Srd5a1 (steroid 5 alpha-reductase 1) - Rat Genome Database

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Gene: Srd5a1 (steroid 5 alpha-reductase 1) Rattus norvegicus
Analyze
Symbol: Srd5a1
Name: steroid 5 alpha-reductase 1
RGD ID: 3757
Description: Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity; NADPH binding activity; and amide binding activity. Involved in several processes, including forebrain development; reproductive structure development; and steroid metabolic process. Located in cell body fiber; neuronal cell body; and perinuclear region of cytoplasm. Used to study prostate cancer. Biomarker of hyperprolactinemia; hypothyroidism; obesity; prostate cancer; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in alcohol dependence; prostate cancer; and prostatic hypertrophy. Orthologous to human SRD5A1 (steroid 5 alpha-reductase 1); PARTICIPATES IN testosterone biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-oxo-5-alpha-steroid 4-dehydrogenase 1; MGC156498; S5AR 1; SR type 1; steroid 5-alpha-reductase; steroid 5-alpha-reductase 1; steroid-5-alpha-reductase 1; Steroid-5-alpha-reductase alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1); steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8135,514,914 - 35,548,898 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl135,514,846 - 35,548,903 (+)EnsemblGRCr8
mRatBN7.2133,686,069 - 33,720,468 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl133,686,391 - 33,720,461 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx133,515,801 - 33,550,297 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0139,514,407 - 39,548,898 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0133,714,648 - 33,748,614 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0136,320,504 - 36,354,694 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl136,320,461 - 36,354,756 (+)Ensemblrn6Rnor6.0
Rnor_5.0137,717,526 - 37,751,716 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4173,845,190 - 3,879,165 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera132,290,558 - 32,325,770 (+)NCBICelera
RGSC_v3.1173,845,345 - 3,877,557 (+)NCBI
Cytogenetic Map1p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(R)-lipoic acid  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5alpha-Pregnan-20alpha-ol-3-one  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bisphenol AF  (ISO)
Bisphenol B  (EXP,ISO)
bisphenol F  (ISO)
butylated hydroxyanisole  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbimazole  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (EXP)
ciguatoxin CTX1B  (ISO)
clofibric acid  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
cypermethrin  (EXP)
cyproconazole  (ISO)
D-aspartic acid  (EXP)
dehydroepiandrosterone  (EXP)
Di-n-octyl phthalate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
dutasteride  (ISO)
dydrogesterone  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
fenthion  (ISO)
finasteride  (EXP,ISO)
fluconazole  (EXP)
fluoroethene  (ISO)
flurbiprofen  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
ganoderol B  (EXP)
genistein  (ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP)
hydroxyflutamide  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
inulin  (ISO)
isoflavones  (EXP)
isotretinoin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
linuron  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lycopene  (EXP)
methidathion  (ISO)
metoclopramide  (EXP)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
PCB138  (EXP)
perfluorodecanoic acid  (EXP,ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP,ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
piperidine  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
propiconazole  (EXP,ISO)
rotenone  (EXP)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
streptozocin  (ISO)
sulpiride  (EXP)
sunitinib  (ISO)
tebufenpyrad  (ISO)
terbutylazine  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
triadimefon  (EXP)
tributylstannane  (ISO)
trichlorfon  (EXP)
trichloroethene  (EXP)
Triptolide  (ISO)
urethane  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP,ISO)
vitamin E  (EXP)
zearalenone  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Acute exercise activates local bioactive androgen metabolism in skeletal muscle. Aizawa K, etal., Steroids. 2010 Mar;75(3):219-23. Epub 2010 Jan 4.
2. Mechanism underlying transient gestational-onset hypothyroidism-induced impairment of posttesticular sperm maturation in adult rats. Anbalagan J, etal., Fertil Steril. 2010 May 15;93(8):2491-7. Epub 2010 Mar 19.
3. Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. Andersson S and Russell DW, Proc Natl Acad Sci U S A 1990 May;87(10):3640-4.
4. Expression cloning and regulation of steroid 5 alpha-reductase, an enzyme essential for male sexual differentiation. Andersson S, etal., J Biol Chem 1989 Sep 25;264(27):16249-55.
5. Expression and regulation of steroid 5 alpha-reductase in the urogenital tract of the fetal rat. Berman DM, etal., Mol Endocrinol. 1995 Nov;9(11):1561-70.
