydrolysis and cyclic AMP cascades in transfected Chinese hamster ovary cells. Nakajima Y, etal., J Biol Chem. 1992 Feb 5;267(4):2437-42.
57. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
58. Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair. Oslund KL, etal., Am J Respir Cell Mol Biol. 2008 Sep;39(3):279-88. Epub 2008 Apr 3.
59. NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin. Pacharinsak C, etal., Pain. 2008 Sep 30;139(1):34-46. Epub 2008 Apr 14.
60. Tachykinin regulation of cholinergic transmission in the limbic/prefrontal territory of the rat dorsal striatum: implication of new neurokinine 1-sensitive receptor binding site and interaction with enkephalin/mu opioid receptor transmission. Perez S, etal., J Neurochem. 2007 Dec;103(6):2153-63. Epub 2007 Oct 18.
61. Respiratory syncytial virus upregulates expression of the substance P receptor in rat lungs. Piedimonte G, etal., Am J Physiol. 1999 Oct;277(4 Pt 1):L831-40.
62. Tachykinin receptor and neutral endopeptidase gene expression in the rat uterus: characterization and regulation in response to ovarian steroid treatment. Pinto FM, etal., Endocrinology. 1999 Jun;140(6):2526-32.
63. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
64. Further evidence that central tachykinin NK-1 receptors mediate the inhibitory effect of tachykinins on angiotensin-induced drinking in rats. Polidori C, etal., Peptides. 1998;19(1):149-55.
65. Neurokinin-1 receptor and substance P messenger RNA levels increase during intraabdominal adhesion formation. Reed KL, etal., J Surg Res 2002 Nov;108(1):165-72.
66. GOA pipeline RGD automated data pipeline
67. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
68. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
69. Ablation of NK1 receptors in rat nucleus tractus solitarii blocks baroreflexes. Riley J, etal., Hypertension 2002 Dec;40(6):823-6.
70. Calcitonin gene-related peptide regulates expression of neurokinin1 receptors by rat spinal neurons. Seybold VS, etal., J Neurosci 2003 Mar 1;23(5):1816-24.
71. [Role of neurokinin-1 receptor in lung injury in rats with acute necrotizing pancreatitis]. Shi X, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003 Jul;15(7):422-5.
72. Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene. Sio SW, etal., Am J Respir Crit Care Med. 2010 Jan 1;181(1):36-46. Epub 2009 Oct 1.
73. The neuropeptide substance P is a critical mediator of burn-induced acute lung injury. Sio SW, etal., J Immunol. 2008 Jun 15;180(12):8333-41.
74. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
75. Decreased substance P and NK1 receptor immunoreactivity and function in the spinal cord dorsal horn of morphine-treated neonatal rats. Thomson LM, etal., J Pain. 2008 Jan;9(1):11-9. Epub 2007 Oct 24.
76. Substance P regulates migration in rat intestinal epithelial cells. Turner DJ, etal., Ann Surg. 2007 Mar;245(3):408-14.
77. TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats. Wang Y, etal., Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1517-23. Epub 2008 Mar 12.
78. Interdependent regulation of afferent renal nerve activity and renal function: role of transient receptor potential vanilloid type 1, neurokinin 1, and calcitonin gene-related peptide receptors. Xie C, etal., J Pharmacol Exp Ther. 2008 Jun;325(3):751-7. Epub 2008 Mar 25.
79. [Expression of substance P receptor mRNA in nasal mucosa of rat in allergic rhinitis model]. Xue J, etal., Zhonghua Er Bi Yan Hou Ke Za Zhi. 2000 Aug;35(4):247-50.
80. Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia. Zhang H, etal., J Neurosci. 2007 Oct 31;27(44):12067-77.
81. Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury. Zhang X, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R2084-96. Epub 2008 Oct 22.
