Klk6 (kallikrein related-peptidase 6) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Klk6 (kallikrein related-peptidase 6) Rattus norvegicus
Analyze
Symbol: Klk6
Name: kallikrein related-peptidase 6
RGD ID: 3419
Description: Enables peptidase activity. Involved in regulation of neuron projection development. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in cornified envelope; extracellular space; and secretory granule. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; demyelinating disease; and multiple system atrophy. Orthologous to human KLK6 (kallikrein related peptidase 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kallikrein 6; kallikrein 6 (neurosin zyme); kallikrein 6 (neurosin); kallikrein 6 (neurosin, zyme); kallikrein i; kallikrein-6; Klni; protease serine 9; protease serine 9 (neurosin); protease, serine, 9; Prss9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,415,411 - 103,422,682 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1103,416,886 - 103,422,690 (+)EnsemblGRCr8
mRatBN7.2194,278,863 - 94,286,136 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,280,340 - 94,286,121 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx199,664,377 - 99,671,533 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,137,048 - 108,144,202 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,426,648 - 101,433,802 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,762,195 - 99,769,486 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,762,253 - 99,769,488 (+)Ensemblrn6Rnor6.0
Rnor_5.01100,830,974 - 100,838,254 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4194,254,350 - 94,261,500 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera188,546,437 - 88,553,549 (+)NCBICelera
RGSC_v3.1194,332,460 - 94,339,610 (+)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
demyelination  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Enzymatic properties of rat myelencephalon-specific protease. Blaber SI, etal., Biochemistry. 2002 Jan 29;41(4):1165-73.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat. Iwai N, etal., Hypertension 2005 May;45(5):947-53. Epub 2005 Apr 4.
5. Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. Iwata A, etal., Hum Mol Genet 2003 Oct 15;12(20):2625-35. Epub 2003 Aug 19.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease. Mitsui S, etal., Ann N Y Acad Sci 2002 Nov;977:216-23.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues. Petraki CD, etal., Prostate Cancer Prostatic Dis. 2003;6(3):223-7.
10. Prognostic implications of the immunohistochemical expression of human kallikreins 5, 6, 10 and 11 in renal cell carcinoma. Petraki CD, etal., Tumour Biol. 2006;27(1):1-7. Epub 2005 Dec 8.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Activity of a newly identified serine protease in CNS demyelination. Scarisbrick IA, etal., Brain 2002 Jun;125(Pt 6):1283-96.
15. Dynamic role of kallikrein 6 in traumatic spinal cord injury. Scarisbrick IA, etal., Eur J Neurosci. 2006 Sep;24(5):1457-69.
16. Nervous system-specific expression of a novel serine protease: regulation in the adult rat spinal cord by excitotoxic injury. Scarisbrick IA, etal., J Neurosci 1997 Nov 1;17(21):8156-68.
17. Ovarian cancer specific kallikrein profile in effusions. Shih IeM, etal., Gynecol Oncol. 2007 May;105(2):501-7. Epub 2007 Feb 15.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. [Expression of KLK6 protein and mRNA in primary breast cancer and its clinical significance.] Wang SM, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Nov;24(11):1087-9.
20. Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients. Zarghooni M, etal., Clin Biochem 2002 May;35(3):225-31.
Additional References at PubMed
PMID:11668196   PMID:16502470   PMID:16885167   PMID:22166940   PMID:36382482  


