Slc16a7 (solute carrier family 16 member 7) - Rat Genome Database

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Gene: Slc16a7 (solute carrier family 16 member 7) Rattus norvegicus
Analyze
Symbol: Slc16a7
Name: solute carrier family 16 member 7
RGD ID: 3691
Description: Enables symporter activity. Involved in plasma membrane lactate transport. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Orthologous to human SLC16A7 (solute carrier family 16 member 7); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MCT 2; Mct2; MGC93092; monocarboxylate transporter 2; solute carrier family 16 (monocarboxylate transporter), member 7; solute carrier family 16 (monocarboxylic acid transporters) member 7; solute carrier family 16 (monocarboxylic acid transporters), member 7; solute carrier family 16, member 7; solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8762,929,067 - 63,096,995 (-)NCBIGRCr8
mRatBN7.2761,043,667 - 61,211,547 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl761,051,167 - 61,154,994 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx762,936,997 - 63,040,542 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0765,139,665 - 65,243,207 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0764,915,969 - 65,019,570 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0768,438,341 - 68,606,312 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl768,446,193 - 68,549,763 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0768,633,417 - 68,801,189 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4765,210,148 - 65,313,572 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1765,230,721 - 65,390,741 (-)NCBI
Celera758,206,868 - 58,309,915 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
obesity  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-iodothyronamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
dibenz[a,h]anthracene  (ISO)
dieldrin  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
geldanamycin  (ISO)
glafenine  (EXP)
heptachlor  (EXP)
hydrogen peroxide  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
lanthanum trichloride  (EXP)
leflunomide  (EXP)
Licochalcone B  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methylseleninic acid  (ISO)
mirex  (EXP)
nefazodone  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking. Bergersen LH, etal., Cereb Cortex. 2005 Apr;15(4):361-70. doi: 10.1093/cercor/bhh138.
2. Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Bröer S, etal., Biochem J. 1999 Aug 1;341 ( Pt 3):529-35. doi: 10.1042/0264-6021:3410529.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation. Jackson VN, etal., Biochem J 1997 Jun 1;324 ( Pt 2):447-53.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Ovens MJ, etal., Biochem J. 2010 Jan 15;425(3):523-30. doi: 10.1042/BJ20091515.
8. The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein. Ovens MJ, etal., Biochem J. 2010 Oct 15;431(2):217-25. doi: 10.1042/BJ20100890.
9. Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain. Rafiki A, etal., Neuroscience 2003;122(3):677-88.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). Wilson MC, etal., J Biol Chem. 2005 Jul 22;280(29):27213-21. Epub 2005 May 24.
Additional References at PubMed
PMID:9482213   PMID:9786900   PMID:12966567   PMID:14534079   PMID:15505343   PMID:15932892   PMID:16516162   PMID:16943667   PMID:17416968   PMID:18084728   PMID:18523157   PMID:19262019  
PMID:19401710   PMID:21488089   PMID:21624469   PMID:21741392   PMID:21753001   PMID:23638108   PMID:24260123   PMID:24610532   PMID:25827488   PMID:26831515   PMID:28388627   PMID:30143583  


Genomics

Comparative Map Data
Slc16a7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8762,929,067 - 63,096,995 (-)NCBIGRCr8
mRatBN7.2761,043,667 - 61,211,547 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl761,051,167 - 61,154,994 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx762,936,997 - 63,040,542 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0765,139,665 - 65,243,207 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0764,915,969 - 65,019,570 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0768,438,341 - 68,606,312 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl768,446,193 - 68,549,763 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0768,633,417 - 68,801,189 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4765,210,148 - 65,313,572 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1765,230,721 - 65,390,741 (-)NCBI
Celera758,206,868 - 58,309,915 (-)NCBICelera
Cytogenetic Map7q22NCBI
SLC16A7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381259,596,029 - 59,789,841 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1259,596,029 - 59,789,855 (+)EnsemblGRCh38hg38GRCh38
GRCh371259,989,810 - 60,183,622 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361258,369,393 - 58,461,675 (+)NCBINCBI36Build 36hg18NCBI36
Build 341258,369,392 - 58,461,674NCBI
Celera1259,745,720 - 59,838,012 (+)NCBICelera
Cytogenetic Map12q14.1NCBI
HuRef1257,038,268 - 57,232,240 (+)NCBIHuRef
CHM1_11259,958,039 - 60,151,803 (+)NCBICHM1_1
T2T-CHM13v2.01259,572,554 - 59,766,418 (+)NCBIT2T-CHM13v2.0
Slc16a7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910125,055,139 - 125,225,455 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10125,055,139 - 125,225,334 (-)EnsemblGRCm39 Ensembl
GRCm3810125,219,270 - 125,389,586 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10125,219,270 - 125,389,465 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710124,664,541 - 124,765,591 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610124,630,545 - 124,731,595 (-)NCBIMGSCv36mm8