Additional References at PubMed
PMID:2154852   PMID:2478537   PMID:11805341   PMID:11815365   PMID:11876485   PMID:11950831   PMID:11959652   PMID:12031786   PMID:12106686   PMID:12169105   PMID:12383972   PMID:12384463  
PMID:12402039   PMID:12421623   PMID:12508374   PMID:12648611   PMID:12687689   PMID:12716968   PMID:12892378   PMID:12893626   PMID:12958028   PMID:14532289   PMID:14632686   PMID:14766794  
PMID:14988833   PMID:15019566   PMID:15033437   PMID:15121234   PMID:15128739   PMID:15390113   PMID:15633223   PMID:15647454   PMID:15703395   PMID:15751026   PMID:15782105   PMID:15800377  
PMID:15896914   PMID:16136007   PMID:16239038   PMID:16297989   PMID:16461432   PMID:16467532   PMID:16477146   PMID:16763782   PMID:16782701   PMID:16849335   PMID:16982039   PMID:17023055  
PMID:17309799   PMID:17366610   PMID:17437961   PMID:17468202   PMID:17495222   PMID:17540463   PMID:17627972   PMID:17640051   PMID:17974009   PMID:17977663   PMID:17981325   PMID:17986524  
PMID:18479828   PMID:18615498   PMID:18634782   PMID:18655130   PMID:18656313   PMID:18673452   PMID:19015883   PMID:19200070   PMID:19222484   PMID:19224600   PMID:19258024   PMID:19296480  
PMID:19344710   PMID:19429049   PMID:19464118   PMID:19490080   PMID:19563686   PMID:19575822   PMID:19699779   PMID:20059697   PMID:20125052   PMID:20128799   PMID:20218316   PMID:20933035  
PMID:21166923   PMID:21451051   PMID:21565534   PMID:21837425   PMID:21958872   PMID:22243518   PMID:22540287   PMID:22734902   PMID:22765158   PMID:22820943   PMID:22849826   PMID:22917610  
PMID:22962286   PMID:22963197   PMID:23172292   PMID:23555638   PMID:23962787   PMID:23979140   PMID:23994276   PMID:24387161   PMID:24389017   PMID:24639151   PMID:25281803   PMID:25312245  
PMID:25843024   PMID:26524655   PMID:27338549   PMID:27706667   PMID:27904941   PMID:27923581   PMID:28097463   PMID:28390968   PMID:28500728   PMID:28566424   PMID:28622274   PMID:28842244  
PMID:31358823   PMID:32000757   PMID:32540418   PMID:32736088  


Genomics

Comparative Map Data
Tacr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84116,478,617 - 116,647,492 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4116,478,617 - 116,647,492 (+)EnsemblGRCr8
mRatBN7.24114,920,844 - 115,089,733 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4114,920,844 - 115,089,733 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4120,383,645 - 120,552,243 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,158,843 - 116,327,453 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04114,778,790 - 114,948,892 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,247,236 - 113,416,139 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,247,795 - 113,414,504 (+)Ensemblrn6Rnor6.0
Rnor_5.04177,926,094 - 178,095,041 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44116,610,595 - 116,780,394 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4103,918,032 - 104,086,347 (+)NCBICelera
RGSC_v3.14116,855,058 - 117,024,964 (+)NCBI
Cytogenetic Map4q34NCBI
TACR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38275,046,463 - 75,199,520 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl275,046,463 - 75,199,520 (-)Ensemblhg38GRCh38
GRCh37275,273,590 - 75,426,646 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36275,129,738 - 75,279,781 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34275,189,817 - 75,337,838NCBI
Celera275,104,880 - 75,257,954 (-)NCBICelera
Cytogenetic Map2p12NCBI
HuRef275,010,440 - 75,164,411 (-)NCBIHuRef
CHM1_1275,202,888 - 75,356,007 (-)NCBICHM1_1
T2T-CHM13v2.0275,055,302 - 75,208,694 (-)NCBIT2T-CHM13v2.0
Tacr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39682,378,990 - 82,537,085 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl682,379,315 - 82,537,085 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38682,402,003 - 82,560,104 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl682,402,334 - 82,560,104 (+)Ensemblmm10GRCm38
MGSCv37682,352,469 - 82,510,098 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36682,368,133 - 82,525,757 (+)NCBIMGSCv36mm8
