Ret (ret proto-oncogene) - Rat Genome Database

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Gene: Ret (ret proto-oncogene) Rattus norvegicus
Analyze
Symbol: Ret
Name: ret proto-oncogene
RGD ID: 3556
Description: Predicted to enable calcium ion binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including innervation; positive regulation of neuron maturation; and retina development in camera-type eye. Located in several cellular components, including dendrite; early endosome; and neuronal cell body. Biomarker of Parkinsonism; brain ischemia; and pheochromocytoma. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Orthologous to human RET (ret proto-oncogene); PARTICIPATES IN endocytosis pathway; thyroid cancer pathway; INTERACTS WITH (+)-pilocarpine; (-)-anisomycin; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: proto-oncogene tyrosine-protein kinase receptor Ret; receptor tyrosine kinase; Ret gene for receptor tyrosin; Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease); Ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Ept5
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84152,998,344 - 153,040,556 (-)NCBIGRCr8
mRatBN7.24151,325,969 - 151,368,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4151,326,431 - 151,368,176 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4157,589,266 - 157,631,480 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04153,373,235 - 153,415,450 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04151,996,254 - 152,038,470 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04150,202,170 - 150,249,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4150,202,058 - 150,244,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04216,130,142 - 216,177,139 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44154,448,179 - 154,491,103 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14154,693,019 - 154,735,944 (-)NCBI
Celera4140,198,457 - 140,240,663 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Source
Original Reference(s)
RetRatBrain Injuries  IEP 2324932mRNA:increased expression:brainRGD 
RetRatbrain ischemia  IEP 6218981protein:increased expression:cerebral cortexRGD 
RetRatDeafness  IEP 2324943mRNA:increased expression:vestibulocochlear VIII nerve cochlear componentRGD 
RetRatFacial Nerve Injuries  IEP 6218984mRNA:increased expression:facial VII nucleusRGD 
RetRathepatocellular carcinoma severityISORET (Homo sapiens)9068941protein:increased expression:liver (human)RGDPMID:28350084 and REF_RGD_ID:150340602
RetRatHirschsprung's disease  ISORET (Homo sapiens)12910713DNA:SNPs:exon and intron:multipleRGD 
RetRatHypoglossal Nerve Injuries  IEP 6218979mRNA:increased expression:hypoglossal XII nerveRGD 
RetRatLymphatic Metastasis  ISORET (Homo sapiens)2324925associated with Pancreatic NeoplasmsRGD 
RetRatmultiple endocrine neoplasia type 2A  ISORET (Homo sapiens)2324920DNA:mutation:cds (human)RGD 
RetRatpancreatic cancer disease_progressionISORET (Homo sapiens)2324926protein:increased expression:pancreasRGD 
RetRatParkinsonism  IEP 6218972mRNA:altered expression:brainRGD 
RetRatpheochromocytoma  IEP 2324930protein:increased expression:adrenal gland medullaRGD 
RetRatrenal hypoplasia  ISORET (Homo sapiens)155641253DNA:SNP:exon 7:rs1800860 (human)RGD 
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1 to 20 of 130 rows
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Original Reference(s)
RetRatappendicitis  ISORET (Homo sapiens)8554872ClinVar Annotator: match by term: AppendicitisClinVarPMID:11230481 more ...
RetRatbreast cancer  ISORET (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10646792 more ...
RetRatBreast Cancer, Familial  ISORET (Homo sapiens)8554872ClinVar Annotator: match by term: Familial cancer of breastClinVarPMID:12000816 more ...
RetRatbreast carcinoma  ISORET (Homo sapiens)8554872ClinVar Annotator: match by term: Breast carcinomaClinVarPMID:25741868 and PMID:28492532
RetRatCAKUT  ISORET (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
RetRatcolorectal cancer  ISORET (Homo sapiens)8554872ClinVar Annotator: match by term: Colorectal cancerClinVar 
RetRatcongenital central hypoventilation syndrome  ISORET (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10076558 more ...
RetRatConstipation  ISORET (Homo sapiens)8554872ClinVar Annotator: match by term: ConstipationClinVarPMID:10369718 more ...
RetRatdiffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype  ISORET (Homo sapiens)8554872ClinVar Annotator: match by term: Diffuse pediatric-type high-grade glioma and H3-wildtype and IDH-wildtypeClinVarPMID:22648184 more ...
RetRatDwarfism  ISORET (Homo sapiens)8554872ClinVar Annotator: match by term: Short statureClinVarPMID:10369718 more ...
