TACR1 (tachykinin receptor 1) - Rat Genome Database

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Gene: TACR1 (tachykinin receptor 1) Canis lupus familiaris
Analyze
Symbol: TACR1
Name: tachykinin receptor 1
RGD ID: 12215791
Description: ENCODES a protein that exhibits substance P receptor activity (ortholog); INVOLVED IN aggressive behavior (ortholog); angiotensin-mediated drinking behavior (ortholog); associative learning (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); acute necrotizing pancreatitis (ortholog); alcohol use disorder (ortholog); FOUND IN cell body (ortholog); cell surface (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: neurokinin receptor subtype NK1; NK-1 receptor; NK-1R; SPR; substance-P receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,038,010 - 48,178,971 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,038,010 - 48,178,971 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1747,681,510 - 47,821,826 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01748,900,538 - 49,041,473 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1748,899,743 - 49,044,192 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11747,916,025 - 48,056,577 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01747,980,726 - 48,121,228 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01748,542,868 - 48,683,479 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aggressive behavior  (ISO)
angiotensin-mediated drinking behavior  (ISO)
associative learning  (ISO)
behavioral response to pain  (ISO)
eating behavior  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
learning or memory  (ISO)
long-term memory  (ISO)
operant conditioning  (ISO)
positive regulation of action potential  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of flagellated sperm motility  (IBA,IEA)
positive regulation of hormone secretion  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of lymphocyte proliferation  (ISO)
positive regulation of ossification  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of synaptic transmission, cholinergic  (ISO)
positive regulation of synaptic transmission, GABAergic  (ISO)
positive regulation of uterine smooth muscle contraction  (ISO)
positive regulation of vascular permeability  (ISO)
positive regulation of vasoconstriction  (ISO)
regulation of blood pressure  (ISO)
regulation of smooth muscle cell migration  (ISO)
regulation of smooth muscle cell proliferation  (ISO)
regulation of uterine smooth muscle contraction  (IEA)
response to auditory stimulus  (ISO)
response to electrical stimulus  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to hormone  (ISO)
response to nicotine  (ISO)
response to organic cyclic compound  (ISO)
response to ozone  (ISO)
response to pain  (IEA,ISO)
response to progesterone  (ISO)
signal transduction  (IEA)
smooth muscle contraction involved in micturition  (ISO)
sperm ejaculation  (ISO)
tachykinin receptor signaling pathway  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:7891345   PMID:22301074   PMID:24751104   PMID:30032202  


Genomics

Comparative Map Data
TACR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,038,010 - 48,178,971 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,038,010 - 48,178,971 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1747,681,510 - 47,821,826 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01748,900,538 - 49,041,473 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1748,899,743 - 49,044,192 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11747,916,025 - 48,056,577 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01747,980,726 - 48,121,228 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01748,542,868 - 48,683,479 (+)NCBIUU_Cfam_GSD_1.0
TACR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38275,046,463 - 75,199,520 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl275,046,463 - 75,199,520 (-)EnsemblGRCh38hg38GRCh38
GRCh37275,273,590 - 75,426,646 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36275,129,738 - 75,279,781 (-)NCBINCBI36Build 36hg18NCBI36
Build 34275,189,817 - 75,337,838NCBI
Celera275,104,880 - 75,257,954 (-)NCBICelera
Cytogenetic Map2p12NCBI
HuRef275,010,440 - 75,164,411 (-)NCBIHuRef
CHM1_1275,202,888 - 75,356,007 (-)NCBICHM1_1
T2T-CHM13v2.0275,055,302 - 75,208,694 (-)NCBIT2T-CHM13v2.0
Tacr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39682,378,990 - 82,537,085 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl682,379,315 - 82,537,085 (+)EnsemblGRCm39 Ensembl
GRCm38682,402,003 - 82,560,104 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl682,402,334 - 82,560,104 (+)EnsemblGRCm38mm10GRCm38
MGSCv37682,352,469 - 82,510,098 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36682,368,133 - 82,525,757 (+)NCBIMGSCv36mm8
Celera684,384,420 - 84,542,486 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Tacr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84116,478,617 - 116,647,492 (+)NCBIGRCr8
mRatBN7.24114,920,844 - 115,089,733 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4114,920,844 - 115,089,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4120,383,645 - 120,552,243 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,158,843 - 116,327,453 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04114,778,790 - 114,948,892 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,247,236 - 113,416,139 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,247,795 - 113,414,504 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04177,926,094 - 178,095,041 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44116,610,595 - 116,780,394 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14116,855,058 - 117,024,964 (+)NCBI
Celera4103,918,032 - 104,086,347 (+)NCBICelera
Cytogenetic Map4q34NCBI
Tacr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542410,614,340 - 10,761,872 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542410,614,340 - 10,761,872 (+)NCBIChiLan1.0ChiLan1.0
TACR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,188,457 - 51,344,443 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,191,211 - 51,347,197 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A75,111,339 - 75,267,320 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A76,614,478 - 76,771,018 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,614,478 - 76,771,018 (-)Ensemblpanpan1.1panPan2
Tacr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,315,839 - 9,471,281 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365561,266,613 - 1,421,275 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365561,266,621 - 1,421,271 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TACR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl367,839,411 - 68,021,724 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1367,839,367 - 68,021,733 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TACR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,080,319 - 32,236,556 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,083,615 - 32,233,596 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,940,541 - 80,098,197 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tacr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474928,243,640 - 28,455,086 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474928,243,667 - 28,455,012 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TACR1
1911 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 18 5 5 4 12 9 6
Below cutoff 5 4 1 6 1 2 6 8 1