Celera684,384,420 - 84,542,486 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Tacr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542410,614,340 - 10,761,872 (+)Ensembl
ChiLan1.0NW_00495542410,614,340 - 10,761,872 (+)NCBIChiLan1.0ChiLan1.0
TACR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,188,457 - 51,344,443 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,191,211 - 51,347,197 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A75,111,339 - 75,267,320 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A76,614,478 - 76,771,018 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,614,478 - 76,771,018 (-)EnsemblpanPan2panpan1.1
TACR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,038,010 - 48,178,971 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,038,010 - 48,178,971 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1747,681,510 - 47,821,826 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01748,900,538 - 49,041,473 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1748,899,743 - 49,044,192 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11747,916,025 - 48,056,577 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01747,980,726 - 48,121,228 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01748,542,868 - 48,683,479 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tacr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,315,839 - 9,471,281 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365561,266,613 - 1,421,275 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365561,266,621 - 1,421,271 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TACR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl367,839,411 - 68,021,724 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1367,839,367 - 68,021,733 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TACR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,080,319 - 32,236,556 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,083,615 - 32,233,596 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604579,940,541 - 80,098,197 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tacr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474928,243,640 - 28,455,086 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474928,243,667 - 28,455,012 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tacr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1663,634,443 - 63,795,694 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tacr1
910 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:190
Count of miRNA genes:128
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000007984
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat

Markers in Region
D4Mgh17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24114,921,280 - 114,921,417 (+)MAPPERmRatBN7.2
Rnor_6.04113,247,673 - 113,247,809NCBIRnor6.0
Rnor_6.04113,100,978 - 113,101,114NCBIRnor6.0
Rnor_5.04177,926,531 - 177,926,667UniSTSRnor5.0
Rnor_5.04177,782,842 - 177,782,978UniSTSRnor5.0
RGSC_v3.44116,611,031 - 116,611,168RGDRGSC3.4
RGSC_v3.44116,611,032 - 116,611,168UniSTSRGSC3.4
Celera4103,918,469 - 103,918,605UniSTS
RGSC_v3.14116,855,512 - 116,855,649RGD
RH 3.4 Map4660.47UniSTS
RH 3.4 Map4660.47RGD
RH 2.0 Map4668.7RGD
Cytogenetic Map4q34UniSTS
D4Wox19  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04177,782,855 - 177,782,975NCBIRnor5.0
Rnor_5.04177,782,854 - 177,782,975NCBIRnor5.0
RGSC_v3.44116,611,045 - 116,611,165RGDRGSC3.4
RGSC_v3.44116,611,046 - 116,611,165UniSTSRGSC3.4
Celera4103,918,483 - 103,918,602UniSTS
D4Mit23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24114,921,294 - 114,921,414 (+)MAPPERmRatBN7.2
Rnor_6.04113,100,992 - 113,101,111NCBIRnor6.0
Rnor_6.04113,247,687 - 113,247,806NCBIRnor6.0
Rnor_5.04177,926,545 - 177,926,664UniSTSRnor5.0
Rnor_5.04177,782,856 - 177,782,975UniSTSRnor5.0
RGSC_v3.44116,611,046 - 116,611,165UniSTSRGSC3.4
Celera4103,918,483 - 103,918,602UniSTS
RGSC_v3.14116,855,526 - 116,855,646RGD
Cytogenetic Map4q34UniSTS
D4Arb39  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24114,921,179 - 114,921,479 (+)MAPPERmRatBN7.2
Rnor_6.04113,100,877 - 113,101,176NCBIRnor6.0
Rnor_6.04113,247,572 - 113,247,871NCBIRnor6.0
Rnor_5.04177,926,430 - 177,926,729UniSTSRnor5.0
