Reln (reelin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Reln (reelin) Rattus norvegicus
Analyze
Symbol: Reln
Name: reelin
RGD ID: 3553
Description: Predicted to enable receptor ligand activity; serine-type peptidase activity; and very-low-density lipoprotein particle receptor binding activity. Involved in several processes, including nervous system development; response to glucocorticoid; and response to progesterone. Located in several cellular components, including axon; dendrite; and perikaryon. Biomarker of hypothyroidism and status epilepticus. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; familial temporal lobe epilepsy 7; and schizophrenia. Orthologous to human RELN (reelin); PARTICIPATES IN Reelin signaling pathway; altered Reelin signaling pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH (R)-lipoic acid; (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Reelen; reeler; Rl
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   KZC/Tky
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8413,628,440 - 14,055,201 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl413,628,399 - 14,055,162 (+)EnsemblGRCr8
mRatBN7.2412,736,177 - 13,162,956 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl412,736,130 - 13,162,211 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx417,880,111 - 18,309,565 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0413,705,793 - 14,126,350 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0412,061,189 - 12,495,212 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.049,347,533 - 9,774,257 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,347,528 - 9,773,670 (+)Ensemblrn6Rnor6.0
Rnor_5.049,349,408 - 9,775,894 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.448,150,873 - 8,609,141 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera48,330,632 - 8,754,202 (+)NCBICelera
RGSC_v3.148,150,872 - 8,609,141 (+)NCBI
Cytogenetic Map4q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chaetocin  (EXP)
chlordecone  (ISO)
chlorpyrifos  (EXP)
cisplatin  (EXP)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDE  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzacamene  (EXP)
epoxiconazole  (EXP,ISO)
esketamine  (ISO)
ethanol  (EXP,ISO)
fentanyl  (EXP)
fluoxetine  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
genistein  (ISO)
glutathione  (EXP)
glyphosate  (EXP)
graphite  (EXP)
haloperidol  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
linuron  (EXP)
lipoic acid  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
LY294002  (ISO)
malathion  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
morphine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
nimesulide  (EXP)
okadaic acid  (ISO)
olanzapine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phencyclidine  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
propiconazole  (ISO)
pyrimidifen  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sterigmatocystin  (EXP)
sulfadimethoxine  (EXP)
sulpiride  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vigabatrin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
associative learning  (ISO)
axon guidance  (ISO,ISS)
brain development  (ISO,ISS)
cell adhesion  (IEA)
cell migration  (ISO)
cell morphogenesis  (ISO,ISS)
cellular response to dexamethasone stimulus  (IEP)
central nervous system development  (IBA,IEA,ISO,ISS)
cerebral cortex development  (IEA,IEP,ISO)
cerebral cortex tangential migration  (ISO,ISS)
dendrite development  (ISO)
dentate gyrus development  (IMP)
forebrain development  (ISO)
glial cell differentiation  (ISO,ISS)
hippocampus development  (IEA,ISO)
hypothalamus development  (IEP)
lateral motor column neuron migration  (ISO)
layer formation in cerebral cortex  (ISO,ISS)
learning  (ISO)
locomotory behavior  (IEA,IMP,ISO)
long-term memory  (ISO)
long-term synaptic potentiation  (ISO)
memory  (IEA,IEP)
midgut development  (IEP)
modulation of chemical synaptic transmission  (ISO)
neuron migration  (IBA,IEA,IMP,ISO,ISS)
NMDA glutamate receptor clustering  (ISO)
obsolete positive regulation of CREB transcription factor activity  (ISO)
