Sell (selectin L) - Rat Genome Database

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Gene: Sell (selectin L) Rattus norvegicus
Analyze
Symbol: Sell
Name: selectin L
RGD ID: 3655
Description: Enables glycolipid binding activity. Involved in several processes, including cellular response to interleukin-8; positive regulation of neutrophil chemotaxis; and regulation of leukocyte adhesion to vascular endothelial cell. Located in cell surface and extracellular space. Used to study colitis; hepatitis; peripheral vascular disease; and ureteral obstruction. Biomarker of abdominal aortic aneurysm; alcoholic hepatitis; endometriosis; pancreatitis; and toxic shock syndrome. Human ortholog(s) of this gene implicated in Crohn's disease; IgA glomerulonephritis; and ulcerative colitis. Orthologous to human SELL (selectin L); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: A.11; CD62 antigen-like family member L; L-selectin; LAM-1; LECAM-1; LECAM1; leukocyte adhesion molecule 1; leukocyte-endothelial cell adhesion molecule 1; ly-22; lymph node homing receptor; lymphocyte antigen 22; lymphocyte surface MEL-14 antigen; selectin, lymphocyte
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81378,950,100 - 78,969,604 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1378,950,015 - 78,969,600 (+)EnsemblGRCr8
mRatBN7.21376,416,969 - 76,436,444 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,416,915 - 76,436,456 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1379,035,789 - 79,053,737 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01380,339,838 - 80,357,792 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01377,594,427 - 77,612,381 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01382,369,820 - 82,387,774 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,369,493 - 82,387,631 (+)Ensemblrn6Rnor6.0
Rnor_5.01387,249,243 - 87,267,197 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41379,827,342 - 79,845,296 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1376,150,815 - 76,168,775 (+)NCBICelera
RGSC_v3.11379,841,529 - 79,859,484 (+)NCBI
Cytogenetic Map13q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-ropivacaine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
aceclofenac  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
ATP  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
biotin  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
budesonide  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
Calcimycin  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorogenic acid  (EXP)
chloroprene  (ISO)
chrysene  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dichloromethane  (EXP)
diclofenac  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
elemental selenium  (ISO)
enalapril  (ISO)
erythromycin A  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (EXP)
ethylenediaminetetraacetic acid  (ISO)
flavonoids  (EXP,ISO)
flufenamic acid  (ISO)
flurbiprofen  (ISO)
formaldehyde  (ISO)
Fulvic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
griseofulvin  (ISO)
GSK-J4  (ISO)
heparin  (ISO)
iloprost  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ketoprofen  (ISO)
leukotriene B4  (EXP)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
meclofenamic acid  (ISO)
mefenamic acid  (ISO)
meloxicam  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
morphine  (EXP)
N-acetyl-beta-D-glucosamine  (EXP)
N-acetyl-D-glucosamine  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
nabumetone  (ISO)
naloxone  (EXP)
naproxen  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nimesulide  (ISO)
nitrates  (ISO)
omeprazole  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paricalcitol  (ISO)
perfluorooctanoic acid  (EXP)
phenylbutazone  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphoramidon  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
Quinupristin-dalfopristin  (ISO)
resveratrol  (EXP,ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium benzoate  (ISO)
sumatriptan  (EXP)
tamibarotene  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetraphene  (ISO)
thalidomide  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vorinostat  (EXP)
XL147  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. T-cell homing receptor expression in IgA nephropathy. Batra A, etal., Nephrol Dial Transplant. 2007 Sep;22(9):2540-8. Epub 2007 Apr 23.
2. Evidence of an increased nitric oxide production in primary biliary cirrhosis. Battista S, etal., Am J Gastroenterol. 2001 Mar;96(3):869-75. doi: 10.1111/j.1572-0241.2001.03470.x.
3. Fucoidin, a neutrophil rolling inhibitor, reduces damage in a rat electrical burn injury model. Benlier E, etal., Burns. 2011 Nov;37(7):1216-21.
4. Inflammatory cytokines and cell adhesion molecules in a rat model of decompression sickness. Bigley NJ, etal., J Interferon Cytokine Res. 2008 Feb;28(2):55-63.
5. Expression of E-selectin mRNA during ischemia/reperfusion injury. Billups KL, etal., J Lab Clin Med. 1995 May;125(5):626-33.
6. Transcriptional changes in adhesion-related genes are site-specific during noise-induced cochlear pathogenesis. Cai Q, etal., Neurobiol Dis. 2012 Feb;45(2):723-32. Epub 2011 Oct 25.
7. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Charles N, etal., Nat Med. 2010 Jun;16(6):701-7. Epub 2010 May 30.
8. Modulation of T-cell adhesion markers, and the CD45R and CD57 antigens in human alcoholics. Cook RT, etal., Alcohol Clin Exp Res. 1995 Jun;19(3):555-63. doi: 10.1111/j.1530-0277.1995.tb01548.x.
9. Reduced plasma levels of P-selectin and L-selectin in a pilot study from Alzheimer disease: relationship with neuro-degeneration. Corsi MM, etal., Biogerontology. 2011 Oct;12(5):451-4. Epub 2011 Apr 12.
10. [Inhibiting effects of interleuin-10 on expression of E-selectin and L-selectin in cerebral ischemia-reperfusion: experiment with rats] Du HW, etal., Zhonghua Yi Xue Za Zhi. 2009 Jan 6;89(1):59-62.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Neutrophil adhesion molecule expression in the developing neonatal rat exposed to hyperoxia. Gerik SM, etal., Am J Respir Cell Mol Biol. 2003 Oct;29(4):506-12. Epub 2003 May 1.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Neutrophil inhibition with L-selectin-directed MAb improves or worsens survival dependent on the route but not severity of infection in a rat sepsis model. Haley M, etal., J Appl Physiol. 2005 Jun;98(6):2155-62. Epub 2005 Jan 27.
15. L-selectin-mediated neutrophil recruitment in experimental rodent aneurysm formation. Hannawa KK, etal., Circulation. 2005 Jul 12;112(2):241-7. Epub 2005 Jul 5.
16. NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammation. Haworth O, etal., J Immunol. 2011 Jun 1;186(11):6129-35. Epub 2011 Apr 22.
17. Sulfatide, a specific sugar ligand for L-selectin, blocks CCl4-induced liver inflammation in rats. Kajihara J, etal., Biosci Biotechnol Biochem. 1995 Jan;59(1):155-7. doi: 10.1271/bbb.59.155.
18. Polymorphism in ICAM-1, PECAM-1, E-selectin, and L-selectin genes in Tunisian patients with inflammatory bowel disease. Khazen D, etal., Eur J Gastroenterol Hepatol. 2009 Feb;21(2):167-75. doi: 10.1097/MEG.0b013e32830e6fc8.
19. De novo induction of endothelial L-selectin ligands during kidney allograft rejection. Kirveskari J, etal., J Am Soc Nephrol. 2000 Dec;11(12):2358-65.
20. Gene expression profiling of the rat endometriosis model. Konno R, etal., Am J Reprod Immunol. 2007 Oct;58(4):330-43.
21. Aggravation of different types of experimental colitis by depletion or adhesion blockade of neutrophils. Kuhl AA, etal., Gastroenterology. 2007 Dec;133(6):1882-92. Epub 2007 Sep 5.
22. GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat. Li L, etal., Free Radic Biol Med. 2009 Jul 1;47(1):103-13. Epub 2009 Apr 15.
23. The Chinese herbal formula Zhibai Dihuang Granule treat Yin-deficiency-heat syndrome rats by regulating the immune responses. Liu CM, etal., J Ethnopharmacol. 2018 Oct 28;225:271-278. doi: 10.1016/j.jep.2018.05.001. Epub 2018 May 2.
24. High frequencies of CD62L naive regulatory T cells in allografts are associated with a low risk of acute graft-versus-host disease following unmanipulated allogeneic haematopoietic stem cell transplantation. Lu SY, etal., Clin Exp Immunol. 2011 Aug;165(2):264-77. doi: 10.1111/j.1365-2249.2011.04418.x. Epub 2011 Jun 2.
25. The effects of inhaled and oral corticosteroids on serum inflammatory biomarkers in COPD: an exploratory study. Man SF, etal., Ther Adv Respir Dis. 2009 Apr;3(2):73-80. Epub 2009 May 22.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats. Mulligan MS, etal., J Clin Invest. 1991 Oct;88(4):1396-406. doi: 10.1172/JCI115446.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity. Ogawa A, etal., J Invest Dermatol. 2010 Jun;130(6):1558-70. Epub 2010 Feb 25.
30. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
31. Chemokine and cell adhesion molecule mRNA expression and neutrophil infiltration in lipopolysaccharide-induced hepatitis in ethanol-fed rats. Pennington HL, etal., Alcohol Clin Exp Res. 1998 Nov;22(8):1713-8.