RetRatextraosseous Ewing sarcoma  ISORET (Homo sapiens)8554872ClinVar Annotator: match by term: Ewing sarcoma of soft tissueClinVarPMID:24336963 more ...
RetRatfamilial medullary thyroid carcinoma  ISORET (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10024437 more ...
RetRatfamilial medullary thyroid carcinoma  ISORET (Homo sapiens)8554872ClinVar more ...ClinVarPMID:29097883 more ...
RetRatgenetic disease  ISORET (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
RetRatgingival overgrowth  ISORET (Homo sapiens)8554872ClinVar Annotator: match by term: Gingival enlargementClinVarPMID:10369718 more ...
RetRathepatocellular carcinoma  ISORET (Homo sapiens)8554872ClinVar Annotator: match by term: Hepatocellular carcinomaClinVarPMID:11230481 more ...
RetRathereditary breast ovarian cancer syndrome  ISORET (Homo sapiens)8554872ClinVar Annotator: match by term: Breast-ovarian cancer more ...ClinVarPMID:10646792 more ...
RetRatHereditary Neoplastic Syndromes  ISORET (Homo sapiens)8554872ClinVar more ...ClinVarPMID:7633441 more ...
RetRatHereditary Neoplastic Syndromes  ISORET (Homo sapiens)8554872ClinVar more ...ClinVarPMID:21626080 more ...
RetRatHereditary Neoplastic Syndromes  ISORET (Homo sapiens)8554872ClinVar more ...ClinVarPMID:31658439 more ...
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Original Reference(s)
RetRatBurkitt lymphoma  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23143597
RetRatColorectal Neoplasms  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18507500 and PMID:21278247
RetRatcongenital central hypoventilation syndrome  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9497256 and PMID:12086152
RetRatFamilial Amyloidosis  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12864791
RetRatfamilial medullary thyroid carcinoma  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7915165 and PMID:12864791
RetRatHirschsprung's disease  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8114938 and PMID:8896568
RetRatMedullary Carcinomas  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7915165
RetRatmedullary thyroid carcinoma  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7915165
RetRatmultiple endocrine neoplasia  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17664273
RetRatmultiple endocrine neoplasia type 2A  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7915165 more ...
RetRatmultiple endocrine neoplasia type 2B  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
RetRatpapillary thyroid carcinoma  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28030816
RetRatpheochromocytoma  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12000816
RetRatrenal agenesis  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18252215
RetRatstatus epilepticus  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12914250
RetRatThyroid Neoplasms  ISORET (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16940797
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Original Reference(s)
RetRatclubfoot  ISSRet (Mus musculus)13592920OMIM:119800MouseDO 
RetRatHirschsprung's disease  ISSRet (Mus musculus)13592920OMIM:600156 more ...MouseDO 
RetRatmultiple endocrine neoplasia type 2B  ISSRet (Mus musculus)13592920OMIM:162300MouseDO 
RetRatpheochromocytoma  ISSRet (Mus musculus)13592920OMIM:171300MouseDO 

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Original Reference(s)
RetRat(+)-pilocarpine multiple interactionsEXP 6480464[Lithium co-treated with Pilocarpine] results in increased expression of RET proteinCTDPMID:12914250
RetRat(-)-anisomycin decreases expressionEXP 6480464Anisomycin results in decreased expression of RET proteinCTDPMID:17555550
RetRat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expressionISORet (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:17555550
RetRat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of RET mRNACTDPMID:12075121
RetRat17beta-estradiol multiple interactionsISORET (Homo sapiens)6480464[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of RET mRNA more ...CTDPMID:20823114 and PMID:24758408
RetRat17beta-estradiol increases expressionISORET (Homo sapiens)6480464Estradiol results in increased expression of RET mRNACTDPMID:24758408 more ...
RetRat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISORet (Mus musculus)6480464[2 more ...CTDPMID:25510870
RetRat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISORet (Mus musculus)6480464[2 more ...CTDPMID:25510870
RetRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORet (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of RET mRNACTDPMID:17337447
RetRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of RET mRNACTDPMID:32109520
RetRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORET (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of RET mRNACTDPMID:22903824
RetRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORet (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of RET mRNACTDPMID:21570461
RetRat2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile affects expressionISORET (Homo sapiens)6480464Verapamil affects the expression of RET proteinCTDPMID:12388792
RetRat4,4'-sulfonyldiphenol increases expressionISORet (Mus musculus)6480464bisphenol S results in increased expression of RET mRNACTDPMID:30951980
RetRat4-hydroxyphenyl retinamide decreases expressionISORet (Mus musculus)6480464Fenretinide results in decreased expression of RET mRNACTDPMID:28973697
RetRat5-azacytidine decreases expressionISORET (Homo sapiens)6480464Azacitidine results in decreased expression of RET mRNACTDPMID:20823114
RetRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of RET mRNA and Propylthiouracil results in increased expression of RET proteinCTDPMID:22504374 more ...
RetRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of RET mRNACTDPMID:30047161
RetRatafimoxifene multiple interactionsISORET (Homo sapiens)6480464afimoxifene inhibits the reaction [Estrogens results in increased expression of RET mRNA]CTDPMID:21233418
RetRataflatoxin B1 decreases methylationISORET (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of RET intronCTDPMID:30157460

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Biological Process
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Original Reference(s)
RetRatbrain-derived neurotrophic factor receptor signaling pathway involved_inIEAGO:00601751600115GO_REF:0000108GOCGO_REF:0000108
RetRatcell surface receptor protein tyrosine kinase signaling pathway involved_inIBAFB:FBgn0003366 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
RetRatcell surface receptor protein tyrosine kinase signaling pathway acts_upstream_of_or_withinISORet (Mus musculus)1624291MGI:108417 more ...RGDPMID:9576965
RetRatcellular response to retinoic acid involved_inISORET (Homo sapiens)1624291 PMID:17910947RGDPMID:17910947
RetRatcollagen-activated tyrosine kinase receptor signaling pathway involved_inIEAGO:00380621600115GO_REF:0000108GOCGO_REF:0000108
RetRatembryonic epithelial tube formation acts_upstream_of_or_withinISORet (Mus musculus)1624291MGI:1930016 PMID:15569713RGDPMID:15569713
RetRatenteric nervous system development acts_upstream_of_or_withinISORet (Mus musculus)1624291MGI:2136894 PMID:9834195RGDPMID:9834195
RetRatephrin receptor signaling pathway involved_inIEAGO:00050041600115GO_REF:0000108GOCGO_REF:0000108
RetRatepidermal growth factor receptor signaling pathway involved_inIEAGO:00050061600115GO_REF:0000108GOCGO_REF:0000108
RetRatfibroblast growth factor receptor signaling pathway involved_inIEAGO:00050071600115GO_REF:0000108GOCGO_REF:0000108
RetRatGDF15-GFRAL signaling pathway involved_inISORET (Homo sapiens)1624291 PMID:31535977RGDPMID:31535977
RetRatglial cell-derived neurotrophic factor receptor signaling pathway involved_inISSUniProtKB:P079491600115GO_REF:0000024UniProtGO_REF:0000024
RetRatglial cell-derived neurotrophic factor receptor signaling pathway involved_inISORET (Homo sapiens)1624291 PMID:24560924 more ...RGDPMID:24560924 more ...
RetRathepatocyte growth factor receptor signaling pathway involved_inIEAGO:00050081600115GO_REF:0000108GOCGO_REF:0000108
RetRathomophilic cell adhesion via plasma membrane adhesion molecules involved_inIEAInterPro:IPR0021261600115GO_REF:0000002InterProGO_REF:0000002
RetRatinnervation  IMP 2324932 RGD 
RetRatinsulin receptor signaling pathway involved_inIEAGO:00050091600115GO_REF:0000108GOCGO_REF:0000108
RetRatinsulin-like growth factor receptor signaling pathway involved_inIEAGO:00050101600115GO_REF:0000108GOCGO_REF:0000108
RetRatKit signaling pathway involved_inIEAGO:00050201600115GO_REF:0000108GOCGO_REF:0000108
RetRatmacrophage colony-stimulating factor signaling pathway involved_inIEAGO:00050111600115GO_REF:0000108GOCGO_REF:0000108
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Cellular Component
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Molecular Function
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Original Reference(s)
RetRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
RetRatboss receptor activity enablesIEAEC:2.7.10.11600115GO_REF:0000003UniProtGO_REF:0000003
RetRatbrain-derived neurotrophic factor receptor activity enablesIEAEC:2.7.10.11600115GO_REF:0000003UniProtGO_REF:0000003
RetRatcalcium ion binding enablesISORET (Homo sapiens)1624291 PMID:11445581 and PMID:9575150RGDPMID:11445581 and PMID:9575150
RetRatepidermal growth factor receptor activity enablesIEAEC:2.7.10.11600115GO_REF:0000003UniProtGO_REF:0000003
