Mpdz (multiple PDZ domain crumbs cell polarity complex component) - Rat Genome Database

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Gene: Mpdz (multiple PDZ domain crumbs cell polarity complex component) Rattus norvegicus
Analyze
Symbol: Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
RGD ID: 3105
Description: Involved in myelination. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human MPDZ (multiple PDZ domain crumbs cell polarity complex component); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: multi-PDZ domain protein 1; multiple PDZ domain protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85100,812,121 - 100,966,566 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5100,812,124 - 100,966,504 (-)EnsemblGRCr8
mRatBN7.2595,766,112 - 95,920,531 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl595,766,118 - 95,920,499 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx598,137,388 - 98,291,673 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0599,947,068 - 100,102,219 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0599,948,242 - 100,102,527 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0599,413,184 - 99,566,356 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl599,413,187 - 99,566,318 (-)Ensemblrn6Rnor6.0
Rnor_5.05103,442,806 - 103,596,600 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45100,008,984 - 100,170,202 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera594,336,315 - 94,488,569 (-)NCBICelera
RGSC_v3.15100,014,212 - 100,175,428 (-)NCBI
Cytogenetic Map5q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldrin  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bicuculline  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chloroethene  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
folic acid  (ISO)
FR900359  (ISO)
glafenine  (EXP)
hexadecanoic acid  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
kainic acid  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
N-nitrosodiethylamine  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentetrazol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
protein binding  (IPI,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. Griffon N, etal., Brain Res Mol Brain Res 2003 Sep 10;117(1):47-57.
4. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Krapivinsky G, etal., Neuron. 2004 Aug 19;43(4):563-74. doi: 10.1016/j.neuron.2004.08.003.
5. Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins. Lee SS, etal., J Virol. 2000 Oct;74(20):9680-93.
6. Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions. Liew CW, etal., FEBS Lett. 2009 Jan 5;583(1):49-54. doi: 10.1016/j.febslet.2008.11.048. Epub 2008 Dec 9.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells. Poliak S, etal., J Cell Biol 2002 Oct 28;159(2):361-72.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. Cloning and characterization of MUPP1, a novel PDZ domain protein. Ullmer C, etal., FEBS Lett 1998 Mar 6;424(1-2):63-8.
Additional References at PubMed
PMID:10967549   PMID:11150294   PMID:11689568   PMID:11802782   PMID:15364909   PMID:15863617   PMID:17397395   PMID:17894389   PMID:18417361   PMID:18537874   PMID:19934217   PMID:20237282  
PMID:25977097  


Genomics

Comparative Map Data
Mpdz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85100,812,121 - 100,966,566 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5100,812,124 - 100,966,504 (-)EnsemblGRCr8
mRatBN7.2595,766,112 - 95,920,531 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl595,766,118 - 95,920,499 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx598,137,388 - 98,291,673 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0599,947,068 - 100,102,219 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0599,948,242 - 100,102,527 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0599,413,184 - 99,566,356 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl599,413,187 - 99,566,318 (-)Ensemblrn6Rnor6.0
Rnor_5.05103,442,806 - 103,596,600 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45100,008,984 - 100,170,202 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera594,336,315 - 94,488,569 (-)NCBICelera
RGSC_v3.15100,014,212 - 100,175,428 (-)NCBI
Cytogenetic Map5q31NCBI
MPDZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38913,105,707 - 13,279,692 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl913,104,620 - 13,279,790 (-)Ensemblhg38GRCh38
GRCh37913,105,706 - 13,279,691 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36913,095,703 - 13,240,365 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34913,096,575 - 13,240,357NCBI
Celera913,038,280 - 13,183,037 (-)NCBICelera
Cytogenetic Map9p23NCBI