32. GOA pipeline RGD automated data pipeline
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Dietary free oleic and linoleic acid enhances neutrophil function and modulates the inflammatory response in rats. Rodrigues HG, etal., Lipids. 2010 Sep;45(9):809-19. Epub 2010 Aug 22.
35. The contribution of L-selectin to airway hyperresponsiveness in chronic allergic airways disease. Royce SG, etal., J Asthma Allergy. 2010 Jun 28;3:9-17.
36. Deletion of L-selectin increases atherosclerosis development in ApoE-/- mice. Rozenberg I, etal., PLoS One. 2011;6(7):e21675. Epub 2011 Jul 8.
37. Evidence of post-transcriptional regulation of L-selectin gene expression in rat lymphoid cells. Sackstein R, etal., Immunology 1995 Jun;85(2):198-204.
38. Cell surface antigens on rat neural progenitors and characterization of the CD3 (+)/CD3 (-) cell populations. Sergent-Tanguy S, etal., Differentiation. 2006 Dec;74(9-10):530-41.
39. L-selectin and its ligands mediate infiltration of mononuclear cells into kidney interstitium after ureteric obstruction. Shikata K, etal., J Pathol. 1999 May;188(1):93-9. doi: 10.1002/(SICI)1096-9896(199905)188:1<93::AID-PATH305>3.0.CO;2-#.
40. Long-term ethanol consumption initiates atherosclerosis in rat aorta through inflammatory stress and endothelial dysfunction. Shirpoor A, etal., Vascul Pharmacol. 2012 Sep;57(2-4):72-7. Epub 2012 Apr 12.
41. Investigation of P213S SELL gene polymorphism in type 2 diabetes mellitus and related end stage renal disease. A case-control study. Stavarachi M, etal., Rom J Morphol Embryol. 2011;52(3 Suppl):995-8.
42. Sulfated glycolipids are ligands for a lymphocyte homing receptor, L-selectin (LECAM-1), Binding epitope in sulfated sugar chain. Suzuki Y, etal., Biochem Biophys Res Commun. 1993 Jan 29;190(2):426-34.
43. Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy. Takei T, etal., Am J Hum Genet. 2002 Mar;70(3):781-6. Epub 2002 Feb 1.
44. Characterization of rat LECAM-1 (L-selectin) by the use of monoclonal antibodies and evidence for the presence of soluble LECAM-1 in rat sera. Tamatani T, etal., Eur J Immunol. 1993 Sep;23(9):2181-8. doi: 10.1002/eji.1830230920.
45. Blood neutrophil functions and cytokine release in severe alcoholic hepatitis: effect of corticosteroids. Taïeb J, etal., J Hepatol. 2000 Apr;32(4):579-86. doi: 10.1016/s0168-8278(00)80219-6.
46. An in-vivo analysis of capillary stasis and endothelial apoptosis in a model of hypertension. Tran ED and Schmid-Schonbein GW, Microcirculation. 2007 Nov-Dec;14(8):793-804.
47. Sequence and expression of a rat cDNA for LECAM-1. Watanabe T, etal., Biochim Biophys Acta 1992 Jul 15;1131(3):321-4.
48. The association of L-selectin polymorphisms with L-selectin serum levels and risk of ischemic stroke. Wei YS, etal., J Thromb Thrombolysis. 2011 Jul;32(1):110-5.
49. Alterations of adhesion molecule expression and inflammatory mediators in acute lung injury induced by septic and non-septic challenges. Zhao X, etal., Lung. 2005 Mar-Apr;183(2):87-100.
50. Protein kinase C modulates the pulmonary inflammatory response in acute pancreatitis. Zhao X, etal., Respir Physiol Neurobiol. 2006 May;152(1):16-26. Epub 2005 Oct 7.
51. L-Selectin and P-Selectin Are Novel Biomarkers of Cervicovaginal Inflammation for Preclinical Mucosal Safety Assessment of Anti-HIV-1 Microbicide. Zhong M, etal., Antimicrob Agents Chemother. 2012 Mar 5.