RetRatfibroblast growth factor receptor activity enablesIEAEC:2.7.10.11600115GO_REF:0000003UniProtGO_REF:0000003
RetRatGPI-linked ephrin receptor activity enablesIEAEC:2.7.10.11600115GO_REF:0000003UniProtGO_REF:0000003
RetRathepatocyte growth factor receptor activity enablesIEAEC:2.7.10.11600115GO_REF:0000003UniProtGO_REF:0000003
RetRatinsulin receptor activity enablesIEAEC:2.7.10.11600115GO_REF:0000003UniProtGO_REF:0000003
RetRatinsulin-like growth factor receptor activity enablesIEAEC:2.7.10.11600115GO_REF:0000003UniProtGO_REF:0000003
RetRatmacrophage colony-stimulating factor receptor activity enablesIEAEC:2.7.10.11600115GO_REF:0000003UniProtGO_REF:0000003
RetRatplacental growth factor receptor activity enablesIEAEC:2.7.10.11600115GO_REF:0000003UniProtGO_REF:0000003
RetRatplatelet-derived growth factor alpha-receptor activity enablesIEAEC:2.7.10.11600115GO_REF:0000003UniProtGO_REF:0000003
RetRatplatelet-derived growth factor beta-receptor activity enablesIEAEC:2.7.10.11600115GO_REF:0000003UniProtGO_REF:0000003
RetRatprotein binding enablesISORET (Homo sapiens) and UniProtKB:P07949-21624291UniProtKB:Q7Z3S9 and PMID:25910212RGDPMID:25910212
RetRatprotein binding enablesISORet (Mus musculus) and PR:P35546-21624291UniProtKB:Q60629 and PMID:22304922RGDPMID:22304922
RetRatprotein binding enablesISORet (Mus musculus)1624291PR:O35118 more ...RGDPMID:15204970 more ...
RetRatprotein binding enablesISORET (Homo sapiens)1624291UniProtKB:P22455 more ...RGDPMID:10545102 more ...
RetRatprotein tyrosine kinase collagen receptor activity enablesIEAEC:2.7.10.11600115GO_REF:0000003UniProtGO_REF:0000003
RetRatstem cell factor receptor activity enablesIEAEC:2.7.10.11600115GO_REF:0000003UniProtGO_REF:0000003
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Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
RetRatendocytosis pathway  IEA 6907045 KEGGrno:04144
RetRatthyroid cancer pathway  IEA 6907045 KEGGrno:05216

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#
Reference Title
Reference Citation
1. Up-regulation of GDNFR-alpha and c-ret mRNA in facial motor neurons following facial nerve injury in the rat. Burazin TC and Gundlach AL, Brain Res Mol Brain Res. 1998 Apr;55(2):331-6.
2. Genetic mapping of the RET protooncogene on rat chromosome 4. Canzian F, etal., Mamm Genome 1995 Jun;6(6):433-5.
3. Time-course of GDNF and its receptor expression after brain injury in the rat. Cheng Q, etal., Neurosci Lett. 2008 Jul 4;439(1):24-9. Epub 2008 May 1.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes. Incoronato M, etal., Cell Signal. 2004 Jul;16(7):847-56.
7. Expression of glial cell line-derived neurotrophic factor family members and their receptors in pancreatic cancers. Ito Y, etal., Surgery. 2005 Oct;138(4):788-94.
8. Hirschsprung disease is linked to defects in neural crest stem cell function. Iwashita T, etal., Science 2003 Aug 15;301(5635):972-6.
9. Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth. Jiao L, etal., Cell Res. 2011 Feb;21(2):327-37. doi: 10.1038/cr.2010.139. Epub 2010 Sep 28.
10. Induction of glial cell line-derived neurotrophic factor receptor proteins in cerebral cortex and striatum after permanent middle cerebral artery occlusion in rats. Kitagawa H, etal., Brain Res. 1999 Jul 10;834(1-2):190-5.
11. Regulation of GDNF and its receptor components GFR-alpha1, -alpha2 and Ret during development and in the mature retino-collicular pathway. Kretz A, etal., Brain Res. 2006 May 23;1090(1):1-14. Epub 2006 May 2.
12. Regulation of c-Ret, GFRalpha1, and GFRalpha2 in the substantia nigra pars compacta in a rat model of Parkinson's disease. Marco S, etal., J Neurobiol. 2002 Sep 15;52(4):343-51.