Rnor_5.04177,782,741 - 177,783,040UniSTSRnor5.0
RGSC_v3.44116,610,931 - 116,611,230UniSTSRGSC3.4
Celera4103,918,368 - 103,918,667UniSTS
Cytogenetic Map4q34UniSTS
D4Got293  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24115,057,756 - 115,057,980 (+)MAPPERmRatBN7.2
Rnor_6.04113,384,167 - 113,384,390NCBIRnor6.0
Rnor_5.04178,063,069 - 178,063,292UniSTSRnor5.0
RGSC_v3.44116,748,422 - 116,748,645UniSTSRGSC3.4
Celera4104,054,420 - 104,054,643UniSTS
Cytogenetic Map4q34UniSTS
RH138512  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24115,026,055 - 115,026,184 (+)MAPPERmRatBN7.2
Rnor_6.04113,352,468 - 113,352,596NCBIRnor6.0
Rnor_5.04178,031,370 - 178,031,498UniSTSRnor5.0
RGSC_v3.44116,716,721 - 116,716,849UniSTSRGSC3.4
Celera4104,022,720 - 104,022,848UniSTS
RH 3.4 Map4660.26UniSTS
Cytogenetic Map4q34UniSTS
UniSTS:480302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24114,921,402 - 114,921,609 (+)MAPPERmRatBN7.2
Rnor_6.04113,101,100 - 113,101,306NCBIRnor6.0
Rnor_6.04113,247,795 - 113,248,001NCBIRnor6.0
Rnor_5.04177,782,964 - 177,783,170UniSTSRnor5.0
Rnor_5.04177,926,653 - 177,926,859UniSTSRnor5.0
RGSC_v3.44116,611,154 - 116,611,360UniSTSRGSC3.4
Celera4103,918,591 - 103,918,797UniSTS
Cytogenetic Map4q34UniSTS


Related Rat Strains
The following Strains have been annotated to Tacr1
BB.SHR-(D4Got41-Tacr1)/K     BB.SHR-(D4Got41-Tacr1)/K    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 40 140 65 66 37 25 37 6 192 94 10 118 38 81 29 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000007984   ⟹   ENSRNOP00000007984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4116,478,617 - 116,647,492 (+)Ensembl
mRatBN7.2 Ensembl4114,920,844 - 115,089,733 (+)Ensembl
Rnor_6.0 Ensembl4113,247,795 - 113,414,504 (+)Ensembl
RefSeq Acc Id: NM_012667   ⟹   NP_036799
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84116,478,617 - 116,647,492 (+)NCBI
mRatBN7.24114,920,844 - 115,089,733 (+)NCBI
Rnor_6.04113,247,236 - 113,416,139 (+)NCBI
Rnor_5.04177,926,094 - 178,095,041 (+)NCBI
RGSC_v3.44116,610,595 - 116,780,394 (+)RGD
Celera4103,918,032 - 104,086,347 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_036799 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42175 (Get FASTA)   NCBI Sequence Viewer  
  AAA42176 (Get FASTA)   NCBI Sequence Viewer  
  AAB59726 (Get FASTA)   NCBI Sequence Viewer  
  EDL91094 (Get FASTA)   NCBI Sequence Viewer  
  EDL91095 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007984
  ENSRNOP00000007984.2
GenBank Protein P14600 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036799   ⟸   NM_012667
- UniProtKB: P14600 (UniProtKB/Swiss-Prot),   A6IAH6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007984   ⟸   ENSRNOT00000007984
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14600-F1-model_v2 AlphaFold P14600 1-407 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3811 AgrOrtholog
BioCyc Gene G2FUF-44051 BioCyc
Ensembl Genes ENSRNOG00000005853 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007984 ENTREZGENE
  ENSRNOT00000007984.6 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Neurokn_rcpt UniProtKB/Swiss-Prot
  NK1_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:24807 UniProtKB/Swiss-Prot
NCBI Gene 24807 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED UniProtKB/Swiss-Prot
  SUBSTANCE-P RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Tacr1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  NEUROKININ1R UniProtKB/Swiss-Prot
  NEUROKININR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005853 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC233578
UniProt A6IAH6 ENTREZGENE, UniProtKB/TrEMBL
  NK1R_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2001-06-20 Tacr1  Tachykinin 1 receptor      Name updated 67952 APPROVED
2001-06-20 Tac1r  Tachykinin 1 receptor (substance P receptor, neurokinin 1 receptor)      Symbol withdrawn, duplicate of Tacr1 (RGD:3811) 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA is stable and expressed in low levels in the lungs 625601
gene_expression expression declined with age in the lungs of pathogen free rats 625601
gene_process mediates the respiratory stimulant effect of substance P 625695