orbitofrontal cortex development  (IEP)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of AMPA receptor activity  (ISO)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of lateral motor column neuron migration  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein kinase activity  (ISO,ISS)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of small GTPase mediated signal transduction  (ISO,ISS)
positive regulation of synapse maturation  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of TOR signaling  (ISO)
postsynaptic density assembly  (ISO)
postsynaptic density protein 95 clustering  (ISO)
protein localization to synapse  (ISO)
proteolysis  (IEA)
receptor localization to synapse  (ISO)
reelin-mediated signaling pathway  (ISO,ISS)
regulation of behavior  (ISO)
regulation of gene expression  (ISO)
regulation of NMDA receptor activity  (ISO)
regulation of synapse maturation  (ISO)
response to amino acid  (IEP)
response to axon injury  (IEP)
response to corticosterone  (IEP)
response to electrical stimulus  (IEP)
response to ethanol  (IEP)
response to fatty acid  (IEP)
response to hormone  (IEP)
response to insecticide  (IEP)
response to mechanical stimulus  (IEP)
response to pain  (ISO,ISS)
response to progesterone  (IEP)
response to toxic substance  (IEP)
response to xenobiotic stimulus  (IEP)
social behavior  (IEP)
spinal cord patterning  (IEA,IEP,ISO,ISS)
synaptic vesicle exocytosis  (EXP,IDA,IMP)
ventral spinal cord development  (ISO)

Cellular Component
axon  (IDA)
cytoplasm  (ISO,ISS)
dendrite  (IDA,ISO,ISS)
extracellular matrix  (IBA,ISO)
extracellular space  (IBA,IDA,IEA,ISO,ISS)
neuron projection  (IBA)
neuronal cell body  (IDA)
perikaryon  (IDA)
plasma membrane  (IEA)
presynapse  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Thyroid hormone regulates reelin and dab1 expression during brain development. Alvarez-Dolado M, etal., J Neurosci 1999 Aug 15;19(16):6979-93.
2. Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission. Bal M, etal., Neuron. 2013 Nov 20;80(4):934-46. doi: 10.1016/j.neuron.2013.08.024. Epub 2013 Nov 7.
3. Three autism candidate genes: a synthesis of human genetic analysis with other disciplines. Bartlett CW, etal., Int J Dev Neurosci 2005 Apr-May;23(2-3):221-34.
4. Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta. Beffert U, etal., J Biol Chem 2002 Dec 20;277(51):49958-64.
5. Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain. Betancourt AM, etal., Toxicol Sci. 2006 Aug;92(2):500-6. Epub 2006 May 4.
6. Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. Bock HH, etal., J Biol Chem 2003 Oct 3;278(40):38772-9. Epub 2003 Jul 25.
7. Reelin is overexpressed in the liver and plasma of bile duct ligated rats and its levels and glycosylation are altered in plasma of humans with cirrhosis. Botella-Lopez A, etal., Int J Biochem Cell Biol. 2008;40(4):766-75.
8. Beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease. Botella-López A, etal., Neurobiol Dis. 2010 Mar;37(3):682-91. doi: 10.1016/j.nbd.2009.12.006. Epub 2009 Dec 16.
9. Developmental emergence of reelin deficits in the prefrontal cortex of Wistar rats reared in social isolation. Cassidy AW, etal., Neuroscience. 2010 Mar 17;166(2):377-85. Epub 2009 Dec 24.
10. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. D'Arcangelo G, etal., Nature. 1995 Apr 20;374(6524):719-23.
11. Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network. Devlin B, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):46-50.
12. Reelin signaling is impaired in autism. Fatemi SH, etal., Biol Psychiatry. 2005 Apr 1;57(7):777-87.
13. Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. Fatemi SH, etal., Mol Psychiatry. 2000 Nov;5(6):654-63, 571.
14. Chronic psychotropic drug treatment causes differential expression of Reelin signaling system in frontal cortex of rats. Fatemi SH, etal., Schizophr Res. 2009 Jun;111(1-3):138-52. Epub 2009 Apr 9.
15. The effect of amygdala kindling on hippocampal neurogenesis coincides with decreased reelin and DISC1 expression in the adult dentate gyrus. Fournier NM, etal., Hippocampus. 2009 Jun 4.
16. Rat small intestine expresses the reelin-Disabled-1 signalling pathway. Garcia-Miranda P, etal., Exp Physiol. 2010 Apr;95(4):498-507. Epub 2009 Nov 27.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Reelin regulates neuronal progenitor migration in intact and epileptic hippocampus. Gong C, etal., J Neurosci. 2007 Feb 21;27(8):1803-11.