Celera10127,630,780 - 127,731,940 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1072.31NCBI
Slc16a7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554587,232,886 - 7,352,782 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554587,232,886 - 7,352,782 (+)NCBIChiLan1.0ChiLan1.0
SLC16A7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21034,537,931 - 34,726,021 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11234,529,686 - 34,722,531 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01229,128,600 - 29,317,797 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11229,390,576 - 29,587,897 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1229,390,576 - 29,528,851 (-)Ensemblpanpan1.1panPan2
SLC16A7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1103,333,000 - 3,500,684 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl103,334,126 - 3,496,150 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha103,398,668 - 3,564,721 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0103,356,472 - 3,522,599 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl103,357,277 - 3,519,865 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1103,323,639 - 3,489,625 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0103,565,685 - 3,731,591 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0103,691,746 - 3,857,780 (+)NCBIUU_Cfam_GSD_1.0
Slc16a7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494555,219,046 - 55,388,105 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366463,533,590 - 3,642,526 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366463,482,148 - 3,647,466 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC16A7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl524,713,267 - 24,875,003 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1524,713,009 - 24,871,891 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2526,710,139 - 26,864,757 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC16A7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11155,541,313 - 55,709,102 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1155,645,129 - 55,708,356 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037190,169,996 - 190,345,973 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc16a7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248028,015,061 - 8,191,012 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248028,015,061 - 8,191,031 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc16a7
1185 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:95
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000058036
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
61435Cia4Collagen induced arthritis QTL 45.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)75811322462004598Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 15 87 83 3 83 77 74 45 19
Low 6 114 128 64 66 64 36 26 161 41 100 38 24
Below cutoff 27 19 12

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC081701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U62316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000058036   ⟹   ENSRNOP00000054845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl761,051,167 - 61,154,994 (-)Ensembl
Rnor_6.0 Ensembl768,446,193 - 68,512,397 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077670   ⟹   ENSRNOP00000075465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl768,446,768 - 68,523,364 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078014   ⟹   ENSRNOP00000073329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl768,446,353 - 68,549,763 (-)Ensembl
RefSeq Acc Id: NM_017302   ⟹   NP_058998
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,937,088 - 63,040,398 (-)NCBI
mRatBN7.2761,051,688 - 61,155,006 (-)NCBI
Rnor_6.0768,446,349 - 68,549,763 (-)NCBI
Rnor_5.0768,633,417 - 68,801,189 (-)NCBI
RGSC_v3.4765,210,148 - 65,313,572 (-)RGD
Celera758,206,868 - 58,309,915 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241432   ⟹   XP_006241494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,020,967 (-)NCBI
mRatBN7.2761,043,667 - 61,135,526 (-)NCBI
Rnor_6.0768,438,341 - 68,530,585 (-)NCBI
Rnor_5.0768,633,417 - 68,801,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241433   ⟹   XP_006241495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,040,695 (-)NCBI
mRatBN7.2761,043,667 - 61,156,096 (-)NCBI
Rnor_6.0768,444,488 - 68,550,023 (-)NCBI
Rnor_5.0768,633,417 - 68,801,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241434   ⟹   XP_006241496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,995 (-)NCBI
mRatBN7.2761,043,667 - 61,211,545 (-)NCBI
Rnor_6.0768,438,341 - 68,606,311 (-)NCBI
Rnor_5.0768,633,417 - 68,801,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241435   ⟹   XP_006241497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,040,695 (-)NCBI
mRatBN7.2761,043,667 - 61,156,096 (-)NCBI
Rnor_6.0768,444,488 - 68,550,023 (-)NCBI
Rnor_5.0768,633,417 - 68,801,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241436   ⟹   XP_006241498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,983 (-)NCBI
mRatBN7.2761,043,667 - 61,211,547 (-)NCBI
Rnor_6.0768,438,341 - 68,606,312 (-)NCBI
Rnor_5.0768,633,417 - 68,801,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078611   ⟹   XP_038934539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,982 (-)NCBI
mRatBN7.2761,043,667 - 61,211,545 (-)NCBI
RefSeq Acc Id: XM_039078612   ⟹   XP_038934540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,982 (-)NCBI
mRatBN7.2761,043,667 - 61,211,545 (-)NCBI
RefSeq Acc Id: XM_039078613   ⟹   XP_038934541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,983 (-)NCBI
mRatBN7.2761,043,667 - 61,211,547 (-)NCBI
