Klk6 (kallikrein related-peptidase 6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Klk6 (kallikrein related-peptidase 6) Rattus norvegicus
Analyze
Symbol: Klk6
Name: kallikrein related-peptidase 6
RGD ID: 3419
Description: Enables peptidase activity. Involved in regulation of neuron projection development. Predicted to be located in several cellular components, including extracellular region; intercellular bridge; and nucleus. Predicted to be active in cornified envelope; extracellular space; and secretory granule. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; demyelinating disease; and multiple system atrophy. Orthologous to human KLK6 (kallikrein related peptidase 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kallikrein 6; kallikrein 6 (neurosin zyme); kallikrein 6 (neurosin); kallikrein 6 (neurosin, zyme); kallikrein i; kallikrein-6; Klni; protease serine 9; protease serine 9 (neurosin); protease, serine, 9; Prss9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,415,411 - 103,422,682 (+)NCBIGRCr8
mRatBN7.2194,278,863 - 94,286,136 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,280,340 - 94,286,121 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,664,377 - 99,671,533 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,137,048 - 108,144,202 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,426,648 - 101,433,802 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,762,195 - 99,769,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,762,253 - 99,769,488 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01100,830,974 - 100,838,254 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,254,350 - 94,261,500 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1194,332,460 - 94,339,610 (+)NCBI
Celera188,546,437 - 88,553,549 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
demyelination  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Enzymatic properties of rat myelencephalon-specific protease. Blaber SI, etal., Biochemistry. 2002 Jan 29;41(4):1165-73.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat. Iwai N, etal., Hypertension 2005 May;45(5):947-53. Epub 2005 Apr 4.
5. Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. Iwata A, etal., Hum Mol Genet 2003 Oct 15;12(20):2625-35. Epub 2003 Aug 19.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease. Mitsui S, etal., Ann N Y Acad Sci 2002 Nov;977:216-23.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues. Petraki CD, etal., Prostate Cancer Prostatic Dis. 2003;6(3):223-7.
10. Prognostic implications of the immunohistochemical expression of human kallikreins 5, 6, 10 and 11 in renal cell carcinoma. Petraki CD, etal., Tumour Biol. 2006;27(1):1-7. Epub 2005 Dec 8.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Activity of a newly identified serine protease in CNS demyelination. Scarisbrick IA, etal., Brain 2002 Jun;125(Pt 6):1283-96.
15. Dynamic role of kallikrein 6 in traumatic spinal cord injury. Scarisbrick IA, etal., Eur J Neurosci. 2006 Sep;24(5):1457-69.
16. Nervous system-specific expression of a novel serine protease: regulation in the adult rat spinal cord by excitotoxic injury. Scarisbrick IA, etal., J Neurosci 1997 Nov 1;17(21):8156-68.
17. Ovarian cancer specific kallikrein profile in effusions. Shih IeM, etal., Gynecol Oncol. 2007 May;105(2):501-7. Epub 2007 Feb 15.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. [Expression of KLK6 protein and mRNA in primary breast cancer and its clinical significance.] Wang SM, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Nov;24(11):1087-9.
20. Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients. Zarghooni M, etal., Clin Biochem 2002 May;35(3):225-31.
Additional References at PubMed
PMID:11668196   PMID:16502470   PMID:16885167   PMID:22166940   PMID:36382482  


Genomics

Comparative Map Data
Klk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,415,411 - 103,422,682 (+)NCBIGRCr8
mRatBN7.2194,278,863 - 94,286,136 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,280,340 - 94,286,121 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,664,377 - 99,671,533 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,137,048 - 108,144,202 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,426,648 - 101,433,802 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,762,195 - 99,769,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,762,253 - 99,769,488 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01100,830,974 - 100,838,254 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,254,350 - 94,261,500 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1194,332,460 - 94,339,610 (+)NCBI
Celera188,546,437 - 88,553,549 (+)NCBICelera
Cytogenetic Map1q22NCBI
KLK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,958,631 - 50,969,591 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1950,958,631 - 50,969,673 (-)EnsemblGRCh38hg38GRCh38
GRCh371951,461,887 - 51,472,847 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,153,699 - 56,164,741 (-)NCBINCBI36Build 36hg18NCBI36
Build 341956,153,699 - 56,164,741NCBI
Celera1948,512,220 - 48,523,480 (-)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1947,794,177 - 47,805,721 (-)NCBIHuRef
CHM1_11951,463,632 - 51,474,713 (-)NCBICHM1_1
T2T-CHM13v2.01954,046,713 - 54,057,995 (-)NCBIT2T-CHM13v2.0
Klk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,473,967 - 43,481,219 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,473,923 - 43,481,454 (+)EnsemblGRCm39 Ensembl
GRCm38743,824,438 - 43,832,027 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl743,824,499 - 43,832,030 (+)EnsemblGRCm38mm10GRCm38
MGSCv37751,079,914 - 51,087,397 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36743,693,492 - 43,699,828 (+)NCBIMGSCv36mm8
Celera739,293,226 - 39,300,707 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.28NCBI
Klk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555581,502,881 - 1,509,558 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555581,501,806 - 1,509,461 (+)NCBIChiLan1.0ChiLan1.0
KLK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22057,028,080 - 57,039,362 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11958,948,642 - 58,959,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01947,925,017 - 47,936,314 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11956,815,073 - 56,826,689 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,815,073 - 56,826,689 (-)Ensemblpanpan1.1panPan2
KLK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11105,902,147 - 105,907,585 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,474,567 - 105,482,203 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,409,595 - 106,419,174 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1106,406,669 - 106,433,683 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11106,082,387 - 106,090,003 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,723,801 - 105,731,455 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,519,343 - 106,526,983 (+)NCBIUU_Cfam_GSD_1.0
Klk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,745,642 - 22,753,731 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889621,630 - 629,678 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936889621,645 - 628,454 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,629,991 - 55,638,080 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,629,983 - 55,639,215 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KLK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1643,980,680 - 43,991,873 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl643,980,701 - 43,990,060 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607324,005,498 - 24,016,398 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klk6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248323,785,644 - 3,793,074 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248323,785,727 - 3,793,078 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klk6
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:66
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000065876
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat

Markers in Region
MCMA27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2194,281,963 - 94,282,284 (+)MAPPERmRatBN7.2
Rnor_6.0199,765,318 - 99,765,638NCBIRnor6.0
Rnor_5.01100,834,076 - 100,834,396UniSTSRnor5.0
RGSC_v3.4194,257,344 - 94,257,664UniSTSRGSC3.4
Celera188,549,431 - 88,549,751UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 4 7 58 35 40 11 15 11 6 61 34 44 6 27 29

Sequence


Ensembl Acc Id: ENSRNOT00000065876   ⟹   ENSRNOP00000060676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl194,280,340 - 94,286,121 (+)Ensembl
Rnor_6.0 Ensembl199,762,253 - 99,769,488 (+)Ensembl
RefSeq Acc Id: NM_019175   ⟹   NP_062048
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81103,415,516 - 103,422,668 (+)NCBI
mRatBN7.2194,278,970 - 94,286,122 (+)NCBI
Rnor_6.0199,762,324 - 99,769,472 (+)NCBI
Rnor_5.01100,830,974 - 100,838,254 (+)NCBI
RGSC_v3.4194,254,350 - 94,261,500 (+)RGD
Celera188,546,437 - 88,553,549 (+)RGD
Sequence:
RefSeq Acc Id: XM_006228982   ⟹   XP_006229044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81103,415,411 - 103,422,682 (+)NCBI
mRatBN7.2194,278,863 - 94,286,136 (+)NCBI
Rnor_6.0199,762,195 - 99,769,486 (+)NCBI
Rnor_5.01100,830,974 - 100,838,254 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_062048 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229044 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC02300 (Get FASTA)   NCBI Sequence Viewer  
  EDM07531 (Get FASTA)   NCBI Sequence Viewer  
  EDM07532 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060676.1
GenBank Protein SFW93265 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062048   ⟸   NM_019175
- Peptide Label: precursor
- UniProtKB: O54854 (UniProtKB/TrEMBL),   F7F6H9 (UniProtKB/TrEMBL),   A0A1R3UDT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229044   ⟸   XM_006228982
- Peptide Label: isoform X1
- UniProtKB: O54854 (UniProtKB/TrEMBL),   F7F6H9 (UniProtKB/TrEMBL),   A0A1R3UDT9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060676   ⟸   ENSRNOT00000065876
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54854-F1-model_v2 AlphaFold O54854 1-251 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3419 AgrOrtholog
BioCyc Gene G2FUF-59818 BioCyc
Ensembl Genes ENSRNOG00000031927 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065876.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  Serine_Proteases_S1 UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:29245 UniProtKB/TrEMBL
NCBI Gene 29245 ENTREZGENE
PANTHER RIKEN CDNA 2210010C04 GENE UniProtKB/TrEMBL
  TRYPSIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Klk6 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031927 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
TIGR TC233233
UniProt A0A1R3UDT9 ENTREZGENE, UniProtKB/TrEMBL
  F7F6H9 ENTREZGENE, UniProtKB/TrEMBL
  O54854 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Klk6  kallikrein related-peptidase 6  Klk6  kallikrein 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Klk6  kallikrein 6    kallikrein 6   Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Klk6  kallikrein 6       Name updated 70585 PROVISIONAL
2001-12-10 Klk6  kallikrein 6 (neurosin)      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is 10 fold greater in the spinal cord and 4 fold greater in the medulla oblongata as compared to the other tissues 69940
gene_homology sequence similar to neuropsin and trypsin 69940
gene_process may be involved in normal homeostasis and the response of the spinal cord to injury 69940