20. Reelin promoter hypermethylation in schizophrenia. Grayson DR, etal., Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9341-6. Epub 2005 Jun 16.
21. C-Terminal Region Truncation of RELN Disrupts an Interaction with VLDLR, Causing Abnormal Development of the Cerebral Cortex and Hippocampus. Ha S, etal., J Neurosci. 2017 Jan 25;37(4):960-971. doi: 10.1523/JNEUROSCI.1826-16.2016.
22. Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. Haas CA, etal., J Neurosci. 2002 Jul 15;22(14):5797-802.
23. Reelin signaling directly affects radial glia morphology and biochemical maturation. Hartfuss E, etal., Development 2003 Oct;130(19):4597-609.
24. Postnatal effect of embryonic neurogenesis disturbance on reelin level in organotypic cultures of rat hippocampus. Hoareau C, etal., Brain Res. 2006 Jun 30;1097(1):43-51. Epub 2006 May 30.
25. Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. Hoe HS, etal., J Neurosci. 2009 Jun 10;29(23):7459-73.
26. Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. Hong SE, etal., Nat Genet 2000 Sep;26(1):93-6.
27. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Impagnatiello F, etal., Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15718-23.
28. Creeping: a new mutant rat with neurological disease. Ishibashi K, etal., Lab Anim Sci 1989 Mar;39(2):132-6.
29. Polymorphisms of candidate genes in Slovak autistic patients. Kelemenova S, etal., Psychiatr Genet. 2010 Aug;20(4):137-9. doi: 10.1097/YPG.0b013e32833a1eb3.
30. Missplicing resulting from a short deletion in the reelin gene causes reeler-like neuronal disorders in the mutant shaking rat Kawasaki. Kikkawa S, etal., J Comp Neurol 2003 Aug 25;463(3):303-15.
31. Expression of reelin in hepatic stellate cells and during hepatic tissue repair: a novel marker for the differentiation of HSC from other liver myofibroblasts. Kobold D, etal., J Hepatol. 2002 May;36(5):607-13.
32. Increased reelin promoter methylation is associated with granule cell dispersion in human temporal lobe epilepsy. Kobow K, etal., J Neuropathol Exp Neurol. 2009 Apr;68(4):356-64. doi: 10.1097/NEN.0b013e31819ba737.
33. Developmental distribution of reelin-positive cells and their secreted product in the rodent spinal cord. Kubasak MD, etal., J Comp Neurol. 2004 Jan 6;468(2):165-78.
34. Repeated exposure to corticosterone, but not restraint, decreases the number of reelin-positive cells in the adult rat hippocampus. Lussier AL, etal., Neurosci Lett. 2009 Aug 28;460(2):170-4. Epub 2009 May 27.
35. Reelin immunoreactivity in the adult neocortex: a comparative study in rodents, carnivores, and non-human primates. Martinez-Cerdeno V and Clasca F, Brain Res Bull. 2002 Feb-Mar 1;57(3-4):485-8.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. Covalent modification of DNA regulates memory formation. Miller CA and Sweatt JD, Neuron. 2007 Mar 15;53(6):857-69.
38. Reelin-expressing neurons in the anterior commissure and corpus callosum of the rat. Misaki K, etal., Brain Res Dev Brain Res. 2004 Jan 31;148(1):89-96.
39. Ethanol induces heterotopias in organotypic cultures of rat cerebral cortex. Mooney SM, etal., Cereb Cortex. 2004 Oct;14(10):1071-80. Epub 2004 May 27.
40. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
41. Lack of Reelin causes malpositioning of nigral dopaminergic neurons: evidence from comparison of normal and Reln(rl) mutant mice. Nishikawa S, etal., J Comp Neurol 2003 Jun 23;461(2):166-73.
42. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
43. Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder. Persico AM, etal., Mol Psychiatry. 2001 Mar;6(2):150-9.
44. Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expression. Pesold C, etal., Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3217-22.
45. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
46. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
47. Reelin promotes peripheral synapse elimination and maturation. Quattrocchi CC, etal., Science 2003 Aug 1;301(5633):649-53.
48. Extracellular matrix molecules and synaptic plasticity: immunomapping of intracellular and secreted Reelin in the adult rat brain. Ramos-Moreno T, etal., Eur J Neurosci. 2006 Jan;23(2):401-22.
49. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Comprehensive gene review and curation RGD comprehensive gene curation
52. Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury. Roglio I, etal., Neuroscience. 2008 Aug 26;155(3):673-85. Epub 2008 Jun 19.
53. Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer's disease. Saez-Valero J, etal., J Neurosci Res 2003 Apr 1;72(1):132-6.
54. Lifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring. Smit-Rigter LA, etal., PLoS One. 2009;4(4):e5167. Epub 2009 Apr 9.
55. Administration of thyroid hormone increases reelin and brain-derived neurotrophic factor expression in rat hippocampus in vivo. Sui L, etal., Brain Res. 2010 Feb 8;1313:9-24. Epub 2009 Dec 16.
56. Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Weaver IC, etal., Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3480-5. Epub 2006 Feb 16.
57. Reelin-deficient mice show impaired neurogenesis and increased stroke size. Won SJ, etal., Exp Neurol. 2006 Mar;198(1):250-9. Epub 2006 Jan 24.
58. Delayed cell migration in the developing rat brain following maternal omega 3 alpha linolenic acid dietary deficiency. Yavin E, etal., Neuroscience. 2009 Sep 15;162(4):1011-22. Epub 2009 May 14.
59. Rat neurological disease creeping is caused by a mutation in the reelin gene. Yokoi N, etal., Brain Res Mol Brain Res 2003 Apr 10;112(1-2):1-7.
60. Reelin is a positional signal for the lamination of dentate granule cells. Zhao S, etal., Development. 2004 Oct;131(20):5117-25.
Additional References at PubMed
PMID:10328932   PMID:10571240   PMID:11226314   PMID:11900467   PMID:12223565   PMID:12526740   PMID:14715136   PMID:14980731   PMID:15062102   PMID:15255972   PMID:15525772   PMID:15677725  
PMID:15703280   PMID:16207762   PMID:16324103   PMID:16580148   PMID:16901480   PMID:17229826   PMID:17694053   PMID:18778775   PMID:19409883   PMID:20347957   PMID:20357114   PMID:20368265  
PMID:20421250   PMID:20438765   PMID:20538740   PMID:20600205   PMID:20711475   PMID:20847152   PMID:21148112   PMID:21491433   PMID:21492744   PMID:21664258   PMID:21784155   PMID:21814183  
PMID:21852430   PMID:21858819   PMID:22469747   PMID:22595232   PMID:22665518   PMID:22871113   PMID:22990595   PMID:23385810   PMID:23478644   PMID:23493620   PMID:23608736   PMID:23803971  
PMID:24134921   PMID:24539699   PMID:25679528   PMID:25790952   PMID:25887698   PMID:27168410   PMID:27653801   PMID:28385118   PMID:28602919   PMID:29880879   PMID:30169690   PMID:30433855  
PMID:32115961   PMID:35797964  


Genomics

Comparative Map Data
Reln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8413,628,440 - 14,055,201 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl413,628,399 - 14,055,162 (+)EnsemblGRCr8
mRatBN7.2412,736,177 - 13,162,956 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl412,736,130 - 13,162,211 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx417,880,111 - 18,309,565 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0413,705,793 - 14,126,350 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0412,061,189 - 12,495,212 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.049,347,533 - 9,774,257 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,347,528 - 9,773,670 (+)Ensemblrn6Rnor6.0
Rnor_5.049,349,408 - 9,775,894 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.448,150,873 - 8,609,141 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera48,330,632 - 8,754,202 (+)NCBICelera