6. Site-directed mutagenesis studies of rat steroid 5alpha-reductase (isozyme-1): mutation of residues in the cofactor binding and C-terminal regions. Bhattacharyya AK and Collins DC, J Steroid Biochem Mol Biol. 2001 May;77(2-3):177-82.
7. Dimorphic expression of testosterone metabolizing enzymes in the hypothalamic area of developing rats. Colciago A, etal., Brain Res Dev Brain Res. 2005 Mar 31;155(2):107-16.
8. Distribution of rat hepatic steroid 5 alpha-reductase 1 as shown by immunohistochemistry. Eicheler W, etal., Exp Clin Endocrinol Diabetes. 1995;103(2):105-12.
9. Steroid 5alpha reductase mRNA type 1 is differentially regulated by androgens and glucocorticoids in the rat liver. El-Awady MK, etal., Endocr J. 2004 Feb;51(1):37-46.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Nerve growth factor induces elevation of steroid 5alpha-reductase mRNA levels in rat C6 glioma cells through expression of transcription factor Egr-1. Her S, etal., Brain Res Mol Brain Res. 2004 Jul 26;126(2):157-64.
13. Trichostatin A stimulates steroid 5alpha-reductase gene expression in rat C6 glioma cells via a mechanism involving Sp1 and Sp3 transcription factors. Her S, etal., J Mol Neurosci. 2010 Jun;41(2):252-62. Epub 2009 Sep 2.
14. Stimulatory effect of insulin on 5alpha-reductase type 1 (SRD5A1) expression through an Akt-dependent pathway in ovarian granulosa cells. Kayampilly PP, etal., Endocrinology. 2010 Oct;151(10):5030-7. Epub 2010 Sep 1.
15. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
16. 5alpha-reductase isoenzymes 1 and 2 in the rat testis during postnatal development. Killian J, etal., Biol Reprod. 2003 May;68(5):1711-8. Epub 2002 Dec 11.
17. Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats. Kim TS, etal., J Toxicol Environ Health A. 2010 Jan;73(21-22):1544-59.
18. A case-based evaluation of SRD5A1, SRD5A2, AR, and ADRA1A as candidate genes for severity of BPH. Klotsman M, etal., Pharmacogenomics J. 2004;4(4):251-9.
19. Ontogeny of 5 alpha-reductase (type 1) messenger ribonucleic acid expression in rat brain: early presence in germinal zones. Lauber ME and Lichtensteiger W, Endocrinology. 1996 Jul;137(7):2718-30.
20. Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma. Lewis MJ, etal., BMC Cancer. 2004 Jun 22;4:27.
21. Heterogeneity of rat type I 5 alpha-reductase cDNA: cloning, expression and regulation by pituitary implants and dihydrotestosterone. Lopez-Solache I, etal., Biochim Biophys Acta 1996 Mar 1;1305(3):139-44.
22. Influence of 17beta-estradiol on the synthesis of reduced neurosteroids in the brain (in vivo) and in glioma cells (in vitro): possible relevance to mental disorders in women. Maayan R, etal., Brain Res. 2004 Sep 10;1020(1-2):167-72.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Variation in genes encoding the neuroactive steroid synthetic enzymes 5α-reductase type 1 and 3α-reductase type 2 is associated with alcohol dependence. Milivojevic V, etal., Alcohol Clin Exp Res. 2011 May;35(5):946-52. doi: 10.1111/j.1530-0277.2010.01425.x. Epub 2011 Feb 15.
25. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
26. Serotonergic 5-HT2A receptor stimulation induces steroid 5alpha-reductase gene expression in rat C6 glioma cells via transcription factor Egr-1. Morita K, etal., Brain Res Mol Brain Res. 2005 Oct 3;139(2):193-200.
27. Adrenergic activation of steroid 5alpha-reductase gene expression in rat C6 glioma cells: involvement of cyclic amp/protein kinase A-mediated signaling pathway. Morita K, etal., J Mol Neurosci. 2004;22(3):205-12.
28. Changes in the expression of steroid metabolism-related genes in rat adrenal glands during selective REM sleep deprivation. Morita K, etal., Life Sci. 2003 Mar 14;72(17):1973-82.