13. cDNA sequence and genomic structure of the rat RET proto-oncogene. Matera I, etal., DNA Seq 2000;11(5):405-17.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation. Pierchala BA, etal., J Neurosci. 2006 Mar 8;26(10):2777-87.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Adrenergic differentiation and Ret expression in rat pheochromocytomas. Powers JF, etal., Endocr Pathol. 2008 Spring;19(1):9-16.
20. Up-regulation of ret by reserpine in the adult rat adrenal medulla. Powers JF, etal., Neuroscience. 2005;132(3):605-12.
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PMID:9576965   PMID:9834195   PMID:10545102   PMID:10921886   PMID:11069590   PMID:11445581   PMID:12195422   PMID:12527893   PMID:14555660   PMID:15233745   PMID:15242795   PMID:15302866  
PMID:15569713   PMID:16569669   PMID:16672314   PMID:16773224   PMID:16818623   PMID:17047028   PMID:17183535   PMID:17322904   PMID:17380130   PMID:17538205   PMID:17553423   PMID:17910947  
PMID:18668157   PMID:18753381   PMID:18845535   PMID:19133164   PMID:19366855   PMID:19551609   PMID:19823924   PMID:20237269   PMID:20392937   PMID:20533997   PMID:20682772   PMID:20702524  
PMID:21134561   PMID:21357690   PMID:21521737   PMID:22128160   PMID:22897442   PMID:23382219   PMID:23413818   PMID:23872421   PMID:27226544   PMID:27994058   PMID:28846097   PMID:28846099  
PMID:28953886   PMID:29018141   PMID:30541958   PMID:34273501   PMID:37178997  



Ret
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84152,998,344 - 153,040,556 (-)NCBIGRCr8
mRatBN7.24151,325,969 - 151,368,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4151,326,431 - 151,368,176 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4157,589,266 - 157,631,480 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04153,373,235 - 153,415,450 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04151,996,254 - 152,038,470 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04150,202,170 - 150,249,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4150,202,058 - 150,244,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04216,130,142 - 216,177,139 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44154,448,179 - 154,491,103 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14154,693,019 - 154,735,944 (-)NCBI
Celera4140,198,457 - 140,240,663 (-)NCBICelera
Cytogenetic Map4q42NCBI
RET
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381043,077,069 - 43,130,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1043,077,064 - 43,130,351 (+)EnsemblGRCh38hg38GRCh38
GRCh371043,572,517 - 43,625,799 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361042,892,523 - 42,945,805 (+)NCBINCBI36Build 36hg18NCBI36
Build 341042,892,532 - 42,944,955NCBI
Celera1039,575,663 - 39,628,954 (+)NCBICelera
Cytogenetic Map10q11.21NCBI
HuRef1040,098,756 - 40,151,896 (+)NCBIHuRef
CHM1_11043,611,715 - 43,665,000 (+)NCBICHM1_1
T2T-CHM13v2.01043,954,542 - 44,007,848 (+)NCBIT2T-CHM13v2.0
Ret
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396118,128,709 - 118,174,705 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6118,128,706 - 118,174,679 (-)EnsemblGRCm39 Ensembl
GRCm386118,151,748 - 118,197,744 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6118,151,745 - 118,197,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv376118,101,766 - 118,147,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366118,119,472 - 118,162,752 (-)NCBIMGSCv36mm8
Celera6119,974,414 - 120,020,450 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map655.86NCBI
Ret
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555461,221,995 - 1,253,946 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555461,221,995 - 1,252,147 (+)NCBIChiLan1.0ChiLan1.0
RET
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2855,790,324 - 55,866,889 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11055,795,492 - 55,848,773 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01040,050,396 - 40,103,629 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11043,256,437 - 43,286,340 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1043,249,468 - 43,284,331 (+)Ensemblpanpan1.1panPan2
RET
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1283,946,132 - 3,995,505 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl283,947,232 - 3,994,210 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha284,180,472 - 4,211,554 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0284,124,929 - 4,176,146 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl284,126,037 - 4,174,867 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1283,922,935 - 3,954,018 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,965,997 - 3,997,076 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,100,288 - 4,131,400 (-)NCBIUU_Cfam_GSD_1.0
Ret
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721383,803,446 - 83,856,824 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366172,927,155 - 2,980,602 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366172,927,185 - 2,980,594 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RET
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1461,305,841 - 61,361,412 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11461,305,818 - 61,361,416 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21466,136,477 - 66,192,220 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RET