RGSC_v3.148,150,872 - 8,609,141 (+)NCBI
Cytogenetic Map4q11NCBI
RELN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387103,471,789 - 103,989,658 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7103,471,381 - 103,989,658 (-)Ensemblhg38GRCh38
GRCh377103,112,236 - 103,630,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367102,899,473 - 103,417,198 (-)NCBIBuild 36Build 36hg18NCBI36
Build 347102,706,187 - 103,223,913NCBI
Celera797,918,553 - 98,435,889 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef797,472,665 - 97,989,692 (-)NCBIHuRef
CHM1_17103,045,544 - 103,563,285 (-)NCBICHM1_1
T2T-CHM13v2.07104,786,230 - 105,303,683 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27102,473,053 - 102,990,385 (-)NCBI
Reln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39522,089,452 - 22,549,703 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl522,089,452 - 22,549,700 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38521,884,454 - 22,344,705 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl521,884,454 - 22,344,702 (-)Ensemblmm10GRCm38
MGSCv37521,390,272 - 21,850,523 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36521,396,293 - 21,856,514 (-)NCBIMGSCv36mm8
Celera518,857,999 - 19,307,447 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map59.98NCBI
Reln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554108,424,394 - 8,863,969 (-)Ensembl
ChiLan1.0NW_0049554108,424,439 - 8,863,966 (-)NCBIChiLan1.0ChiLan1.0
RELN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26140,332,563 - 140,853,083 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17188,602,533 - 189,123,051 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0795,464,285 - 95,984,813 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17108,208,344 - 108,728,037 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7108,208,344 - 108,728,037 (-)EnsemblpanPan2panpan1.1
RELN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11816,275,822 - 16,773,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1816,275,837 - 16,773,875 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1815,920,416 - 16,416,804 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01816,579,791 - 17,064,382 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1816,579,785 - 17,064,382 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11816,349,469 - 16,829,572 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01816,282,254 - 16,767,463 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01816,555,196 - 17,036,210 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Reln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511858,504,719 - 58,964,509 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647919,628,940 - 20,087,250 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647919,628,488 - 20,088,278 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RELN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9103,460,863 - 103,963,883 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19103,460,855 - 103,963,728 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29114,069,880 - 114,180,603 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RELN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12172,440,988 - 72,951,173 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2172,440,160 - 72,950,747 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604231,044,210 - 31,561,114 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Reln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473925,472,561 - 25,918,167 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473925,472,626 - 25,918,064 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Reln
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16151,190,879 - 151,615,949 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Reln
4138 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:426