Sequence


RefSeq Acc Id: ENSCAFT00000013011   ⟹   ENSCAFP00000012041
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1748,038,010 - 48,178,971 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845029508   ⟹   ENSCAFP00845023180
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1748,899,743 - 49,044,192 (+)Ensembl
RefSeq Acc Id: NM_001012619   ⟹   NP_001012637
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11748,038,010 - 48,178,971 (+)NCBI
Dog10K_Boxer_Tasha1747,681,510 - 47,821,826 (+)NCBI
ROS_Cfam_1.01748,900,538 - 49,041,473 (+)NCBI
UMICH_Zoey_3.11747,916,025 - 48,056,577 (+)NCBI
UNSW_CanFamBas_1.01747,980,726 - 48,121,228 (+)NCBI
UU_Cfam_GSD_1.01748,542,868 - 48,683,479 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001012637 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD14166 (Get FASTA)   NCBI Sequence Viewer  
  CAI58656 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000012041.3
  ENSCAFP00030028765.1
  ENSCAFP00040010993.1
  ENSCAFP00805033817
  ENSCAFP00845023180
  ENSCAFP00845023180.1
GenBank Protein Q5DUB3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012637   ⟸   NM_001012619
- UniProtKB: Q5DUB3 (UniProtKB/Swiss-Prot),   A0A8C0R0R9 (UniProtKB/TrEMBL),   A0A8P0SDI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000012041   ⟸   ENSCAFT00000013011
RefSeq Acc Id: ENSCAFP00845023180   ⟸   ENSCAFT00845029508
Promoters
RGD ID:13686300
Promoter ID:EPDNEW_C4368
Type:single initiation site
Name:TACR1_1
Description:tachykinin receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11748,037,393 - 48,037,453EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008184 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017843 UniProtKB/Swiss-Prot
  ENSCAFG00040006803 UniProtKB/Swiss-Prot
  ENSCAFG00805023879 UniProtKB/Swiss-Prot
  ENSCAFG00845016647 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000013011.5 UniProtKB/TrEMBL
  ENSCAFT00030032971.1 UniProtKB/Swiss-Prot
  ENSCAFT00040012681.1 UniProtKB/Swiss-Prot
  ENSCAFT00805043218 UniProtKB/Swiss-Prot
  ENSCAFT00845029508 ENTREZGENE
  ENSCAFT00845029508.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurokn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NK1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403815 UniProtKB/Swiss-Prot
NCBI Gene TACR1 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBSTANCE-P RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROKININ1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROKININR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0R0R9 ENTREZGENE
  A0A8P0SDI4 ENTREZGENE, UniProtKB/TrEMBL
  NK1R_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:47066 ENTREZGENE