Genomics

Comparative Map Data
Klk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,415,411 - 103,422,682 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1103,416,886 - 103,422,690 (+)EnsemblGRCr8
mRatBN7.2194,278,863 - 94,286,136 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,280,340 - 94,286,121 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx199,664,377 - 99,671,533 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,137,048 - 108,144,202 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,426,648 - 101,433,802 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,762,195 - 99,769,486 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,762,253 - 99,769,488 (+)Ensemblrn6Rnor6.0
Rnor_5.01100,830,974 - 100,838,254 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4194,254,350 - 94,261,500 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera188,546,437 - 88,553,549 (+)NCBICelera
RGSC_v3.1194,332,460 - 94,339,610 (+)NCBI
Cytogenetic Map1q22NCBI
KLK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,958,631 - 50,969,591 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1950,958,631 - 50,969,673 (-)Ensemblhg38GRCh38
GRCh371951,461,887 - 51,472,847 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,153,699 - 56,164,741 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341956,153,699 - 56,164,741NCBI
Celera1948,512,220 - 48,523,480 (-)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1947,794,177 - 47,805,721 (-)NCBIHuRef
CHM1_11951,463,632 - 51,474,713 (-)NCBICHM1_1
T2T-CHM13v2.01954,046,713 - 54,057,995 (-)NCBIT2T-CHM13v2.0
Klk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,473,967 - 43,481,219 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,473,923 - 43,481,454 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38743,824,438 - 43,832,027 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl743,824,499 - 43,832,030 (+)Ensemblmm10GRCm38
MGSCv37751,079,914 - 51,087,397 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36743,693,492 - 43,699,828 (+)NCBIMGSCv36mm8
Celera739,293,226 - 39,300,707 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.28NCBI
Klk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555581,502,881 - 1,509,558 (+)Ensembl
ChiLan1.0NW_0049555581,501,806 - 1,509,461 (+)NCBIChiLan1.0ChiLan1.0
KLK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22057,028,080 - 57,039,362 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11958,948,642 - 58,959,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01947,925,017 - 47,936,314 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11956,815,073 - 56,826,689 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,815,073 - 56,826,689 (-)EnsemblpanPan2panpan1.1
KLK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11105,902,147 - 105,907,585 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,474,567 - 105,482,203 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01106,409,595 - 106,419,174 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1106,406,669 - 106,433,683 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11106,082,387 - 106,090,003 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,723,801 - 105,731,455 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,519,343 - 106,526,983 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Klk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,745,642 - 22,753,731 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889621,630 - 629,678 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936889621,645 - 628,454 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,629,991 - 55,638,080 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1655,629,983 - 55,639,215 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KLK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1643,980,680 - 43,991,873 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl643,980,701 - 43,990,060 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607324,005,498 - 24,016,398 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klk6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248323,785,644 - 3,793,074 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248323,785,727 - 3,793,078 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Klk6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12155,560,835 - 155,568,113 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Klk6
128 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:66
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000065876
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
MCMA27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2194,281,963 - 94,282,284 (+)MAPPERmRatBN7.2
Rnor_6.0199,765,318 - 99,765,638NCBIRnor6.0
Rnor_5.01100,834,076 - 100,834,396UniSTSRnor5.0
RGSC_v3.4194,257,344 - 94,257,664UniSTSRGSC3.4
Celera188,549,431 - 88,549,751UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
12 4 11 80 35 40 11 17 11 6 76 40 66 9 33 29

Sequence


Ensembl Acc Id: ENSRNOT00000065876   ⟹   ENSRNOP00000060676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1103,416,886 - 103,422,690 (+)Ensembl
mRatBN7.2 Ensembl194,280,340 - 94,286,121 (+)Ensembl
Rnor_6.0 Ensembl199,762,253 - 99,769,488 (+)Ensembl
RefSeq Acc Id: NM_019175   ⟹   NP_062048
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81103,415,516 - 103,422,668 (+)NCBI
mRatBN7.2194,278,970 - 94,286,122 (+)NCBI
Rnor_6.0199,762,324 - 99,769,472 (+)NCBI
Rnor_5.01100,830,974 - 100,838,254 (+)NCBI
RGSC_v3.4194,254,350 - 94,261,500 (+)RGD
Celera188,546,437 - 88,553,549 (+)RGD
Sequence:
RefSeq Acc Id: XM_006228982   ⟹   XP_006229044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81103,415,411 - 103,422,682 (+)NCBI
mRatBN7.2194,278,863 - 94,286,136 (+)NCBI
Rnor_6.0199,762,195 - 99,769,486 (+)NCBI
Rnor_5.01100,830,974 - 100,838,254 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_062048 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229044 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC02300 (Get FASTA)   NCBI Sequence Viewer  
  EDM07531 (Get FASTA)   NCBI Sequence Viewer  
  EDM07532 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060676
  ENSRNOP00000060676.1
GenBank Protein SFW93265 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062048   ⟸   NM_019175
- Peptide Label: precursor
- UniProtKB: O54854 (UniProtKB/TrEMBL),   F7F6H9 (UniProtKB/TrEMBL),   A0A1R3UDT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229044   ⟸   XM_006228982
- Peptide Label: isoform X1
- UniProtKB: O54854 (UniProtKB/TrEMBL),   F7F6H9 (UniProtKB/TrEMBL),   A0A1R3UDT9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060676   ⟸   ENSRNOT00000065876
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54854-F1-model_v2 AlphaFold O54854 1-251 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3419 AgrOrtholog
BioCyc Gene G2FUF-59818 BioCyc
Ensembl Genes ENSRNOG00000031927 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065876 ENTREZGENE
  ENSRNOT00000065876.4 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:29245 UniProtKB/TrEMBL
NCBI Gene 29245 ENTREZGENE
PANTHER KALLIKREIN-6 UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Klk6 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031927 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
TIGR TC233233
UniProt A0A1R3UDT9 ENTREZGENE, UniProtKB/TrEMBL
  F7F6H9 ENTREZGENE, UniProtKB/TrEMBL
  O54854 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Klk6  kallikrein related-peptidase 6  Klk6  kallikrein 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Klk6  kallikrein 6    kallikrein 6   Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Klk6  kallikrein 6       Name updated 70585 PROVISIONAL
2001-12-10 Klk6  kallikrein 6 (neurosin)      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is 10 fold greater in the spinal cord and 4 fold greater in the medulla oblongata as compared to the other tissues 69940
gene_homology sequence similar to neuropsin and trypsin 69940
gene_process may be involved in normal homeostasis and the response of the spinal cord to injury 69940