Count of miRNA genes:220
Interacting mature miRNAs:265
Transcripts:ENSRNOT00000010521, ENSRNOT00000061858
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)41308014658080146Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4128392287Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4131106810Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4128392287Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4128392287Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4842855130449094Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41075870140490708Rat

Markers in Region
D4Rat136  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8413,937,648 - 13,937,879 (+)Marker Load Pipeline
mRatBN7.2413,045,402 - 13,045,633 (+)MAPPERmRatBN7.2
Rnor_6.049,657,095 - 9,657,325NCBIRnor6.0
Rnor_5.049,658,484 - 9,658,714UniSTSRnor5.0
RGSC_v3.448,490,767 - 8,490,998RGDRGSC3.4
RGSC_v3.448,490,768 - 8,490,998UniSTSRGSC3.4
Celera48,637,529 - 8,637,759UniSTS
RGSC_v3.148,490,768 - 8,490,998RGD
RH 3.4 Map439.9UniSTS
RH 3.4 Map439.9RGD
RH 2.0 Map465.7RGD
SHRSP x BN Map40.0RGD
Cytogenetic Map4q11.2UniSTS
U24703  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2413,162,841 - 13,162,927 (+)MAPPERmRatBN7.2
Rnor_6.049,774,143 - 9,774,228NCBIRnor6.0
Rnor_5.049,775,780 - 9,775,865UniSTSRnor5.0
RGSC_v3.448,609,169 - 8,609,254UniSTSRGSC3.4
Celera48,754,230 - 8,754,315UniSTS
Cytogenetic Map4q11.2UniSTS
RH129604  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2413,162,714 - 13,162,894 (+)MAPPERmRatBN7.2
Rnor_6.049,774,016 - 9,774,195NCBIRnor6.0
Rnor_5.049,775,653 - 9,775,832UniSTSRnor5.0
RGSC_v3.448,609,042 - 8,609,221UniSTSRGSC3.4
Celera48,754,103 - 8,754,282UniSTS
Cytogenetic Map4q11.2UniSTS
BE108114  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2413,055,115 - 13,055,266 (+)MAPPERmRatBN7.2
Rnor_6.049,666,429 - 9,666,579NCBIRnor6.0
Rnor_5.049,667,818 - 9,667,968UniSTSRnor5.0
RGSC_v3.448,501,582 - 8,501,732UniSTSRGSC3.4
Celera48,646,654 - 8,646,804UniSTS
RH 3.4 Map441.7UniSTS
Cytogenetic Map4q11.2UniSTS
RH138906  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2413,068,522 - 13,068,659 (+)MAPPERmRatBN7.2
Rnor_6.049,679,836 - 9,679,972NCBIRnor6.0
Rnor_5.049,681,225 - 9,681,361UniSTSRnor5.0
RGSC_v3.448,514,989 - 8,515,125UniSTSRGSC3.4
Celera48,660,061 - 8,660,197UniSTS
RH 3.4 Map439.9UniSTS
Cytogenetic Map4q11.2UniSTS
RH140445  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2413,162,625 - 13,162,852 (+)MAPPERmRatBN7.2
Rnor_6.049,773,927 - 9,774,153NCBIRnor6.0
Rnor_5.049,775,564 - 9,775,790UniSTSRnor5.0
RGSC_v3.448,608,953 - 8,609,179UniSTSRGSC3.4
Celera48,754,014 - 8,754,240UniSTS
RH 3.4 Map441.4UniSTS
Cytogenetic Map4q11.2UniSTS
BF391264  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2412,823,106 - 12,823,329 (+)MAPPERmRatBN7.2
Rnor_6.049,435,815 - 9,436,037NCBIRnor6.0
Rnor_5.049,436,037 - 9,436,259UniSTSRnor5.0
RGSC_v3.448,257,094 - 8,257,316UniSTSRGSC3.4
Celera48,415,973 - 8,416,195UniSTS
RH 3.4 Map441.4UniSTS
Cytogenetic Map4q11.2UniSTS


Related Rat Strains
The following Strains have been annotated to Reln
KZC/Tky    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 80 59 6 341 180 11 142 78 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010521   ⟹   ENSRNOP00000010521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl413,628,399 - 14,054,847 (+)Ensembl
mRatBN7.2 Ensembl412,736,130 - 13,162,211 (+)Ensembl
Rnor_6.0 Ensembl49,347,528 - 9,773,670 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000061858   ⟹   ENSRNOP00000058574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl413,628,399 - 14,055,162 (+)Ensembl
mRatBN7.2 Ensembl412,736,130 - 13,162,211 (+)Ensembl
Rnor_6.0 Ensembl49,347,779 - 9,773,217 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129632   ⟹   ENSRNOP00000099957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl413,628,399 - 14,049,138 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000166047   ⟹   ENSRNOP00000101019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl413,628,541 - 14,055,162 (+)Ensembl