Additional References at PubMed
PMID:2663882   PMID:7589135   PMID:8043862   PMID:10072077   PMID:11389866   PMID:14597732   PMID:14609575   PMID:15477346   PMID:15914561   PMID:16203996   PMID:16227984   PMID:16769892  
PMID:16973387   PMID:17525255   PMID:17548643   PMID:18628982   PMID:18836449   PMID:18948084   PMID:19008373   PMID:19240088   PMID:23620790   PMID:28011641  


Genomics

Comparative Map Data
Sell
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81378,950,100 - 78,969,604 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1378,950,015 - 78,969,600 (+)EnsemblGRCr8
mRatBN7.21376,416,969 - 76,436,444 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,416,915 - 76,436,456 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1379,035,789 - 79,053,737 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01380,339,838 - 80,357,792 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01377,594,427 - 77,612,381 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01382,369,820 - 82,387,774 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,369,493 - 82,387,631 (+)Ensemblrn6Rnor6.0
Rnor_5.01387,249,243 - 87,267,197 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41379,827,342 - 79,845,296 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1376,150,815 - 76,168,775 (+)NCBICelera
RGSC_v3.11379,841,529 - 79,859,484 (+)NCBI
Cytogenetic Map13q23NCBI
SELL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,690,667 - 169,711,620 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,690,665 - 169,712,202 (-)Ensemblhg38GRCh38
GRCh371169,659,808 - 169,680,761 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,926,432 - 167,947,461 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341166,391,465 - 166,412,385NCBI
Celera1142,769,612 - 142,790,649 (-)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1140,882,225 - 140,903,187 (-)NCBIHuRef
CHM1_11171,081,961 - 171,102,996 (-)NCBICHM1_1
T2T-CHM13v2.01169,046,455 - 169,067,407 (-)NCBIT2T-CHM13v2.0
Sell
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,889,556 - 163,908,354 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1163,889,551 - 163,911,750 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381164,061,987 - 164,082,930 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1164,061,982 - 164,084,181 (+)Ensemblmm10GRCm38
MGSCv371165,992,207 - 166,010,916 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361165,898,779 - 165,917,346 (+)NCBIMGSCv36mm8
Celera1166,503,711 - 166,522,465 (+)NCBICelera
Cytogenetic Map1H2.2NCBI
cM Map171.37NCBI
Sell
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554627,591,366 - 7,612,846 (+)Ensembl
ChiLan1.0NW_0049554627,591,997 - 7,611,408 (+)NCBIChiLan1.0ChiLan1.0
SELL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2180,057,232 - 80,078,252 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1179,725,636 - 79,746,670 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01145,173,700 - 145,194,927 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11148,895,373 - 148,916,393 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,895,373 - 148,916,393 (-)EnsemblpanPan2panpan1.1
SELL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1728,906,752 - 28,927,959 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl728,906,809 - 29,094,008 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha728,438,413 - 28,459,659 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0728,708,675 - 28,729,947 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl728,708,712 - 28,731,608 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1728,556,811 - 28,578,018 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0728,592,509 - 28,613,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0728,829,481 - 28,850,708 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sell
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934499,171,899 - 99,194,147 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648117,022,580 - 17,032,124 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648117,022,421 - 17,032,105 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SELL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl481,306,353 - 81,326,444 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1481,306,363 - 81,325,296 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2488,931,520 - 88,950,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SELL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12559,345,080 - 59,365,684 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2559,345,069 - 59,366,946 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605561,000,872 - 61,021,571 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sell
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248267,587,970 - 7,610,163 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248267,590,576 - 7,612,370 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sell
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11043,293,043 - 43,312,327 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sell
232 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:117
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000003733
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