HuRef913,069,879 - 13,214,632 (-)NCBIHuRef
CHM1_1913,105,992 - 13,279,791 (-)NCBICHM1_1
T2T-CHM13v2.0913,115,022 - 13,289,091 (-)NCBIT2T-CHM13v2.0
Mpdz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39481,196,736 - 81,361,112 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl481,196,742 - 81,361,052 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38481,278,499 - 81,442,897 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl481,278,500 - 81,442,815 (-)Ensemblmm10GRCm38
MGSCv37480,924,404 - 81,088,709 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36480,750,824 - 80,913,903 (-)NCBIMGSCv36mm8
Celera479,839,558 - 79,997,048 (-)NCBICelera
Cytogenetic Map4C3NCBI
cM Map438.0NCBI
Mpdz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543416,284,123 - 16,418,092 (-)Ensembl
ChiLan1.0NW_00495543416,284,123 - 16,431,853 (-)NCBIChiLan1.0ChiLan1.0
MPDZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211111,253,670 - 111,430,166 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19111,259,645 - 111,436,524 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0912,943,252 - 13,120,126 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1913,390,642 - 13,564,246 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl913,391,903 - 13,535,292 (-)EnsemblpanPan2panpan1.1
MPDZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11133,691,434 - 33,826,500 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1133,692,296 - 33,826,437 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1132,400,323 - 32,561,595 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01134,595,030 - 34,756,348 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1134,595,575 - 34,756,388 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11133,300,994 - 33,462,185 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01133,086,512 - 33,254,154 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01133,749,245 - 33,910,664 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mpdz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947148,481,482 - 148,631,516 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365396,932,473 - 7,084,227 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365396,934,180 - 7,084,117 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPDZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1209,181,467 - 209,349,297 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11209,181,441 - 209,351,797 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21233,122,084 - 233,215,771 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MPDZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11266,275,725 - 66,450,398 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1266,304,514 - 66,449,110 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603854,508,794 - 54,683,624 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mpdz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473617,397,405 - 17,533,674 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473617,392,132 - 17,555,612 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mpdz
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1172,186,554 - 72,333,973 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mpdz
1092 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:89
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000051028
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)573779642103472210Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)565089051103648916Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat

Markers in Region
D5Rat98  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85100,820,198 - 100,820,403 (+)Marker Load Pipeline
mRatBN7.2595,774,194 - 95,774,399 (+)MAPPERmRatBN7.2
Rnor_6.0599,421,434 - 99,421,638NCBIRnor6.0
Rnor_5.05103,451,053 - 103,451,257UniSTSRnor5.0
RGSC_v3.45100,017,060 - 100,017,265RGDRGSC3.4
RGSC_v3.45100,017,061 - 100,017,265UniSTSRGSC3.4
Celera594,344,392 - 94,344,614UniSTS
RGSC_v3.15100,022,287 - 100,022,491RGD
RH 3.4 Map5724.1UniSTS
RH 3.4 Map5724.1RGD
RH 2.0 Map5603.7RGD
SHRSP x BN Map553.5899RGD
Cytogenetic Map5q31UniSTS
D5Got256  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85100,906,872 - 100,907,091 (+)Marker Load Pipeline
mRatBN7.2595,860,869 - 95,861,088 (+)MAPPERmRatBN7.2
Rnor_6.0599,506,864 - 99,507,082NCBIRnor6.0
Rnor_5.05103,537,072 - 103,537,290UniSTSRnor5.0
RGSC_v3.45100,111,273 - 100,111,491UniSTSRGSC3.4
Celera594,430,290 - 94,430,492UniSTS
Cytogenetic Map5q31UniSTS
D5Got312  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,793,950 - 95,794,214 (+)MAPPERmRatBN7.2
Rnor_6.0599,440,546 - 99,440,809NCBIRnor6.0
Rnor_5.05103,470,165 - 103,470,428UniSTSRnor5.0