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. Adrenocortical insufficiency in Otsuka Long-Evans Tokushima Fatty rats, a type 2 diabetes mellitus model. Noguchi S, etal., Metabolism. 2007 Oct;56(10):1326-33.
31. Gender differences in the responsiveness of the sex-dependent isoforms of hepatic P450 to the feminine plasma growth hormone profile. Pampori NA and Shapiro BH, Endocrinology. 1999 Mar;140(3):1245-54.
32. Anatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cord. Patte-Mensah C, etal., J Comp Neurol. 2004 Sep 20;477(3):286-99.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. Identification of type 1 5alpha-reductase in myelin membranes of male and female rat brain. Poletti A, etal., Mol Cell Endocrinol. 1997 May 16;129(2):181-90.
35. Differential regulation of rat testicular 5alpha-reductase type 1 and 2 isoforms by testosterone and FSH. Pratis K, etal., J Endocrinol. 2003 Mar;176(3):393-403.
36. GOA pipeline RGD automated data pipeline
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Oleoyl-estrone increases adrenal corticosteroid synthesis gene expression in overweight male rats. Romero Mdel M, etal., Steroids. 2010 Jan;75(1):20-6. Epub 2009 Sep 28.
40. Effects of sulpiride on mRNA levels of steroid 5alpha-reductase isozymes in prostate of adult rats. Sanchez P, etal., IUBMB Life. 2008 Jan;60(1):68-72.
41. Effects of sulpiride on prolactin and mRNA levels of steroid 5alpha-reductase isozymes in adult rat brain. Sanchez P, etal., Neurochem Res. 2008 May;33(5):820-5. Epub 2007 Oct 17.
42. Effects of dutasteride on prostate growth in the large probasin-large T antigen mouse model of prostate cancer. Shao TC, etal., J Urol. 2007 Oct;178(4 Pt 1):1521-7. Epub 2007 Aug 16.
43. Effects of proportions of dietary macronutrients on glucocorticoid metabolism in diet-induced obesity in rats. Stimson RH, etal., PLoS One. 2010 Jan 19;5(1):e8779.
44. Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5alpha-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat. Stuart JD, etal., Biochem Pharmacol 2001 Oct 1;62(7):933-42.
45. Determination of rat 5alpha-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines. Szecsi M, etal., Acta Biol Hung. 2010 Sep;61(3):274-81.
46. Inhibition of rat steroid 5 alpha-reductase (isozyme 1) by suramin. Taylor MF, etal., Steroids. 1995 Jul;60(7):452-6.
47. Expression of rat steroid 5 alpha-reductase (isozyme-1) in Spodoptera frugiperda, SF21, insect cells: expression of rat steroid 5 alpha-reductase. Taylor MF, etal., Steroids. 1997 Apr;62(4):373-8.
48. Four-amino acid segment in steroid 5 alpha-reductase 1 confers sensitivity to finasteride, a competitive inhibitor. Thigpen AE and Russell DW, J Biol Chem. 1992 Apr 25;267(12):8577-83.
49. Testosterone, cytochrome P450, and cardiac hypertrophy. Thum T and Borlak J, FASEB J. 2002 Oct;16(12):1537-49.
50. Expression and regulation of steroid 5 alpha-reductase in the genital tubercle of the fetal rat. Tian H and Russell DW, Dev Dyn. 1997 May;209(1):117-26.
51. Steroid 5alpha-reductase isozymes in the adult female rat brain: central role of dihydrotestosterone. Torres JM and Ortega E, J Mol Endocrinol. 2006 Apr;36(2):239-45.
52. Influence of serum-free culture conditions on subcellular localization of steroid 5alpha-reductase in rat C6 glioma cells. Tsuruo Y, etal., Brain Res. 1998 Aug 10;801(1-2):130-6.
53. Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation. van der Eerden BC, etal., J Endocrinol. 2004 Mar;180(3):457-67.
54. Expression of androgen receptor through androgen-converting enzymes is associated with biological aggressiveness in prostate cancer. Wako K, etal., J Clin Pathol. 2008 Apr;61(4):448-54. Epub 2007 Aug 24.
55. Effects of resveratrol on rat neurosteroid synthetic enzymes. Wang Y, etal., Fitoterapia. 2017 Oct;122:61-66. doi: 10.1016/j.fitote.2017.08.005. Epub 2017 Aug 18.
56. Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers. Xu Y, etal., Clin Cancer Res. 2006 Jul 1;12(13):4072-9.
57. Steroid 5 alpha-reductase type 1 immunolocalized in the adrenal gland of normal, gonadectomized, and sex hormone-supplemented rats. Yokoi H, etal., Histochem Cell Biol. 1998 Feb;109(2):127-34.
Additional References at PubMed
PMID:12477932   PMID:15249131   PMID:17826869   PMID:17986282   PMID:18354385   PMID:20447326   PMID:22131296   PMID:23122426   PMID:23405234   PMID:25239636   PMID:26021641   PMID:28707553  


Genomics

Comparative Map Data
Srd5a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8135,514,914 - 35,548,898 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl135,514,846 - 35,548,903 (+)EnsemblGRCr8
mRatBN7.2133,686,069 - 33,720,468 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl133,686,391 - 33,720,461 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx133,515,801 - 33,550,297 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0139,514,407 - 39,548,898 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0133,714,648 - 33,748,614 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0136,320,504 - 36,354,694 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl136,320,461 - 36,354,756 (+)Ensemblrn6Rnor6.0
Rnor_5.0137,717,526 - 37,751,716 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4173,845,190 - 3,879,165 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera132,290,558 - 32,325,770 (+)NCBICelera
RGSC_v3.1173,845,345 - 3,877,557 (+)NCBI
Cytogenetic Map1p11NCBI
SRD5A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3856,633,440 - 6,674,386 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl56,633,290 - 6,676,539 (+)Ensemblhg38GRCh38
GRCh3756,633,553 - 6,674,499 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3656,686,500 - 6,722,675 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3456,686,562 - 6,722,673NCBI
Celera56,660,560 - 6,696,748 (+)NCBICelera
Cytogenetic Map5p15.31NCBI
HuRef56,608,126 - 6,644,172 (+)NCBIHuRef
CHM1_156,633,460 - 6,669,635 (+)NCBICHM1_1
T2T-CHM13v2.056,564,115 - 6,605,062 (+)NCBIT2T-CHM13v2.0
Srd5a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391369,721,568 - 69,759,611 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1369,721,568 - 69,759,561 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381369,573,449 - 69,611,485 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1369,573,449 - 69,611,442 (-)Ensemblmm10GRCm38
MGSCv371369,712,327 - 69,750,341 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361370,040,821 - 70,078,835 (-)NCBIMGSCv36mm8
Celera1371,919,533 - 71,956,201 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1335.55NCBI
Srd5a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555044,360,453 - 4,391,133 (+)Ensembl
ChiLan1.0NW_0049555044,360,909 - 4,388,964 (+)NCBIChiLan1.0ChiLan1.0
SRD5A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v246,880,973 - 6,916,220 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan155,034,510 - 5,069,665 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v056,953,795 - 6,996,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.156,629,093 - 6,664,264 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl56,629,093 - 6,664,264 (+)EnsemblpanPan2panpan1.1
SRD5A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1347,118,814 - 7,144,828 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl347,118,814 - 7,144,828 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3411,627,110 - 11,653,073 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0347,026,936 - 7,052,848 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl347,026,936 - 7,052,848 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1347,074,036 - 7,099,998 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0347,054,526 - 7,080,522 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0347,269,539 - 7,295,565 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Srd5a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213240,167,012 - 240,207,515 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936634758,231 - 798,809 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRD5A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1675,310,211 - 75,335,391 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11675,309,830 - 75,335,438 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21681,671,335 - 81,695,167 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SRD5A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.146,312,770 - 6,348,449 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl46,312,757 - 6,350,550 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606422,370,694 - 22,406,674 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srd5a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247514,309,447 - 4,336,083 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247514,309,518 - 4,335,332 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Srd5a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12200,992,999 - 201,028,278 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:255