RefSeq Acc Id: XM_039078614   ⟹   XP_038934542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,983 (-)NCBI
mRatBN7.2761,043,667 - 61,211,547 (-)NCBI
RefSeq Acc Id: XM_039078615   ⟹   XP_038934543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,983 (-)NCBI
mRatBN7.2761,043,667 - 61,211,547 (-)NCBI
RefSeq Acc Id: XM_039078616   ⟹   XP_038934544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,020,967 (-)NCBI
mRatBN7.2761,043,667 - 61,135,533 (-)NCBI
RefSeq Acc Id: XM_039078617   ⟹   XP_038934545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,020,967 (-)NCBI
mRatBN7.2761,052,466 - 61,135,520 (-)NCBI
RefSeq Acc Id: XM_063263138   ⟹   XP_063119208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,982 (-)NCBI
RefSeq Acc Id: XM_063263139   ⟹   XP_063119209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,040,699 (-)NCBI
RefSeq Acc Id: XM_063263140   ⟹   XP_063119210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,002,987 (-)NCBI
RefSeq Acc Id: XM_063263141   ⟹   XP_063119211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,982 (-)NCBI
RefSeq Acc Id: NP_058998   ⟸   NM_017302
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241498   ⟸   XM_006241436
- Peptide Label: isoform X1
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241496   ⟸   XM_006241434
- Peptide Label: isoform X1
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241497   ⟸   XM_006241435
- Peptide Label: isoform X1
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241495   ⟸   XM_006241433
- Peptide Label: isoform X1
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241494   ⟸   XM_006241432
- Peptide Label: isoform X1
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054845   ⟸   ENSRNOT00000058036
Ensembl Acc Id: ENSRNOP00000075465   ⟸   ENSRNOT00000077670
Ensembl Acc Id: ENSRNOP00000073329   ⟸   ENSRNOT00000078014
RefSeq Acc Id: XP_038934543   ⟸   XM_039078615
- Peptide Label: isoform X1
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934542   ⟸   XM_039078614
- Peptide Label: isoform X1
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934541   ⟸   XM_039078613
- Peptide Label: isoform X1
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934540   ⟸   XM_039078612
- Peptide Label: isoform X1
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934539   ⟸   XM_039078611
- Peptide Label: isoform X1
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934544   ⟸   XM_039078616
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038934545   ⟸   XM_039078617
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063119208   ⟸   XM_063263138
- Peptide Label: isoform X1
- UniProtKB: Q66HS9 (UniProtKB/Swiss-Prot),   Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063119211   ⟸   XM_063263141
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063119209   ⟸   XM_063263139
- Peptide Label: isoform X1
- UniProtKB: Q66HS9 (UniProtKB/Swiss-Prot),   Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063119210   ⟸   XM_063263140
- Peptide Label: isoform X1
- UniProtKB: Q66HS9 (UniProtKB/Swiss-Prot),   Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63344-F1-model_v2 AlphaFold Q63344 1-489 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695239
Promoter ID:EPDNEW_R5764
Type:multiple initiation site
Name:Slc16a7_1
Description:solute carrier family 16 member 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0768,549,776 - 68,549,836EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3691 AgrOrtholog
BioCyc Gene G2FUF-33826 BioCyc
Ensembl Genes ENSRNOG00000007839 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055027006 UniProtKB/Swiss-Prot
  ENSRNOG00060010003 UniProtKB/Swiss-Prot
  ENSRNOG00065016859 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000058036.4 UniProtKB/Swiss-Prot
  ENSRNOT00055046632 UniProtKB/Swiss-Prot
  ENSRNOT00060016927 UniProtKB/Swiss-Prot
  ENSRNOT00065028155 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7130138 IMAGE-MGC_LOAD
InterPro MCT UniProtKB/Swiss-Prot
  MFS UniProtKB/Swiss-Prot
  MFS_dom UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Proton-linked_MCT UniProtKB/Swiss-Prot
KEGG Report rno:29735 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93092 IMAGE-MGC_LOAD
NCBI Gene 29735 ENTREZGENE
PANTHER MONOCARBOXYLATE TRANSPORTER UniProtKB/Swiss-Prot
  PTHR11360:SF25 UniProtKB/Swiss-Prot
Pfam MFS_1 UniProtKB/Swiss-Prot
PhenoGen Slc16a7 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007839 RatGTEx
  ENSRNOG00055027006 RatGTEx
  ENSRNOG00060010003 RatGTEx
  ENSRNOG00065016859 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
TIGR TC222839
UniProt MOT2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63649 ENTREZGENE
  Q66HS9 ENTREZGENE
UniProt Secondary Q63649 UniProtKB/Swiss-Prot
  Q66HS9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc16a7  solute carrier family 16 member 7  Slc16a7  solute carrier family 16 (monocarboxylate transporter), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc16a7  solute carrier family 16 (monocarboxylate transporter), member 7  Slc16a7  solute carrier family 16, member 7 (monocarboxylic acid transporter 2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc16a7  solute carrier family 16, member 7 (monocarboxylic acid transporter 2)  Slc16a7  solute carrier family 16 (monocarboxylic acid transporters), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc16a7  solute carrier family 16 (monocarboxylic acid transporters), member 7    solute carrier family 16, member 7  Name updated 1299863 APPROVED
2002-06-10 Slc16a7  solute carrier family 16, member 7      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in neurons and some astrocyte populations 734496