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1938,746,088 - 38,798,773 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl938,769,170 - 38,796,712 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605647,691,006 - 47,743,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ret
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624922382,399 - 413,281 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624922382,462 - 413,227 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Ret
297 total Variants

Predicted Target Of
Summary Value
Count of predictions:445
Count of miRNA genes:245
Interacting mature miRNAs:296
Transcripts:ENSRNOT00000047685
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 48 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat

1 to 10 of 48 rows
AA859878  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24151,328,880 - 151,329,062 (+)MAPPERmRatBN7.2
Rnor_6.04150,205,086 - 150,205,267NCBIRnor6.0
Rnor_5.04216,133,054 - 216,133,235UniSTSRnor5.0
RGSC_v3.44154,451,091 - 154,451,272UniSTSRGSC3.4
Celera4140,201,369 - 140,201,550UniSTS
RH 3.4 Map4969.31UniSTS
Cytogenetic Map4q42UniSTS
Ret  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24151,329,531 - 151,329,638 (+)MAPPERmRatBN7.2
Rnor_6.04150,205,737 - 150,205,843NCBIRnor6.0
Rnor_5.04216,133,705 - 216,133,811UniSTSRnor5.0
RGSC_v3.44154,451,742 - 154,451,848UniSTSRGSC3.4
Celera4140,202,020 - 140,202,126UniSTS
Cytogenetic Map4q42UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 85 84 53 25 53 6 210 97 93 43 60 31


1 to 18 of 18 rows
RefSeq Transcripts NM_001110099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH006777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ298999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 18 of 18 rows

Ensembl Acc Id: ENSRNOT00000047685   ⟹   ENSRNOP00000047793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4151,326,431 - 151,368,176 (-)Ensembl
Rnor_6.0 Ensembl4150,202,058 - 150,244,372 (-)Ensembl
RefSeq Acc Id: NM_001110099   ⟹   NP_001103569
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84153,001,167 - 153,040,556 (-)NCBI
mRatBN7.24151,328,786 - 151,368,176 (-)NCBI
Rnor_6.04150,204,991 - 150,244,380 (-)NCBI
Rnor_5.04216,130,142 - 216,177,139 (-)NCBI
RGSC_v3.44154,448,179 - 154,491,103 (-)RGD
Celera4140,201,274 - 140,240,663 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012643   ⟹   NP_036775
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84152,998,350 - 153,040,556 (-)NCBI
mRatBN7.24151,325,969 - 151,368,176 (-)NCBI
Rnor_6.04150,202,174 - 150,244,380 (-)NCBI
Rnor_5.04216,130,142 - 216,177,139 (-)NCBI
RGSC_v3.44154,448,179 - 154,491,103 (-)RGD
Celera4140,198,457 - 140,240,663 (-)RGD
Sequence:
RefSeq Acc Id: XM_063285561   ⟹   XP_063141631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84152,998,344 - 153,032,403 (-)NCBI
RefSeq Acc Id: NP_036775   ⟸   NM_012643
- Peptide Label: isoform a precursor
- UniProtKB: G3V9H8 (UniProtKB/Swiss-Prot),   Q9EPA1 (UniProtKB/Swiss-Prot),   Q9EPC3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001103569   ⟸   NM_001110099
- Peptide Label: isoform b precursor
- UniProtKB: A6IL58 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047793   ⟸   ENSRNOT00000047685
RefSeq Acc Id: XP_063141631   ⟸   XM_063285561
- Peptide Label: isoform X1
Cadherin   Protein kinase   Ret cadherin like

Name Modeler Protein Id AA Range Protein Structure
AF-G3V9H8-F1-model_v2 AlphaFold G3V9H8 1-1115 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 51 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-43236 BioCyc
Ensembl Genes ENSRNOG00000014751 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000047685.5 UniProtKB/Swiss-Prot
Gene3D-CATH Cadherins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cadherin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ret_CLD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ret_CLD3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RET_CLD4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RET_CRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_Ret_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24716 UniProtKB/Swiss-Prot
NCBI Gene 24716 ENTREZGENE
PANTHER PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  RET_CLD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RET_CLD3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RET_CLD4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RET_CRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ret PhenoGen
PIRSF TyrPK_receptor_Ret UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CADHERIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014751 RatGTEx
SMART TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Cadherin-like UniProtKB/TrEMBL
1 to 40 of 51 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Ret  ret proto-oncogene    Ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease)  Name updated 629478 APPROVED
2002-06-10 Ret  Ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease)      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_function receptor for glial cell line-derived neurotrophic factor family ligands 1304247
gene_product member of the receptor tyrosine kinase family 633884