RefSeq Acc Id: NM_080394   ⟹   NP_536319
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8413,628,568 - 14,055,059 (+)NCBI
mRatBN7.2412,736,299 - 13,162,814 (+)NCBI
Rnor_6.049,347,607 - 9,774,115 (+)NCBI
Rnor_5.049,349,408 - 9,775,894 (+)NCBI
RGSC_v3.448,150,873 - 8,609,141 (+)RGD
Celera48,330,632 - 8,754,202 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235873   ⟹   XP_006235935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8413,628,451 - 14,055,201 (+)NCBI
mRatBN7.2412,736,177 - 13,162,956 (+)NCBI
Rnor_6.049,347,533 - 9,774,257 (+)NCBI
Rnor_5.049,349,408 - 9,775,894 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107060   ⟹   XP_038962988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8413,628,440 - 14,054,075 (+)NCBI
mRatBN7.2412,736,177 - 13,156,893 (+)NCBI
RefSeq Acc Id: XM_039107062   ⟹   XP_038962990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8413,628,451 - 14,054,075 (+)NCBI
mRatBN7.2412,736,177 - 13,156,893 (+)NCBI
RefSeq Acc Id: NP_536319   ⟸   NM_080394
- Peptide Label: precursor
- UniProtKB: Q80T65 (UniProtKB/Swiss-Prot),   P58751 (UniProtKB/Swiss-Prot),   F1LM29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235935   ⟸   XM_006235873
- Peptide Label: isoform X3
- UniProtKB: Q80T65 (UniProtKB/Swiss-Prot),   P58751 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010521   ⟸   ENSRNOT00000010521
Ensembl Acc Id: ENSRNOP00000058574   ⟸   ENSRNOT00000061858
RefSeq Acc Id: XP_038962988   ⟸   XM_039107060
- Peptide Label: isoform X1
- UniProtKB: A6K598 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962990   ⟸   XM_039107062
- Peptide Label: isoform X2
- UniProtKB: A6K598 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099957   ⟸   ENSRNOT00000129632
Ensembl Acc Id: ENSRNOP00000101019   ⟸   ENSRNOT00000166047
Protein Domains
EGF-like   Reelin

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692804
Promoter ID:EPDNEW_R3328
Type:single initiation site
Name:Reln_1
Description:reelin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.049,347,781 - 9,347,841EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3553 AgrOrtholog
BioCyc Gene G2FUF-45993 BioCyc
Ensembl Genes ENSRNOG00000021441 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000010521 ENTREZGENE
  ENSRNOT00000061858 ENTREZGENE
  ENSRNOT00000129632 ENTREZGENE
Gene3D-CATH 2.60.40.4060 UniProtKB/Swiss-Prot
  Galactose-binding domain-like UniProtKB/Swiss-Prot
InterPro EGF-like_dom UniProtKB/Swiss-Prot
  Reeler_dom UniProtKB/Swiss-Prot
  Reeler_sf UniProtKB/Swiss-Prot
  Reelin UniProtKB/Swiss-Prot
  Reelin_subrepeat-B UniProtKB/Swiss-Prot
  Sialidase_sf UniProtKB/Swiss-Prot
KEGG Report rno:24718 UniProtKB/Swiss-Prot
NCBI Gene 24718 ENTREZGENE
PANTHER PTHR11841 UniProtKB/Swiss-Prot
  REELIN UniProtKB/Swiss-Prot
Pfam EGF_Teneurin UniProtKB/Swiss-Prot
  Reelin_subrepeat-B UniProtKB/Swiss-Prot
PhenoGen Reln PhenoGen
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  REELIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021441 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50939 UniProtKB/Swiss-Prot
UniProt A0ABK0KYD2_RAT UniProtKB/TrEMBL
  A0ABK0L7W6_RAT UniProtKB/TrEMBL
  A6K598 ENTREZGENE, UniProtKB/TrEMBL
  F1LM29 ENTREZGENE, UniProtKB/TrEMBL
  F1LZI7_RAT UniProtKB/TrEMBL
  P58751 ENTREZGENE
  Q80T65 ENTREZGENE
  RELN_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q80T65 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2001-05-08 Reln  Reelin      Name changed to reflect Human and Mouse nomenclature 62408 APPROVED
2001-05-08 Reln  Reeler      Name withdrawn, does not match Human and Mouse nomenclature 62408 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_disease mutation causes the autosomal recessive mutant creeping (cre) in the Komeda Zucker creeping (KZC) rat strain 727518
gene_disease mutation causes the autosomal recessive reeler-like abnormal locomoter phenotype in the shaking rat Kawasaki (SRK) 729917