D13Got57  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21376,415,834 - 76,416,086 (+)MAPPERmRatBN7.2
Rnor_6.01382,368,417 - 82,368,668NCBIRnor6.0
Rnor_5.01387,247,840 - 87,248,091UniSTSRnor5.0
RGSC_v3.41379,825,938 - 79,826,190RGDRGSC3.4
RGSC_v3.41379,825,939 - 79,826,190UniSTSRGSC3.4
Celera1376,149,412 - 76,149,663UniSTS
RGSC_v3.11379,840,127 - 79,840,378RGD
RH 3.4 Map13484.2UniSTS
RH 3.4 Map13484.2RGD
RH 2.0 Map13571.5RGD
Cytogenetic Map13q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 57 121 91 90 59 92 59 6 345 181 11 98 81 85 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000003733   ⟹   ENSRNOP00000003733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1378,950,432 - 78,969,600 (+)Ensembl
mRatBN7.2 Ensembl1376,416,915 - 76,432,377 (+)Ensembl
Rnor_6.0 Ensembl1382,369,493 - 82,387,631 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106952   ⟹   ENSRNOP00000089128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1378,950,015 - 78,969,600 (+)Ensembl
mRatBN7.2 Ensembl1376,416,915 - 76,436,456 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153927   ⟹   ENSRNOP00000112528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1378,950,392 - 78,969,600 (+)Ensembl
RefSeq Acc Id: NM_019177   ⟹   NP_062050
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81378,950,401 - 78,968,355 (+)NCBI
mRatBN7.21376,417,240 - 76,435,195 (+)NCBI
Rnor_6.01382,369,820 - 82,387,774 (+)NCBI
Rnor_5.01387,249,243 - 87,267,197 (+)NCBI
RGSC_v3.41379,827,342 - 79,845,296 (+)RGD
Celera1376,150,815 - 76,168,775 (+)RGD
Sequence:
RefSeq Acc Id: XM_039090616   ⟹   XP_038946544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81378,950,100 - 78,969,604 (+)NCBI
mRatBN7.21376,416,969 - 76,436,444 (+)NCBI
Protein Sequences
Protein RefSeqs NP_062050 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946544 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC60710 (Get FASTA)   NCBI Sequence Viewer  
  BAA01613 (Get FASTA)   NCBI Sequence Viewer  
  EDM09363 (Get FASTA)   NCBI Sequence Viewer  
  EDM09364 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000089128
  ENSRNOP00000112528
GenBank Protein P30836 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062050   ⟸   NM_019177
- Peptide Label: precursor
- UniProtKB: P30836 (UniProtKB/Swiss-Prot),   Q63762 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003733   ⟸   ENSRNOT00000003733
RefSeq Acc Id: XP_038946544   ⟸   XM_039090616
- Peptide Label: isoform X1
- UniProtKB: F7EY63 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089128   ⟸   ENSRNOT00000106952
Ensembl Acc Id: ENSRNOP00000112528   ⟸   ENSRNOT00000153927
Protein Domains
C-type lectin   EGF-like   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30836-F1-model_v2 AlphaFold P30836 1-372 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3655 AgrOrtholog
BioCyc Gene G2FUF-17603 BioCyc
Ensembl Genes ENSRNOG00000002776 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000106952 ENTREZGENE
  ENSRNOT00000153927 ENTREZGENE
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot
  Complement Module, domain 1 UniProtKB/Swiss-Prot
InterPro C-type_lectin-like UniProtKB/Swiss-Prot
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  C-type_lectin_CS UniProtKB/Swiss-Prot
  Compl-Cell_Adhes-Reg UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF_extracell UniProtKB/Swiss-Prot
  L-selectin UniProtKB/Swiss-Prot
  Selectin_CTLD UniProtKB/Swiss-Prot
  Selectin_superfamily UniProtKB/Swiss-Prot
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot
NCBI Gene 29259 ENTREZGENE
PANTHER COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING UniProtKB/Swiss-Prot
  L-SELECTIN UniProtKB/Swiss-Prot
Pfam EGF_2 UniProtKB/Swiss-Prot
  Lectin_C UniProtKB/Swiss-Prot
  Sushi UniProtKB/Swiss-Prot
PhenoGen Sell PhenoGen
PIRSF L-selectin UniProtKB/Swiss-Prot
PRINTS SELECTIN UniProtKB/Swiss-Prot
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  SUSHI UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002776 RatGTEx
SMART CCP UniProtKB/Swiss-Prot
  CLECT UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF56436 UniProtKB/Swiss-Prot
  SSF57535 UniProtKB/Swiss-Prot
UniProt A0A8I6A7Z4_RAT UniProtKB/TrEMBL
  A0ABK0M0W3_RAT UniProtKB/TrEMBL
  A6IDD4_RAT UniProtKB/TrEMBL
  F7EY63 ENTREZGENE, UniProtKB/TrEMBL
  LYAM1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63762 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-15 Sell  selectin L  Sell  selectin, lymphocyte  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sell  selectin, lymphocyte      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed on thymocytes, thoracic duct lymphocytes and lymph node lymphocytes 729788
gene_expression expressed in peripheral blood mononuclear cells, spleen and thymus 69989
gene_physical_interaction interacts with PPME 69989
gene_process expression on lymphocytes allows binding of cells to high endothelial venules (HEV) 729788
gene_protein protein is 372 amino acids with a 38 amino acid signal peptide 69989
gene_regulation expression in thymocytes may be regulated post-transcriptionally 729788
gene_regulation expression in peripheral blood mononuclear and splenic T cells is downregulated upon stimulation with mitogen 69989
gene_transcript transcript is 3 kb 69989