RGSC_v3.45100,037,650 - 100,037,913UniSTSRGSC3.4
Celera594,363,928 - 94,364,189UniSTS
Cytogenetic Map5q31UniSTS
RH138353  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,782,346 - 95,782,503 (+)MAPPERmRatBN7.2
Rnor_6.0599,429,135 - 99,429,291NCBIRnor6.0
Rnor_5.05103,458,754 - 103,458,910UniSTSRnor5.0
RGSC_v3.45100,025,212 - 100,025,368UniSTSRGSC3.4
Celera594,352,561 - 94,352,717UniSTS
RH 3.4 Map5749.3UniSTS
Cytogenetic Map5q31UniSTS
RH134440  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,766,308 - 95,766,513 (+)MAPPERmRatBN7.2
Rnor_6.0599,413,381 - 99,413,585NCBIRnor6.0
Rnor_5.05103,443,000 - 103,443,204UniSTSRnor5.0
RGSC_v3.45100,009,178 - 100,009,382UniSTSRGSC3.4
Celera594,336,509 - 94,336,713UniSTS
RH 3.4 Map5749.5UniSTS
Cytogenetic Map5q31UniSTS
AU046394  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,793,950 - 95,794,188 (+)MAPPERmRatBN7.2
Rnor_6.0599,440,546 - 99,440,783NCBIRnor6.0
Rnor_5.05103,470,165 - 103,470,402UniSTSRnor5.0
RGSC_v3.45100,037,650 - 100,037,887UniSTSRGSC3.4
Celera594,363,928 - 94,364,163UniSTS
Cytogenetic Map5q31UniSTS
Mpdz  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,874,646 - 95,875,800 (+)MAPPERmRatBN7.2
Rnor_6.0599,520,641 - 99,521,794NCBIRnor6.0
Rnor_5.05103,550,849 - 103,552,002UniSTSRnor5.0
RGSC_v3.45100,125,050 - 100,126,203UniSTSRGSC3.4
Celera594,444,045 - 94,445,198UniSTS
Cytogenetic Map5q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 49 59 6 313 149 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ001320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000051028   ⟹   ENSRNOP00000051321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5100,812,124 - 100,966,504 (-)Ensembl
mRatBN7.2 Ensembl595,766,118 - 95,920,499 (-)Ensembl
Rnor_6.0 Ensembl599,413,190 - 99,566,317 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089235   ⟹   ENSRNOP00000072433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5100,812,124 - 100,966,504 (-)Ensembl
mRatBN7.2 Ensembl595,766,118 - 95,920,499 (-)Ensembl
Rnor_6.0 Ensembl599,413,187 - 99,566,318 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099740   ⟹   ENSRNOP00000081232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5100,812,124 - 100,942,823 (-)Ensembl
mRatBN7.2 Ensembl595,766,118 - 95,896,820 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105796   ⟹   ENSRNOP00000088952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5100,812,124 - 100,966,504 (-)Ensembl
mRatBN7.2 Ensembl595,766,118 - 95,920,499 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108047   ⟹   ENSRNOP00000095980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5100,812,124 - 100,966,504 (-)Ensembl
mRatBN7.2 Ensembl595,766,118 - 95,920,499 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112827   ⟹   ENSRNOP00000092356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5100,812,124 - 100,942,823 (-)Ensembl
mRatBN7.2 Ensembl595,766,118 - 95,896,820 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154665   ⟹   ENSRNOP00000107991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5100,812,124 - 100,966,504 (-)Ensembl
RefSeq Acc Id: NM_019196   ⟹   NP_062069
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,504 (-)NCBI
mRatBN7.2595,766,115 - 95,920,499 (-)NCBI
Rnor_6.0599,413,187 - 99,566,317 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
RGSC_v3.45100,008,984 - 100,170,202 (-)RGD
Celera594,336,315 - 94,488,569 (-)RGD
Sequence:
RefSeq Acc Id: XM_006238340   ⟹   XP_006238402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,112 - 95,920,527 (-)NCBI
Rnor_6.0599,413,184 - 99,566,356 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238341   ⟹   XP_006238403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,973 - 95,920,526 (-)NCBI
Rnor_6.0599,414,045 - 99,566,356 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238342   ⟹   XP_006238404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,973 - 95,920,527 (-)NCBI
Rnor_6.0599,414,045 - 99,566,356 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238343   ⟹   XP_006238405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,973 - 95,920,525 (-)NCBI
Rnor_6.0599,414,045 - 99,566,355 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238344   ⟹   XP_006238406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,973 - 95,920,526 (-)NCBI
Rnor_6.0599,414,045 - 99,566,355 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109363   ⟹   XP_038965291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,973 - 95,920,528 (-)NCBI
RefSeq Acc Id: XM_039109364   ⟹   XP_038965292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,973 - 95,920,527 (-)NCBI
RefSeq Acc Id: XM_039109365   ⟹   XP_038965293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