Count of miRNA genes:175
Interacting mature miRNAs:211
Transcripts:ENSRNOT00000023659
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat

Markers in Region
RH140207  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2133,720,058 - 33,720,268 (+)MAPPERmRatBN7.2
Rnor_6.0136,354,290 - 36,354,499NCBIRnor6.0
Rnor_5.0137,751,312 - 37,751,521UniSTSRnor5.0
RGSC_v3.4173,878,761 - 3,878,970UniSTSRGSC3.4
Celera132,325,366 - 32,325,575UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 87 59 6 351 187 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023659   ⟹   ENSRNOP00000023659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl135,514,846 - 35,548,903 (+)Ensembl
mRatBN7.2 Ensembl133,686,391 - 33,720,461 (+)Ensembl
Rnor_6.0 Ensembl136,320,461 - 36,354,756 (+)Ensembl
RefSeq Acc Id: NM_017070   ⟹   NP_058766
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8135,514,914 - 35,548,896 (+)NCBI
mRatBN7.2133,686,470 - 33,720,463 (+)NCBI
Rnor_6.0136,320,504 - 36,354,694 (+)NCBI
Rnor_5.0137,717,526 - 37,751,716 (+)NCBI
RGSC_v3.4173,845,190 - 3,879,165 (+)RGD
Celera132,290,558 - 32,325,770 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101160   ⟹   XP_038957088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8135,515,070 - 35,548,898 (+)NCBI
mRatBN7.2133,686,069 - 33,720,468 (+)NCBI
RefSeq Acc Id: NP_058766   ⟸   NM_017070
- UniProtKB: A0JPJ6 (UniProtKB/Swiss-Prot),   P24008 (UniProtKB/Swiss-Prot),   A6JV19 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023659   ⟸   ENSRNOT00000023659
RefSeq Acc Id: XP_038957088   ⟸   XM_039101160
- Peptide Label: isoform X1
Protein Domains
3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24008-F1-model_v2 AlphaFold P24008 1-259 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689576
Promoter ID:EPDNEW_R100
Type:multiple initiation site
Name:Srd5a1_1
Description:steroid 5 alpha-reductase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0136,320,634 - 36,320,694EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3757 AgrOrtholog
BioCyc Gene G2FUF-61869 BioCyc
BioCyc Pathway PWY-7455 [allopregnanolone biosynthesis] BioCyc
  PWY-8200 [backdoor pathway of androgen biosynthesis] BioCyc
  PWY-8202 [11-oxyandrogens biosynthesis] BioCyc
  PWY66-378 [androgen biosynthesis] BioCyc
BioCyc Pathway Image PWY-7455 BioCyc
  PWY-8200 BioCyc
  PWY-8202 BioCyc
  PWY66-378 BioCyc
Ensembl Genes ENSRNOG00000017601 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023659 ENTREZGENE
  ENSRNOT00000023659.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.1630 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7313862 IMAGE-MGC_LOAD
InterPro 3-oxo-5-alpha-steroid_4-DH UniProtKB/Swiss-Prot
  3-oxo-5_a-steroid_4-DH_C UniProtKB/Swiss-Prot
  SRD5A/TECR UniProtKB/Swiss-Prot
KEGG Report rno:24950 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156498 IMAGE-MGC_LOAD
NCBI Gene 24950 ENTREZGENE
PANTHER 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1 UniProtKB/Swiss-Prot
  PTHR10556 UniProtKB/Swiss-Prot
Pfam Steroid_dh UniProtKB/Swiss-Prot
PhenoGen Srd5a1 PhenoGen
PIRSF 5_alpha-SR2 UniProtKB/Swiss-Prot
PROSITE S5A_REDUCTASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017601 RatGTEx
UniProt A0JPJ6 ENTREZGENE
  A6JV19 ENTREZGENE, UniProtKB/TrEMBL
  P24008 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0JPJ6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Srd5a1  steroid 5 alpha-reductase 1  Srd5a1  steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Srd5a1  steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)  Srd5a1  steroid 5 alpha-reductase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Srd5a1  steroid 5 alpha-reductase 1      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Srd5a1  steroid 5 alpha-reductase 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression steroid 5- alpha-reductase is present in liver and pancreas 70276
gene_expression steroid 5- alpha-reductase is present in liver and pancreas 70289
gene_function converts testosterone into dihydrotestosterone 70289
gene_regulation expression is increased by pituitary hormones and castration and is decreased by dihydrotestosterone and hypophysectomy 730122
gene_regulation expression is differentially regulated by testosterone in androgen-responsive and androgen non-responsive tissues 730219
gene_transcript alternative mRNA transcripts encode proteins with different affinities for testosterone 730122