mRatBN7.2595,766,973 - 95,920,531 (-)NCBI
RefSeq Acc Id: XM_039109366   ⟹   XP_038965294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,892,791 (-)NCBI
mRatBN7.2595,766,973 - 95,846,788 (-)NCBI
RefSeq Acc Id: XM_063287255   ⟹   XP_063143325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
RefSeq Acc Id: XM_063287256   ⟹   XP_063143326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85100,812,121 - 100,966,566 (-)NCBI
RefSeq Acc Id: NP_062069   ⟸   NM_019196
- UniProtKB: O55164 (UniProtKB/Swiss-Prot),   A6J832 (UniProtKB/TrEMBL),   A0A8I6AGX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238404   ⟸   XM_006238342
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GLE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238405   ⟸   XM_006238343
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006238406   ⟸   XM_006238344
- Peptide Label: isoform X8
- UniProtKB: A0A8I6GLE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238403   ⟸   XM_006238341
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GLE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238402   ⟸   XM_006238340
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000072433   ⟸   ENSRNOT00000089235
Ensembl Acc Id: ENSRNOP00000051321   ⟸   ENSRNOT00000051028
RefSeq Acc Id: XP_038965293   ⟸   XM_039109365
- Peptide Label: isoform X9
- UniProtKB: A0A8I6AAR0 (UniProtKB/TrEMBL),   A0A8I6GLE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965291   ⟸   XM_039109363
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AGX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965292   ⟸   XM_039109364
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AGX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965294   ⟸   XM_039109366
- Peptide Label: isoform X11
Ensembl Acc Id: ENSRNOP00000095980   ⟸   ENSRNOT00000108047
Ensembl Acc Id: ENSRNOP00000092356   ⟸   ENSRNOT00000112827
Ensembl Acc Id: ENSRNOP00000081232   ⟸   ENSRNOT00000099740
Ensembl Acc Id: ENSRNOP00000088952   ⟸   ENSRNOT00000105796
RefSeq Acc Id: XP_063143326   ⟸   XM_063287256
- Peptide Label: isoform X10
- UniProtKB: A0A8I6GLE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143325   ⟸   XM_063287255
- Peptide Label: isoform X7
- UniProtKB: A0A8I6GLE5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107991   ⟸   ENSRNOT00000154665
Protein Domains
L27   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55164-F1-model_v2 AlphaFold O55164 1-2054 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693818
Promoter ID:EPDNEW_R4340
Type:initiation region
Name:Mpdz_1
Description:multiple PDZ domain crumbs cell polarity complex component
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0599,566,344 - 99,566,404EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3105 AgrOrtholog
BioCyc Gene G2FUF-40910 BioCyc
Ensembl Genes ENSRNOG00000007894 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000051028 ENTREZGENE
  ENSRNOT00000089235 ENTREZGENE
  ENSRNOT00000105796 ENTREZGENE
  ENSRNOT00000108047 ENTREZGENE
  ENSRNOT00000154665 ENTREZGENE
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
  L27 domain UniProtKB/Swiss-Prot
InterPro L27_2 UniProtKB/Swiss-Prot
  L27_dom UniProtKB/Swiss-Prot
  L27_dom_sf UniProtKB/Swiss-Prot
  MPDZ UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_scaffold UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
KEGG Report rno:29365 UniProtKB/Swiss-Prot
NCBI Gene 29365 ENTREZGENE
PANTHER MULTIPLE PDZ DOMAIN PROTEIN UniProtKB/Swiss-Prot
  PDZ DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam L27_2 UniProtKB/Swiss-Prot
  MPDZ_u10 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
PhenoGen Mpdz PhenoGen
PROSITE L27 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007894 RatGTEx
SMART L27 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF101288 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
TIGR TC231731
UniProt A0A0G2K2Y8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AAR0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGX6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G7P8_RAT UniProtKB/TrEMBL
  A0A8I6GLE5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QPJ0 ENTREZGENE, UniProtKB/TrEMBL
  A6J832 ENTREZGENE, UniProtKB/TrEMBL
  MPDZ_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Mpdz  multiple PDZ domain crumbs cell polarity complex component  Mpdz  multiple PDZ domain protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mpdz  multiple PDZ domain protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains thirteen PDZ domains and no obvious catalytic domain 69894
gene_expression abundant in the brain 69894
gene_physical_interaction interacts with the C-terminal domain of the 5-HT2C receptor 69894